J Ausio

Summary

Affiliation: University of Victoria
Country: Canada

Publications

  1. ncbi request reprint Evolution of vertebrate chromosomal sperm proteins: implications for fertility and sperm competition
    Juan Ausio
    Department of Biochemistry and Microbiology, University of Victoria, Victoria, British Columbia, Canada
    Soc Reprod Fertil Suppl 65:63-79. 2007
  2. pmc Brain H2A.Z: the long and the short
    Juan Ausio
    Department of Biochemistry and Microbiology, University of Victoria, Victoria, BC V8W 3P6, Canada
    BMC Biol 11:84. 2013
  3. doi request reprint Vertebrate nucleoplasmin and NASP: egg histone storage proteins with multiple chaperone activities
    Ron M Finn
    Department of Biochemistry and Microbiology, University of Victoria, Victoria, BC, Canada V8W 3P6
    FASEB J 26:4788-804. 2012
  4. pmc A unified phylogeny-based nomenclature for histone variants
    Paul B Talbert
    Howard Hughes Medical Institute, Basic Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, 98109, USA
    Epigenetics Chromatin 5:7. 2012
  5. pmc The characterization of amphibian nucleoplasmins yields new insight into their role in sperm chromatin remodeling
    Lindsay J Frehlick
    Department of Biochemistry and Microbiology, University of Victoria, Petch Building, Victoria, BC, V8W 3P6, Canada
    BMC Genomics 7:99. 2006
  6. pmc The evolutionary differentiation of two histone H2A.Z variants in chordates (H2A.Z-1 and H2A.Z-2) is mediated by a stepwise mutation process that affects three amino acid residues
    José M Eirín-López
    Departamento de Biologia Celular y Molecular, Universidade da Coruna, Coruna, Spain
    BMC Evol Biol 9:31. 2009
  7. pmc Characterization of the histone H2A.Z-1 and H2A.Z-2 isoforms in vertebrates
    Deanna Dryhurst
    Department of Biochemistry and Microbiology and The Center for Biomedical Research, University of Victoria, Petch Building, Victoria, BC, V8W 3P6, Canada
    BMC Biol 7:86. 2009
  8. ncbi request reprint Histone variants--the structure behind the function
    Juan Ausio
    Department of Biochemistry and Microbiology, University of Victoria, Victoria, BC, Canada
    Brief Funct Genomic Proteomic 5:228-43. 2006
  9. ncbi request reprint The many tales of a tail: carboxyl-terminal tail heterogeneity specializes histone H2A variants for defined chromatin function
    Juan Ausio
    Department of Biochemistry and Microbiology, University of Victoria, Victoria, British Columbia, Canada V8W 3P6
    Biochemistry 41:5945-9. 2002
  10. ncbi request reprint Histone variants and histone modifications: a structural perspective
    J Ausio
    Department of Biochemistry and Microbiology, University of Victoria, BC, Canada
    Biochem Cell Biol 79:693-708. 2001

Collaborators

  • X Wang
  • F G van der Goot
  • Deanna Dryhurst
  • Caren C Helbing
  • Lindsay J Frehlick
  • Jose M. Eirin-Lopez
  • D B Levin
  • H E Kasinsky
  • J B Dacks
  • Marvin Meistrich
  • Satomi Kohno
  • Ming Zhao
  • F Y Choy
  • Alisdair B Boraston
  • Susan P Lees-Miller
  • Louis J Guillette
  • Brian P Chadwick
  • Andrei O Zalensky
  • Toyotaka Ishibashi
  • Anita A Thambirajah
  • Andra Li
  • John D Lewis
  • Ron M Finn
  • D Wade Abbott
  • Allison H Maffey
  • Paul B Talbert
  • Lyndsay Sprigg
  • Susan C Moore
  • Alison Calestagne-Morelli
  • Isbaal Ramos
  • Alicia Lammerts van Bueren
  • Sabira M Bagha
  • Miriam E de Jong
  • Yue Song
  • Manel Chiva
  • Pepita Gimenez-Bonafe
  • Jan Postberg
  • Detlef Doenecke
  • Prem L Bhalla
  • Kinga Kamieniarz
