Sean M Bagshaw

Summary

Affiliation: University of Alberta
Country: Canada

Publications

  1. ncbi Risk factors and outcomes associated with acute kidney injury following ruptured abdominal aortic aneurysm
    Ilana Kopolovic
    Division of Critical Care Medicine, Faculty of Medicine and Dentistry, University of Alberta, 3C1, 12 Walter Mackenzie Centre, 8440 112 Street, Edmonton, Alberta T6G 2B7, Canada
    BMC Nephrol 14:99. 2013
  2. ncbi Cystatin C in acute kidney injury
    Sean M Bagshaw
    Division of Critical Care Medicine, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada
    Curr Opin Crit Care 16:533-9. 2010
  3. ncbi Novel biomarkers of AKI: the challenges of progress 'Amid the noise and the haste'
    Sean M Bagshaw
    Division of Critical Care Medicine, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada T6G2B
    Nephrol Dial Transplant 28:235-8. 2013
  4. ncbi Frailty in the critically ill: a novel concept
    Robert C McDermid
    Division of Critical Care Medicine, Faculty of Medicine and Dentistry, University of Alberta, 3C1 12 Walter C Mackenzie Centre, 8440 112 St NW, Edmonton, Canada T6G 2B7
    Crit Care 15:301. 2011
  5. ncbi Clinical factors associated with initiation of renal replacement therapy in critically ill patients with acute kidney injury-a prospective multicenter observational study
    Sean M Bagshaw
    University of Alberta Hospital, Edmonton, Alberta, Canada T6G 2B7
    J Crit Care 27:268-75. 2012
  6. ncbi A prospective evaluation of urine microscopy in septic and non-septic acute kidney injury
    Sean M Bagshaw
    Division of Critical Care Medicine, University of Alberta Hospital, University of Alberta, Alberta, Canada
    Nephrol Dial Transplant 27:582-8. 2012
  7. ncbi The need to reform our assessment of evidence from clinical trials: a commentary
    Sean M Bagshaw
    Department of Intensive Care, Austin Hospital, Melbourne, Victoria, Australia
    Philos Ethics Humanit Med 3:23. 2008
  8. ncbi Prolonging life and delaying death: the role of physicians in the context of limited intensive care resources
    Robert C McDermid
    Division of Critical Care Medicine, University of Alberta Hospital, University of Alberta, Edmonton, Alberta, Canada
    Philos Ethics Humanit Med 4:3. 2009
  9. ncbi Difference between pre-operative and cardiopulmonary bypass mean arterial pressure is independently associated with early cardiac surgery-associated acute kidney injury
    Hussein D Kanji
    Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Canada
    J Cardiothorac Surg 5:71. 2010
  10. ncbi Clinical characteristics and outcomes of patients with acute myelogenous leukemia admitted to intensive care: a case-control study
    Amanda L Roze des Ordons
    Division of Critical Care Medicine, Faculty of Medicine and Dentistry, University of Alberta Hospital, Edmonton, Alberta, T6G2B7 Canada
    BMC Cancer 10:516. 2010

Detail Information

Publications97

  1. ncbi Risk factors and outcomes associated with acute kidney injury following ruptured abdominal aortic aneurysm
    Ilana Kopolovic
    Division of Critical Care Medicine, Faculty of Medicine and Dentistry, University of Alberta, 3C1, 12 Walter Mackenzie Centre, 8440 112 Street, Edmonton, Alberta T6G 2B7, Canada
    BMC Nephrol 14:99. 2013
    ..Our objectives were to describe the incidence rate, risk factors, clinical course and long-term outcomes of AKI following rAAA repair...
  2. ncbi Cystatin C in acute kidney injury
    Sean M Bagshaw
    Division of Critical Care Medicine, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada
    Curr Opin Crit Care 16:533-9. 2010
    ..This review will summarize and discuss the role of cystatin C in the diagnosis of acute kidney injury...
  3. ncbi Novel biomarkers of AKI: the challenges of progress 'Amid the noise and the haste'
    Sean M Bagshaw
    Division of Critical Care Medicine, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada T6G2B
    Nephrol Dial Transplant 28:235-8. 2013
    ....
  4. ncbi Frailty in the critically ill: a novel concept
    Robert C McDermid
    Division of Critical Care Medicine, Faculty of Medicine and Dentistry, University of Alberta, 3C1 12 Walter C Mackenzie Centre, 8440 112 St NW, Edmonton, Canada T6G 2B7
    Crit Care 15:301. 2011
    ....
  5. ncbi Clinical factors associated with initiation of renal replacement therapy in critically ill patients with acute kidney injury-a prospective multicenter observational study
    Sean M Bagshaw
    University of Alberta Hospital, Edmonton, Alberta, Canada T6G 2B7
    J Crit Care 27:268-75. 2012
    ..There is uncertainty regarding the optimal time to initiate renal replacement therapy (RRT) in critically ill patients with acute kidney injury (AKI)...
  6. ncbi A prospective evaluation of urine microscopy in septic and non-septic acute kidney injury
    Sean M Bagshaw
    Division of Critical Care Medicine, University of Alberta Hospital, University of Alberta, Alberta, Canada
    Nephrol Dial Transplant 27:582-8. 2012
    ..Sepsis is the most common trigger for acute kidney injury (AKI) in critically ill patients. We sought to determine whether there are unique patterns to urine sediment in septic compared with non-septic AKI...
