Liliana Attisano

Summary

Affiliation: University of Toronto
Country: Canada

Publications

  1. ncbi Signal transduction by the TGF-beta superfamily
    Liliana Attisano
    Department of Anatomy and Cell Biology, University of Toronto, Toronto M5S 1A8, Canada
    Science 296:1646-7. 2002
  2. ncbi TGFbeta and Wnt pathway cross-talk
    Liliana Attisano
    Department of Biochemistry, University of Toronto, Toronto, ON, Canada, M5S 1A8
    Cancer Metastasis Rev 23:53-61. 2004
  3. pmc The Smads
    L Attisano
    Department of Anatomy and Cell Biology, University of Toronto, 1 King s College Circle, Toronto, Ontario M5S 1A8, Canada
    Genome Biol 2:REVIEWS3010. 2001
  4. ncbi The transcriptional role of Smads and FAST (FoxH1) in TGFbeta and activin signalling
    L Attisano
    Department of Anatomy and Cell Biology, Medical Sciences Building, Rm 6336, 1 King s College Circle, University of Toronto, ON, M5S 1A8, Toronto, Canada
    Mol Cell Endocrinol 180:3-11. 2001
  5. ncbi Smads as transcriptional co-modulators
    L Attisano
    Department of Anatomy and Cell Biology, University of Toronto, Toronto, M5S 1A8, Canada
    Curr Opin Cell Biol 12:235-43. 2000
  6. ncbi The Drosophila type II receptor, Wishful thinking, binds BMP and myoglianin to activate multiple TGFbeta family signaling pathways
    Si Tuen Lee-Hoeflich
    Department of Medical Biophysics, University of Toronto, Toronto, Ont, Canada
    FEBS Lett 579:4615-21. 2005
  7. pmc Foxh1 recruits Gsc to negatively regulate Mixl1 expression during early mouse development
    Luisa Izzi
    Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada
    EMBO J 26:3132-43. 2007
  8. pmc Embryonic cortical neural stem cells migrate ventrally and persist as postnatal striatal stem cells
    Sandrine Willaime-Morawek
    Department of Medical Genetics and Microbiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada
    J Cell Biol 175:159-68. 2006
  9. doi Genome-wide identification of Smad/Foxh1 targets reveals a role for Foxh1 in retinoic acid regulation and forebrain development
    Cristoforo Silvestri
    Institute of Medical Science, University of Toronto, 160 College Street, Toronto, Ontario M5S 3E1, Canada
    Dev Cell 14:411-23. 2008
  10. ncbi The Smad pathway
    J L Wrana
    Program in Molecular Biology and Cancer, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Room 1075, 600 University Avenue, Toronto, Canada
    Cytokine Growth Factor Rev 11:5-13. 2000

