Vincent G Bain

Summary

Affiliation: University of Alberta
Country: Canada

Publications

  1. ncbi request reprint Prospective study of biliary strictures to determine the predictors of malignancy
    V G Bain
    Department of Medicine, Walter Mackenzie Health Sciences Centre, University of Alberta, Edmonton, Canada
    Can J Gastroenterol 14:397-402. 2000
  2. ncbi request reprint Polycystic liver disease: experience at a teaching hospital
    Lana Bistritz
    Division of Gastroenterology, University of Alberta, Edmonton, Alberta, Canada
    Am J Gastroenterol 100:2212-7. 2005
  3. doi request reprint A shorter duration of pre-transplant abstinence predicts problem drinking after liver transplantation
    Puneeta Tandon
    Department of Medicine, University of Alberta, Edmonton, Canada
    Am J Gastroenterol 104:1700-6. 2009
  4. pmc Bench-to-bedside review: current evidence for extracorporeal albumin dialysis systems in liver failure
    Constantine J Karvellas
    University of Alberta Liver Unit, Zeidler Ledcor Building, 130 University Campus, Edmonton, Alberta, T6G 2X8 Canada
    Crit Care 11:215. 2007
  5. doi request reprint Safety and antiviral activity of albinterferon alfa-2b dosed every four weeks in genotype 2/3 chronic hepatitis C patients
    Vincent G Bain
    University of Alberta, Edmonton, Canada
    Clin Gastroenterol Hepatol 6:701-6. 2008
  6. ncbi request reprint Hepatology and the Canadian gastroenterologist: interest, attitudes and patterns of practice: results of a national survey from the Canadian Association of Gastroenterology
    Vincent G Bain
    Department of Medicine, University of Alberta, Edmonton, Canada
    Can J Gastroenterol 17:25-9. 2003
  7. doi request reprint Clinical trial: exposure to ribavirin predicts EVR and SVR in patients with HCV genotype 1 infection treated with peginterferon alpha-2a plus ribavirin
    V G Bain
    Department of Medicine, University of Alberta, Edmonton, AB, Canada
    Aliment Pharmacol Ther 28:43-50. 2008
  8. ncbi request reprint A phase 2 study to evaluate the antiviral activity, safety, and pharmacokinetics of recombinant human albumin-interferon alfa fusion protein in genotype 1 chronic hepatitis C patients
    Vincent G Bain
    University of Alberta, Liver Unit, Zeidler Ledcor Center, 130 University Campus, Edmonton, Alberta, Canada, T6G 2X8
    J Hepatol 44:671-8. 2006
  9. ncbi request reprint Hepatitis B in transplantation
    V G Bain
    Alberta Liver Transplant Program, Department of Medicine, University of Alberta, Division of Gastroenterology, Edmonton, Alberta, Canada
    Transpl Infect Dis 2:153-65. 2000
  10. ncbi request reprint A multicentre study of the usefulness of liver biopsy in hepatitis C
    V G Bain
    Division of Gastroenterology, University of Alberta, 205, 8215 112 St, Edmonton, Alberta, Canada
    J Viral Hepat 11:375-82. 2004

Collaborators

Detail Information

Publications49

  1. ncbi request reprint Prospective study of biliary strictures to determine the predictors of malignancy
    V G Bain
    Department of Medicine, Walter Mackenzie Health Sciences Centre, University of Alberta, Edmonton, Canada
    Can J Gastroenterol 14:397-402. 2000
    ..Serum biochemistry and imaging studies were evaluated for their role in distinguishing benign from malignant strictures...
  2. ncbi request reprint Polycystic liver disease: experience at a teaching hospital
    Lana Bistritz
    Division of Gastroenterology, University of Alberta, Edmonton, Alberta, Canada
    Am J Gastroenterol 100:2212-7. 2005
    ..This study describes the natural history of patients with polycystic liver disease, a rare disorder characterized by multiple hepatic cysts...
  3. doi request reprint A shorter duration of pre-transplant abstinence predicts problem drinking after liver transplantation
    Puneeta Tandon
    Department of Medicine, University of Alberta, Edmonton, Canada
    Am J Gastroenterol 104:1700-6. 2009
    ....