  7. ncbi The need to reform our assessment of evidence from clinical trials: a commentary
    Sean M Bagshaw
    Department of Intensive Care, Austin Hospital, Melbourne, Victoria, Australia
    Philos Ethics Humanit Med 3:23. 2008
    ..That does not confer upon us a freedom to ignore the knowledge we already have, or to postpone the action that it appears to demand at a given time". (Sir Bradford Austin Hill 1)...
  8. ncbi Prolonging life and delaying death: the role of physicians in the context of limited intensive care resources
    Robert C McDermid
    Division of Critical Care Medicine, University of Alberta Hospital, University of Alberta, Edmonton, Alberta, Canada
    Philos Ethics Humanit Med 4:3. 2009
    ....
  9. ncbi Difference between pre-operative and cardiopulmonary bypass mean arterial pressure is independently associated with early cardiac surgery-associated acute kidney injury
    Hussein D Kanji
    Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Canada
    J Cardiothorac Surg 5:71. 2010
    ..However, its pathophysiology remains incompletely understood. We hypothesized that intra-operative mean arterial pressure (MAP) relative to pre-operative MAP would be an important predisposing factor for CSA-AKI...
  10. ncbi Clinical characteristics and outcomes of patients with acute myelogenous leukemia admitted to intensive care: a case-control study
    Amanda L Roze des Ordons
    Division of Critical Care Medicine, Faculty of Medicine and Dentistry, University of Alberta Hospital, Edmonton, Alberta, T6G2B7 Canada
    BMC Cancer 10:516. 2010
    ..Our objectives were to describe the clinical characteristics and outcomes in critically ill AML patients...
  11. ncbi Disorders of sodium and water balance in hospitalized patients
    Sean M Bagshaw
    Department of Anesthesiology and Pain Medicine, Division of Critical Care Medicine, University of Alberta Hospital, 3C1 16 Walter C Mackenzie Centre, 8440 112 Street, Edmonton, AB, Canada, T6G 2B7
    Can J Anaesth 56:151-67. 2009
    ..To review and discuss the epidemiology, contributing factors, and approach to clinical management of disorders of sodium and water balance in hospitalized patients...
  12. ncbi Early blood glucose control and mortality in critically ill patients in Australia
    Sean M Bagshaw
    Division of Critical Care Medicine, University of Alberta Hospital, University of Alberta, Edmonton, Alberta, Canada
    Crit Care Med 37:463-70. 2009
    ..To measure temporal trends in blood glucose (BG) control and describe their association with hospital mortality in a cohort of critically ill patients from Australia...
  13. ncbi Timing of renal replacement therapy and clinical outcomes in critically ill patients with severe acute kidney injury
    Sean M Bagshaw
    Department of Intensive Care and Department of Medicine, Austin and Repatriation Medical Centre, Melbourne, Australia
    J Crit Care 24:129-40. 2009
    ..The aim of this study is to evaluate the relationship between timing of renal replacement therapy (RRT) in severe acute kidney injury and clinical outcomes...
  14. ncbi Fluid overload as a biomarker of heart failure and acute kidney injury
    Sean M Bagshaw
    Division of Critical Care Medicine, University of Alberta Hospital, University of Alberta, Edmonton, Alta, Canada
    Contrib Nephrol 164:54-68. 2010
    ..Fluid accumulation and overload are common themes in the pathophysiology and clinical course of both HF and AKI...
  15. ncbi A multi-center evaluation of early acute kidney injury in critically ill trauma patients
    Sean M Bagshaw
    Division of Critical Care Medicine, Walter C Mackenzie Centre, University of Alberta Hospital, University of Alberta, Edmonton, Alberta, Canada
    Ren Fail 30:581-9. 2008
    ..Few studies have evaluated the epidemiology of acute kidney injury (AKI) in trauma...
  16. ncbi Best evidence in critical care medicine. Steroids to prevent post-extubation airway obstruction in adult critically ill patients
    Sean M Bagshaw
    University of Alberta Hospital, University of Alberta, Edmonton, Alberta, Canada
    Can J Anaesth 55:382-5. 2008
  17. ncbi Early acute kidney injury and sepsis: a multicentre evaluation
    Sean M Bagshaw
    Division of Critical Care Medicine, Faculty of Medicine and Dentistry, 3C1, 12 Walter C Mackenzie Centrel, University of Alberta Hospital, University of Alberta, 8440 112 St NW, Edmonton, Alberta, T6G2B7 Canada
    Crit Care 12:R47. 2008
    ..We conducted a study to evaluate the incidence, risk factors and outcomes associated with early acute kidney injury (AKI) in sepsis...
  18. ncbi Oliguria, volume overload, and loop diuretics
    Sean M Bagshaw
    Division of Critical Care Medicine, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada
    Crit Care Med 36:S172-8. 2008
    ..This contradiction between clinical practice and available evidence would suggest there is equipoise and need for higher-quality evidence to better characterize the role of loop diuretics in ICU patients with AKI...