  • David John Tremethick
  • William F Marzluff
  • Andreas G Ladurner
  • Benjamin Loppin
  • Robert Schneider
  • David Landsman
  • Katherine Ellard
  • Ramesh Yelagandula
  • W Zacheus Cande
  • Liwang Cui
  • Heike Wollmann
  • Genevieve Almouzni
  • Harmit S Malik
  • M Mitchell Smith
  • Eric Thompson
  • Bryan M Turner
  • Sarah Holec
  • William M Bonner
  • Simon W L Chan
  • Frederic Berger
  • Jakob Harm Waterborg
  • BARBARA A HAMKALO
  • Saadi Khochbin
  • Bing Zhu
  • Sandra B Hake
  • Steven Henikoff
  • Maria Elena Torres-Padilla
  • Martin A Gorovsky
  • Steven E Jacobsen
  • Kami Ahmad
  • John R Pehrson
  • John A Latham
  • Mohan B Singh
  • Stefan I Dimitrov
  • George A M Cross
  • Kristal Missiaen
  • Michael J Hendzel
  • Sheng Chun Lee
  • Yaping Yu
  • Donald F Hunt
  • Kristie L Rose
  • James H Eubanks
  • Jeffrey Shabanowitz
  • Kristen Browne
  • Kim C Hodgson
  • Claire G Cupples
  • Kevin So
  • Cheng He
  • Colleen C Nelson
  • Stephen C Hendy

Detail Information

Publications57

  1. ncbi request reprint Evolution of vertebrate chromosomal sperm proteins: implications for fertility and sperm competition
    Juan Ausio
    Department of Biochemistry and Microbiology, University of Victoria, Victoria, British Columbia, Canada
    Soc Reprod Fertil Suppl 65:63-79. 2007
    ..All of this suggests a potential involvement of protamines in sperm competition which is discussed in this paper...
  2. pmc Brain H2A.Z: the long and the short
    Juan Ausio
    Department of Biochemistry and Microbiology, University of Victoria, Victoria, BC V8W 3P6, Canada
    BMC Biol 11:84. 2013
    ..Z subtype that is specific for brain and pituitary in the carp and provides additional information about the functional epigenetic complexity of the PTMs associated with histone H2A.Z...
  3. doi request reprint Vertebrate nucleoplasmin and NASP: egg histone storage proteins with multiple chaperone activities
    Ron M Finn
    Department of Biochemistry and Microbiology, University of Victoria, Victoria, BC, Canada V8W 3P6
    FASEB J 26:4788-804. 2012
    ..In contrast to members of the NPM family, which share a common monophyletic evolutionary origin, the different types of NASP appear to have evolved recurrently within different taxa...
  4. pmc A unified phylogeny-based nomenclature for histone variants
    Paul B Talbert
    Howard Hughes Medical Institute, Basic Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, 98109, USA
    Epigenetics Chromatin 5:7. 2012
    ..For clarity and searchability, we encourage the use of descriptors that are separate from the phylogeny-based variant name to indicate developmental and other properties of variants that may be independent of structure...
  5. pmc The characterization of amphibian nucleoplasmins yields new insight into their role in sperm chromatin remodeling
    Lindsay J Frehlick
    Department of Biochemistry and Microbiology, University of Victoria, Petch Building, Victoria, BC, V8W 3P6, Canada
    BMC Genomics 7:99. 2006
    ....
  6. pmc The evolutionary differentiation of two histone H2A.Z variants in chordates (H2A.Z-1 and H2A.Z-2) is mediated by a stepwise mutation process that affects three amino acid residues
    José M Eirín-López
    Departamento de Biologia Celular y Molecular, Universidade da Coruna, Coruna, Spain
    BMC Evol Biol 9:31. 2009
    ..Z generically as a single protein, in vertebrates it is a mixture of two protein forms H2A.Z-1 (previously H2A.Z) and H2A.Z-2 (previously H2A.F/Z or H2A.V) that differ by three amino acids...
