Ildiko Badea

Summary

Affiliation: University of Saskatchewan
Country: Canada

Publications

  1. pmc Nanodiamonds as novel nanomaterials for biomedical applications: drug delivery and imaging systems
    Randeep Kaur
    Drug Design and Discovery Research Group, College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, Saskatchewan, Canada
    Int J Nanomedicine 8:203-20. 2013
  2. pmc Lysine-functionalized nanodiamonds: synthesis, physiochemical characterization, and nucleic acid binding studies
    Randeep Kaur
    Drug Design and Discovery Research Group, College of Pharmacy and Nutrition, University of Saskatchewan, 110 Science Place, Saskatoon, SK, Canada
    Int J Nanomedicine 7:3851-66. 2012
  3. pmc Evaluation of cellular uptake and intracellular trafficking as determining factors of gene expression for amino acid-substituted gemini surfactant-based DNA nanoparticles
    Jagbir Singh
    College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, Canada
    J Nanobiotechnology 10:7. 2012
  4. ncbi request reprint Amino acid-substituted gemini surfactant-based nanoparticles as safe and versatile gene delivery agents
    Jagbir Singh
    Drug Design and Discovery Research Group, College of Pharmacy and Nutrition, University of Saskatchewan, Canada
    Curr Drug Deliv 8:299-306. 2011
  5. ncbi request reprint Gene delivery into human skin in vitro using biphasic lipid vesicles
    Marianna Foldvari
    College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, SK S7N 5C9, Canada
    Curr Drug Deliv 3:89-93. 2006
  6. ncbi request reprint Topical non-invasive gene delivery using gemini nanoparticles in interferon-gamma-deficient mice
    Ildiko Badea
    College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, SK, Canada
    Eur J Pharm Biopharm 65:414-22. 2007
  7. ncbi request reprint Development of lyophilized gemini surfactant-based gene delivery systems: influence of lyophilization on the structure, activity and stability of the lipoplexes
    Waleed Mohammed-Saeid
    Drug Design and Discovery Research Group, College of Pharmacy and Nutrition, University of Saskatchewan, 110 Science Place, Saskatoon, Canada
    J Pharm Pharm Sci 15:548-67. 2012
  8. doi request reprint Design and evaluation of cyclodextrin-based delivery systems to incorporate poorly soluble curcumin analogs for the treatment of melanoma
    Deborah Michel
    Drug Design and Discovery Research Group, University of Saskatchewan, Saskatoon, Canada
    Eur J Pharm Biopharm 81:548-56. 2012
  9. doi request reprint Enhanced gene expression in epithelial cells transfected with amino acid-substituted gemini nanoparticles
    Peng Yang
    Department of Chemistry, University of Saskatchewan, Saskatoon, Canada
    Eur J Pharm Biopharm 75:311-20. 2010
  10. doi request reprint A general liquid chromatography tandem mass spectrometry method for the quantitative determination of diquaternary ammonium gemini surfactant drug delivery agents in mouse keratinocytes' cellular lysate
    Joshua Buse
    College of Pharmacy and Nutrition, University of Saskatchewan, 110 Science Place, Saskatoon, SK S7N 5C9, Canada
    J Chromatogr A 1294:98-105. 2013

Collaborators

Detail Information

Publications16

  1. pmc Nanodiamonds as novel nanomaterials for biomedical applications: drug delivery and imaging systems
    Randeep Kaur
    Drug Design and Discovery Research Group, College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, Saskatchewan, Canada
    Int J Nanomedicine 8:203-20. 2013
    ..Considering the progress that has been made in understanding the properties of NDs, they can be envisioned as highly efficient drug delivery and imaging biomaterials for use in animals and humans...
  2. pmc Lysine-functionalized nanodiamonds: synthesis, physiochemical characterization, and nucleic acid binding studies
    Randeep Kaur
    Drug Design and Discovery Research Group, College of Pharmacy and Nutrition, University of Saskatchewan, 110 Science Place, Saskatoon, SK, Canada
    Int J Nanomedicine 7:3851-66. 2012
    ..Here, the authors describe the covalent functionalization of NDs with lysine in an attempt to develop nanoparticles able to act as suitable nonviral vectors for transferring genetic materials across cellular membranes...
  3. pmc Evaluation of cellular uptake and intracellular trafficking as determining factors of gene expression for amino acid-substituted gemini surfactant-based DNA nanoparticles
    Jagbir Singh
    College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, Canada
    J Nanobiotechnology 10:7. 2012
    ..In this study, we evaluated the mechanism of cellular uptake of the plasmid/gemini surfactant/helper lipid nanoparticles and their effect on the transfection efficiency...
  4. ncbi request reprint Amino acid-substituted gemini surfactant-based nanoparticles as safe and versatile gene delivery agents
    Jagbir Singh
    Drug Design and Discovery Research Group, College of Pharmacy and Nutrition, University of Saskatchewan, Canada
    Curr Drug Deliv 8:299-306. 2011
    ....
  5. ncbi request reprint Gene delivery into human skin in vitro using biphasic lipid vesicles
    Marianna Foldvari
    College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, SK S7N 5C9, Canada
    Curr Drug Deliv 3:89-93. 2006
    ..The successful delivery of this large (approximately 4,400 kDa) charged molecule through intact stratum corneum represents a major advance in transdermal macromolecule delivery...
  6. ncbi request reprint Topical non-invasive gene delivery using gemini nanoparticles in interferon-gamma-deficient mice
    Ildiko Badea
    College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, SK, Canada
    Eur J Pharm Biopharm 65:414-22. 2007
    ....
  7. ncbi request reprint Development of lyophilized gemini surfactant-based gene delivery systems: influence of lyophilization on the structure, activity and stability of the lipoplexes
    Waleed Mohammed-Saeid
    Drug Design and Discovery Research Group, College of Pharmacy and Nutrition, University of Saskatchewan, 110 Science Place, Saskatoon, Canada
    J Pharm Pharm Sci 15:548-67. 2012
    ..Additionally, we evaluated the feasibility of lyophilization as a technique for preparing lipoplexes with long term stability...
  8. doi request reprint Design and evaluation of cyclodextrin-based delivery systems to incorporate poorly soluble curcumin analogs for the treatment of melanoma
    Deborah Michel
    Drug Design and Discovery Research Group, University of Saskatchewan, Saskatoon, Canada
    Eur J Pharm Biopharm 81:548-56. 2012
    ..The goal is to develop this novel nanoparticle approach into a non-invasive therapy for in-transit melanoma metastasis that lacks adequate treatment to date...
  9. doi request reprint Enhanced gene expression in epithelial cells transfected with amino acid-substituted gemini nanoparticles
    Peng Yang
    Department of Chemistry, University of Saskatchewan, Saskatoon, Canada
    Eur J Pharm Biopharm 75:311-20. 2010
    ..The superior performance of these spacer-substituted gemini surfactants might be attributed to their better biocompatibility compared to the surfactants possessing unsubstituted spacers...
  10. doi request reprint A general liquid chromatography tandem mass spectrometry method for the quantitative determination of diquaternary ammonium gemini surfactant drug delivery agents in mouse keratinocytes' cellular lysate
    Joshua Buse
    College of Pharmacy and Nutrition, University of Saskatchewan, 110 Science Place, Saskatoon, SK S7N 5C9, Canada
    J Chromatogr A 1294:98-105. 2013
    ....
  11. ncbi request reprint DNA delivery for vaccination and therapeutics through the skin
    Marianna Foldvari
    College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, Sask, Canada
    Curr Drug Deliv 3:17-28. 2006
    ..This paper reviews the formulation approaches and delivery methods for DNA through the skin in the context of the barriers both at the tissue and cellular levels for both vaccine and gene therapy applications...
  12. doi request reprint Advancing nonviral gene delivery: lipid- and surfactant-based nanoparticle design strategies
    McDonald Donkuru
    College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, SK, Canada
    Nanomedicine (Lond) 5:1103-27. 2010
    ..This article provides an overview of the strategies employed to improve in vitro and in vivo transfection, focusing on the use of cationic lipids and surfactants as building blocks for nonviral gene delivery systems...
  13. doi request reprint Study on protein conformation and adsorption behaviors in nanodiamond particle-protein complexes
    Hai Dong Wang
    Department of Biomedical Engineering, University of Saskatchewan, Saskatoon S7N5A9, Canada
    Nanotechnology 22:145703. 2011
    ..The results show that ND is an excellent platform for protein immobilization with high affinity and holds great potential to be used for biosensor applications...
  14. ncbi request reprint In vivo cutaneous interferon-gamma gene delivery using novel dicationic (gemini) surfactant-plasmid complexes
    Ildiko Badea
    College of Pharmacy and Nutrition, University of Saskatchewan, SK S7N 5C9, Canada
    J Gene Med 7:1200-14. 2005
    ..In this study, the feasibility of topical delivery of the IFNgamma gene and expression of IFNgamma were investigated in mice...
  15. doi request reprint Tandem mass spectrometric analysis of novel diquaternary ammonium gemini surfactants and their bromide adducts in electrospray-positive ion mode ionization
    Joshua Buse
    College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, SK, Canada
    J Mass Spectrom 46:1060-70. 2011
    ..Understanding the ionization and fragmentation behaviour of gemini surfactants, including bromine adducts, will allow for future qualitative and quantitative identification of these novel drug delivery agents within biological samples...
  16. ncbi request reprint Transdermal delivery of insulin from a novel biphasic lipid system in diabetic rats
    Martin J King
    PharmaDerm Laboratories Ltd, Saskatoon, Saskatchewan, Canada
    Diabetes Technol Ther 4:479-88. 2002
    ..These results support the feasibility of developing a transdermal insulin patch for human applications...