  19. ncbi Conventional markers of kidney function
    Sean M Bagshaw
    Division of Critical Care Medicine, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada
    Crit Care Med 36:S152-8. 2008
    ....
  20. ncbi Continuous versus intermittent renal replacement therapy for critically ill patients with acute kidney injury: a meta-analysis
    Sean M Bagshaw
    Division of Critical Care Medicine, University of Alberta Hospital, University of Alberta, Edmonton, Alberta, Canada
    Crit Care Med 36:610-7. 2008
    ..To appraise the literature on the effect of initial renal replacement therapy (RRT) modality on clinical outcomes...
  21. ncbi The impact of early hypoglycemia and blood glucose variability on outcome in critical illness
    Sean M Bagshaw
    Division of Critical Care Medicine, University of Alberta Hospital, University of Alberta, 8440 112 ST NW Edmonton, Alberta, Canada
    Crit Care 13:R91. 2009
    ..We describe the incidence, clinical factors and outcomes associated with an early hypoglycemia and BG variability in critically ill patients...
  22. ncbi A survey of nurses' beliefs about the medical emergency team system in a canadian tertiary hospital
    Sean M Bagshaw
    University of Alberta, Edmonton, Canada
    Am J Crit Care 19:74-83. 2010
    ..Nurses are the primary activators of the medical emergency team (MET). Although the MET system can empower nurses to seek help in managing acutely ill patients, few data on nurses' beliefs about the system are available...
  23. ncbi Association between implementation of an intensivist-led medical emergency team and mortality
    Constantine J Karvellas
    Division of Critical Care Medicine, University of Alberta Hospital, Edmonton, Alberta, Canada
    BMJ Qual Saf 21:152-9. 2012
    ..To evaluate the impact of implementation of a dedicated intensivist-led medical emergency team (IL-MET) on mortality in patients admitted to the intensive care unit (ICU)...
  24. ncbi Renal replacement therapy: when to start
    Sean M Bagshaw
    Division of Critical Care Medicine, University of Alberta Hospital, University of Alberta, Edmonton, Alta, Canada
    Contrib Nephrol 174:232-41. 2011
    ..In this review, we discuss the theoretical benefits and risks of earlier, as compared to later initiation RRT, the accumulated data, and future directions for investigation...
  25. ncbi Octogenarians in the ICU: are you ever too old?
    Robert C McDermid
    Division of Critical Care Medicine, University of Alberta Hospital, University of Alberta, 3C1, 12 Walter C Mackenzie Centre, 8440 112 St NW, Edmonton, Alberta, Canada T6G 2B7
    Crit Care 15:125. 2011
    ....
  26. ncbi A comparison of early versus late initiation of renal replacement therapy in critically ill patients with acute kidney injury: a systematic review and meta-analysis
    Constantine J Karvellas
    Division of Critical Care Medicine, University of Alberta, 3C1, 12 Walter C, Mackenzie Centre, 8440 122 Street, Edmonton, AB T6G2B7, Canada
    Crit Care 15:R72. 2011
    ..Our aim was to investigate the impact of early versus late initiation of renal replacement therapy (RRT) on clinical outcomes in critically ill patients with acute kidney injury (AKI)...
  27. ncbi Acute kidney injury in 2010: Advances in diagnosis and estimating disease prognosis
    Sean M Bagshaw
    Division of Critical Care Medicine, University of Alberta Hospital, University of Alberta, 3C1 12 Walter C Mackenzie Centre, 8440 112 Street NW, Edmonton, AB T6G 2B7, Canada
    Nat Rev Nephrol 7:70-1. 2011
    ..It is hoped that these findings will lead to improvements in the diagnosis and prognosis of affected individuals...
  28. ncbi [Review article: Acute kidney injury in critical illness]
    Sean M Bagshaw
    Division of Critical Care Medicine, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB T6G 2B7, Canada
    Can J Anaesth 57:985-98. 2010
    ..This review provides a focused and comprehensive update on emerging evidence related to acute kidney injury (AKI)...
  29. ncbi Review article: Renal support in critical illness
    Sean M Bagshaw
    Division of Critical Care Medicine, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB T6G 2B7, Canada
    Can J Anaesth 57:999-1013. 2010
    ..This review provides a focused and comprehensive update on established and emerging evidence in acute renal replacement therapy (RRT) for critically ill patients with acute kidney injury (AKI)...
  30. ncbi The SPARK Study: a phase II randomized blinded controlled trial of the effect of furosemide in critically ill patients with early acute kidney injury
    Sean M Bagshaw
    Division of Critical Care Medicine, Faculty of Medicine and Dentistry, University of Alberta, 12 Walter C, Mackenzie Centre, 8440 112 Street, Edmonton, Alberta, Canada
    Trials 11:50. 2010
    ..The primary analysis will be intention-to-treat. Planned recruitment will be complete by June 2011 and results available by December 2011. TRIAL REGISTRATION: ClinicalTrials.gov Identifier NCT00978354...
  31. ncbi Urine abnormalities in acute kidney injury and sepsis
    Sean M Bagshaw
    Division of Critical Care Medicine, University of Alberta Hospital, Edmonton, Alta, Canada
    Contrib Nephrol 165:274-83. 2010
    ..This review will summarize the urinary biochemistry and microscopy in septic AKI...