  4. pmc Bench-to-bedside review: current evidence for extracorporeal albumin dialysis systems in liver failure
    Constantine J Karvellas
    University of Alberta Liver Unit, Zeidler Ledcor Building, 130 University Campus, Edmonton, Alberta, T6G 2X8 Canada
    Crit Care 11:215. 2007
    ..The appropriate comparator is standard medical therapy rather than head-to-head comparisons of different forms of albumin dialysis...
  5. doi request reprint Safety and antiviral activity of albinterferon alfa-2b dosed every four weeks in genotype 2/3 chronic hepatitis C patients
    Vincent G Bain
    University of Alberta, Edmonton, Canada
    Clin Gastroenterol Hepatol 6:701-6. 2008
    ..A phase 2, randomized, multicenter, open-label study evaluated the safety and efficacy of albinterferon alfa-2b in interferon-alpha treatment-naïve patients with genotype 2/3, chronic hepatitis C virus infection...
  6. ncbi request reprint Hepatology and the Canadian gastroenterologist: interest, attitudes and patterns of practice: results of a national survey from the Canadian Association of Gastroenterology
    Vincent G Bain
    Department of Medicine, University of Alberta, Edmonton, Canada
    Can J Gastroenterol 17:25-9. 2003
    ..Hepatology has emerged as a subspecialty distinct from gastroenterology. Despite this, there is no formal certification examination or accredited training program, and training remains combined with gastroenterology...
  7. doi request reprint Clinical trial: exposure to ribavirin predicts EVR and SVR in patients with HCV genotype 1 infection treated with peginterferon alpha-2a plus ribavirin
    V G Bain
    Department of Medicine, University of Alberta, Edmonton, AB, Canada
    Aliment Pharmacol Ther 28:43-50. 2008
    ..The impact of reduced drug exposure on outcomes in patients with chronic hepatitis C has not been determined in routine clinical practice...
  8. ncbi request reprint A phase 2 study to evaluate the antiviral activity, safety, and pharmacokinetics of recombinant human albumin-interferon alfa fusion protein in genotype 1 chronic hepatitis C patients
    Vincent G Bain
    University of Alberta, Liver Unit, Zeidler Ledcor Center, 130 University Campus, Edmonton, Alberta, Canada, T6G 2X8
    J Hepatol 44:671-8. 2006
    ..Recombinant human albumin-interferon alfa (alb-IFN) is a novel 85.7-kD recombinant protein consisting of interferon alfa-2b genetically fused to human serum albumin...
  9. ncbi request reprint Hepatitis B in transplantation
    V G Bain
    Alberta Liver Transplant Program, Department of Medicine, University of Alberta, Division of Gastroenterology, Edmonton, Alberta, Canada
    Transpl Infect Dis 2:153-65. 2000
    ..It is a rapidly evolving field and there is every reason for continued optimism...
  10. ncbi request reprint A multicentre study of the usefulness of liver biopsy in hepatitis C
    V G Bain
    Division of Gastroenterology, University of Alberta, 205, 8215 112 St, Edmonton, Alberta, Canada
    J Viral Hepat 11:375-82. 2004
    ..Liver biopsy is an essential investigation to accurately evaluate the grade and stage of liver disease patients with hepatitis C...
  11. ncbi request reprint De novo sirolimus-based immunosuppression after liver transplantation for hepatocellular carcinoma: long-term outcomes and side effects
    Christian Toso
    Department of Surgery, Section of Hepatobiliary, Pancreatic and Transplant Surgery, University of Alberta, Edmonton, Canada
    Transplantation 83:1162-8. 2007
    ..We report long-term outcomes and side effects after transplantation for hepatocellular carcinoma (HCC) using de novo, sirolimus-based immunosuppression (IS)...
  12. ncbi request reprint Is pre-treatment liver biopsy necessary for all hepatitis C genotypes?
