T R Bai

Summary

Affiliation: University of British Columbia
Country: Canada

Publications

  1. ncbi Evidence for airway remodeling in chronic asthma
    Tony R Bai
    UBC James Hogg Research Centre, Providence Heart and Lung Institute, St Paul s Hospital and Department of Medicine, University of British Columbia, Vancouver, Canada
    Curr Opin Allergy Clin Immunol 10:82-6. 2010
  2. ncbi Structural changes in the airways in asthma: observations and consequences
    Tony R Bai
    James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, University of British Columbia, St Paul s Hospital, 1081 Burrard Street, Vancouver, BC V6Z 1Y6, Canada
    Clin Sci (Lond) 108:463-77. 2005
  3. ncbi Do written self-management plans improve asthma control? The evidence is not conclusive
    Tony R Bai
    University of British Columbia McDonald Research Laboratories, St Paul s Hospital, Vancouver, Canada
    Can Respir J 10:155-6. 2003
  4. ncbi Severe exacerbations predict excess lung function decline in asthma
    T R Bai
    Respiratory Division, University of British Columbia, St Paul s Hospital, 1081 Burrard Street, Vancouver, BC, Canada
    Eur Respir J 30:452-6. 2007
  5. ncbi The effect of age and duration of disease on airway structure in fatal asthma
    T R Bai
    UBC Pulmonary Research Lab, St Paul s Hospital, Vancouver, British Columbia, Canada
    Am J Respir Crit Care Med 162:663-9. 2000
  6. ncbi NO does not mediate inhibitory neural responses in sheep airway and bronchial vascular smooth muscle
    E M Baile
    University of British Columbia Pulmonary Research Laboratory, St Paul s Hospital, Vancouver, British Columbia, Canada V6Z 1Y6
    J Appl Physiol 84:809-14. 1998
  7. ncbi Induction of epithelial-mesenchymal transition in primary airway epithelial cells from patients with asthma by transforming growth factor-beta1
    Tillie Louise Hackett
    James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Disease, St Paul s Hospital, 1081 Burrard Street, Vancouver, BC, Canada
    Am J Respir Crit Care Med 180:122-33. 2009
  8. ncbi Characterization of airway plugging in fatal asthma
    Laura M Kuyper
    University of British Columbia McDonald Research Laboratories, St. Paul's Hospital, Vancouver, British Columbia, Canada
    Am J Med 115:6-11. 2003
  9. ncbi Leukemia inhibitory factor (LIF) and LIF receptor in human lung. Distribution and regulation of LIF release
    D A Knight
    University of British Columbia Pulmonary Research Laboratory, St Paul s Hospital, Vancouver, British Columbia, Canada
    Am J Respir Cell Mol Biol 20:834-41. 1999
  10. ncbi Expression of beta 2-adrenergic receptor mRNA in peripheral lung in asthma and chronic obstructive pulmonary disease
    T R Bai
    UBC Pulmonary Research Laboratory, St Paul s Hospital, Vancouver, Canada
    Am J Respir Cell Mol Biol 8:325-33. 1993