  32. ncbi Epidemiology of cardiorenal syndromes
    Sean M Bagshaw
    Division of Critical Care Medicine, University of Alberta Hospital, Edmonton, Alta, Canada
    Contrib Nephrol 165:68-82. 2010
    ..This review will provide a summary of the epidemiology of the CRS and its subtypes...
  33. ncbi Plasma and urine neutrophil gelatinase-associated lipocalin in septic versus non-septic acute kidney injury in critical illness
    Sean M Bagshaw
    Division of Critical Care Medicine, University of Alberta Hospital, University of Alberta, 3C1 16 Walter C Mackenzie Centre, 8440 122 Street, Edmonton, AB T6G2B7, Canada
    Intensive Care Med 36:452-61. 2010
    ..We sought to determine whether there are unique patterns to plasma and urine neutrophil gelatinase-associated lipocalin (NGAL) in septic compared with non-septic AKI...
  34. ncbi A comparison of observed versus estimated baseline creatinine for determination of RIFLE class in patients with acute kidney injury
    Sean M Bagshaw
    Department of Intensive Care, Austin and Repatriation Medical Centre, Melbourne, Australia
    Nephrol Dial Transplant 24:2739-44. 2009
    ..When unknown, current recommendations are to estimate a baseline SCr by the MDRD equation. However, the MDRD approach assumes a glomerular filtration rate of approximately 75 mL/min/1.73 m(2). This method has not been validated...
  35. ncbi A systematic review of urinary findings in experimental septic acute renal failure
    Sean M Bagshaw
    Division of Critical Care Medicine, University of Alberta Hospital, University of Alberta, Edmonton, AB, Canada
    Crit Care Med 35:1592-8. 2007
    ..However, the scientific basis for such use has not been systematically evaluated. Thus, we appraised the value of common urinary findings for the diagnosis and classification of experimental septic acute renal failure...
  36. ncbi A multi-centre evaluation of the RIFLE criteria for early acute kidney injury in critically ill patients
    Sean M Bagshaw
    Division of Critical Care Medicine, University of Alberta Hospital, 3C1 16 Walter C Mackenzie Centre, 8440 122 Street, Edmonton, Alberta T6G2B7, Canada
    Nephrol Dial Transplant 23:1203-10. 2008
    ..We sought to evaluate the RIFLE criteria on the day of ICU admission in a large heterogenous population of critically ill patients...
  37. ncbi Urinary biomarkers in septic acute kidney injury
    Sean M Bagshaw
    Division of Critical Care Medicine, University of Alberta Hospital, 3C1 16 Walter C Mackenzie Centre, 8440 112 Street, T6G 2B7, Edmonton, Alberta, Canada
    Intensive Care Med 33:1285-96. 2007
    ..To appraise the literature on the value of urinary biomarkers in septic acute kidney injury (AKI)...
  38. ncbi Changes in the incidence and outcome for early acute kidney injury in a cohort of Australian intensive care units
    Sean M Bagshaw
    Division of Critical Care Medicine, University of Alberta Hospital, Edmonton, Canada
    Crit Care 11:R68. 2007
    ..There is limited information on whether the incidence of acute kidney injury (AKI) in critically ill patients has changed over time and there is controversy on whether its outcome has improved...
  39. ncbi Septic acute kidney injury in critically ill patients: clinical characteristics and outcomes
    Sean M Bagshaw
    Department of Intensive Care and Department of Medicine, Austin and Repatriation Medical Centre, Melbourne, Australia
    Clin J Am Soc Nephrol 2:431-9. 2007
    ..Patients with septic AKI had an increased risk for death and longer duration of hospitalization yet showed trends toward greater renal recovery and independence from RRT...
  40. ncbi Recent trials in critical care nephrology
    Rinaldo Bellomo
    Department of Intensive Care, Austin Hospital, Melbourne, Vic, Australia, USA
    Contrib Nephrol 165:299-309. 2010
    ....
  41. ncbi Very old patients admitted to intensive care in Australia and New Zealand: a multi-centre cohort analysis
    Sean M Bagshaw
    Department of Intensive Care, Austin Hospital, Studley Road, Heidelberg, VIC 3084, Australia
    Crit Care 13:R45. 2009
    ..The primary objective was to evaluate the rate, characteristics and outcomes of very old (age >or= 80 years) patients admitted to intensive care units (ICUs)...
  42. ncbi Prognosis for long-term survival and renal recovery in critically ill patients with severe acute renal failure: a population-based study
    Sean M Bagshaw
    Department of Critical Care Medicine, Calgary Health Region, University of Calgary, Calgary, Alberta, Canada
    Crit Care 9:R700-9. 2005
    ..Severe acute renal failure (sARF) is associated with considerable morbidity, mortality and use of healthcare resources; however, its precise epidemiology and long-term outcomes have not been well described in a non-specified population...
  43. ncbi Greater increase in urinary hepcidin predicts protection from acute kidney injury after cardiopulmonary bypass
    John R Prowle
    Department of Intensive Care, Austin Hospital, Melbourne, Victoria, Australia
    Nephrol Dial Transplant 27:595-602. 2012
    ..Acute kidney injury (AKI) is a common and serious complication of cardiopulmonary bypass (CPB) surgery. Hepcidin, a peptide hormone that regulates iron homeostasis, is a potential biomarker of AKI following CPB...
