D G Bailey

Summary

Affiliation: University of Western Ontario
Country: Canada

Publications

  1. ncbi Fruit juices inhibit organic anion transporting polypeptide-mediated drug uptake to decrease the oral availability of fexofenadine
    George K Dresser
    Department of Medicine, University of Western Ontario, London, Ontario, Canada
    Clin Pharmacol Ther 71:11-20. 2002
  2. ncbi Fruit juice inhibition of uptake transport: a new type of food-drug interaction
    David G Bailey
    Department of Medicine and Lawson Health Research Institute, London Health Sciences Centre Department of Physiology and Pharmacology, University of Western Ontario, London, Ontario, Canada
    Br J Clin Pharmacol 70:645-55. 2010
  3. ncbi Grapefruit juice-felodipine interaction: effect of naringin and 6',7'-dihydroxybergamottin in humans
    D G Bailey
    Department of Medicine, London Health Sciences Centre, Ontario, Canada
    Clin Pharmacol Ther 64:248-56. 1998
  4. ncbi Naringin is a major and selective clinical inhibitor of organic anion-transporting polypeptide 1A2 (OATP1A2) in grapefruit juice
    D G Bailey
    Lawson Health Research Institute, London Health Sciences Centre, University of Western Ontario, London, Ontario, Canada
    Clin Pharmacol Ther 81:495-502. 2007
  5. ncbi Interactions between grapefruit juice and cardiovascular drugs
    David G Bailey
    Department of Medicine and Lawson Health Research Institute, London Health Sciences Centre, London, Ontario, Canada
    Am J Cardiovasc Drugs 4:281-97. 2004
  6. ncbi Bergamottin, lime juice, and red wine as inhibitors of cytochrome P450 3A4 activity: comparison with grapefruit juice
    David G Bailey
    Department of Medicine, London Health Sciences Centre, Ontario, Canada
    Clin Pharmacol Ther 73:529-37. 2003
  7. ncbi Grapefruit-felodipine interaction: effect of unprocessed fruit and probable active ingredients
    D G Bailey
    Department of Medicine, London Health Sciences Centre, University of Western Ontario, Canada
    Clin Pharmacol Ther 68:468-77. 2000
  8. ncbi Evaluation of peppermint oil and ascorbyl palmitate as inhibitors of cytochrome P4503A4 activity in vitro and in vivo
    George K Dresser
    Department of Medicine, London Health Sciences Centre, University of Western Ontario, London, Ontario, Canada
    Clin Pharmacol Ther 72:247-55. 2002
  9. ncbi The effects of fruit juices on drug disposition: a new model for drug interactions
    G K Dresser
    Department of Medicine, London Health Sciences Centre, and University of Western Ontario, London, Ontario, Canada
    Eur J Clin Invest 33:10-6. 2003
  10. ncbi Natural products and adverse drug interactions
    David G Bailey
    Lawson Health Research Institute, London Health Sciences Centre, and Department of Medicine, University of Western Ontario, London, Ont
    CMAJ 170:1531-2. 2004

