S L Asa

Summary

Affiliation: University of Toronto
Country: Canada

Publications

  1. doi request reprint CtBP1 interacts with Ikaros and modulates pituitary tumor cell survival and response to hypoxia
    Katie Dorman
    Departments of Laboratory Medicine and Pathobiology, University of Toronto, Ontario, Canada
    Mol Endocrinol 26:447-57. 2012
  2. doi request reprint Pancreatic endocrine tumors
    Sylvia L Asa
    Department of Pathology and Ontario Cancer Institute, University Health Network, University of Toronto, Toronto, ON, Canada
    Mod Pathol 24:S66-77. 2011
  3. ncbi request reprint How familial cancer genes and environmentally induced oncogenes have changed the endocrine landscape
    S L Asa
    University Health Network and Toronto Medical Laboratories, Toronto, Ontario, Canada
    Mod Pathol 14:246-53. 2001
  4. ncbi request reprint Transgenic and knockout mouse models clarify pituitary development, function and disease
    S L Asa
    Department of Pathology, University Health Network, University of Toronto, Ontario, Canada
    Brain Pathol 11:371-84. 2001
  5. doi request reprint Practical pituitary pathology: what does the pathologist need to know?
    Sylvia L Asa
    Department of Pathology, University Health Network, Toronto, Ontario, Canada
    Arch Pathol Lab Med 132:1231-40. 2008
  6. ncbi request reprint Cell-cell communication in the pituitary: orchestrator of pulsatile growth hormone secretion?
    Sylvia L Asa
    Department of Laboratory Medicine and Pathobiology, University of Toronto and Department of Pathology, University Health Network and Toronto Medical Laboratories, Toronto, Ontario M5G 2C4, Canada
    Trends Endocrinol Metab 17:299-300. 2006
  7. ncbi request reprint The pathogenesis of pituitary tumours
    Sylvia L Asa
    Department of Pathology and Laboratory Medicine, University of Toronto, University Health Network and Toronto Medical Laboratories, 610 University Avenue, Toronto, Ontario, Canada M5G 2M5
    Nat Rev Cancer 2:836-49. 2002
  8. doi request reprint The pathogenesis of pituitary tumors
    Sylvia L Asa
    Department of Laboratory Medicine and Pathobiology, University of Toronto, University Health Network and Ontario Cancer Institute, Toronto, Ontario, Canada
    Annu Rev Pathol 4:97-126. 2009
  9. ncbi request reprint Molecular basis of pituitary development and cytogenesis
    Sylvia L Asa
    Laboratory Medicine and Pathobiology, University of Toronto, Canada
    Front Horm Res 32:1-19. 2004
  10. ncbi request reprint Medical management of pituitary adenomas: structural and ultrastructural changes
    Sylvia L Asa
    Department of Laboratory Medicine and Pathobiology, University of Toronto, University Health Network and Toronto Medical Laboratories, Ontario, Canada
    Pituitary 5:133-9. 2002

Collaborators

Detail Information

Publications118 found, 100 shown here

  1. doi request reprint CtBP1 interacts with Ikaros and modulates pituitary tumor cell survival and response to hypoxia
    Katie Dorman
    Departments of Laboratory Medicine and Pathobiology, University of Toronto, Ontario, Canada
    Mol Endocrinol 26:447-57. 2012
    ..These results identify putative oncogenic properties of CtBP1 and provide new insights into the overlapping functions of two members of the chromatin remodeling network in the response to hypoxic pituitary tumor cell drive...
  2. doi request reprint Pancreatic endocrine tumors
    Sylvia L Asa
    Department of Pathology and Ontario Cancer Institute, University Health Network, University of Toronto, Toronto, ON, Canada
    Mod Pathol 24:S66-77. 2011
    ....
  3. ncbi request reprint How familial cancer genes and environmentally induced oncogenes have changed the endocrine landscape
    S L Asa
    University Health Network and Toronto Medical Laboratories, Toronto, Ontario, Canada
    Mod Pathol 14:246-53. 2001
    ..This has led to a better understanding of papillary thyroid carcinoma and provides a novel immunohistochemical marker that widens our diagnostic armamentarium...
  4. ncbi request reprint Transgenic and knockout mouse models clarify pituitary development, function and disease
    S L Asa
    Department of Pathology, University Health Network, University of Toronto, Ontario, Canada
    Brain Pathol 11:371-84. 2001
    ..These models may also be used in the future to examine novel therapeutic strategies for the management of patients with pituitary disorders...
  5. doi request reprint Practical pituitary pathology: what does the pathologist need to know?
    Sylvia L Asa
    Department of Pathology, University Health Network, Toronto, Ontario, Canada
    Arch Pathol Lab Med 132:1231-40. 2008
    ....
  6. ncbi request reprint Cell-cell communication in the pituitary: orchestrator of pulsatile growth hormone secretion?
    Sylvia L Asa
    Department of Laboratory Medicine and Pathobiology, University of Toronto and Department of Pathology, University Health Network and Toronto Medical Laboratories, Toronto, Ontario M5G 2C4, Canada
    Trends Endocrinol Metab 17:299-300. 2006
    ..This challenges the conventional view of endocrine cells as collections of dispersed cells and suggests that physical connectivity mediates cellular responses to coordinate pulsatile secretion...
  7. ncbi request reprint The pathogenesis of pituitary tumours
    Sylvia L Asa
    Department of Pathology and Laboratory Medicine, University of Toronto, University Health Network and Toronto Medical Laboratories, 610 University Avenue, Toronto, Ontario, Canada M5G 2M5
    Nat Rev Cancer 2:836-49. 2002
  8. doi request reprint The pathogenesis of pituitary tumors
    Sylvia L Asa
    Department of Laboratory Medicine and Pathobiology, University of Toronto, University Health Network and Ontario Cancer Institute, Toronto, Ontario, Canada
    Annu Rev Pathol 4:97-126. 2009
    ....
  9. ncbi request reprint Molecular basis of pituitary development and cytogenesis
    Sylvia L Asa
    Laboratory Medicine and Pathobiology, University of Toronto, Canada
    Front Horm Res 32:1-19. 2004
    ..Understanding these normal processes of differentiation and proliferation sheds new light on the factors implicated in disordered structure and function of the mature gland during pituitary tumorigenesis...
  10. ncbi request reprint Medical management of pituitary adenomas: structural and ultrastructural changes
    Sylvia L Asa
    Department of Laboratory Medicine and Pathobiology, University of Toronto, University Health Network and Toronto Medical Laboratories, Ontario, Canada
    Pituitary 5:133-9. 2002
    ..In some cases, these morphologic alterations can evoke diagnostic problems...
  11. pmc My approach to oncocytic tumours of the thyroid
    S L Asa
    Department of Pathology, University Health Network, University of Toronto, 610 University Avenue, Toronto, Ontario, Canada M5G 2M9
    J Clin Pathol 57:225-32. 2004
    ....
  12. ncbi request reprint Genetics and proteomics of pituitary tumors
    Sylvia L Asa
    Endocrine Oncology Site Group, Mount Sinai and Princess Margaret Hospitals, University of Toronto, Toronto, Ontario, Canada
    Endocrine 28:43-7. 2005
    ..The underlying mechanisms for dysregulated cell adhesive molecules including cadherins and FGFRs are reviewed. The combined use of genetic and proteomic approaches will enhance novel drug therapeutic development...
  13. ncbi request reprint The endogenous fibroblast growth factor-2 antisense gene product regulates pituitary cell growth and hormone production
    S L Asa
    Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Ontario, Canada M5G 2M9
    Mol Endocrinol 15:589-99. 2001
    ..GFG represents a novel mechanism involved in restraining pituitary tumor cell growth while promoting hormonal activity...
  14. pmc Ikaros isoforms in human pituitary tumors: distinct localization, histone acetylation, and activation of the 5' fibroblast growth factor receptor-4 promoter
    Shereen Ezzat
    Department of Medicine, Mount Sinai Hospital, University Health Network, University of Toronto, 610 University Avenue, 4 302, Toronto, Ontario, Canada M5G 2M9
    Am J Pathol 163:1177-84. 2003
    ..We conclude that dominant-negative Ik6 isoforms with their distinct localization and effects on Ik1 action may contribute to the altered expression of FGFR4 and possibly other target genes in human pituitary tumors...
  15. ncbi request reprint The role of immunohistochemical markers in the diagnosis of follicular-patterned lesions of the thyroid
    Sylvia L Asa
    Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada
    Endocr Pathol 16:295-309. 2005
    ..Application of these markers will enhance the diagnosis of thyroid nodules and better guide the management of patients with these lesions...
  16. ncbi request reprint A growth hormone receptor mutation impairs growth hormone autofeedback signaling in pituitary tumors
    Sylvia L Asa
    Department of Pathology, University Health Network and Toronto Medical Laboratories, Mount Sinai Hospital, Ontario Cancer Institute, Toronto, Ontario, Canada
    Cancer Res 67:7505-11. 2007
    ....
  17. ncbi request reprint Adenohypophysial changes in mice transgenic for human growth hormone-releasing factor: a histological, immunocytochemical, and electron microscopic investigation
    L Stefaneanu
    Department of Pathology, St Michael s Hospital, University of Toronto, Ontario, Canada
    Endocrinology 125:2710-8. 1989
    ..Focal PRL cell hyperplasia noted in three pituitaries could also be due to a GRF effect. Longer exposure to GRF is needed to clarify whether GRF can cause adenoma...
  18. ncbi request reprint Immunohistochemical diagnosis of papillary thyroid carcinoma
    C C Cheung
    Department of Pathology Medicine, The Freeman Center in Endocrine Onology, Mount Sinai Hospital, University of Toronto, Toronto Canada
    Mod Pathol 14:338-42. 2001
    ..HBME-1 positivity indicates malignancy but not papillary differentiation. Only rarely are all three markers negative in PC; this panel therefore provides an objective and reproducible tool for the analysis of difficult thyroid nodules...
  19. ncbi request reprint Essential requirement for Pax6 in control of enteroendocrine proglucagon gene transcription
    M E Hill
    Department of Medicine, The Banting and Best Diabetes Centre, Toronto General Hospital, Ontario, Canada
    Mol Endocrinol 13:1474-86. 1999
    ..These findings implicate an essential role for Pax6 in the development and function of glucagon-producing cells in both pancreatic and intestinal endodermal lineages...
  20. ncbi request reprint The transcription activator steroidogenic factor-1 is preferentially expressed in the human pituitary gonadotroph
    S L Asa
    Department of Pathology, Mount Sinai Hospital, Toronto, Ontario, Canada
    J Clin Endocrinol Metab 81:2165-70. 1996
    ..We conclude that SF-1 expression correlates with the expression of gonadotropins. These findings implicate SF-1 as a cell-specific transcription factor that may regulate gonadotroph differentiation in the pituitary...
  21. ncbi request reprint The MEN-1 gene is rarely down-regulated in pituitary adenomas
    S L Asa
    Department of Pathology, Mount Sinai Hospital, University of Toronto, Ontario, Canada
    J Clin Endocrinol Metab 83:3210-2. 1998
    ....
  22. ncbi request reprint Pituitary lactotroph adenomas develop after prolonged lactotroph hyperplasia in dopamine D2 receptor-deficient mice
    S L Asa
    Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, University of Toronto, Ontario, Canada
    Endocrinology 140:5348-55. 1999
    ..The unexpected development of adenomas in males without preexisting or concomitant hyperplasia suggests that prolonged loss of dopamine inhibition may also cause neoplasia by distinct cellular mechanisms in male and female animals...
  23. ncbi request reprint Double adenomas of the pituitary: transcription factors Pit-1, T-pit, and SF-1 identify cytogenesis and differentiation
    R A Jastania
    Department of Pathology, University Health Network and Toronto Medical Laboratories, and Department of Laboratory Medicine and Pathobiology, University of Toronto
    Endocr Pathol 16:187-94. 2005
    ..We conclude that immunohistochemical localization of the transcription factors Pit-1, T-pit, and SF-1 accurately detects and classifies the distinct cytodifferentiation of double adenomas of the pituitary...
  24. doi request reprint The insulin resistance Grb14 adaptor protein promotes thyroid cancer ret signaling and progression
    K Balogh
    Department of Medicine, University Health Network, Toronto, Ontario, Canada
    Oncogene 31:4012-21. 2012
    ..Our findings uncover a new role for Grb14 in finely tuning receptor signaling and modulating thyroid cancer progression...
  25. ncbi request reprint CEACAM1 impedes thyroid cancer growth but promotes invasiveness: a putative mechanism for early metastases
    W Liu
    Department of Pathology, University Health Network and Toronto Medical Laboratories, and University Hospital Hamburg Eppendorf, Ontario, Canada
    Oncogene 26:2747-58. 2007
    ..Our data highlight a complex repertoire of actions providing a putative mechanism underlying the spectrum of biologic behaviors associated with thyroid cancer...
  26. ncbi request reprint The spectrum and significance of primary hypophysitis
    C C Cheung
    The Freeman Center for Endocrine Oncology, Mount Sinai Hospital, Department of Pathology, University of Toronto, Toronto, Ontario M5G 1X5, Canada
    J Clin Endocrinol Metab 86:1048-53. 2001
    ..Histological confirmation of the diagnosis of hypophysitis can be obtained by performing a biopsy or by requesting an intraoperative frozen section consultation...
  27. ncbi request reprint Effects of growth hormone-releasing hormone (GHRH) on densely granulated somatotroph adenomas and sparsely granulated somatotroph adenomas in vitro: a morphological and functional investigation
    S Kawakita
    Department of Pathology, St Michael s Hospital, University of Toronto, Ontario, Canada
    J Endocrinol Invest 12:443-48. 1989
    ..These results indicate that (1) both types of somatotroph adenoma cells react similarly to GHRH stimulation, despite their morphologic differences, and (2) GHRH stimulates GH synthesis as well as GH release by somatotroph adenoma cells...
  28. ncbi request reprint Islet cell and extrapancreatic expression of the LIM domain homeobox gene isl-1
    J Dong
    Department of Medicine, University of Toronto, Ontario, Canada
    Mol Endocrinol 5:1633-41. 1991
    ..The results of these studies implicate a potential role for isl-1 outside the endocrine pancreas in the nervous system and kidney...
  29. ncbi request reprint Pituitary adenomas in mice transgenic for growth hormone-releasing hormone
    S L Asa
    Department of Pathology, St Michael s Hospital University of Toronto, Ontario, Canada
    Endocrinology 131:2083-9. 1992
    ..These findings provide conclusive evidence that protracted GRH stimulation of secretory activity can result in proliferation, hyperplasia, and adenoma of adenohypophysial cells...
  30. ncbi request reprint Distinct clonal composition of primary and metastatic adrencorticotrophic hormone-producing pituitary carcinoma
    A Zahedi
    Department of Medicine, The University of Toronto, Toronto, Ontario, Canada
    Clin Endocrinol (Oxf) 55:549-56. 2001
    ..This is the first description of a metastatic pituitary carcinoma with a distinct clonal composition from its primary source...
  31. ncbi request reprint Hormone secretion in vitro by plurihormonal pituitary adenomas of the acidophil cell line
    S L Asa
    Department of Pathology, St Michael s Hospital, Toronto, Ontario, Canada
    J Clin Endocrinol Metab 75:68-75. 1992
    ..Our data strengthen the view that these three plurihormonal adenomas of the acidophil cell line are not only morphologically but also functionally different and warrant separation...
  32. pmc My approach to pathology of the pituitary gland
    N Y Y Al-Brahim
    Department of Laboratory Medicine and Pathobiology, University of Toronto Toronto Medical Laboratories, Toronto, Ontario, Canada
    J Clin Pathol 59:1245-53. 2006
    ..The complex subclassification of pituitary adenomas is now recognised to reflect specific clinical features and genetic changes that predict targeted treatments for patients with pituitary disorders...
  33. ncbi request reprint Enteroendocrine localization of GLP-2 receptor expression in humans and rodents
    B Yusta
    Department of Medicine, Toronto General Hospital, Banting and Best Diabetes Centre, University of Toronto, Toronto, Ontario, Canada
    Gastroenterology 119:744-55. 2000
    ..GLP-2 acts via binding to a single G protein-coupled GLP-2 receptor (GLP-2R), but the cellular targets for the diverse actions of GLP-2 remain unknown...
  34. ncbi request reprint Analysis of ret/PTC gene rearrangements refines the fine needle aspiration diagnosis of thyroid cancer
    C C Cheung
    Department of Pathology and Laboratory Medicine, The Freeman Center for Endocrine Oncology, Mount Sinai Hospital, University of Toronto, Ontario, Canada M5G 2M9
    J Clin Endocrinol Metab 86:2187-90. 2001
    ..The results indicate that RT-PCR for ret/PTC is a specific marker that can be applied to fine needle aspiration biopsies and improves the diagnosis of malignancy when used as an adjunct to traditional cytology...
  35. pmc Evidence for growth hormone (GH) autoregulation in pituitary somatotrophs in GH antagonist-transgenic mice and GH receptor-deficient mice
    S L Asa
    Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada
    Am J Pathol 156:1009-15. 2000
    ..This represents the first evidence of direct GH feedback inhibition on pituitary somatotrophs, which may have implications for the use of GH analogs in different clinical settings...
  36. ncbi request reprint Growth hormone-releasing hormone (GHRH) and GHRH receptor (GHRH-R) isoform expression in ectopic acromegaly
    N H Othman
    Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, 600 University Avenue, Toronto, Ontario, Canada
    Clin Endocrinol (Oxf) 55:135-40. 2001
    ....
  37. ncbi request reprint Fibroblast growth factor receptor 4 is a target for the zinc-finger transcription factor Ikaros in the pituitary
    ShunJiang Yu
    Department of Medicine, Mount Sinai Hospital and University of Toronto, Toronto, Ontario, Canada M5G 2M9
    Mol Endocrinol 16:1069-78. 2002
    ..Our findings point to a new role for Ik outside the hematopoietic system and suggest a novel transcriptional contribution with Ets and Sp1 in regulation of FGFR4 in the pituitary...
  38. ncbi request reprint The zinc finger Ikaros transcription factor regulates pituitary growth hormone and prolactin gene expression through distinct effects on chromatin accessibility
    Shereen Ezzat
    Department of Medicine, Mount Sinai Hospital and University of Toronto, Ontario, Canada
    Mol Endocrinol 19:1004-11. 2005
    ..These data provide evidence for Ikaros-mediated histone acetylation and chromatin remodeling in the selective regulation of pituitary GH and PRL hormone gene expression...
  39. ncbi request reprint Targeting N-cadherin through fibroblast growth factor receptor-4: distinct pathogenetic and therapeutic implications
    Shereen Ezzat
    Department of Medicine, University of Toronto, Toronto, Ontario, Canada
    Mol Endocrinol 20:2965-75. 2006
    ..These data highlight the pathogenetic significance of N-cadherin misexpression and emphasize the importance of FGFR partnership in mediating its functions...
  40. ncbi request reprint Alpha-transforming growth factor in the bovine anterior pituitary gland: secretion by dispersed cells and immunohistochemical localization
    M S Kobrin
    Department of Clinical Biochemistry, University of Toronto, Ontario, Canada
    Endocrinology 121:1412-6. 1987
    ..This is the first report documenting the secretion of alpha TGF by nonneoplastic adult cells and the presence of alpha TGF immunoreactivity in the corresponding normal adult tissue...
  41. ncbi request reprint A soluble dominant negative fibroblast growth factor receptor 4 isoform in human MCF-7 breast cancer cells
    S Ezzat
    Department of Medicine, University of Toronto, 600 University Avenue, Toronto, Ontario, Canada M5G 1X5
    Biochem Biophys Res Commun 287:60-5. 2001
    ..These findings represent the first description of an endogenous soluble C-terminally truncated FGFR4 isoform with FGF modulatory properties...
  42. ncbi request reprint The predictive value of CK19 and CD99 in pancreatic endocrine tumors
    Abdullah Ali
    Department of Pathology, University Health Network Toronto Medical Laboratories, University of Toronto, Ont, Canada
    Am J Surg Pathol 30:1588-94. 2006
    ..CD99 does not appear to be as useful. There is no compelling evidence, from our study, to suggest that both these markers may be used in concert to predict the behavior of PETs...
  43. ncbi request reprint Tumor-derived Ikaros 6 acetylates the Bcl-XL promoter to up-regulate a survival signal in pituitary cells
    Shereen Ezzat
    Department of Medicine, Mount Sinai Hospital and University of Toronto, Toronto, Ontario, Canada
    Mol Endocrinol 20:2976-86. 2006
    ..Thus, the contribution of Ik6 to tumor pathogenesis involves up-regulation of an antiapoptotic signal generated through selective acetylation of the Bcl-XL promoter...
  44. doi request reprint Expression of the melanoma-associated antigen is associated with progression of human thyroid cancer
    Sonia Cheng
    Department of Pathology, University Health Network and the Ontario Cancer Institute, Toronto, Ontario, Canada M5G 2C4
    Endocr Relat Cancer 16:455-66. 2009
    ..The use of TMA analyses identifies IHC techniques that are translatable to the clinical setting for prognostic assessment of patients with thyroid cancer...
  45. pmc Ikaros integrates endocrine and immune system development
    Shereen Ezzat
    Department of Medicine, Mount Sinai Hospital and University of Toronto, Toronto, Ontario, Canada
    J Clin Invest 115:1021-9. 2005
    ..Given the established immunomodulatory properties of glucocorticoid hormones, these findings reveal a novel role for Ikaros in orchestrating immune-endocrine development and function...
  46. ncbi request reprint Granulomatous hypophysitis with psammoma bodies: a diagnostic dilemma
    R Jastania
    Department of Laboratory Medicine and Pathobiology, University of Toronto, University Health Network and Toronto Medical Laboratories, Canada
    Endocr Pathol 15:359-63. 2004
    ..This finding has not previously been described in the literature. The diagnostic implications of this finding are complex, and the pathogenesis of psammoma body formation in this idiopathic disorder remains unknown...
  47. pmc The molecular pathogenetic role of cell adhesion in endocrine neoplasia
    S Ezzat
    Department of Medicine, University of Toronto, Endocrine Oncology Site Group, Mount Sinai and Princess Margaret Hospitals, Ontario Cancer Institute, University Health Network, Toronto, Ontario, Canada M5G 1X5
    J Clin Pathol 58:1121-5. 2005
    ..Validation of the functional relevance of these adhesive pathways will be discussed in light of targeted pharmacotherapeutic studies that are unmasking novel approaches to the treatment of neuroendocrine tumours...
  48. doi request reprint The melanoma-associated antigen A3 mediates fibronectin-controlled cancer progression and metastasis
    Wei Liu
    Department of Pathology, University Health Network, Ontario Cancer Institute, Toronto, Ontario, Canada
    Cancer Res 68:8104-12. 2008
    ..We conclude that MAGE A3 is a functional integrator of diverse signals, including FGFR2 and FN, to modulate cancer progression...
  49. doi request reprint Loss of membrane localization and aberrant nuclear E-cadherin expression correlates with invasion in pancreatic endocrine tumors
    Runjan Chetty
    Department of Pathology, University Health Network Toronto Medical Laboratories, University of Toronto, Toronto, Canada
    Am J Surg Pathol 32:413-9. 2008
    ..Aberrant expression of both beta-catenin and E-cadherin correlated strongly with lymph node spread and liver metastases...
  50. doi request reprint Primary frozen section diagnosis by robotic microscopy and virtual slide telepathology: the University Health Network experience
    Andrew J Evans
    Department of Pathology Laboratory Medicine Program, University Health Network, Toronto, Ontario, Canada
    Hum Pathol 40:1070-81. 2009
    ..In addition to its superior speed and image quality, the VS approach readily facilitates consultation with colleagues on difficult cases. As a result, there has been greater overall pathologist satisfaction with VS TP...
  51. ncbi request reprint Pancreatic endocrine tumour with ductules: further observations of an unusual histological subtype
    Runjan Chetty
    Department of Pathology, University Health Network Toronto Medical Laboratories, Princess Margaret Hospital, University of Toronto, Toronto, Canada
    Pathology 38:5-9. 2006
    ..A study of 21 cases of this variant was undertaken with particular attention paid to the distribution and morphology of the ductules, the presence of entrapped acinar tissue and the surrounding uninvolved pancreatic tissue...
  52. ncbi request reprint Malignant teratoma of the thyroid: aggressive chemoradiation therapy is required after surgery
    Richard W Tsang
    Department of Radiation Oncology, Princess Margaret Hospital, University Health Network, University of Toronto, Toronto, Canada
    Thyroid 13:401-4. 2003
    ..This case and the modern experience of combined modality therapy in extragonadal germ cell tumors of the thyroid and other sites illustrate that these tumors should be managed aggressively in order to achieve best results...
  53. ncbi request reprint Pituitary tumor AP-2alpha recognizes a cryptic promoter in intron 4 of fibroblast growth factor receptor 4
    ShunJiang Yu
    Department of Medicine, Mount Sinai Hospital, Toronto, Ontario M5G 2M9, Canada
    J Biol Chem 278:19597-602. 2003
    ..AP-2alpha and chromatin changes may contribute to the utilization of an alternative transcription start site leading to the genesis of the tumorigenic ptd-FGFR4 isoform...
  54. ncbi request reprint Genetic abnormalities of the endothelium
    Jagdish W Butany
    Department of Pathology, University Health Network, Toronto General Hospital, Ontario, Canada
    Microsc Res Tech 60:30-7. 2003
    ..This review highlights some of the growing body of evidence implicating endothelial dysfunction as an important mediator of diverse diseases...
  55. pmc An essential role for the hematopoietic transcription factor Ikaros in hypothalamic-pituitary-mediated somatic growth
    Shereen Ezzat
    Department of Medicine, Mount Sinai Hospital, University of Toronto, 610 University Avenue, Toronto, ON, Canada M5G 2M9
    Proc Natl Acad Sci U S A 103:2214-9. 2006
    ..These findings unmask a wider role for Ikaros in the neuroendocrine system, highlighting a critical contribution to the development of the hypothalamic-pituitary somatotrophic axis...
  56. ncbi request reprint Mechanisms of disease: The pathogenesis of pituitary tumors
    Shereen Ezzat
    The Freeman Centre for Endocrine Oncology, Mount Sinai Hospital, Toronto, Ontario, Canada
    Nat Clin Pract Endocrinol Metab 2:220-30. 2006
    ..Mouse models have validated the roles of these alterations, which can be targets for the development of therapies that can manage these lesions. These therapies are increasingly recognized as critical for quality of life...
  57. ncbi request reprint The cancer/testis antigen melanoma-associated antigen-A3/A6 is a novel target of fibroblast growth factor receptor 2-IIIb through histone H3 modifications in thyroid cancer
    Tetsuo Kondo
    Department of Pathology, Princess Margaret Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada
    Clin Cancer Res 13:4713-20. 2007
    ..In this analysis, we examined a novel target of FGFR2-IIIb signaling, melanoma-associated antigen-A3 and A6 (MAGE-A3/6)...
  58. doi request reprint Fibroblast growth factor 2 and estrogen control the balance of histone 3 modifications targeting MAGE-A3 in pituitary neoplasia
    Xuegong Zhu
    Department of Medicine, University of Toronto, Toronto, Ontario, Canada
    Clin Cancer Res 14:1984-96. 2008
    ..cDNA profiling identified the cancer-testis antigen melanoma-associated antigen A3 (MAGE-A3) as a putative target negatively regulated by FGFR2...
  59. doi request reprint Mice lacking the transcription factor Ikaros display behavioral alterations of an anti-depressive phenotype
    Tim Rasmus Kiehl
    Department of Pathology, University Health Network, 610 University Avenue, Toronto, Ontario, Canada
    Exp Neurol 211:107-14. 2008
    ....
  60. pmc Genetic and epigenetic mechanisms down-regulate FGF receptor 2 to induce melanoma-associated antigen A in breast cancer
    Xuegong Zhu
    Department of Medicine, University Health Network, University of Toronto, Toronto, Ontario, Canada
    Am J Pathol 176:2333-43. 2010
    ..Our findings underscore the significance of epigenetic and somatic changes that can potentially modify the effects of germline polymorphisms in determining FGFR2 gene expression...
  61. ncbi request reprint Pancreatic endocrine pathology in von Hippel-Lindau disease: an expanding spectrum of lesions
    Runjan Chetty
    Department of Pathology, University Health Network Toronto Medical Laboratories, University of Toronto, Toronto, ON M5G 2M9, Canada
    Endocr Pathol 15:141-8. 2004
    ..In addition, the endocrine lesions were composed of two main cell types (typical and oncocytic cells) with the oncocytic component invading lymphatic channels and spreading to regional lymph nodes...
  62. pmc Targeted expression of a human pituitary tumor-derived isoform of FGF receptor-4 recapitulates pituitary tumorigenesis
    Shereen Ezzat
    Department of Medicine, University of Toronto, Toronto, Ontario, Canada
    J Clin Invest 109:69-78. 2002
    ..Here we show that targeted expression of ptd-FGFR4, but not FGFR4, results in pituitary tumors that morphologically recapitulate the human disease...
  63. ncbi request reprint Fibroblast growth factor receptors as molecular targets in thyroid carcinoma
    Rosanne St Bernard
    Department of Pathology, University Health Network and University of Toronto, Toronto, Ontario, Canada
    Endocrinology 146:1145-53. 2005
    ..These data indicate a role for FGFR-4 in human thyroid cancer cell progression and provide a rationale for FGFR manipulation as a potentially novel therapeutic approach...
  64. ncbi request reprint Primary frozen section diagnosis by robotic microscopy and virtual slide telepathology: the University Health Network experience
    Andrew J Evans
    Department of Pathology Laboratory Medicine Program, University Health Network, Toronto, Ontario, Canada
    Semin Diagn Pathol 26:165-76. 2009
    ..In addition to its superior speed and image quality, the VS approach readily facilitates consultation with colleagues on difficult cases. As a result, there has been greater overall pathologist satisfaction with VS TP...
  65. pmc Worrisome histologic alterations following fine-needle aspiration of the parathyroid
    S Alwaheeb
    Department of Laboratory Medicine and Pathobiology, University of Toronto, University Health Network and Toronto Medical Laboratories, Toronto, Canada
    J Clin Pathol 59:1094-6. 2006
    ..Parathyroid cells were identified by a review of the previous FNA. The concept of WHAFFT, which can mimic the features of malignancy in the parathyroid gland, is therefore introduced...
  66. pmc Cutaneous manifestations of thyroid cancer: a report of four cases and review of the literature
    S Alwaheeb
    Department of Pathology and Laboratory Medicine, University of Toronto, University Health Network and Toronto Medical Laboratories, Ontario M5G 2M9, Canada
    J Clin Pathol 57:435-8. 2004
    ..Subsequent investigations identified primary thyroid lesions. In two cases, the skin metastasis was the first evidence of the recurrence of known thyroid carcinoma. These cases identify a novel presentation of thyroid carcinoma...
  67. ncbi request reprint FGF receptor signaling at the crossroads of endocrine homeostasis and tumorigenesis
    S Ezzat
    Department of Medicine, University of Toronto, Endocrine Oncology Site Group, Mount Sinai and Princess Margaret Hospitals, Ontario Cancer Institute, University Health Network, Toronto, Ontario, Canada
    Horm Metab Res 37:355-60. 2005
    ..This review will examine the evidence that FGF/FGFRs play a role in sporadic endocrine neoplasia and the pathways in which these molecules may be selectively targeted for therapeutic purposes...
  68. pmc Increased expression of the stefin A cysteine proteinase inhibitor occurs in the myelomonocytic cell-infiltrated tissues of autoimmune motheaten mice
    I Mlinaric-Rascan
    Department of Medicine, University of Toronto, Ontario, Canada
    Am J Pathol 145:902-12. 1994
    ....
  69. ncbi request reprint Neuroendocrine function and response to stress in mice with complete disruption of glucagon-like peptide-1 receptor signaling
    N J MacLusky
    Department of Reproductive Science, University of Toronto, Ontario, Canada
    Endocrinology 141:752-62. 2000
    ....
  70. pmc Vitamin D arrests thyroid carcinoma cell growth and induces p27 dephosphorylation and accumulation through PTEN/akt-dependent and -independent pathways
    Wei Liu
    Department of Medicine, Mount Sinai Hospital, Toronto, Ontario, Canada
    Am J Pathol 160:511-9. 2002
    ..These properties support the potential utility of VD analogs in the treatment of thyroid carcinomas irrespective of their PTEN/pAkt status...
  71. doi request reprint Transcript level modulates the inherent oncogenicity of RET/PTC oncoproteins
    Douglas S Richardson
    Department of Pathology and Molecular Medicine, Division of Cancer Biology and Genetics, Cancer Research Institute, Queen s University, Kingston, Ontario, Canada
    Cancer Res 69:4861-9. 2009
    ....
  72. pmc Histone-acetylated control of fibroblast growth factor receptor 2 intron 2 polymorphisms and isoform splicing in breast cancer
    Xuegong Zhu
    Department of Medicine, and the Endocrine Oncology Site Group, Princess Margaret Hospital, Ontario Cancer Institute, University Health Network, Toronto, Ontario, Canada M5G 2M9
    Mol Endocrinol 23:1397-405. 2009
    ..Our findings highlight the potential role of histone acetylation in modulating access to selected polymorphic sites within intron 2 as well as downstream splicing sites in generating variable FGFR2 levels and isoforms in breast cancer...
  73. pmc Epigenetic silencing through DNA and histone methylation of fibroblast growth factor receptor 2 in neoplastic pituitary cells
    Xuegong Zhu
    Department of Medicine, Mount Sinai Hospital and University of Toronto, Canada
    Am J Pathol 170:1618-28. 2007
    ..These data highlight the contribution from DNA and histone methylation as epigenetic mechanisms responsible for FGFR2 silencing in pituitary neoplasia...
  74. ncbi request reprint The implication of somatotroph adenoma phenotype to somatostatin analog responsiveness in acromegaly
    Shelly Bhayana
    Department of Medicine, Mount Sinai Hospital, 600 University Avenue, Room 437, Toronto, Ontario, Canada M5G 1X5
    J Clin Endocrinol Metab 90:6290-5. 2005
    ..Persistently elevated GH and IGF-I levels are associated with increased mortality. Their response to somatostatin analogs (SSA) is variable...
  75. ncbi request reprint Sp1-mediated transcriptional control of fibroblast growth factor receptor 4 in sarcomas of skeletal muscle lineage
    Shun Jiang Yu
    Department of Medicine, Mount Sinai Hospital and University of Toronto, The Freeman Centre for Endocrine Oncology and The Ontario Cancer Institute, Toronto, Ontario, Canada
    Clin Cancer Res 10:6750-8. 2004
    ..Our findings point to Sp1 as an important contributor to FGFR4 transcriptional control and elucidate a potential mechanism for the heterogeneous expression of FGFR4 in neoplasms derived from the same cell lineage...
  76. ncbi request reprint Pituitary tumor-derived fibroblast growth factor receptor 4 isoform disrupts neural cell-adhesion molecule/N-cadherin signaling to diminish cell adhesiveness: a mechanism underlying pituitary neoplasia
    Shereen Ezzat
    Department of Medicine, University of Toronto, Canada
    Mol Endocrinol 18:2543-52. 2004
    ....
  77. ncbi request reprint Transforming growth factor-alpha in the mammalian brain. Immunohistochemical detection in neurons and characterization of its mRNA
    J E Kudlow
    Department of Clinical Biochemistry, University of Toronto, Banting and Best Diabetes Centre, Ontario, Canada
    J Biol Chem 264:3880-3. 1989
    ..These studies indicate that the normal mammalian brain neurons express TGF-alpha...
  78. ncbi request reprint Glucagon gene 5'-flanking sequences direct expression of simian virus 40 large T antigen to the intestine, producing carcinoma of the large bowel in transgenic mice
    Y C Lee
    Department of Medicine, Banting and Best Diabetes Centre, University of Toronto, Ontario, Canada
    J Biol Chem 267:10705-8. 1992
    ..The results of these studies provide functional evidence for the existence of an upstream cis-acting regulatory domain that directs glucagon gene transcription to the endocrine cells of the intestine in transgenic mice...
  79. pmc Pancreatic endocrine tumour with cytoplasmic keratin whorls. Is the term "rhabdoid" appropriate?
    R Chetty
    Department of Pathology, University Health Network Toronto Medical Laboratories, University of Toronto, Toronto, ON M5G 2M9, Canada
    J Clin Pathol 57:1106-10. 2004
    ..It is suggested that the term "cytokeratin aggresomes" should be used to describe this distinctive phenotype...
  80. pmc Adenohypophysitis in rat pituitary allografts
    Fabio Rotondo
    Department of Laboratory Medicine, Division of Pathology, St Michael s Hospital, University of Toronto, Toronto, ON, Canada
    Int J Exp Pathol 91:445-50. 2010
    ....
  81. doi request reprint Ikaros modulates cholesterol uptake: a link between tumor suppression and differentiation
    Siobhan Loeper
    Departments of Medicine and Pathology, University Health Network, Ontario Cancer Institute, Toronto, Ontario, Canada
    Cancer Res 68:3715-23. 2008
    ..These findings expand the repertoire of Ikaros actions to include regulation of the cholesterol uptake metabolic pathway with therapeutic implications for lipid-modifying drugs in Ikaros-associated cancers...
  82. ncbi request reprint Dual inhibition of RET and FGFR4 restrains medullary thyroid cancer cell growth
    Shereen Ezzat
    Department of Medicine, Mount Sinai Hospital and University of Toronto, Toronto, Ontario, Canada
    Clin Cancer Res 11:1336-41. 2005
    ..These data highlight RET and FGFR4 as therapeutic targets and suggest a potential role for the combined use of tyrosine kinase inhibitors in the management of inoperable medullary thyroid cancers...
  83. doi request reprint CEACAM1 expression in pancreatic endocrine tumors
    Stefano Serra
    Department of Pathology, University Health Network, University of Toronto, Toronto, Canada
    Appl Immunohistochem Mol Morphol 17:286-93. 2009
    ..05). PETs showing CEACAM1 positivity have a statistically significant correlation with several of the pathologic parameters of aggressive behavior and its overexpression is seen in those cases with increased invasiveness...
  84. ncbi request reprint Vitamin D3 administration induces nuclear p27 accumulation, restores differentiation, and reduces tumor burden in a mouse model of metastatic follicular thyroid cancer
    Alan P B Dackiw
    Department of Surgery, University Health Network and Mount Sinai Hospital, Toronto, Ontario, Canada
    Endocrinology 145:5840-6. 2004
    ....
  85. ncbi request reprint Osteopontin (OPN) expression in thyroid carcinoma
    Juliane Briese
    Department of Laboratory Medicine and Pathobiology, University of Toronto, Department of Pathology, University Health Network, and Ontario Cancer Institute, Toronto, Ontario, Canada
    Anticancer Res 30:1681-8. 2010
    ..Here we investigated the prognostic significance of OPN in thyroid tumours and correlated our findings with the expression of CEACAM1...
  86. doi request reprint Application of immunohistochemistry to thyroid neoplasms
    Sandra Fischer
    Department of Pathology, University Health Network and Toronto Medical Laboratories, 200 Elizabeth St, 11th Floor, Toronto, Ontario, Canada M5G 2C4
    Arch Pathol Lab Med 132:359-72. 2008
    ..Occasionally, thyroid tumors represent unusual or metastatic lesions and their accurate diagnosis requires immunohistochemical confirmation...
  87. ncbi request reprint Angiopoietins are expressed in the normal rat pituitary gland
    Sukriti Nag
    Toronto Western Research Institute and Department of Pathology, University Health Network, University of Toronto, Toronto, Canada
    Endocr Pathol 16:67-73. 2005
    ..This first report of angiopoietin localization in the rat pituitary gland opens a new line of investigation on angiogenesis in pituitary glands that will impact human endocrinology in the future...
  88. ncbi request reprint Intracytoplasmic inclusions (including the so-called "rhabdoid" phenotype) in pancreatic endocrine tumors
    Stefano Serra
    Department of Pathology, University Health Network Toronto Medical Laboratories and University of Toronto, Toronto, Canada
    Endocr Pathol 17:75-81. 2006
    ..This phenotype, in particular the rhabdoid cells, is worthy of attention as a proportion may show lymphovascular invasion with evidence of metastasis at the time of presentation, irrespective of size, mitotic rates, or necrosis...
  89. ncbi request reprint Vitamin D and its analog EB1089 induce p27 accumulation and diminish association of p27 with Skp2 independent of PTEN in pituitary corticotroph cells
    Wei Liu
    Department of Medicine, Mount Sinai Hospital, Toronto, Ontario, Canada
    Brain Pathol 12:412-9. 2002
    ..Our findings highlight p27 and VD analogs as targets for manipulation and drug development respectively in the treatment of inoperable corticotroph adenomas...
  90. ncbi request reprint Intrathyroidal lymphoepithelial cysts of probable branchial origin
    R L Apel
    Department of Pathology, Mount Sinai Hospital, Toronto, Ontario, Canada
    Hum Pathol 25:1238-42. 1994
    ..These branchial cleft-like cysts also may arise from branchial cleft derivatives, and their enlargement may be related to the immunological mechanisms associated with autoimmune thyroiditis...
  91. doi request reprint Radionuclide therapy in neuroendocrine tumours: a systematic review
    K Y Gulenchyn
    Department of Nuclear Medicine, Hamilton Health Sciences and St Joseph s Healthcare Hamilton, Hamilton, Ontario, Canada
    Clin Oncol (R Coll Radiol) 24:294-308. 2012
    ..No strong evidence exists to support that one therapeutic radiopharmaceutical is more effective than others. Well-designed and good-quality randomised controlled trials are required on this research topic...
  92. doi request reprint Controversies in thyroid pathology: the diagnosis of follicular neoplasms
    Stefano Serra
    Department of Pathology, University Health Network, 200 Elizabeth Street, 11th Floor, Toronto, Ontario, Canada M5G 2C4
    Endocr Pathol 19:156-65. 2008
    ..We review the differential diagnosis of well-differentiated follicular thyroid neoplasms and the ancillary techniques and molecular characteristics that have been proposed for application in the diagnosis of PTC...
  93. ncbi request reprint The 2004 World Health Organization classification of pituitary tumors: what is new?
    Mubarak Al-Shraim
    Department of Pathology, University Health Network and Toronto Medical Laboratories, University of Toronto, Toronto, Ontario, M5G 2M9, Canada
    Acta Neuropathol 111:1-7. 2006
    ..Here we review the new information and identify areas of concern for the next effort at classification of pituitary tumors...
  94. doi request reprint Thyroid cancer is the most common malignancy arising from hormone-producing glands. Preface
    Shereen Ezzat
    Princess Margaret Hospital, Toronto, ON, Canada
    Endocrinol Metab Clin North Am 37:xvii-xviii. 2008
  95. ncbi request reprint Pulmonary pathology of severe acute respiratory syndrome in Toronto
    David M Hwang
    Toronto Medical Laboratories, Toronto, Ontario, Canada
    Mod Pathol 18:1-10. 2005
    ..Cases of SARS may be complicated by coexistent infections and therapy-related lung injury...
  96. ncbi request reprint Intratumoral lymphatics and lymph node metastases in papillary thyroid carcinoma
    Francis T Hall
    Department of Otolaryngology Head and Neck Surgery, Mount Sinai Hospital, Toronto, Ontario, Canada
    Arch Otolaryngol Head Neck Surg 129:716-9. 2003
    ..To examine the relationship between lymphatic vessel density and clinical and pathological variables in patients with well-differentiated papillary thyroid carcinoma...
  97. ncbi request reprint Papillary thyroid carcinoma: an overview
    Nabeel Al-Brahim
    Department of Pathology, University Health Network and Toronto Medical Laboratories, Toronto, Ontario
    Arch Pathol Lab Med 130:1057-62. 2006
    ..In this short review, we discuss an approach to papillary carcinoma, the diagnostic dilemmas and controversies, and the ancillary studies that are helpful in resolving them, including immunohistochemistry and molecular studies...
  98. ncbi request reprint Ikaros is regulated through multiple histone modifications and deoxyribonucleic acid methylation in the pituitary
    Xuegong Zhu
    Department of Medicine, Mount Sinai Hospital and University of Toronto, Canada
    Mol Endocrinol 21:1205-15. 2007
    ..These findings have important implications for the understanding of Ikaros' role in epigenetic functions and suggest a potential role for demethylating agents in the treatment of related disorders...
  99. ncbi request reprint Plurihormonality in pituitary adenomas associated with acromegaly
    Fateme Salehi
    Department of Laboratory Medicine, St Michael s Hospital, University of Toronto, Canada
    Endocr Pathol 17:291-6. 2006
    ..The application of different reagents yielded different patterns of positivity indicating that the validity of some common immunohistochemical reagents must be re-evaluated...
  100. ncbi request reprint Overexpression of cyclin D1 and underexpression of p27 predict lymph node metastases in papillary thyroid carcinoma
    Mark L C Khoo
    Department of Pathology, University Health Network, Toronto, Ontario, Canada
    J Clin Endocrinol Metab 87:1814-8. 2002
    ..We suggest that immunohistochemistry for cyclin D1 and p27 will prove valuable in identifying papillary thyroid carcinomas with metastatic potential...
  101. ncbi request reprint AIP Mutations are not identified in patients with sporadic pituitary adenomas
    Rebecca Digiovanni
    Department of Pathology, University Health Network and Toronto Medical Laboratories, Ontario Cancer Institute, Toronto, Ontario, Canada
    Endocr Pathol 18:76-8. 2007
    ..Our results indicate that mutations in AIP are not identified in sporadic pituitary adenomas of Canadian patients. This rare mechanism of pituitary tumorigenesis appears to be unique to the initial Finnish and Italian families described...