    Kevork M Peltekian
    Division of Gastroenterology, Dalhousie University, Halifax, Nova Scotia, Canada
    Ann Hepatol 10:260-9. 2011
    ..Current practice guidelines recommend liver biopsy prior to treatment of hepatitis C genotype-1 but not for genotype-2/3; this is based on expert opinion, not on published evidence...
  13. doi request reprint Incidence and risk factors associated with de novo autoimmune hepatitis after liver transplantation
    Aldo J Montano-Loza
    Division of Gastroenterology and Liver Unit, University of Alberta, Edmonton, Canada
    Liver Int 32:1426-33. 2012
    ..De novo autoimmune hepatitis (AIH) describes the development of hepatitis with autoimmune features in liver transplant (LT) patients without prior diagnosis of AIH. We aimed to evaluate the incidence and risk factors for de novo AIH...
  14. doi request reprint Risk factors for recurrence of autoimmune hepatitis after liver transplantation
    Aldo J Montano-Loza
    Division of Gastroenterology and Liver Unit, University of Alberta Hospital, Edmonton, Alberta, Canada
    Liver Transpl 15:1254-61. 2009
    ..These findings suggest that recurrence of autoimmune hepatitis may reflect incomplete suppression of disease activity prior to liver transplantation...
  15. ncbi request reprint Evaluation of renal function in liver transplant recipients receiving daclizumab (Zenapax), mycophenolate mofetil, and a delayed, low-dose tacrolimus regimen vs. a standard-dose tacrolimus and mycophenolate mofetil regimen: a multicenter randomized clinic
    Eric M Yoshida
    Department of Medicine, University of British Columbia, Vancouver, BC, Canada
    Liver Transpl 11:1064-72. 2005
    ..5 mL/min/1.73 m(2); P = 0.038). In conclusion, delayed low-dose tacrolimus, in combination with daclizumab and mycophenolate mofetil, preserves early renal function post-liver transplantation without the cost of increased acute rejection...
  16. doi request reprint Severe muscle depletion in patients on the liver transplant wait list: its prevalence and independent prognostic value
    Puneeta Tandon
    Division of Gastroenterology and Liver Unit, University of Alberta, Edmonton, Alberta, Canada
    Liver Transpl 18:1209-16. 2012
    ..If this is validated in larger studies, the objective assessment of sarcopenia holds promise for prognostication in this patient population...
  17. ncbi request reprint ABO-incompatible liver transplantation for critically ill adult patients
    Christian Toso
    Department of Surgery, Section of Hepatobiliary, Pancreatic and Transplant Surgery, University of Alberta, Edmonton, Canada
    Transpl Int 20:675-81. 2007
    ..Our results suggest that ABO-incompatible transplants should be viewed as an important therapeutic option in adult patients with acute liver failure awaiting an emergency procedure...
  18. ncbi request reprint Liver transplantation for incidental cholangiocarcinoma: analysis of the Canadian experience
    Peter Ghali
    Department of Medicine, McGill University, Montreal, Quebec, Canada
    Liver Transpl 11:1412-6. 2005
    ..Aggressive investigation for cholangiocarcinoma is mandated. Incidentally found tumours remain a difficult treatment problem, and prospective adjuvant chemo-, radio-, and immunotherapies should be investigated...
  19. ncbi request reprint Transplant immunosuppressive agents in non-transplant chronic autoimmune hepatitis: the Canadian association for the study of liver (CASL) experience with mycophenolate mofetil and tacrolimus
    Nazira Chatur
    Department of Medicine, University of British Columbia, Vancouver, BC, Canada
    Liver Int 25:723-7. 2005
    ..Novel drug treatments include immunosuppressive drugs such as tacrolimus (TAC), mycophenolate mofetil (MMF), methotrexate and cyclosporine. We describe a multi-centre Canadian experience with MMF and TAC...
  20. doi request reprint Muscle wasting is associated with mortality in patients with cirrhosis
    Aldo J Montano-Loza
    Division of Gastroenterology and Liver Unit, University of Alberta Hospital, Edmonton, Alberta, Canada
    Clin Gastroenterol Hepatol 10:166-73, 173.e1. 2012
    ..We assessed its incidence among cirrhotic patients undergoing evaluation for liver transplantation to investigate associations between sarcopenia and mortality and prognosis...