  44. ncbi Pilot double-blind, randomized controlled trial of short-term atorvastatin for prevention of acute kidney injury after cardiac surgery
    John R Prowle
    Department of Intensive Care, Austin Health, Melbourne, Victoria, Australia
    Nephrology (Carlton) 17:215-24. 2012
    ..To test whether short-term perioperative administration of oral atorvastatin could reduce incidence of postoperative acute kidney injury (AKI) in cardiac surgical patients...
  45. ncbi Urinary biochemistry and microscopy in septic acute renal failure: a systematic review
    Sean M Bagshaw
    Department of Intensive Care, Austin Hospital, Heidelberg, Victoria 3084, Australia
    Am J Kidney Dis 48:695-705. 2006
    ..More research is required to describe their accuracy, pattern, and time course in patients with septic ARF...
  46. ncbi Loop diuretics in the management of acute renal failure: a systematic review and meta-analysis
    Sean M Bagshaw
    Department of Intensive Care, Austin Hospital, Melbourne, Vic, Australia
    Crit Care Resusc 9:60-8. 2007
    ..We systematically reviewed the literature comparing loop diuretics with control in the management of ARF...
  47. ncbi One-year mortality of bloodstream infection-associated sepsis and septic shock among patients presenting to a regional critical care system
    Kevin B Laupland
    Department of Critical Care Medicine, University of Calgary, 3535 Research Road NW, Calgary, AB, T2L 2K8, Canada
    Intensive Care Med 31:213-9. 2005
    ....
  48. ncbi Oliguria as predictive biomarker of acute kidney injury in critically ill patients
    John R Prowle
    Department of Intensive Care, Austin Hospital, 145 Studley Road, Heidleberg, Victoria 3084, Australia
    Crit Care 15:R172. 2011
    ..During critical illness, oliguria is often used as a biomarker of acute kidney injury (AKI). However, its relationship with the subsequent development of AKI has not been prospectively evaluated...
  49. ncbi One-year mortality in critically ill patients by severity of kidney dysfunction: a population-based assessment
    Sean M Bagshaw
    Department of Critical Care Medicine, Calgary Health Region and University of Calgary, Alberta, Canada
    Am J Kidney Dis 48:402-9. 2006
    ..Kidney dysfunction in the intensive care unit (ICU) results in increased morbidity, mortality, and health care costs; however, long-term mortality has not been described across strata of severity in kidney dysfunction...
  50. ncbi A comparison of the RIFLE and AKIN criteria for acute kidney injury in critically ill patients
    Sean M Bagshaw
    Department of Intensive Care, Austin Hospital, Heidelberg, Victoria 3084, Australia
    Nephrol Dial Transplant 23:1569-74. 2008
    ..The Acute Kidney Injury Network (AKIN) group has recently proposed modifications to this system. It is currently unknown whether there are advantages between these criteria...
  51. ncbi An evaluation of intraoperative renal support during liver transplantation: a matched cohort study
    Ambica Parmar
    Division of Critical Care Medicine, University of Alberta, Edmonton, AB, Canada
    Blood Purif 32:238-48. 2011
    ..Intraoperative continuous renal replacement therapy (CRRT) has been utilized during liver transplantation (LT). Our objective was to assess intraoperative CRRT for metabolic control, postoperative complications and outcomes...
  52. ncbi Phase II, randomized, controlled trial of high-dose N-acetylcysteine in high-risk cardiac surgery patients
    Michael Haase
    Department of Intensive Care, Austin Hospital, University of Melbourne, Australia
    Crit Care Med 35:1324-31. 2007
    ..To assess the effect of high-dose N-acetylcysteine on renal function in cardiac surgery patients at higher risk of postoperative renal failure...
  53. ncbi Epidemiology of septic acute kidney injury
    Ambica Parmar
    University of Alberta Hospital, Walter C Mackenzie Centre, Edmonton, Canada
    Curr Drug Targets 10:1169-78. 2009
    ....
  54. ncbi Diuretics in the management of acute kidney injury: a multinational survey
    Sean M Bagshaw
    Division of Critical Care Medicine, University of Alberta Hospital, University of Alberta, Edmonton, Alta, Canada
    Contrib Nephrol 156:236-49. 2007
    ..Diuretics are a common intervention in critically ill patients with acute kidney injury (AKI). However, there is no information that describes the practice patterns of diuretic use by clinicians...
  55. ncbi Blood glucose control among critically ill patients with brain injury
    Michael J Jacka
    Department of Anaesthesiology and Pain Medicine, Division of Critical Care Medicine, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada
    Can J Neurol Sci 36:436-42. 2009
    ..To evaluate the incidence of hypoglycemia, hyperglycemia and blood glucose (BG) variability in brain-injured patients and their association with clinical outcomes...