  7. pmc Characterization of the histone H2A.Z-1 and H2A.Z-2 isoforms in vertebrates
    Deanna Dryhurst
    Department of Biochemistry and Microbiology and The Center for Biomedical Research, University of Victoria, Petch Building, Victoria, BC, V8W 3P6, Canada
    BMC Biol 7:86. 2009
    ..Z mediates its effects are not entirely understood. However, it is now known that H2A.Z has two protein isoforms in vertebrates, H2A.Z-1 and H2A.Z-2, which are encoded by separate genes and differ by 3 amino acid residues...
  8. ncbi request reprint Histone variants--the structure behind the function
    Juan Ausio
    Department of Biochemistry and Microbiology, University of Victoria, Victoria, BC, Canada
    Brief Funct Genomic Proteomic 5:228-43. 2006
    ..Understanding and deciphering the underlying structural amino acid code behind such variability remains one of the most exciting future challenges in chromatin research...
  9. ncbi request reprint The many tales of a tail: carboxyl-terminal tail heterogeneity specializes histone H2A variants for defined chromatin function
    Juan Ausio
    Department of Biochemistry and Microbiology, University of Victoria, Victoria, British Columbia, Canada V8W 3P6
    Biochemistry 41:5945-9. 2002
    ....
  10. ncbi request reprint Histone variants and histone modifications: a structural perspective
    J Ausio
    Department of Biochemistry and Microbiology, University of Victoria, BC, Canada
    Biochem Cell Biol 79:693-708. 2001
    ..Recent work on this topic emphasizes an earlier notion that suggests that, in many instances, the functional response to histone variability is possibly the result of a synergistic structural effect...
  11. ncbi request reprint Syndromes of disordered chromatin remodeling
    J Ausio
    Department of Biochemistry and Microbiology, University of Victoria, Victoria, British Columbia, Canada
    Clin Genet 64:83-95. 2003
    ....
  12. ncbi request reprint Analytical ultracentrifugation and the characterization of chromatin structure
    J Ausio
    Department of Biochemistry and Microbiology, University of Victoria, British Columbia, Canada
    Biophys Chem 86:141-53. 2000
    ..As an example he has devoted some of his research effort to the characterization of chromatin in solution. This review includes these important contributions...
  13. ncbi request reprint Are linker histones (histone H1) dispensable for survival?
    J Ausio
    Department of Biochemistry and Microbiology, University of Victoria, Petch Building 220, Victoria, British Columbia, Canada V8W 3P6
    Bioessays 22:873-7. 2000
    ..These results suggest that while linker histones may be dispensable for the relatively short life span of an individual cell, they are most likely indispensable for survival of higher eukaryote organisms...
  14. ncbi request reprint The histidine-rich protamine from ostrich and tinamou sperm. A link between reptile and bird protamines
    J Ausio
    Department of Biochemistry and Microbiology, University of Victoria, B C, Canada
    Biochemistry 38:180-4. 1999
    ..Furthermore, these results shed some additional light on the controversial origin of birds. They provide further molecular support to the fossil record that suggests that reptiles and birds are closely related...
  15. ncbi request reprint Effects of histone acetylation on the solubility and folding of the chromatin fiber
    X Wang
    Department of Biochemistry and Microbiology, University of Victoria, Victoria, British Columbia V8W 3P6, Canada
    J Biol Chem 276:12764-8. 2001
    ....
  16. pmc Long-term evolution and functional diversification in the members of the nucleophosmin/nucleoplasmin family of nuclear chaperones
    José M Eirín-López
    Department of Biochemistry and Microbiology, University of Victoria, British Columbia, Canada
    Genetics 173:1835-50. 2006
    ....
  17. ncbi request reprint Dimerization stabilizes the pore-forming toxin aerolysin in solution
    F G van der Goot
    Department of Biochemistry and Microbiology, University of Victoria, British Columbia, Canada
    J Biol Chem 268:18272-9. 1993
    ..These substitutions are known to increase the protein's ability to oligomerize, supporting the conclusion that dimer dissociation is necessary for oligomerization to occur...
