P W Armstrong

Summary

Affiliation: University of Alberta
Country: Canada

Publications

  1. pmc Efficacy and safety of unfractionated heparin versus enoxaparin: a pooled analysis of ASSENT-3 and -3 PLUS data
    Paul W Armstrong
    University of Alberta, Edmonton, Alta
    CMAJ 174:1421-6. 2006
  2. ncbi request reprint Evaluation of the Heart and Stroke Foundation of Canada Research Scholarship Program: research productivity and impact
    P W Armstrong
    Department of Medicine, University of Alberta, Edmonton, Canada
    Can J Cardiol 13:507-16. 1997
  3. ncbi request reprint Concerning the mechanism of pexelizumab's benefit in acute myocardial infarction
    Paul W Armstrong
    The University of Alberta, Edmonton, Alberta, Canada
    Am Heart J 151:787-90. 2006
  4. pmc Methods of creatine kinase-MB analysis to predict mortality in patients with myocardial infarction treated with reperfusion therapy
    Renato D Lopes
    Duke Clinical Research Institute, Duke University Medical Center, 2400 Pratt Street, Room 0311, Terrace Level, Box 3850, Durham, NC 27705, USA
    Trials 14:123. 2013
  5. doi request reprint Quantitative ST-depression in acute coronary syndromes: the PLATO electrocardiographic substudy
    Paul W Armstrong
    Canadian VIGOUR Centre, University of Alberta, Edmonton, Canada
    Am J Med 126:723-729.e1. 2013
  6. ncbi request reprint A comparison of pharmacologic therapy with/without timely coronary intervention vs. primary percutaneous intervention early after ST-elevation myocardial infarction: the WEST (Which Early ST-elevation myocardial infarction Therapy) study
    Paul W Armstrong
    Canadian VIGOUR Centre, 2 51 Medical Sciences Building, University of Alberta Edmonton, AB, Canada T6G 2H7
    Eur Heart J 27:1530-8. 2006
  7. doi request reprint Baseline Q-wave surpasses time from symptom onset as a prognostic marker in ST-segment elevation myocardial infarction patients treated with primary percutaneous coronary intervention
    Paul W Armstrong
    University of Alberta, Edmonton, Canada
    J Am Coll Cardiol 53:1503-9. 2009
  8. pmc Advancing interdisciplinary health research: a synergism not to be denied
    Paul W Armstrong
    Department of Medicine, University of Alberta, Edmonton, Alta
    CMAJ 175:761. 2006
  9. ncbi request reprint Innovative strategic Canadian research training from TomorrOw's Research Cardiovascular Health Care Professionals (TORCH)
    Paul W Armstrong
    University of Alberta, Edmonton, Alta
    Clin Invest Med 27:33-41. 2004
  10. ncbi request reprint Ruminating on OAT: is the case closed?
    Paul W Armstrong
    University of Alberta Edmonton, Alberta, T6G 2H7 Canada
    Eur Heart J 28:531-2. 2007

Detail Information

Publications127 found, 100 shown here

  1. pmc Efficacy and safety of unfractionated heparin versus enoxaparin: a pooled analysis of ASSENT-3 and -3 PLUS data
    Paul W Armstrong
    University of Alberta, Edmonton, Alta
    CMAJ 174:1421-6. 2006
    ..We undertook a prespecified pooled analysis of data from the ASSENT-3 and ASSENT-3 PLUS trials...
  2. ncbi request reprint Evaluation of the Heart and Stroke Foundation of Canada Research Scholarship Program: research productivity and impact
    P W Armstrong
    Department of Medicine, University of Alberta, Edmonton, Canada
    Can J Cardiol 13:507-16. 1997
    ....
  3. ncbi request reprint Concerning the mechanism of pexelizumab's benefit in acute myocardial infarction
    Paul W Armstrong
    The University of Alberta, Edmonton, Alberta, Canada
    Am Heart J 151:787-90. 2006
    ....
  4. pmc Methods of creatine kinase-MB analysis to predict mortality in patients with myocardial infarction treated with reperfusion therapy
    Renato D Lopes
    Duke Clinical Research Institute, Duke University Medical Center, 2400 Pratt Street, Room 0311, Terrace Level, Box 3850, Durham, NC 27705, USA
    Trials 14:123. 2013
    ..We evaluated alternative approaches to quantifying infarct size using CK-MB values, and the relationship between infarct size and clinical outcomes...