Collaborators

Detail Information

Publications39

  1. ncbi Signal transduction by the TGF-beta superfamily
    Liliana Attisano
    Department of Anatomy and Cell Biology, University of Toronto, Toronto M5S 1A8, Canada
    Science 296:1646-7. 2002
    ..Current research efforts investigating the contribution of SMAD-independent pathways promise to reveal advances to enhance our understanding of the signaling cascade...
  2. ncbi TGFbeta and Wnt pathway cross-talk
    Liliana Attisano
    Department of Biochemistry, University of Toronto, Toronto, ON, Canada, M5S 1A8
    Cancer Metastasis Rev 23:53-61. 2004
    ..In addition, their cooperation in promoting tumorigenesis in mice has been described. Here, we focus on reviewing our current understanding of the molecular mechanisms that may mediate these cooperative effects...
  3. pmc The Smads
    L Attisano
    Department of Anatomy and Cell Biology, University of Toronto, 1 King s College Circle, Toronto, Ontario M5S 1A8, Canada
    Genome Biol 2:REVIEWS3010. 2001
    ..Smads therefore play an essential role in mediating TGFbeta-superfamily signals in development and disease...
  4. ncbi The transcriptional role of Smads and FAST (FoxH1) in TGFbeta and activin signalling
    L Attisano
    Department of Anatomy and Cell Biology, Medical Sciences Building, Rm 6336, 1 King s College Circle, University of Toronto, ON, M5S 1A8, Toronto, Canada
    Mol Cell Endocrinol 180:3-11. 2001
    ..Thus, it is the interaction of Smads with a wide range of specific transcriptional partners that is important for the generation of diverse biological responses to TGFbeta superfamily members...
  5. ncbi Smads as transcriptional co-modulators
    L Attisano
    Department of Anatomy and Cell Biology, University of Toronto, Toronto, M5S 1A8, Canada
    Curr Opin Cell Biol 12:235-43. 2000
    ..Thus, Smads function as transcriptional co-modulators to regulate TGFbeta-dependent gene expression...
  6. ncbi The Drosophila type II receptor, Wishful thinking, binds BMP and myoglianin to activate multiple TGFbeta family signaling pathways
    Si Tuen Lee-Hoeflich
    Department of Medical Biophysics, University of Toronto, Toronto, Ont, Canada
    FEBS Lett 579:4615-21. 2005
    ..Given that myoglianin is expressed in muscle and glial-derived cells, these results also suggest that Wit may mediate myoglianin-dependent signals in the nervous system...
  7. pmc Foxh1 recruits Gsc to negatively regulate Mixl1 expression during early mouse development
    Luisa Izzi
    Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada
    EMBO J 26:3132-43. 2007
    ..As Gsc is itself induced in a Foxh1-dependent manner, we propose that Foxh1 initiates positive and negative transcriptional circuits to refine cell fate decisions during gastrulation...
  8. pmc Embryonic cortical neural stem cells migrate ventrally and persist as postnatal striatal stem cells
    Sandrine Willaime-Morawek
    Department of Medical Genetics and Microbiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada
    J Cell Biol 175:159-68. 2006
    ..This demonstrates the existence of a novel dorsal-to-ventral migration of neural stem cells in the perinatal forebrain...
  9. doi Genome-wide identification of Smad/Foxh1 targets reveals a role for Foxh1 in retinoic acid regulation and forebrain development
    Cristoforo Silvestri
    Institute of Medical Science, University of Toronto, 160 College Street, Toronto, Ontario M5S 3E1, Canada
    Dev Cell 14:411-23. 2008
    ..Integrated mapping of a developmental transcription factor network thus reveals a key role for Foxh1 in patterning and initiating RA signaling in the forebrain...
  10. ncbi The Smad pathway
    J L Wrana
    Program in Molecular Biology and Cancer, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Room 1075, 600 University Avenue, Toronto, Canada
    Cytokine Growth Factor Rev 11:5-13. 2000
    ..In addition, we will summarize recent findings on the role of Smads as transcriptional co-modulators...
  11. ncbi Foxh1 is essential for development of the anterior heart field
    Ingo Von Both
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, Ontario M5G 1X5, Canada
    Dev Cell 7:331-45. 2004
    ..Thus, Foxh1 and Nkx2-5 functionally interact and are essential for development of the AHF and its derivatives, the RV and OFT, in response to TGFbeta-like signals...
  12. pmc Microtubule stabilization by bone morphogenetic protein receptor-mediated scaffolding of c-Jun N-terminal kinase promotes dendrite formation
    Monika Podkowa
    Department of Biochemistry and Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario M5S 3E1, Canada
    Mol Cell Biol 30:2241-50. 2010
    ..These data indicate that BMPRII acts as a scaffold to localize and coordinate cytoskeletal remodeling and thereby provides an efficient means for extracellular cues, such as BMPs, to control neuronal dendritogenesis...
  13. doi Sumoylation differentially regulates Goosecoid-mediated transcriptional repression
    Luisa Izzi
    Department of Medical Biophysics, Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, 160 College Street, Toronto, Ontario Canada M5S 3E1
    Exp Cell Res 314:1585-94. 2008
    ....
  14. doi The Hippo pathway regulates Wnt/beta-catenin signaling
    Xaralabos Varelas
    Center for Systems Biology, Mount Sinai Hospital, 600 University Avenue, Toronto, ON M5G 1X5, Canada