  18. ncbi request reprint Nucleoplasmin-mediated unfolding of chromatin involves the displacement of linker-associated chromatin proteins
    Isbaal Ramos
    Department of Biochemistry and Microbiology, University of Victoria, Victoria, British Columbia, Canada
    Biochemistry 44:8274-81. 2005
    ..The results are discussed within the context of the possible implication of nucleoplasmin in processes such as transcription and replication licensing which take place after egg fertilization at the onset of development...
  19. ncbi request reprint Origin of H1 linker histones
    H E Kasinsky
    Department of Biochemistry and Microbiology, University of Victoria, Victoria, B C, Canada
    FASEB J 15:34-42. 2001
    ....
  20. pmc Acetylation of vertebrate H2A.Z and its effect on the structure of the nucleosome
    Toyotaka Ishibashi
    Department of Biochemistry and Microbiology and The Center for Biomedical Research, University of Victoria, Petch Building, Victoria, BC, Canada V8W 3P6
    Biochemistry 48:5007-17. 2009
    ..Furthermore, the simultaneous occurrence of H2A.Z and H2A in heteromorphic NCPs that most likely occurs in vivo slightly destabilizes the NCP, but only in the presence of acetylation...
  21. doi request reprint The sperm proteins from amphioxus mirror its basal position among chordates and redefine the origin of vertebrate protamines
    Jose Maria Eirin-Lopez
    Department of Biochemistry and Microbiology, University of Victoria, Victoria, British Columbia, Canada
    Mol Biol Evol 25:1705-13. 2008
    ..Given that tunicates are now viewed as a sister group of vertebrates, the lysine to arginine transition responsible for the origin of vertebrate protamines must be set a step back from tunicates...
  22. doi request reprint Interaction of daunomycin with acetylated chromatin
    Lyndsay Sprigg
    Department of Biochemistry and Microbiology, University of Victoria, Victoria, British Columbia, V8W 3P6, Canada
    J Med Chem 53:6457-65. 2010
    ..Furthermore, the binding of anthracycline to acetylated chromatin sheds additional light into the conformational chromatin alterations resulting from core histone acetylation...
  23. ncbi request reprint Structural characterization of macroH2A containing chromatin
    D Wade Abbott
    Department of Biochemistry and Microbiology, University of Victoria, Victoria, British Columbia, Canada, V8W 3P6
    Biochemistry 43:1352-9. 2004
    ....
  24. ncbi request reprint Common phylogenetic origin of protamine-like (PL) proteins and histone H1: Evidence from bivalve PL genes
    José M Eirín-López
    Department of Biochemistry and Microbiology, University of Victoria, Victoria, British Columbia, Canada
    Mol Biol Evol 23:1304-17. 2006
    ....
  25. ncbi request reprint A walk though vertebrate and invertebrate protamines
    John D Lewis
    Department of Biochemistry and Microbiology, University of Victoria, Victoria, British Columbia V8W 3P6, Canada
    Chromosoma 111:473-82. 2003
    ..The review is based on some of the most recent publications in the field and builds upon previously published reviews on this topic...
  26. ncbi request reprint Sperm nuclear basic proteins of two closely related species of Scorpaeniform fish (Sebastes maliger, Sebastolobus sp.) with different sexual reproduction and the evolution of fish protamines
    Lindsay J Frehlick
    Department of Biochemistry and Microbiology, University of Victoria, Victoria, British Columbia, Canada V8W 3P6
    J Exp Zool A Comp Exp Biol 305:277-87. 2006
    ....
  27. doi request reprint MeCP2 preferentially binds to methylated linker DNA in the absence of the terminal tail of histone H3 and independently of histone acetylation
    Toyotaka Ishibashi
    Department of Biochemistry and Microbiology, The Center for Biomedical Research, University of Victoria, Victoria, BC, Canada V8W 3P6
    FEBS Lett 582:1157-62. 2008
    ..However, its binding specificity strongly depends on DNA methylation. We also observed that as with linker histones, this binding is independent of the core histone H3 N-terminal tail and is not affected by histone acetylation...