  56. ncbi Intensive care unit-acquired urinary tract infections in a regional critical care system
    Kevin B Laupland
    Department of Critical Care Medicine, Center for Anti microbial Resistance, Calgary Health Region, Calgary Laboratory Services, and University of Calgary, Calgary, Alberta, Canada
    Crit Care 9:R60-5. 2005
    ..The objectives of this study were to describe the occurrence, microbiology, and risk factors for acquiring UTIs in the ICU and to determine whether these infections independently increase mortality...
  57. ncbi A proposed algorithm for initiation of renal replacement therapy in adult critically ill patients
    Sean M Bagshaw
    Division of Critical Care Medicine, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta T6G 2B7, Canada
    Crit Care 13:317. 2009
    ..In addition, the proposed algorithm is intended to provide a foundation for prospective evaluation and the development of a broad consensus on when to initiate RRT in critically ill patients...
  58. ncbi Urinary biochemistry in experimental septic acute renal failure
    Christoph Langenberg
    Department of Intensive Care, Austin and Repatriation Medical Centre, Heidelberg, Victoria 3084, Australia
    Nephrol Dial Transplant 21:3389-97. 2006
    ..Despite increased renal perfusion, UNa, FeNa and FeUn decreased significantly. Our findings suggest that, in sepsis, these urinary biochemical changes are not reliable markers of renal hypoperfusion...
  59. ncbi Intraoperative renal support during liver transplantation
    Derek R Townsend
    Division of Critical Care Medicine, University of Alberta Hospital, University of Alberta, Edmonton, Alberta, Canada
    Liver Transpl 15:73-8. 2009
    ..In conclusion, our data suggest that intraoperative CRRT during OLT is achievable and safe. Intraoperative CRRT may be a valuable adjuvant therapy for those with preoperative AKI. Additional investigations are warranted...
  60. ncbi Early diagnosis of acute kidney injury
    Sean M Bagshaw
    Division of Critical Care Medicine, University of Alberta Hospital, University of Alberta, Edmonton, Canada
    Curr Opin Crit Care 13:638-44. 2007
    ..The early detection of acute kidney injury may allow for timely preventive or therapeutic measures. This review discusses the role of traditional and novel biomarkers in early acute kidney injury diagnosis...
  61. ncbi Best evidence in critical care medicine. Steroids in sepsis: bulking up the evidence
    Peter G Brindley
    University of Alberta, Edmonton, Canada
    Can J Anaesth 55:648-50. 2008
  62. ncbi Blood cytokine, chemokine and gene expression in cholestasis patients with intractable pruritis treated with a molecular adsorbent recirculating system: a case series
    Luiz F Lisboa
    Transplant Infectious Diseases, University of Alberta, Edmonton, Alberta, Canada
    Can J Gastroenterol 26:799-805. 2012
    ..The molecular adsorbent recirculating system (MARS) is an albumin-dialysis modality that has been investigated predominantly in patients with acute and acute-on-chronic liver failure...
  63. ncbi Major complications, mortality, and resource utilization after open abdominal surgery: 0.9% saline compared to Plasma-Lyte
    Andrew D Shaw
    Department of Anesthesiology, Duke University Medical Center, Durham, NC 27705, USA
    Ann Surg 255:821-9. 2012
    ..To assess the association of 0.9% saline use versus a calcium-free physiologically balanced crystalloid solution with major morbidity and clinical resource use after abdominal surgery...
  64. ncbi Cardiopulmonary bypass-associated acute kidney injury: a pigment nephropathy?
    Michael Haase
    Department of Intensive Care, Austin Health, Austin Hospital, Melbourne, Vic, Australia, and Department of Nephrology, Charite University Medicine, Berlin, Germany
    Contrib Nephrol 156:340-53. 2007
    ..A trial of such treatment might be a reasonable future investigation in higher risk patients receiving CPB...
  65. ncbi The role of the medical emergency team in end-of-life care: a multicenter, prospective, observational study
    Daryl A Jones
    Division of Critical Care Medicine, University of Alberta, University of Alberta Hospital, Edmonton, Alberta, Canada
    Crit Care Med 40:98-103. 2012
    ..To investigate the role of medical emergency teams in end-of-life care planning...
  66. ncbi The histopathology of septic acute kidney injury: a systematic review
    Christoph Langenberg
    Department of Intensive Care, Austin Hospital, Studley Rd, Heidelberg, Melbourne, Victoria 3084, Australia
    Crit Care 12:R38. 2008
    ..Accordingly, we systematically reviewed the literature to assess current knowledge on the histopathology of septic AKI...
  67. ncbi Is regional citrate superior to systemic heparin anticoagulation for continuous renal replacement therapy? A prospective observational study in an adult regional critical care system
    Sean M Bagshaw
    Department of Critical Care Medicine, University of Calgary and Calgary Health Region, Foothills Medical Centre, Alberta, Canada
    J Crit Care 20:155-61. 2005
    ..We report our regional CRRT protocol that was developed using the principles of quality improvement and compare the effect of regional citrate with systemic heparin anticoagulation on filter life span...
  68. ncbi Tracheostomy: from insertion to decannulation
    Paul T Engels
    Department of Surgery, Division of Critical Care Medicine, University of Alberta, Edmonton, Alta
    Can J Surg 52:427-33. 2009
    ..We outline the potential acute and chronic complications of tracheostomy and their management, and we review the different tracheostomy tubes, their indications and when to remove them...