Detail Information

Publications21

  1. ncbi Evidence for airway remodeling in chronic asthma
    Tony R Bai
    UBC James Hogg Research Centre, Providence Heart and Lung Institute, St Paul s Hospital and Department of Medicine, University of British Columbia, Vancouver, Canada
    Curr Opin Allergy Clin Immunol 10:82-6. 2010
    ..This review focuses on recent findings in relation to potential functional consequences of structural changes in the asthmatic airway...
  2. ncbi Structural changes in the airways in asthma: observations and consequences
    Tony R Bai
    James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, University of British Columbia, St Paul s Hospital, 1081 Burrard Street, Vancouver, BC V6Z 1Y6, Canada
    Clin Sci (Lond) 108:463-77. 2005
    ..Structural changes may increase airway narrowing by alteration of smooth muscle dynamics through limitation of the ability of the smooth muscle to periodically lengthen...
  3. ncbi Do written self-management plans improve asthma control? The evidence is not conclusive
    Tony R Bai
    University of British Columbia McDonald Research Laboratories, St Paul s Hospital, Vancouver, Canada
    Can Respir J 10:155-6. 2003
  4. ncbi Severe exacerbations predict excess lung function decline in asthma
    T R Bai
    Respiratory Division, University of British Columbia, St Paul s Hospital, 1081 Burrard Street, Vancouver, BC, Canada
    Eur Respir J 30:452-6. 2007
    ..2 mL greater annual decline in FEV(1). These data support the hypothesis that exacerbations, indicating intermittent periods of worsening airway inflammation, are associated with excess lung function decline in asthma...
  5. ncbi The effect of age and duration of disease on airway structure in fatal asthma
    T R Bai
    UBC Pulmonary Research Lab, St Paul s Hospital, Vancouver, British Columbia, Canada
    Am J Respir Crit Care Med 162:663-9. 2000
    ....
  6. ncbi NO does not mediate inhibitory neural responses in sheep airway and bronchial vascular smooth muscle
    E M Baile
    University of British Columbia Pulmonary Research Laboratory, St Paul s Hospital, Vancouver, British Columbia, Canada V6Z 1Y6
    J Appl Physiol 84:809-14. 1998
    ....
  7. ncbi Induction of epithelial-mesenchymal transition in primary airway epithelial cells from patients with asthma by transforming growth factor-beta1
    Tillie Louise Hackett
    James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Disease, St Paul s Hospital, 1081 Burrard Street, Vancouver, BC, Canada
    Am J Respir Crit Care Med 180:122-33. 2009
    ..The process by which the number of fibroblasts increases in asthma is poorly understood, but epithelial-mesenchymal transition (EMT) may play a significant role...
  8. ncbi Characterization of airway plugging in fatal asthma
    Laura M Kuyper
    University of British Columbia McDonald Research Laboratories, St. Paul's Hospital, Vancouver, British Columbia, Canada
    Am J Med 115:6-11. 2003
    ..0007) and in Polynesian patients with asthma (P = 0.04). CONCLUSION: Airway lumenal obstruction by an exudate composed of mucus and cells is a major contributing cause of fatal asthma in most patients...
  9. ncbi Leukemia inhibitory factor (LIF) and LIF receptor in human lung. Distribution and regulation of LIF release
    D A Knight
    University of British Columbia Pulmonary Research Laboratory, St Paul s Hospital, Vancouver, British Columbia, Canada
    Am J Respir Cell Mol Biol 20:834-41. 1999
    ....
  10. ncbi Expression of beta 2-adrenergic receptor mRNA in peripheral lung in asthma and chronic obstructive pulmonary disease
    T R Bai
    UBC Pulmonary Research Laboratory, St Paul s Hospital, Vancouver, Canada
    Am J Respir Cell Mol Biol 8:325-33. 1993
    ..High levels of beta 2AR mRNA, presumably reflecting lung growth or asthma, were demonstrated in peripheral lung of a 4-yr-old child with asthma.(ABSTRACT TRUNCATED AT 250 WORDS)..
  11. ncbi The role of the C-C chemokine receptor-5 Delta32 polymorphism in asthma and in the production of regulated on activation, normal T cells expressed and secreted
    A J Sandford
    UBC McDonald Research Laboratories, St Paul s Hospital, and the Respiratory Division, Vancouver General Hospital, Vancouver, British Columbia, Canada
    J Allergy Clin Immunol 108:69-73. 2001
    ..RANTES is a chemokine that is known to play an important role in the pathogenesis of allergic asthma...
  12. ncbi Lung structural changes in chronic obstructive pulmonary diseases
    Warren Davidson