  21. pmc Cardiac work-up protocol for liver transplant candidates: experience from a single liver transplant centre
    Carrie Ye
    Liver Unit, Department of Medicine, University of Alberta, Edmonton, Alberta T6G 2X8, Canada
    Can J Gastroenterol 26:806-10. 2012
    ..Ischemic cardiac events can cause significant morbidity and mortality postliver transplantation; however, no validated protocols to screen patients before transplantation exist...
  22. doi request reprint Prediction of cardiac complications after liver transplantation
    Tamer R Fouad
    Liver Unit, University of Calgary, Calgary, AB, Canada
    Transplantation 87:763-70. 2009
    ..Orthotopic liver transplantation (OLT) stresses the cardiovascular system, and cardiac complications after OLT are common...
  23. doi request reprint The effect of 1 month of therapy with midodrine, octreotide-LAR and albumin in refractory ascites: a pilot study
    Puneeta Tandon
    Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
    Liver Int 29:169-74. 2009
    ....
  24. doi request reprint Locoregional radiological treatment for hepatocellular carcinoma; Which, when and how?
    Judith Meza-Junco
    Department of Oncology, Cross Cancer Institute, Edmonton, Alberta, Canada
    Cancer Treat Rev 38:54-62. 2012
    ..The aim of our study was to review and analyze the current evidence for radiological interventions in HCC, and to propose evidence based recommendations to improve the management of these patients...
  25. ncbi request reprint Treating chronic hepatitis C with pegylated interferon alfa-2a (40 KD) and ribavirin in clinical practice
    S S Lee
    Liver Unit, University of Calgary, Calgary, AB, Canada
    Aliment Pharmacol Ther 23:397-408. 2006
    ..Pegylated interferon alfa-2a (40 KD) plus ribavirin therapy induces sustained virological response rates up to 63% in randomized-controlled trials...
  26. pmc Exploring differences in response to treatment with peginterferon alpha 2a (40kD) and ribavirin in chronic hepatitis C between genotypes 2 and 3
    J Powis
    Department of Medicine, University of Toronto, Toronto, ON, Canada
    J Viral Hepat 15:52-7. 2008
    ..027). There is significant interaction between cirrhosis and genotype 3 leading to a poor antiviral response in such patients requiring an alternate management strategy. This finding should be confirmed in a larger population...
  27. doi request reprint Alcohol use while on the liver transplant waiting list: a single-center experience
    Michelle Carbonneau
    Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
    Liver Transpl 16:91-7. 2010
    ..We hope that these measures will reduce the rate of relapse to alcohol use post-transplantation...
  28. pmc Cholangiocarcinoma: has there been any progress?
    Judith Meza-Junco
    Cross Cancer Institute, Edmonton, Canada
    Can J Gastroenterol 24:52-7. 2010
    ..Wider application of this strategy, especially for patients with potentially resectable disease, will require validation by other centres...
  29. ncbi request reprint Nonalcoholic fatty liver disease in patients investigated for elevated liver enzymes
    Krikor Kichian
    Department of Medicine, University of Alberta, Edmonton
    Can J Gastroenterol 17:38-42. 2003
    ..It is therefore recommended that patients with raised liver enzymes and suspected NAFLD be targeted for liver biopsy in their evaluation...
  30. ncbi request reprint Effect of HCV viral dynamics on treatment design: lessons learned from HIV
    V G Bain
    Department of Medicine, University of Alberta, Edmonton, Canada
    Am J Gastroenterol 96:2818-28. 2001
    ..By enabling the design and rapid assessment of new treatment regimens, viral load measurement will revolutionize the clinical management of the hepatitis C virus infection, as it has the HIV...
  31. ncbi request reprint Sirolimus-based immunosuppression for liver transplantation in the presence of extended criteria for hepatocellular carcinoma
    Norman M Kneteman
    Department of Surgery, Section of Hepatobiliary, Pancreatic and Transplantation Surgery, University of Alberta, Edmonton, Alberta T6G 2B7, Canada
    Liver Transpl 10:1301-11. 2004
    ..This sirolimus based immunosuppression protocol appears to have beneficial effects on tumor recurrence and survival with an acceptable rate of rejection and toxicity...