  28. pmc MBD4-mediated glycosylase activity on a chromatin template is enhanced by acetylation
    Toyotaka Ishibashi
    Department of Biochemistry and Microbiology, University of Victoria, P O Box 3055, Victoria, BC, Canada V8W 3P6
    Mol Cell Biol 28:4734-44. 2008
    ..However, histone hyperacetylation facilitated the efficiency with which the bases were excised from the nucleosome templates, irrespective of the position of the mismatch relative to the pseudodyad axis of symmetry of the nucleosome...
  29. pmc H2A.Bbd: an X-chromosome-encoded histone involved in mammalian spermiogenesis
    Toyotaka Ishibashi
    Department of Biochemistry and Microbiology, University of Victoria, Victoria, BC V8W 3P6, Canada
    Nucleic Acids Res 38:1780-9. 2010
    ..This common rate of evolution provides further support for the functional and structural involvement of this protein in male gametogenesis in mammals...
  30. ncbi request reprint Characterization of Inhibitor of Growth 2 tumor suppressor in Alligator mississippiensis, its conservation in Archosauria, and response to thyroid stimulating hormone
    Caren C Helbing
    Department of Biochemistry and Microbiology, University of Victoria, Victoria, BC, Canada
    Comp Biochem Physiol B Biochem Mol Biol 146:279-88. 2007
    ..ING2 expression in the thyroid gland, gonad, and heart was unaffected by TSH treatment. These data indicate that control of ING2 expression by the thyroid axis may be conserved among species and is tissue-dependent...
  31. ncbi request reprint Beyond the Xi: macroH2A chromatin distribution and post-translational modification in an avian system
    D Wade Abbott
    Department of Biochemistry and Microbiology, University of Victoria, Victoria, British Columbia V8W 3P6, Canada
    J Biol Chem 280:16437-45. 2005
    ..This report provides new clues into how mH2A distribution and a previously unidentified post-translational modification may help regulate the repression of autosomal chromatin...
  32. ncbi request reprint Protamine-like proteins: evidence for a novel chromatin structure
    John D Lewis
    Department of Biochemistry and Microbiology, University of Victoria, BC, Canada
    Biochem Cell Biol 80:353-61. 2002
    ..Potential post-translational modifications and the control of PL protein expression and deposition are also discussed...
  33. ncbi request reprint H2A.Z stabilizes chromatin in a way that is dependent on core histone acetylation
    Anita A Thambirajah
    Department of Biochemistry and Microbiology, University of Victoria, Victoria, British Columbia V8W 3P6, Canada
    J Biol Chem 281:20036-44. 2006
    ..These studies also showed that the late elution of this variant (correlated to enhanced binding stability) was independent of the chromatin size and of the presence or absence of linker histones...
  34. ncbi request reprint All roads lead to arginine: the squid protamine gene
    John D Lewis
    Department of Biochemistry and Microbiology, University of Victoria, P O Box 3055, Petch Building Room 220, Victoria, B C, V8W 3P6, Canada
    J Mol Evol 58:673-80. 2004
    ..It is unclear whether the similarities of protamines in species from both the deuterostome and the protostome branches represent the result of phylogenetic conservation or evolutionary convergence...
  35. pmc Histone H1 and the origin of protamines
    John D Lewis
    Department of Biochemistry and Microbiology, University of Victoria, P O Box 3055, Petch Building, Victoria, British Columbia, Canada V8W 3P6
    Proc Natl Acad Sci U S A 101:4148-52. 2004
    ....
  36. ncbi request reprint Protamine-like sperm nuclear basic proteins in the primitive frog Ascaphus truei and histone reversions among more advanced frogs
    H E Kasinsky
    Department of Zoology, University of British Columbia, Vancouver, Canada
    J Exp Zool 284:717-28. 1999
    ..truei introsperm to neobatrachian aquasperm that Jamieson et al. (1993. Herpetologica 49:52-65) attribute as a secondary reversion to external fertilization...
  37. ncbi request reprint H2A.Bbd: a quickly evolving hypervariable mammalian histone that destabilizes nucleosomes in an acetylation-independent way
    Jose Maria Eirin-Lopez
    Department of Biochemistry and Microbiology, University of Victoria, Petch Building, 258a, Victoria, BC, Canada V8W 3P6
    FASEB J 22:316-26. 2008
    ..This suggests that replacement by H2A.Bbd provides an alternative mechanism to unfold chromatin structure, possibly in euchromatic regions, in a way that is not dependent on acetylation...