    Dev Cell 18:579-91. 2010
    ..These results uncover a cytoplasmic function of TAZ in regulating Wnt signaling and highlight the role of the Hippo pathway in coordinating morphogenetic signaling with growth control...
  15. doi A role for Hipk in the Hippo pathway
    Emad Heidary Arash
    Department of Biochemistry and Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, 160 College Street, Toronto, ON M5S 3E1, Canada
    Sci Signal 6:pe18. 2013
    ..Two studies have delineated a role for HIPK (homeodomain-interacting protein kinase) in promoting Yki/TAZ/YAP transcriptional activity...
  16. doi Regulation of planar cell polarity by Smurf ubiquitin ligases
    Masahiro Narimatsu
    Center for Systems Biology, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, ON, Canada, M5G 1X5
    Cell 137:295-307. 2009
    ..Our work thus uncovers ubiquitin ligases in a mechanistic link between noncanonical Wnt signaling and PCP/CE...
  17. pmc Activation of LIMK1 by binding to the BMP receptor, BMPRII, regulates BMP-dependent dendritogenesis
    Si Tuen Lee-Hoeflich
    Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada
    EMBO J 23:4792-801. 2004
    ....
  18. ncbi Transcriptional cooperation between the transforming growth factor-beta and Wnt pathways in mammary and intestinal tumorigenesis
    Etienne Labbé
    Departments of Medical Biophysics and Biochemistry, University of Toronto, 160 College Street, Toronto, Ontario, Canada
    Cancer Res 67:75-84. 2007
    ..Our results indicate that the TGF-beta and Wnt/beta-catenin pathways are firmly intertwined and generate a unique gene expression pattern that can contribute to tumor progression...
  19. ncbi SARA, a FYVE domain protein that recruits Smad2 to the TGFbeta receptor
    T Tsukazaki
    Program in Developmental Biology, The Hospital for Sick Children, Toronto, Ontario, Canada
    Cell 95:779-91. 1998
    ..These results thus define SARA as a component of the TGFbeta pathway that brings the Smad substrate to the receptor...
  20. pmc Association of Smads with lymphoid enhancer binding factor 1/T cell-specific factor mediates cooperative signaling by the transforming growth factor-beta and wnt pathways
    E Labbe
    Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada, M5S 1A8
    Proc Natl Acad Sci U S A 97:8358-63. 2000
    ..Thus, our results show that TGFbeta and Wnt signaling pathways can independently or cooperatively regulate LEF1/TCF target genes and suggest a model for how these pathways can synergistically activate target genes...
  21. ncbi Mads and Smads in TGF beta signalling
    L Attisano
    Department of Anatomy and Cell Biology, University of Toronto, Ontario, Canada
    Curr Opin Cell Biol 10:188-94. 1998
    ..This pathway, which is comprised of a family of proteins related to Mad, acts to convey signals directly from TGF beta receptors to the nucleus and is implicated in the pathogenesis of human diseases...
  22. ncbi Smad2 and Smad3 positively and negatively regulate TGF beta-dependent transcription through the forkhead DNA-binding protein FAST2
    E Labbe
    Department of Anatomy and Cell Biology, University of Toronto, Ontario, Canada
    Mol Cell 2:109-20. 1998
    ..Thus, we describe a mechanism whereby Smad2 and Smad3 positively and negatively regulate a TGF beta/activin target gene...
  23. pmc Inhibition of tankyrases induces Axin stabilization and blocks Wnt signalling in breast cancer cells
    Renyue Bao
    Department of Biochemistry, Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario, Canada
    PLoS ONE 7:e48670. 2012
    ..These results indicate that stabilization of Axin by inhibition of tankyrases alone, may not be an effective means to block tumor cell growth and that combinatorial therapeutic approaches should be considered...
  24. pmc Application of an integrated physical and functional screening approach to identify inhibitors of the Wnt pathway
    Bryan W Miller
    Department of Biochemistry, University of Toronto, Toronto, Ontario, Canada
    Mol Syst Biol 5:315. 2009
    ..Thus, integrated physical and functional mapping in mammalian cells can identify signaling components with high confidence and provides unanticipated insights into pathway regulators...
  25. ncbi Transcriptional regulation by Smads: crosstalk between the TGF-beta and Wnt pathways
    A Letamendia
    Department of Anatomy and Cell Biology, University of Toronto, Ontario, Canada
    J Bone Joint Surg Am 83:S31-9. 2001
    ..This suggests that the cooperation between these pathways may be important for the specification of cell fates during development...
  26. ncbi Signal transduction by members of the transforming growth factor-beta superfamily
    L Attisano
    Department of Anatomy and Cell Biology, University of Toronto, Ontario, Canada
    Cytokine Growth Factor Rev 7:327-39. 1996
    ..Recent advances, particularly in our understanding of the function of Mothers against dpp-related (MADR) proteins, are providing new insights into how the TGF beta superfamily signals its diverse biological activities...
  27. doi Wnt inhibitor screen reveals iron dependence of β-catenin signaling in cancers
    Siyuan Song
    Department of Biochemistry, Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario, Canada
    Cancer Res 71:7628-39. 2011
    ..Taken together, our results reveal a critical requirement for iron in Wnt signaling and they show that iron chelation serves as an effective mechanism to inhibit Wnt signaling in humans...
  28. ncbi Regulation of the TGFbeta signalling pathway by ubiquitin-mediated degradation
    Luisa Izzi
    Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada M5S 1A8
    Oncogene 23:2071-8. 2004
    ..Finally, growing evidence demonstrates that ubiquitination and proteasomal degradation is also implicated in the turnover of tumor-derived Smad mutants and may thus contribute to disease progression...
  29. pmc Myostatin signals through a transforming growth factor beta-like signaling pathway to block adipogenesis
    A Rebbapragada
    Department of Biochemistry, University of Toronto, Toronto, ON M5S 1A8, Canada
    Mol Cell Biol 23:7230-42. 2003
    ..Thus, our results reveal a strikingly specific antagonism of BMP7-mediated processes by myostatin and suggest that myostatin is an important regulator of adipogenesis...
  30. ncbi MADR2 maps to 18q21 and encodes a TGFbeta-regulated MAD-related protein that is functionally mutated in colorectal carcinoma
    K Eppert
    Division of Gastroenterology, The Hospital for Sick Children, Toronto, Ontario, Canada
    Cell 86:543-52. 1996
    ..These findings suggest that MADR2 is a tumor suppressor and that mutations acquired in colorectal carcinomas may function to disrupt TGFbeta signaling...
  31. doi p21-Activated kinase (PAK) is required for Bone Morphogenetic Protein (BMP)-induced dendritogenesis in cortical neurons
    Monika Podkowa
    Department of Biochemistry and Donnelly CCBR, University of Toronto, Toronto, ON, Canada
    Mol Cell Neurosci 57:83-92. 2013
    ..We propose that this scaffold plays a key role in mediating BMP7-dependent dendritogenesis in primary cortical neurons. ..
  32. pmc Ubiquitin-dependent regulation of TGFbeta signaling in cancer
    Luisa Izzi
    Department of Biochemistry, University of Toronto, Toronto, Ontario, Canada
    Neoplasia 8:677-88. 2006
    ..Therefore, understanding how these two pathways intertwine will contribute to the advancement of our knowledge of cancer development...
  33. ncbi MADR2 is a substrate of the TGFbeta receptor and its phosphorylation is required for nuclear accumulation and signaling
    M Macias-Silva
    Program in Developmental Biology, Division of Gastroenterology, The Hospital for Sick Children, Toronto, ON, Canada
    Cell 87:1215-24. 1996
    ..Thus, transient association and phosphorylation of MADR2 by the TGFbeta receptor is necessary for nuclear accumulation and initiation of signaling...
  34. ncbi Mouse NKR-P1B, a novel NK1.1 antigen with inhibitory function
    J R Carlyle
    Departments ofImmunology and Anatomy and Cell Biology, University of Toronto, Toronto, Ontario, Canada
    J Immunol 162:5917-23. 1999
    ..The existence of these two NK1.1 Ags with opposite functions suggests a potential role for NKR-P1 molecules, such as those of the Ly-49 gene family, in regulating NK cell function...
  35. ncbi TbetaRI phosphorylation of Smad2 on Ser465 and Ser467 is required for Smad2-Smad4 complex formation and signaling
    S Abdollah
    Program in Developmental Biology and Division of Gastroenterology, The Hospital for Sick Children, Toronto, Ontario, Canada, M5G 1X8
    J Biol Chem 272:27678-85. 1997
    ..These results indicate that receptor-dependent phosphorylation of Smad2 on serines 465 and 467 is required in mammalian cells to permit association with Smad4 and to propagate TGF-beta signals...
  36. pmc The RING-H2 protein RNF11 is overexpressed in breast cancer and is a target of Smurf2 E3 ligase
    V Subramaniam
    Laboratory of Molecular Pathology and Molecular and Cellular Biology Research, Sunnybrook and Women s College Health Sciences Centre, CIHR Group in Matrix Dynamics, University of Toronto, Toronto, Ontario, Canada
    Br J Cancer 89:1538-44. 2003
    ..Smurf2 plays an active role in the repression of TGFbeta signalling, and our data indicate that overexpression of RNF11, through its interaction with Smurf2, can restore TGFbeta responsiveness in transfected cells...
  37. ncbi DRAGON, a bone morphogenetic protein co-receptor
    Tarek A Samad
    Neural Plasticity Research Group, Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02129, USA
    J Biol Chem 280:14122-9. 2005
    ..The direct interaction of DRAGON with BMP ligands and receptors indicates that it is a BMP co-receptor that potentiates BMP signaling...
  38. ncbi TGF-beta1-mediated alterations of renal proximal tubular epithelial cell phenotype
    Ya Chung Tian
    Institute of Nephrology, University of Wales College of Medicine, Heath Park, Cardiff
    Am J Physiol Renal Physiol 285:F130-42. 2003
    ..In contrast, phenotypic changes in response to TGF-beta1 were abrogated by inhibitors of the RhoA downstream target ROCK, which also prevented loss of cell-cell contact and adherens junction disassembly...
  39. ncbi Endoglin increases eNOS expression by modulating Smad2 protein levels and Smad2-dependent TGF-beta signaling
    Juan F Santibanez
    Centro de Investigaciones Biologicas, CSIC, Madrid, Spain
    J Cell Physiol 210:456-68. 2007
    ..These results suggest that endoglin enhances Smad2 protein levels potentiating TGF-beta signaling, and leading to an increased eNOS expression in endothelial cells...