  32. ncbi request reprint Prevalence of occult gastrointestinal bleeding in celiac disease
    Michael J Mant
    Division of Hematology and Oncology, Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
    Clin Gastroenterol Hepatol 4:451-4. 2006
    ..We therefore hypothesized that an accurate, quantitative, and specific method for blood loss, rather than a guaiac test, might give different findings. We report the results of stool blood loss measurement by using such a method...
  33. pmc Chronic viral hepatitis C: management update
    K S Gutfreund
    Department of Medicine, University of Alberta, Edmonton
    CMAJ 162:827-33. 2000
    ..e., below 30%) for patients with hepatitis C virus genotype 1 emphasize the need for novel antiviral medications that will target the functional sites of the HCV genome...
  34. ncbi request reprint Predicting the liver histology in chronic hepatitis C: how good is the clinician?
    J Romagnuolo
    Division of Gastroenterology, McGill University Health Centre, Montreal, Quebec, Canada
    Am J Gastroenterol 96:3165-74. 2001
    ..In practice, a combination of factors is used to anticipate histology. The aim of this study is to evaluate the ability of global clinical assessment to predict histology in hepatitis C...
  35. ncbi request reprint Systematic review: renal and other clinically relevant outcomes in hepatorenal syndrome trials
    P Tandon
    Division of Gastroenterology, Department of Medicine, University of Alberta, Edmonton, AB, Canada
    Aliment Pharmacol Ther 25:1017-28. 2007
    ..Although reversal of pretransplant renal dysfunction in hepatorenal syndrome reduces post-transplant complications, the overall impact on morbidity and mortality requires clarification...
  36. doi request reprint Adult liver transplant survey: policies towards eligibility criteria in Canada and the United States 2007
    Karen I Kroeker
    Department of Medicine, University of Alberta, Edmonton, AB, Cananda
    Liver Int 28:1250-5. 2008
    ..To assess the current practice patterns of liver transplant centres in Canada and the USA regarding transplant eligibility...
  37. pmc Hepatitis C eradication and improvement of cryoglobulinemia-associated rash and membranoproliferative glomerulonephritis with interferon and ribavirin after kidney transplantation
    Marilyn Zeman
    Division of Gastroenterology, University of Alberta, Edmonton
    Can J Gastroenterol 20:427-31. 2006
    ..In conclusion, in selected patients, combination antiviral therapy may still be a viable option postrenal transplant...
  38. doi request reprint Elevated lipogenesis and diminished cholesterol synthesis in patients with hepatitis C viral infection compared to healthy humans
    Jennifer E Lambert
    Alberta Institute for Human Nutrition, University of Alberta, Edmonton, AB, Canada
    Hepatology 57:1697-704. 2013
    ..Low PUFA levels combined with elevated lipogenesis suggests a role for dietary PUFA supplementation in HCV patients. (HEPATOLOGY 2013)...
  39. ncbi request reprint Late acute rejection after liver transplantation: the Western Canada experience
    Alnoor Ramji
    Department of Medicine, The University of British Columbia, Vancouver, BC, Canada
    Liver Transpl 8:945-51. 2002
    ..LAR is common and occurs after more than 1 year posttransplantation. Patients undergoing transplantation for viral etiologies seem to have a lower risk of LAR. There may be an increased risk of chronic rejection in those developing LAR...
  40. ncbi request reprint Evolution of autoimmune hepatitis to primary sclerosing cholangitis: A sequential syndrome
    Ayman A Abdo
    Liver Unit, Division of Gastroenterology, University of Calgary, Calgary, Alberta, Canada
    Hepatology 36:1393-9. 2002
    ..In conclusion, patients with well-established AIH can, after variable duration of follow-up, develop PSC. In patients with AIH who become resistant to immunosuppression or develop significant cholestasis, PSC should be ruled out by ERCP...