Detail Information

Publications18

  1. ncbi Fruit juices inhibit organic anion transporting polypeptide-mediated drug uptake to decrease the oral availability of fexofenadine
    George K Dresser
    Department of Medicine, University of Western Ontario, London, Ontario, Canada
    Clin Pharmacol Ther 71:11-20. 2002
    ..Results support a new model of intestinal drug absorption and mechanism of food-drug interaction...
  2. ncbi Fruit juice inhibition of uptake transport: a new type of food-drug interaction
    David G Bailey
    Department of Medicine and Lawson Health Research Institute, London Health Sciences Centre Department of Physiology and Pharmacology, University of Western Ontario, London, Ontario, Canada
    Br J Clin Pharmacol 70:645-55. 2010
    ..The interaction between grapefruit juice and etoposide also seemed relevant. Knowledge of both affected uptake transporter and drug hydrophilicity assisted prediction of the clinical interaction with grapefruit or orange juice...
  3. ncbi Grapefruit juice-felodipine interaction: effect of naringin and 6',7'-dihydroxybergamottin in humans
    D G Bailey
    Department of Medicine, London Health Sciences Centre, Ontario, Canada
    Clin Pharmacol Ther 64:248-56. 1998
    ..To test whether naringin or 6',7'-dihydroxybergamottin is a major active substance in grapefruit juice-felodipine interaction in humans...
  4. ncbi Naringin is a major and selective clinical inhibitor of organic anion-transporting polypeptide 1A2 (OATP1A2) in grapefruit juice
    D G Bailey
    Lawson Health Research Institute, London Health Sciences Centre, University of Western Ontario, London, Ontario, Canada
    Clin Pharmacol Ther 81:495-502. 2007
    ..Inherent OATP1A2 activity may be influenced by genetic factors. This appears to be the first report of a single dietary constituent clinically modulating drug transport...
  5. ncbi Interactions between grapefruit juice and cardiovascular drugs
    David G Bailey
    Department of Medicine and Lawson Health Research Institute, London Health Sciences Centre, London, Ontario, Canada
    Am J Cardiovasc Drugs 4:281-97. 2004
    ..The elderly are at particular risk, as they are often prescribed medications and frequently consume grapefruit juice...
  6. ncbi Bergamottin, lime juice, and red wine as inhibitors of cytochrome P450 3A4 activity: comparison with grapefruit juice
    David G Bailey
    Department of Medicine, London Health Sciences Centre, Ontario, Canada
    Clin Pharmacol Ther 73:529-37. 2003
    ..Our objective was to assess the importance of bergamottin in drug interactions through comparisons between grapefruit juice and lime juice and the potential for drug interactions with red wine...
  7. ncbi Grapefruit-felodipine interaction: effect of unprocessed fruit and probable active ingredients
    D G Bailey
    Department of Medicine, London Health Sciences Centre, University of Western Ontario, Canada
    Clin Pharmacol Ther 68:468-77. 2000
    ..To determine whether unprocessed grapefruit can cause a drug interaction, whether the active ingredients are naturally occurring, and whether specific furanocoumarins or flavonoids are involved...
  8. ncbi Evaluation of peppermint oil and ascorbyl palmitate as inhibitors of cytochrome P4503A4 activity in vitro and in vivo
    George K Dresser
    Department of Medicine, London Health Sciences Centre, University of Western Ontario, London, Ontario, Canada
    Clin Pharmacol Ther 72:247-55. 2002
    ..Peppermint oil may also have acted by this mechanism. However, this requires further investigation. Ascorbyl palmitate did not inhibit CYP3A4 activity in vivo...
  9. ncbi The effects of fruit juices on drug disposition: a new model for drug interactions
    G K Dresser
    Department of Medicine, London Health Sciences Centre, and University of Western Ontario, London, Ontario, Canada
    Eur J Clin Invest 33:10-6. 2003
    ..These findings with grapefruit and other fruit juices continue to enhance our understanding of the complex nature of food-drug interactions, and their possible influence on the clinical effects of medications...
  10. ncbi Natural products and adverse drug interactions
    David G Bailey
    Lawson Health Research Institute, London Health Sciences Centre, and Department of Medicine, University of Western Ontario, London, Ont
    CMAJ 170:1531-2. 2004
  11. ncbi Effect of grapefruit juice volume on the reduction of fexofenadine bioavailability: possible role of organic anion transporting polypeptides
    George K Dresser
    Lawson Health Research Institute, London Health Sciences Centre, UK
    Clin Pharmacol Ther 77:170-7. 2005
    ..A much higher volume caused an additional modest effect, possibly from reduced intestinal concentration and transit time of fexofenadine. This food-drug interaction appears to be novel and may be relevant to other fruit juices and drugs...
  12. ncbi A basic conceptual and practical overview of interactions with highly prescribed drugs
    George K Dresser
    Department of Medicine, University of Western Ontario, Lawson Health Research Institute, London, Canada
    Can J Clin Pharmacol 9:191-8. 2002
    ..Commonly prescribed drugs that are unlikely to cause a drug interaction involving CYPs or P-glycoprotein are also discussed...
  13. ncbi Impact of citrus soft drinks relative to grapefruit juice on ciclosporin disposition
    Ute I Schwarz
    Pharmaceutical Services, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Br J Clin Pharmacol 62:485-91. 2006
    ....
  14. ncbi Grapefruit juice ingestion significantly reduces talinolol bioavailability
    Ute I Schwarz
    Institute of Clinical Pharmacology, Medical Faculty, Technical University, and Medical Department I, Technical University Hospital, Dresden
    Clin Pharmacol Ther 77:291-301. 2005
    ....
  15. ncbi Sun drop citrus soda and cyclosporine interaction: comments on causality and recommendations
    David G Bailey
    Transplantation 79:747. 2005
  16. ncbi Bergamottin contribution to the grapefruit juice-felodipine interaction and disposition in humans
    Theunis C Goosen
    Department of Pharmacology, North West University, Potchefstroom
    Clin Pharmacol Ther 76:607-17. 2004
    ..Our objectives were to evaluate the contribution of bergamottin to the grapefruit juice-felodipine interaction and to characterize bergamottin disposition...
  17. ncbi Herbal product-drug interactions mediated by induction
    Rommel G Tirona
    Division of Clinical Pharmacology, Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN, USA
    Br J Clin Pharmacol 61:677-81. 2006
    ..This type of interaction is likely to be relevant to other herbal products. Caregivers need to be aware of the issues and options for therapeutic management...
  18. ncbi Effect of drug transporter genotypes on pravastatin disposition in European- and African-American participants
    Richard H Ho
    Department of Pediatrics and Pharmacology, Vanderbilt University School of Medicine, Nashville, TN, USA
    Pharmacogenet Genomics 17:647-56. 2007
    ....