  38. pmc Phosphorylation of histone H2A.X by DNA-dependent protein kinase is not affected by core histone acetylation, but it alters nucleosome stability and histone H1 binding
    Andra Li
    Department of Biochemistry and Microbiology, University of Victoria, Victoria, British Columbia V8W 3P6, Canada
    J Biol Chem 285:17778-88. 2010
    ..Finally, we show that although H2A.X does not affect nucleosome conformation, it has a de-stabilizing effect that is enhanced by the DNA-PK-mediated phosphorylation and results in an impaired histone H1 binding...
  39. ncbi request reprint Probasin promoter assembles into a strongly positioned nucleosome that permits androgen receptor binding
    Allison H Maffey
    Department of Biochemistry and Microbiology, University of Victoria, P O Box 3055, Petch Building, Victoria, BC, Canada V8W 3P6
    Mol Cell Endocrinol 268:10-9. 2007
    ..Thus the AR-DBD is able to bind to its cognate sequences within the PB promoter in a way that is indifferent to the presence or absence of histones and nucleosomal structure...
  40. ncbi request reprint Characterization of nucleosomes consisting of the human testis/sperm-specific histone H2B variant (hTSH2B)
    Andra Li
    Department of Biochemistry and Microbiology, University of Victoria, Victoria, British Columbia, Canada
    Biochemistry 44:2529-35. 2005
    ..Furthermore, the presence of hTSH2B in the nucleosome does not affect its ability to bind to linker histones...
  41. ncbi request reprint New insights into the nucleophosmin/nucleoplasmin family of nuclear chaperones
    Lindsay J Frehlick
    Department of Biochemistry and Microbiology, University of Victoria, Victoria, BC, Canada
    Bioessays 29:49-59. 2007
    ....
  42. ncbi request reprint A haploid affair: core histone transitions during spermatogenesis
    John D Lewis
    Department of Biochemistry and Microbiology, Unversity of Victoria, BC, Canada
    Biochem Cell Biol 81:131-40. 2003
    ..This review will examine recent discoveries concerning the role of histone modifications and variants during meiosis and spermatogenesis...
  43. ncbi request reprint Protamines, in the footsteps of linker histone evolution
    Jose Maria Eirin-Lopez
    Department of Biochemistry and Microbiology, University of Victoria, Victoria, British Columbia V8W 3P6, Canada
    J Biol Chem 281:1-4. 2006
  44. ncbi request reprint Long-range histone acetylation: biological significance, structural implications, and mechanisms
    Alison Calestagne-Morelli
    Department of Biochemistry and Microbiology, University of Victoria, Petch Building, 220, Victoria, BC V8W 3P6, Canada
    Biochem Cell Biol 84:518-27. 2006
    ..These include the thermal, ionic, cumulative, and isoform-specific (H4 K16) consequences of acetylation that result in a more dynamic core complex and chromatin fiber...
  45. ncbi request reprint Chromatin condensation, cysteine-rich protamine, and establishment of disulphide interprotamine bonds during spermiogenesis of Eledone cirrhosa (Cephalopoda)
    Pepita Gimenez-Bonafe
    The Prostate Center, Vancouver General Hospital, BC, Canada
    Eur J Cell Biol 81:341-9. 2002
    ....
  46. ncbi request reprint The elusive structural role of ubiquitinated histones
    Susan C Moore
    Department of Biochemistry and Microbiology, University of Victoria, BC, Canada
    Biochem Cell Biol 80:311-9. 2002
    ..Consequently, the search for a structural role for ubiquitinated histones continues and their effect on and importance in chromatin dynamics remains elusive...
  47. doi request reprint New developments in post-translational modifications and functions of histone H2A variants
    Anita A Thambirajah
    Department of Biochemistry and Microbiology and The Center for Biomedical Research, University of Victoria, Victoria, BCV8W3P6, Canada
    Biochem Cell Biol 87:7-17. 2009
    ..It is of additional interest that analogous sites within these different histone variants can be similarly modified. Whether this is a redundant function or a finely tuned one, designed to meet specific needs, remains to be elucidated...