  41. pmc Dramatic reduction in tumour size in hepatocellular carcinoma patients on thalidomide therapy
    Denny Demeria
    Department of Gastroenterology, University of Alberta Liver Unit, Edmonton, Canada
    Can J Gastroenterol 21:517-8. 2007
  42. ncbi request reprint Hepatorenal syndrome, hepatopulmonary syndrome, and now, hepatospinal syndrome?
    Vincent G Bain
    University of Alberta Liver Unit, 205 22, 8215 112 St, Edmonton, Alberta, Canada T6G 2C8
    Liver Transpl 9:995-6. 2003
  43. ncbi request reprint Simultaneous liver and kidney transplants: optimizing use of this double resource
    Angeli Chopra
    1 Division of Gastroenterology, University of Alberta, Edmonton, AB, Canada 2 Department of Medicine, Multi Organ Transplant Program, Royal Victoria Hospital, McGill University Health Center, Montreal, QC, Canada 3 Liver Unit, Division of Gastroenterology, University of Alberta, Edmonton, AB, Canada
    Transplantation 91:1305-9. 2011
    ..Shared multicenter experience or clinical trials or both will be required to refine our ability to optimally manage these patients with combined liver and kidney dysfunction...
  44. doi request reprint A case-control study of single-pass albumin dialysis for acetaminophen-induced acute liver failure
    Constantine J Karvellas
    Division of Critical Care Medicine, University of Alberta, Edmonton, Alta, Canada
    Blood Purif 28:151-8. 2009
    ..We evaluated the clinical, physiological and laboratory parameters of SPAD in acetaminophen-induced acute liver failure (AALF)...
  45. ncbi request reprint Sphincter of Oddi dysfunction: managing the patient with chronic biliary pain
    Lana Bistritz
    Division of Gastroenterology, University of Alberta, Edmonton, Canada
    World J Gastroenterol 12:3793-802. 2006
    ..Endoscopic injection of botulinum toxin appears to predict subsequent outcome to sphincterotomy, and could be useful in selection of patients for therapy, especially in the setting where manometry is unavailable...
  46. ncbi request reprint A Canadian multicenter retrospective study evaluating transjugular liver biopsy in patients with congenital bleeding disorders and hepatitis C: is it safe and useful?
    Jennifer L Shin
    Department of Medicine at University Health Network, University of Toronto, Toronto, Ontario, Canada
    Am J Hematol 78:85-93. 2005
    ..We conclude that this procedure can be safely performed on an outpatient basis. The diagnosis of cirrhosis and/or portal hypertension was made in a substantial proportion of individuals (26%), all of whom had asymptomatic liver disease...
  47. ncbi request reprint Twelve weeks of follow-up is sufficient for the determination of sustained virologic response in patients treated with interferon alpha for chronic hepatitis C
    Stefan Zeuzem
    Klinik fur Innere Medizin II, Universitatskliniken des Saarlandes, 66421 Homburg Saar, Germany
    J Hepatol 39:106-11. 2003
    ..Sensitive molecular tests may permit earlier determination of sustained virologic response following the completion of therapy in end-of-treatment responders...
  48. doi request reprint Albinterferon alfa-2b dosed every two or four weeks in interferon-naïve patients with genotype 1 chronic hepatitis C
    Stefan Zeuzem
    JW Goethe University Hospital, Frankfurt, Germany
    Hepatology 48:407-17. 2008
    ..1 versus 4.3 days; P = 0.006). CONCLUSION: Alb-IFN administered q2wk or q4wk may offer comparable efficacy, with an improved dosing schedule, compared with PEG-IFNalpha-2a...
  49. ncbi request reprint Simple clinical variables predict liver histology in hepatitis C: prospective validation of a clinical prediction model
    Joseph Romagnuolo
    Digestive Disease Center, University of South Carolina, 96 Jonathon Lucas Street, PO Box 250 327, Charleston, SC 29425, USA
    Scand J Gastroenterol 40:1365-71. 2005
    ..Absence of predictors also predicted a lack of inflammation and fibrosis. Our aim was prospectively to validate this clinical prediction model using an independent multicenter sample...