    Respiratory Division, St. Paul's Hospital, University of British Columbia, Vancouver, BC, Canada
    Curr Drug Targets Inflamm Allergy 4:643-9. 2005
    ..Thus a careful assessment of the structural phenotype of subpopulations of COPD patients is likely to lead to optimal categorization for therapeutic trials, and earlier disease is more likely to response to interventions...
  13. ncbi Endothelin-1 induces hypertrophy and inhibits apoptosis in human airway smooth muscle cells
    Ralph McWhinnie
    James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, St Paul s Hospital, University of British Columbia, 1081 Burrard St, Vancouver, BC, Canada V6Z 1Y6
    Am J Physiol Lung Cell Mol Physiol 292:L278-86. 2007
    ..These results suggest that ET-1 is a candidate mediator for the induction of increased smooth muscle mass in asthma and identify signaling pathways activated by this mediator...
  14. ncbi An evaluation of patients' willingness to trade symptom-free days for asthma-related treatment risks: a discrete choice experiment
    Helen M McTaggart-Cowan
    Department of Health Care and Epidemiology, University of British Columbia, Vancouver, British Columbia, Canada
    J Asthma 45:630-8. 2008
    ..The objective of this study was to quantify these preferences, in terms of risk-benefits trade-offs, for six asthma treatment attributes using a discrete choice experiment (DCE)...
  15. ncbi Interleukin-3, but not granulocyte-macrophage colony-stimulating factor and interleukin-5, inhibits apoptosis of human basophils through phosphatidylinositol 3-kinase: requirement of NF-kappaB-dependent and -independent pathways
    Xueyan Zheng
    iCAPTURE Center, McDonald Research Laboratory, University of British Columbia, St Paul s Hospital, 1081 Burrard Street, Vancouver, BC, Canada V6Z 1Y6
    Immunology 107:306-15. 2002
    ....
  16. ncbi Estradiol in severe asthma with premenstrual worsening
    Mary H H Ensom
    Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, British Columbia, Canada
    Ann Pharmacother 37:1610-3. 2003
    ..Thus, estradiol's potential role in women with severe asthma and PMA may warrant further exploration in this subgroup...
  17. ncbi Estradiol in premenstrual asthma: a double-blind, randomized, placebo-controlled, crossover study
    Mary H H Ensom
    Faculty of Pharmaceutical Sciences, University of British Columbia, Canada
    Pharmacotherapy 23:561-71. 2003
    ..Further trials, involving women with more severe asthma under poorer control, are warranted to discern underlying mechanisms for the worsening of asthma in relation to menstruation...
  18. ncbi On the terminology for describing the length-force relationship and its changes in airway smooth muscle
    Tony R Bai
    James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, University of British Columbia, Vancouver, Canada
    J Appl Physiol 97:2029-34. 2004
    ..We also discuss frequently used terms that do not have commonly accepted definitions that should be used cautiously...
  19. ncbi Reconcilable differences: a cross-sectional study of the relationship between socioeconomic status and the magnitude of short-acting beta-agonist use in asthma
    Larry D Lynd
    Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, BC, Canada
    Chest 126:1161-8. 2004
    ..Results were consistent for neighborhood unemployment rate. CONCLUSIONS: The social gradient in asthma-related outcomes may be at least partially attributable to poorer asthma control in lower-SES asthmatics...
  20. ncbi Cardiotrophin-1 alters airway smooth muscle structure and mechanical properties in airway explants
    Xueyan Zheng
    The James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, University of British Columbia, St. Paul's Hospital, 1081 Burrard St, Vancouver, B. C, Canada V6Z 1Y6
    Am J Physiol Lung Cell Mol Physiol 287:L1165-71. 2004
    ..These data indicate that CT-1 alters ASM structural and mechanical properties in the tissue environment and suggest that structural changes found in the airway wall in asthma are not necessarily associated with increased responsiveness...
  21. ncbi Airway basement membrane perimeter distensibility and airway smooth muscle area in asthma
    Alan L James
    Department of Pulmonary Physiology, West Australian Sleep Disorders Research Institute, Perth, Western Australia, Australia
    J Appl Physiol 104:1703-8. 2008
    ..We conclude that the effects of inflation on the relationship between Pbm and ASM are small and do not account for the differences observed in ASM between cases of asthma and nonasthmatic controls...