  69. ncbi Acetylcysteine in the prevention of contrast-induced nephropathy: a case study of the pitfalls in the evolution of evidence
    Sean M Bagshaw
    Department of Critical Care Medicine, University of Calgary, Calgary, Alberta, Canada
    Arch Intern Med 166:161-6. 2006
    ....
  70. ncbi Pathophysiology of septic acute kidney injury: what do we really know?
    Li Wan
    Department of Intensive Care, Austin Hospital, Melbourne, Australia
    Crit Care Med 36:S198-203. 2008
    ..If this were to happen, our therapeutic approaches would also be profoundly altered...
  71. ncbi Prolonged refractory status epilepticus following acute traumatic brain injury: a case report of excellent neurological recovery
    Adam D Peets
    Department of Critical Care, University of Calgary, Calgary, Alberta, Canada
    Crit Care 9:R725-8. 2005
    ..Refractory status epilepticus (RSE) secondary to traumatic brain injury (TBI) may be under-recognized and is associated with significant morbidity and mortality...
  72. ncbi Epidemiology of intensive care unit-acquired urinary tract infections
    Sean M Bagshaw
    Department of Critical Care Medicine, Calgary Laboratory Services, Calgary Health Region, and University of Calgary, Calgary, Alberta, Canada
    Curr Opin Infect Dis 19:67-71. 2006
    ..There is a relative paucity of research on nosocomial urinary tract infection specifically acquired in the intensive care unit and further studies are needed to better define the epidemiology and management of these infections...
  73. ncbi New insights on intravenous fluids, diuretics and acute kidney injury
    Derek R Townsend
    Division of Critical Care Medicine, Faculty of Medicine and Dentistry, University of Alberta Hospital, University of Alberta, Edmonton, Alta, Canada
    Nephron Clin Pract 109:c206-16. 2008
    ..In this review, we explore recent insights on intravenous fluid therapy, volume overload, and diuretic therapy in the context of the critically ill patients with AKI...
  74. ncbi Peri-operative medical emergency team activation in liver transplantation
    Ambica Parmar
    Division of Critical Care Medicine, University of Alberta Hospital, 3C1 12 Walter C Mackenzie Centre, 8440 122 Street, Edmonton, Alberta T6G2B7 Canada
    BMJ Qual Saf 20:243-50. 2011
    ..The medical emergency team (MET) system functions to promptly identify acutely ill patients at-risk for deterioration. Liver transplant (LT) patients are at-risk for serious post-operative complications...
  75. ncbi Acute kidney injury in septic shock: clinical outcomes and impact of duration of hypotension prior to initiation of antimicrobial therapy
    Sean M Bagshaw
    Division of Critical Care Medicine, University of Alberta, Edmonton, AB, Canada
    Intensive Care Med 35:871-81. 2009
    ..To describe the incidence and outcomes associated with early acute kidney injury (AKI) in septic shock and explore the association between duration from hypotension onset to effective antimicrobial therapy and AKI...
  76. ncbi A case-control study of single-pass albumin dialysis for acetaminophen-induced acute liver failure
    Constantine J Karvellas
    Division of Critical Care Medicine, University of Alberta, Edmonton, Alta, Canada
    Blood Purif 28:151-8. 2009
    ..We evaluated the clinical, physiological and laboratory parameters of SPAD in acetaminophen-induced acute liver failure (AALF)...
  77. ncbi The long-term outcome after acute renal failure
    Sean M Bagshaw
    Department of Intensive Care, Austin Hospital, Melbourne, Australia
    Curr Opin Crit Care 12:561-6. 2006
    ..Research priorities in critical care are increasingly focusing on long-term outcomes and prognosis for survivors of critical illness. This review will focus on long-term outcomes after acute renal failure...
  78. ncbi Early diagnosis of acute kidney injury in critically ill patients
    Robert Keyes
    Division of Critical Care Medicine, University of Alberta Hospital, University of Alberta, Edmonton, Alberta, Canada
    Expert Rev Mol Diagn 8:455-64. 2008
    ..This article will review the pitfalls of current conventional testing in kidney injury and discuss the emergence of novel biomarkers with the potential to revolutionize the field of critical care nephrology...
  79. ncbi Dialysis Disequilibrium Syndrome: brain death following hemodialysis for metabolic acidosis and acute renal failure--a case report
    Sean M Bagshaw
    Department of Critical Care Medicine, Calgary Health Region, University of Calgary, Calgary, Alberta, Canada
    BMC Nephrol 5:9. 2004
    ..We describe a case of DDS-induced cerebral edema that resulted in irreversible brain injury and death following acute HD and review the relevant literature of the association of DDS and HD...
  80. ncbi Drug-induced rash with eosinophilia and systemic symptoms syndrome with bupropion administration
    Sean M Bagshaw
    Department of Medicine, Foothills Medical Centre, University of Calgary, Calgary, Alberta, Canada
    Ann Allergy Asthma Immunol 90:572-5. 2003
    ..We report this case to notify clinicians of the potential serious multisystem complications that can occur with sustained-release bupropion therapy...
  81. ncbi Theophylline for prevention of contrast-induced nephropathy: a systematic review and meta-analysis
    Sean M Bagshaw
    Department of Critical Care Medicine, Calgary Health Region, and Departments of Internal Medicine, University of Calgary, Calgary, Alberta, Canada
    Arch Intern Med 165:1087-93. 2005
    ..However, findings are inconsistent across studies. A large, well-designed trial that incorporates the evaluation of clinically relevant outcomes is required to more adequately assess the role for theophylline in CIN prevention...
  82. ncbi Prophylactic amiodarone for prevention of atrial fibrillation after cardiac surgery: a meta-analysis
    Sean M Bagshaw
    Department of Critical Care Medicine, University of Calgary, Calgary, Alberta, Canada; Department of Community Health Sciences, University of Calgary, Calgary, Alberta, Canada; Department of Intensive Care, Austin Hospital, Melbourne, Victoria, Australia
    Ann Thorac Surg 82:1927-37. 2006
    ..The current evidence supports recommending the routine use of perioperative amiodarone for cardiac surgery...
  83. ncbi Epidemiology of renal recovery after acute renal failure
    Sean M Bagshaw
    Department of Intensive Care, Austin Hospital, Melbourne, Australia
    Curr Opin Crit Care 12:544-50. 2006
    ..Herein, the epidemiology of renal recovery after acute renal failure will be described, along with potential predictive factors and interventions...
  84. ncbi The influence of volume management on outcome
    Sean M Bagshaw
    Division of Critical Care Medicine, University of Alberta Hospital, University of Alberta, Edmonton, Alberta, Canada
    Curr Opin Crit Care 13:541-8. 2007
    ..There is much controversy, however, about the type, timing and amount of fluid therapy. Here, we discuss the evidence available to guide such choices...
  85. ncbi Caterpillar-induced bleeding syndrome in a returning traveller
    Kris Chan
    Department of Internal Medicine, University of Alberta, Edmonton, Alberta
    CMAJ 179:158-61. 2008
  86. ncbi Fluid resuscitation and the septic kidney
    Sean M Bagshaw
    Curr Opin Crit Care 12:527-30. 2006
    ..Thus, in this editorial, we consider the relevant literature and more recent insights into the effect of fluid resuscitation on the septic kidney...
  87. ncbi Acetylcysteine and renal function following coronary angiographic procedures
    Sean M Bagshaw
    JAMA 289:2795; author reply 2796. 2003
  88. ncbi N-Acetylcysteine does not artifactually lower plasma creatinine concentration
    Michael Haase
    Director of Intensive Care Research, Austin Hospital, University of Melbourne, 3084 Heidelberg, Victoria, Australia
    Nephrol Dial Transplant 23:1581-7. 2008
    ..However, it has been suggested that NAC may lower plasma creatinine levels independent of any effects on glomerular filtration rate (GFR)...
  89. ncbi Short- and long-term survival after acute kidney injury
    Sean M Bagshaw
    Nephrol Dial Transplant 23:2126-8. 2008
  90. ncbi Renal support in critically ill patients with acute kidney injury
    Sean M Bagshaw
    N Engl J Med 359:1960-1. 2008
  91. ncbi Normotensive ischemic acute renal failure
    Rinaldo Bellomo
    N Engl J Med 357:2205; author reply 2205-6. 2007
  92. ncbi Is there a place for levosimendan in the intensive care unit?
    Anthony Delaney
    Northern Clinical School, Faculty of Medicine, University of Sydney, Sydney, NSW, Australia
    Crit Care Resusc 9:290-2. 2007
    ..Until their results can be fully scrutinised, and placed in the context of all available evidence, we should conclude that there is no place for levosimendan in the ICU...
  93. ncbi A systematic evaluation of the quality of meta-analyses in the critical care literature
    Anthony Delaney
    Department of Intensive Care Medicine, Royal North Shore Hospital, Sydney, NSW, Australia
    Crit Care 9:R575-82. 2005
    ..The purpose of this study was to systematically evaluate the quality of meta-analyses that address topics pertinent to critical care...
  94. ncbi Acetylcysteine for prevention of contrast-induced nephropathy after intravascular angiography: a systematic review and meta-analysis
    Sean M Bagshaw
    Department of Critical Care Medicine, Calgary Health Region, Calgary, Canada
    BMC Med 2:38. 2004
    ..Contrast-induced nephropathy is an important cause of acute renal failure. We assess the efficacy of acetylcysteine for prevention of contrast-induced nephropathy among patients undergoing intravascular angiography...
  95. ncbi The quality of reports of critical care meta-analyses in the Cochrane Database of Systematic Reviews: an independent appraisal
    Anthony Delaney
    Department of Intensive Care Medicine, Royal North Shore Hospital, and Northern Clinical School, University of Sydney, St Leonards, NSW, Australia
    Crit Care Med 35:589-94. 2007
    ....
  96. ncbi Percutaneous dilatational tracheostomy versus surgical tracheostomy in critically ill patients: a systematic review and meta-analysis
    Anthony Delaney
    Intensive Care Unit, Royal North Shore Hospital, Sydney, NSW, Australia
    Crit Care 10:R55. 2006
    ....
  97. ncbi Erythropoietin and transfusions among critically ill patients
    Sean M Bagshaw
    JAMA 289:1511; author reply 1512. 2003