  48. pmc sNASP, a histone H1-specific eukaryotic chaperone dimer that facilitates chromatin assembly
    Ron M Finn
    Department of Biochemistry and Microbiology, University of Victoria, Petch Building, Victoria, BC V8W 3P6, Canada
    Biophys J 95:1314-25. 2008
    ..In vitro chromatin reconstitution experiments show that this protein facilitates the incorporation of linker histones onto nucleosome arrays and hence is a bona fide linker histone chaperone...
  49. ncbi request reprint Characterization of the PL-I-related SP2 protein from Xenopus
    Lindsay J Frehlick
    Department of Biochemistry and Microbiology, University of Victoria, Petch Building, 258, Victoria, B C, Canada
    Biochemistry 46:12700-8. 2007
    ..However, its interaction with circular DNA does not exhibit an enhanced preference for the supercoiled conformation, and it appears to be mainly driven by ionic interactions...
  50. ncbi request reprint New twists on H2A.Z: a histone variant with a controversial structural and functional past
    Deanna Dryhurst
    Department of Biochemistry and Microbiology, University of Victoria, BC, Canada
    Biochem Cell Biol 82:490-7. 2004
    ..The nature of these structural changes has remained somewhat controversial but nevertheless exemplifies the seemingly multifaceted nature of H2A.Z...
  51. ncbi request reprint PL-I of Spisula solidissima, a highly elongated sperm-specific histone H1
    John D Lewis
    Department of Biochemistry and Microbiology, University of Victoria, Victoria, British Columbia, Canada, V8W 3P6
    Biochemistry 43:7766-75. 2004
    ..This information provides additional molecular support for the classification and underlying evolution of sperm nuclear basic proteins in bivalve molluscs...
  52. ncbi request reprint H2AX: tailoring histone H2A for chromatin-dependent genomic integrity
    Andra Li
    Department of Biochemistry and Microbiology, University of Victoria, BC, Canada
    Biochem Cell Biol 83:505-15. 2005
    ....
  53. ncbi request reprint Physical and chemical characterization of the oligomerization state of the Aeromonas hydrophila lipase/acyltransferase
    J Ausio
    Department of Biochemistry and Microbiology, University of Victoria, BC, Canada
    FEBS Lett 333:296-300. 1993
    ..An important change occurs in the apparent partial specific volume of the molecule upon activation...
  54. doi request reprint A moment's pause: putative nucleosome-based influences on MeCP2 regulation
    Anita A Thambirajah
    Department of Biochemistry and Microbiology, University of Victoria, Victoria, BC V8W3P6, Canada
    Biochem Cell Biol 87:791-8. 2009
    ..By understanding the chromatin and (or) tissue context in which MeCP2 interacts, it may be possible to discern the specific etiology of diseases linked to MeCP2 dysfunction...
  55. doi request reprint MeCP2 post-translational regulation through PEST domains: two novel hypotheses: potential relevance and implications for Rett syndrome
    Anita A Thambirajah
    Department of Biochemistry and Microbiology, University of Victoria, Victoria, British Columbia, Canada
    Bioessays 31:561-9. 2009
    ..The second hypothesis explores the use of histone deacetylase inhibitors to modulate the amounts of MeCP2 expressed in conjunction with the aforementioned therapeutic approaches...
  56. ncbi request reprint Protamines: structural complexity, evolution and chromatin patterning
    Harold E Kasinsky
    Department of Zoology, University of British Columbia, Vancouver, British Columbia, Canada
    Protein Pept Lett 18:755-71. 2011
    ....
  57. ncbi request reprint Alpha-glucan recognition by a new family of carbohydrate-binding modules found primarily in bacterial pathogens
    Alicia Lammerts van Bueren
    Department of Biochemistry and Microbiology, University of Victoria, P O Box 3055 STN CSC, Victoria, British Columbia V8W 3P6, Canada
    Biochemistry 43:15633-42. 2004
    ..e., a CBM dimer ligated by an oligosaccharide). The presence of an alpha-(1-6) linkage in the oligosaccharide appears to prevent this phenomenon...