  5. doi request reprint Quantitative ST-depression in acute coronary syndromes: the PLATO electrocardiographic substudy
    Paul W Armstrong
    Canadian VIGOUR Centre, University of Alberta, Edmonton, Canada
    Am J Med 126:723-729.e1. 2013
    ....
  6. ncbi request reprint A comparison of pharmacologic therapy with/without timely coronary intervention vs. primary percutaneous intervention early after ST-elevation myocardial infarction: the WEST (Which Early ST-elevation myocardial infarction Therapy) study
    Paul W Armstrong
    Canadian VIGOUR Centre, 2 51 Medical Sciences Building, University of Alberta Edmonton, AB, Canada T6G 2H7
    Eur Heart J 27:1530-8. 2006
    ..We evaluated whether optimal pharmacologic therapy at the earliest point of care, emphasizing pre-hospital randomization and treatment was non-inferior to expeditious primary percutaneous coronary intervention (PCI)...
  7. doi request reprint Baseline Q-wave surpasses time from symptom onset as a prognostic marker in ST-segment elevation myocardial infarction patients treated with primary percutaneous coronary intervention
    Paul W Armstrong
    University of Alberta, Edmonton, Canada
    J Am Coll Cardiol 53:1503-9. 2009
    ..We assessed the incremental value of baseline Q waves over time from symptom onset as a marker of clinical outcome in ST-segment elevation myocardial infarction (STEMI)...
  8. pmc Advancing interdisciplinary health research: a synergism not to be denied
    Paul W Armstrong
    Department of Medicine, University of Alberta, Edmonton, Alta
    CMAJ 175:761. 2006
  9. ncbi request reprint Innovative strategic Canadian research training from TomorrOw's Research Cardiovascular Health Care Professionals (TORCH)
    Paul W Armstrong
    University of Alberta, Edmonton, Alta
    Clin Invest Med 27:33-41. 2004
    ..The program has recruited 19 trainees from a broad cross-section of disciplines, integrating 2 University of Alberta campuses. The preliminary experience has been both favourable and gratifying...
  10. ncbi request reprint Ruminating on OAT: is the case closed?
    Paul W Armstrong
    University of Alberta Edmonton, Alberta, T6G 2H7 Canada
    Eur Heart J 28:531-2. 2007
  11. pmc Do guidelines influence practice?
    Paul W Armstrong
    University of Alberta, Edmonton, Alberta, T6G 2H7, Canada
    Heart 89:349-52. 2003
  12. pmc A Canadian context for the Acute Study of Clinical Effectiveness of Nesiritide and Decompensated Heart Failure (ASCEND-HF) trial
    Paul W Armstrong
    Department of Medicine, Division of Cardiology, University of Alberta, Edmonton, Alberta
    Can J Cardiol 24:30B-2B. 2008
    ..The trial is embedded in an academic research organization motif and promises to provide a significant contribution to the body of knowledge in acute heart failure and the care of patients so afflicted...
  13. ncbi request reprint Pexelizumab for acute ST-elevation myocardial infarction in patients undergoing primary percutaneous coronary intervention: a randomized controlled trial
    Paul W Armstrong
    University of Alberta, Edmonton, Alberta, T6G 2H7 Canada
    JAMA 297:43-51. 2007
    ..However, in patients without prompt reestablishment of brisk coronary flow and tissue perfusion, mortality remains high, providing an opportunity for novel treatments, including anti-inflammatory agents...
  14. doi request reprint Defining myocardial infarction: a work in progress: Ischaemic heart disease
    Paul W Armstrong
    Division of Cardiology, University of Alberta, 2 51 Medical Sciences Building, Edmonton, Alberta T6G 2H7, Canada
    Heart 94:1076-9. 2008
  15. ncbi request reprint Fibrinolysis for acute myocardial infarction: the future is here and now
    Paul W Armstrong
    Department of Medicine, 2 51 Medical Sciences Building, University of Alberta, Edmonton, Alberta, Canada T6G 2H7
    Circulation 107:2533-7. 2003
  16. pmc Tailoring therapy to best suit ST-segment elevation myocardial infarction: searching for the right fit
    Paul W Armstrong
    Division of Cardiology, Department of Medicine, University of Alberta, Edmonton, Alta
    CMAJ 169:925-7. 2003
  17. ncbi request reprint A time for transformative leadership in academic health sciences
    Paul W Armstrong
    University of Alberta, Edmonton, Alberta, Canada
    Clin Invest Med 30:E127-32. 2007
    ....
  18. pmc Balancing the cyclooxygenase portfolio
    Paul W Armstrong
    Department of Medicine, University of Alberta, Edmonton, Alta
    CMAJ 174:1581-2. 2006
  19. ncbi request reprint ST segment resolution in ASSENT 3: insights into the role of three different treatment strategies for acute myocardial infarction
    Paul W Armstrong
    University of Alberta, Edmonton, Canada
    Eur Heart J 24:1515-22. 2003
    ..We compared ST resolution in each of the three treatment regimens in order to evaluate the speed, extent and stability of ST segment resolution and its relationship to the primary composite endpoint(s) of the trial...
  20. ncbi request reprint Evolution of the CCU from rhythm, function and protection to reperfusion and beyond: a personal journey and perspective
    P W Armstrong
    Department of Medicine, University of Alberta, Edmonton
    Can J Cardiol 12:909-13. 1996
    ..To trace the evolution of coronary care and the management of acute coronary syndromes...
  21. ncbi request reprint Acute coronary syndromes in the GUSTO-IIb trial: prognostic insights and impact of recurrent ischemia. The GUSTO-IIb Investigators
    P W Armstrong
    University of Alberta, Edmonton, Alberta, Canada
    Circulation 98:1860-8. 1998
    ..This issue has not been studied systematically among the spectrum of patients with acute coronary presentations, encompassing those with and without ST-segment elevation...
  22. ncbi request reprint Collaborative angiographic patency trial of recombinant staphylokinase (CAPTORS)
    P W Armstrong
    University of Alberta, Edmonton, Canada
    Am Heart J 139:820-3. 2000
    ..We undertook an angiographic, dose-finding study of staphylokinase (SAK42D variant) to evaluate its efficacy and safety in patients with acute ST-segment myocardial infarction...
  23. doi request reprint ST-elevation acute coronary syndromes in the Platelet Inhibition and Patient Outcomes (PLATO) trial: insights from the ECG substudy
    Paul W Armstrong
    University of Alberta, Edmonton, AB T6G 2H7, Canada
    Circulation 125:514-21. 2012
    ....
  24. ncbi request reprint Lessons learned from a clinical trial
    Paul W Armstrong
    University of Alberta, Edmonton, Alberta, Canada
    Circulation 110:3610-4. 2004
  25. ncbi request reprint Assessment of Pexelizumab in Acute Myocardial Infarction (APEX AMI): a multicenter, randomized, double-blind, parallel-group, placebo-controlled study of pexelizumab in patients with acute myocardial infarction undergoing primary percutaneous coronary int
    Paul W Armstrong
    Division of Cardiology, Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
    Am Heart J 149:402-7. 2005
  26. ncbi request reprint The 2004 ACC/AHA Guidelines: a perspective and adaptation for Canada by the Canadian Cardiovascular Society Working Group
    Paul W Armstrong
    VIGOUR Centre, University of Alberta, Edmonton
    Can J Cardiol 20:1075-9. 2004
    ....
  27. doi request reprint Reperfusion paradox in ST-segment elevation myocardial infarction
    Paul W Armstrong
    University of Alberta, Edmonton, Alberta, Canada
    Ann Intern Med 155:389-91. 2011
    ..The authors believe it is time to embrace an integrated dual reperfusion strategy to best serve all patients with STEMI...
  28. doi request reprint Refining clinical trial composite outcomes: an application to the Assessment of the Safety and Efficacy of a New Thrombolytic-3 (ASSENT-3) trial
    Paul W Armstrong
    University of Alberta, Edmonton, Canada
    Am Heart J 161:848-54. 2011
    ..Traditional time-to-event analysis assigns equal weight to the first event in the composite end point. This is counterintuitive to many stakeholders...
  29. ncbi request reprint Coronary reperfusion: numerators searching for denominators
    Paul W Armstrong
    Department of Medicine, University of Alberta, Edmonton, Alberta T6G 2H7, Canada
    Lancet 359:371-2. 2002
  30. doi request reprint The Strategic Reperfusion Early After Myocardial Infarction (STREAM) study
    Paul W Armstrong
    University of Alberta, Edmonton, Alberta, Canada
    Am Heart J 160:30-35.e1. 2010
    ....
  31. ncbi request reprint Collaborative Angiographic Patency Trial Of Recombinant Staphylokinase (CAPTORS II)
    P W Armstrong
    University of Alberta, Edmonton, Alberta, Canada
    Am Heart J 146:484-8. 2003
    ..Pilot studies with bolus pegulated staphylokinase (PEG-Sak) have revealed excellent Thrombolysis In Myocardial Infarction (TIMI) 3 60-minute flow...
  32. pmc Time to treatment and the impact of a physician on prehospital management of acute ST elevation myocardial infarction: insights from the ASSENT-3 PLUS trial
    R C Welsh
    University of Alberta, Edmonton, Alberta, Canada
    Heart 91:1400-6. 2005
    ....
  33. ncbi request reprint Prognostic value of ST segment depression in acute coronary syndromes: insights from PARAGON-A applied to GUSTO-IIb. PARAGON-A and GUSTO IIb Investigators. Platelet IIb/IIIa Antagonism for the Reduction of Acute Global Organization Network
    P Kaul
    University of Alberta, Edmonton, Canada
    J Am Coll Cardiol 38:64-71. 2001
    ..CONCLUSIONS: These data provide new evidence supporting the powerful prognostic value of the baseline electrocardiogram and, in particular, the magnitude and distribution of ST segment depression in predicting unfavorable events...
  34. ncbi request reprint Non-Q-wave versus Q-wave myocardial infarction after thrombolytic therapy: angiographic and prognostic insights from the global utilization of streptokinase and tissue plasminogen activator for occluded coronary arteries-I angiographic substudy. GUSTO-I A
    S G Goodman
    The Terrence Donnelly Heart Centre, Division of Cardiology, St Michael s Hospital, University of Toronto, Ontario, Canada
    Circulation 97:444-50. 1998
    ....
  35. ncbi request reprint Time to treatment influences the impact of ST-segment resolution on one-year prognosis: insights from the assessment of the safety and efficacy of a new thrombolytic (ASSENT-2) trial
    Y Fu
    University of Alberta, Edmonton, Alberta, Canada
    Circulation 104:2653-9. 2001
    ..Time to treatment further differentiates between high- and low-risk patients and further highlights the importance of reducing time delay to initiation of fibrinolysis in acute myocardial infarction...
  36. pmc Relation between baseline risk and treatment decisions in non-ST elevation acute coronary syndromes: an examination of international practice patterns
    P Kaul
    University of Alberta, Edmonton, Alberta, Canada
    Heart 91:876-81. 2005
    ..To examine whether ST segment depression influenced clinical decision making and whether there was international variation in the use of cardiac procedures across ST segment depression categories...
  37. ncbi request reprint Do the investigative sites that take part in a positive clinical trial translate that evidence into practice?
    Sumit R Majumdar
    Division of General Internal Medicine, Department of Medicine, University of Alberta, Edmonton, Canada
    Am J Med 113:140-5. 2002
    ....
  38. ncbi request reprint A novel enoxaparin regime for ST elevation myocardial infarction patients undergoing primary percutaneous coronary intervention: a WEST sub-study
    Robert C Welsh
    Division of Cardiology, Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
    Catheter Cardiovasc Interv 70:341-8. 2007
    ..To evaluate the anticoagulation effect of subcutaneous (SQ) and intravenous (IV) enoxaparin through systematic anti-Xa sampling during primary PCI for acute STEMI...
  39. ncbi request reprint Impact of sex on long-term mortality from acute myocardial infarction vs unstable angina
    Wei Ching Chang
    Department of Medicine, University of Alberta, Edmonton, Canada
    Arch Intern Med 163:2476-84. 2003
    ..However, to our knowledge, no prior population-based studies have examined both cohorts simultaneously to explain this intriguing variation. Hence, we undertook to explore and explain sex differences in 5-year mortality after UA and AMI...
  40. ncbi request reprint Does eptifibatide confer a greater benefit to patients with unstable angina than with non-ST segment elevation myocardial infarction? Insights from the PURSUIT Trial
    W C Chang
    University of Alberta, Edmonton, Alberta, Canada
    Eur Heart J 23:1102-11. 2002
    ....
  41. ncbi request reprint Does the discharge ECG provide additional prognostic insight(s) in non-ST elevation ACS patients from that acquired on admission?
    A Hersi
    University of Alberta, 2 51 Medical Science Building, Edmonton, Canada T6G 2H7
    Eur Heart J 24:522-31. 2003
    ....
  42. pmc Randomised trials of secondary prevention programmes in coronary heart disease: systematic review
    F A McAlister
    Division of General Internal Medicine, University of Alberta Hospital, Edmonton, Alberta, Canada
    BMJ 323:957-62. 2001
    ..To determine whether multidisciplinary disease management programmes for patients with coronary heart disease improve processes of care and reduce morbidity and mortality...
  43. ncbi request reprint Randomized evaluation of the safety and efficacy of enoxaparin versus unfractionated heparin in high-risk patients with non-ST-segment elevation acute coronary syndromes receiving the glycoprotein IIb/IIIa inhibitor eptifibatide
    Shaun G Goodman
    Canadian Heart Research Centre and Terrence Donnelly Heart Centre, Division of Cardiology, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada
    Circulation 107:238-44. 2003
    ..A key issue of uncertainty is the safety and efficacy of combination glycoprotein IIb/IIIa inhibitor and low-molecular-weight heparin therapy...
  44. ncbi request reprint Anemia is common in heart failure and is associated with poor outcomes: insights from a cohort of 12 065 patients with new-onset heart failure
    Justin A Ezekowitz
    Division of Cardiology, University of Alberta, Edmonton, Alberta, Canada
    Circulation 107:223-5. 2003
    ....
  45. ncbi request reprint A marriage of enhancement: fibrinolysis and conjunctive therapy
    Robert C Welsh
    The University of Alberta, Department of Medicine, Division of Cardiology, Edmonton, AB T6G 2H7 Canada
    Thromb Haemost 92:1194-200. 2004
    ..The future is likely to emphasize greater application of the already effective therapies at our disposal and the development of novel anti-platelet and anti-thrombin agents as well as those directed toward inflammation...
  46. ncbi request reprint Variations in pre-hospital fibrinolysis process of care: insights from the Assessment of the Safety and Efficacy of a New Thrombolytic 3 Plus international acute myocardial infarction pre-hospital care survey
    Robert C Welsh
    University of Albert, Edmonton, Canada
    Eur J Emerg Med 11:134-40. 2004
    ....
  47. ncbi request reprint Do cardiac troponins provide prognostic insight in hemodialysis patients?
    Jonathan B Choy
    Division of Cardiology, University of Alberta Hospital, Edmonton, Canada
    Can J Cardiol 19:907-11. 2003
    ..The relative incidence of elevated cardiac troponins in this population and their relationship to clinical events remain unknown...
  48. pmc N-terminal pro-brain natriuretic peptide and the timing, extent and mortality in ST elevation myocardial infarction
    Justin A Ezekowitz
    University of Alberta, Edmonton, Canada
    Can J Cardiol 22:393-7. 2006
    ....
  49. ncbi request reprint Development and prognosis of non-Q-wave myocardial infarction in the thrombolytic era
    Shaun G Goodman
    Division of Cardiology, Canadian Heart Research Center, St Michael s Hospital, Toronto, Ontario, Canada
    Am Heart J 144:243-50. 2002
    ..Data on non-Q myocardial infarctions (MI) are derived primarily from prethrombolytic era studies. Previous trials demonstrated different development rates and none reported on clinical outcomes...
  50. ncbi request reprint Interinstitutional variation in the use of abciximab for percutaneous coronary intervention
    Cynthia M Westerhout
    Department of Public Health Sciences, University of Alberta, Edmonton
    Can J Cardiol 20:405-10. 2004
    ..Several clinical trials have established abciximab as an efficacious agent for use in conjunction with percutaneous coronary intervention; however, there is little documented about its use in routine clinical practice in Canada...
  51. ncbi request reprint Feasibility and applicability of paramedic-based prehospital fibrinolysis in a large North American center
    Robert C Welsh
    University of Alberta, Edmonton, Alberta, Canada
    Am Heart J 152:1007-14. 2006
    ....
  52. doi request reprint Sex differences in patients seeking medical attention for prodromal symptoms before an acute coronary event
    Michelle M Graham
    Division of Cardiology, Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
    Am Heart J 156:1210-1216.e1. 2008
    ..We used population-level data to determine the rate at which such patients seek medical attention for these symptoms, whether sex differences are present, and if an association between prodromes and 1-year mortality exists...
  53. ncbi request reprint Dynamic prognostication in non-ST-elevation acute coronary syndromes: insights from GUSTO-IIb and PURSUIT
    Wei Ching Chang
    University of Alberta, Edmonton, Alberta, Canada
    Am Heart J 148:62-71. 2004
    ..The objective of the current study was to develop an approach to predicting outcome in NSTE-ACS that could account for the changing nature of risk...
  54. ncbi request reprint Benefit of angiographic spontaneous reperfusion in STEMI: does it extend to diabetic patients?
    K R Bainey
    University of Alberta, Edmonton, Alberta, Canada
    Heart 95:1331-6. 2009
    ..Spontaneous reperfusion (SR) in ST elevation myocardial infarction (STEMI) improves clinical outcome, yet its incidence and impact among diabetic patients is unclear...
  55. ncbi request reprint Aborted myocardial infarction in patients with ST-segment elevation: insights from the Assessment of the Safety and Efficacy of a New Thrombolytic Regimen-3 Trial Electrocardiographic Substudy
    Taha Taher
    University of Alberta, Edmonton, Alberta, Canada
    J Am Coll Cardiol 44:38-43. 2004
    ....
  56. doi request reprint Do baseline atrial electrocardiographic and infarction patterns predict new-onset atrial fibrillation after ST-elevation myocardial infarction? Insights from the Assessment of Pexelizumab in Acute Myocardial Infarction Trial
    Sean van Diepen
    Division of Cardiology, University of Alberta, Edmonton, Alberta, Canada
    J Electrocardiol 43:351-8. 2010
    ..Hence, in STEMI patients treated with primary percutaneous coronary intervention, we examined whether baseline atrial electrocardiographic changes or atrial infarction patterns predicted new AF or mortality...
  57. ncbi request reprint Failure of investigator adherence to electrocardiographic entry criteria is frequent and influences clinical outcomes: lessons from APEX-AMI
    Michael C Tjandrawidjaja
    Division of Cardiology, Department of Medicine, University of Alberta, 2 51 Medical Sciences Building, Edmonton, Alberta T6G 2H7, Canada
    Eur Heart J 28:2850-7. 2007
    ..To examine the extent and impact on clinical outcomes of adherence to electrocardiogram (ECG) entry criteria in ST-elevation myocardial infarction patients in the assessment of pexelizumab in acute myocardial infarction (APEX-AMI) trial...
  58. ncbi request reprint Proportion of patients followed in a specialized heart failure clinic needing an implantable cardioverter defibrillator as determined by applying different trial eligibility criteria
    Mustafa Toma
    Division of General Internal Medicine, University of Alberta, Edmonton, Canada
    Am J Cardiol 97:882-5. 2006
    ..Thus, the development and validation of a risk stratification scheme to identify those patients most likely to benefit from ICDs for primary prophylaxis should be a research priority...
  59. ncbi request reprint The impact of gender on the treatment and outcomes of patients with early reinfarction after fibrinolysis: insights from ASSENT-2
    Michael C Tjandrawidjaja
    Department of Medicine, Division of Cardiology, 2 51 Medical Sciences Building, University of Alberta, Edmonton, Alberta, Canada
    Eur Heart J 24:1024-34. 2003
    ..To assess gender differences in patients with early reinfarction after fibrinolysis for acute myocardial infarction (AMI) and the impact of these differences on treatment and outcomes...
  60. ncbi request reprint Does chronic Chlamydia pneumoniae infection increase the risk of myocardial injury? Insights from patients with non-ST-elevation acute coronary syndromes
    Brian Y L Wong
    University of Alberta, Edmonton, Alberta, Canada
    Am Heart J 144:987-94. 2002
    ..Accordingly, we evaluated plasma samples acquired at presentation in 178 patients with ACS for a possible association between Cpn IgA titer and biochemical evidence of myocardial injury...
  61. ncbi request reprint Usefulness of spironolactone in a specialized heart failure clinic
    Wendy Sligl
    Division of General Internal Medicine, Edmonton, Alberta, Canada
    Am J Cardiol 94:443-7. 2004
    ..Thus, although the complication rate was higher, the benefits of spironolactone seen in RALES extended to participants not in a trial who were treated with similar doses and followed closely in a clinic specializing in heart failure...
  62. doi request reprint Adverse outcomes in fibrinolytic-based facilitated percutaneous coronary intervention: insights from the ASSENT-4 PCI electrocardiographic substudy
    Michael A McDonald
    Division of Cardiology, University of Alberta, 251 Medical Sciences Building, Edmonton, Alberta, Canada T6G 2H7
    Eur Heart J 29:871-9. 2008
    ..Patients in ASSENT-4 PCI undergoing tenecteplase-facilitated percutaneous coronary intervention (PCI) had more adverse events than those undergoing primary PCI. We analysed this to gain further insights...
  63. ncbi request reprint Prehospital management of acute ST-elevation myocardial infarction: a time for reappraisal in North America
    Robert C Welsh
    University of Alberta, Edmonton, Alberta, Canada
    Am Heart J 145:1-8. 2003
    ..We review past research in prehospital therapy for STEMI and practical impediments to implementation to establish a framework for interpretation of future developments...
  64. ncbi request reprint Forecasting mortality: dynamic assessment of risk in ST-segment elevation acute myocardial infarction
    Wei Ching Chang
    Department of Medicine, University of Alberta, 2 51 Medical Sciences Building, Edmonton, Alberta, Canada T6G 2H7
    Eur Heart J 27:419-26. 2006
    ..To demonstrate the feasibility and clinical utility of developing dynamic risk assessment models for ST-segment elevation myocardial infarction (STEMI) patients...
  65. pmc Are international differences in the outcomes of acute coronary syndromes apparent or real? A multilevel analysis
    Wei Ching Chang
    University of Alberta, Edmonton, Alberta T6G 2H7, Canada
    J Epidemiol Community Health 59:427-33. 2005
    ..The relative contributions of patient, hospital, and country level factors on clinical outcomes, however, remain unclear, and thus, was the objective of this study...
  66. pmc Impact of specialist follow-up in outpatients with congestive heart failure
    Justin A Ezekowitz
    Division of Cardiology, University of Alberta, Edmonton, Alta
    CMAJ 172:189-94. 2005
    ..Our objective was to determine the impact of physician specialty on outcomes in outpatients with new-onset congestive heart failure...
  67. ncbi request reprint An international perspective on heart failure and left ventricular systolic dysfunction complicating myocardial infarction: the VALIANT registry
    Eric J Velazquez
    Division of Cardiology, Department of Medicine, Duke University Medical Center and Duke Clinical Research Institute, P O Box 17969, Durham, NC 27715, USA
    Eur Heart J 25:1911-9. 2004
    ....
  68. pmc It's a matter of time: contemporary pre-hospital management of acute ST elevation myocardial infarction
    R C Welsh
    University of Alberta, Edmonton, Alberta, Canada
    Heart 91:1524-6. 2005
  69. ncbi request reprint The use of beta-blockers in a tertiary care heart failure clinic: dosing, tolerance, and outcomes
    Puneeta Tandon
    Division of General Internal Medicine, University of Alberta, Edmonton, Canada
    Arch Intern Med 164:769-74. 2004
    ..Little is known about the dosing, tolerability, and impact of beta-blockers in nontrial participants. This study was conducted to evaluate the use and outcomes of beta-blockers in a tertiary care heart failure clinic...
  70. ncbi request reprint Do evidence-based treatments provide incremental benefits to patients with congestive heart failure already receiving angiotensin-converting enzyme inhibitors? A secondary analysis of one-year outcomes from the Assessment of Treatment with Lisinopril and
    Sumit R Majumdar
    Division of General Internal Medicine, Department of Medicine, University of Alberta, 251 Medical Sciences Building, Edmonton, Alberta, Canada T6G 2H7
    Clin Ther 26:694-703. 2004
    ....
  71. doi request reprint Spontaneous reperfusion in ST-elevation myocardial infarction: comparison of angiographic and electrocardiographic assessments
    Kevin R Bainey
    University of Alberta, Edmonton, Alberta, Canada
    Am Heart J 156:248-55. 2008
    ....
  72. ncbi request reprint The prognostic value of the admission and predischarge electrocardiogram in acute coronary syndromes: the GUSTO-IIb ECG Core Laboratory experience
    Shaun G Goodman
    The Canadian Heart Research Centre, Division of Cardiology, St Michael s Hospital, University of Toronto, Toronto, