Cheryl Arrowsmith

Summary

Affiliation: University Health Network
Country: Canada

Publications

  1. pmc Structure of the catalytic domain of EZH2 reveals conformational plasticity in cofactor and substrate binding sites and explains oncogenic mutations
    Hong Wu
    Structural Genomics Consortium, University of Toronto, Toronto, Ontario, Canada
    PLoS ONE 8:e83737. 2013
  2. doi request reprint Epigenetic protein families: a new frontier for drug discovery
    Cheryl H Arrowsmith
    Structural Genomics Consortium, University of Toronto, 101 College Street, Toronto, Ontario M5G 1L7, Canada
    Nat Rev Drug Discov 11:384-400. 2012
  3. pmc Cruciform structures are a common DNA feature important for regulating biological processes
    Vaclav Brazda
    Institute of Biophysics, Academy of Sciences of the Czech Republic, V, V, I, Kralovopolska 135, Brno, 612 65, Czech Republic
    BMC Mol Biol 12:33. 2011
  4. ncbi request reprint Genome-scale protein expression and structural biology of Plasmodium falciparum and related Apicomplexan organisms
    Masoud Vedadi
    Structural Genomics Consortium, U of Toronto, 100 College St Rm 522B, Toronto, Ont, Canada M5G 1L5
    Mol Biochem Parasitol 151:100-10. 2007
  5. pmc In situ proteolysis for protein crystallization and structure determination
    Aiping Dong
    Structural Genomics Consortium, University of Toronto, 100 College Street, Toronto, Ontario M5G 1L5, Canada
    Nat Methods 4:1019-21. 2007
  6. pmc Chemical screening methods to identify ligands that promote protein stability, protein crystallization, and structure determination
    Masoud Vedadi
    Structural Genomics Consortium, University of Toronto, 100 College Street, Toronto, ON, Canada M5G 1L5
    Proc Natl Acad Sci U S A 103:15835-40. 2006

Collaborators

Detail Information

Publications6

  1. pmc Structure of the catalytic domain of EZH2 reveals conformational plasticity in cofactor and substrate binding sites and explains oncogenic mutations
    Hong Wu
    Structural Genomics Consortium, University of Toronto, Toronto, Ontario, Canada
    PLoS ONE 8:e83737. 2013
    ..We propose that protein interactions within the PRC2 complex modulate the trajectory of the post-SET and I-SET domains of EZH2 in favor of a catalytically competent conformation. ..
  2. doi request reprint Epigenetic protein families: a new frontier for drug discovery
    Cheryl H Arrowsmith
    Structural Genomics Consortium, University of Toronto, 101 College Street, Toronto, Ontario M5G 1L7, Canada
    Nat Rev Drug Discov 11:384-400. 2012
    ..In this article, we discuss the known links with disease, basic molecular mechanisms of action and recent progress in the pharmacological modulation of each class of proteins...
  3. pmc Cruciform structures are a common DNA feature important for regulating biological processes
    Vaclav Brazda
    Institute of Biophysics, Academy of Sciences of the Czech Republic, V, V, I, Kralovopolska 135, Brno, 612 65, Czech Republic
    BMC Mol Biol 12:33. 2011
    ..The prevalence of cruciform structures and their roles in protein interactions, epigenetic regulation and the maintenance of cell homeostasis are also discussed...
  4. ncbi request reprint Genome-scale protein expression and structural biology of Plasmodium falciparum and related Apicomplexan organisms
    Masoud Vedadi
    Structural Genomics Consortium, U of Toronto, 100 College St Rm 522B, Toronto, Ont, Canada M5G 1L5
    Mol Biochem Parasitol 151:100-10. 2007
    ....
  5. pmc In situ proteolysis for protein crystallization and structure determination
    Aiping Dong
    Structural Genomics Consortium, University of Toronto, 100 College Street, Toronto, Ontario M5G 1L5, Canada
    Nat Methods 4:1019-21. 2007
    ..This is a work in progress; so far we determined structures of 9 bacterial proteins and the human aminoimidazole ribonucleotide synthetase (AIRS) domain...
  6. pmc Chemical screening methods to identify ligands that promote protein stability, protein crystallization, and structure determination
    Masoud Vedadi
    Structural Genomics Consortium, University of Toronto, 100 College Street, Toronto, ON, Canada M5G 1L5
    Proc Natl Acad Sci U S A 103:15835-40. 2006
    ..The methods are cost-effective, can be implemented in any laboratory, promise to increase the success rates of purifying and crystallizing human proteins significantly, and identify new ligands for these proteins...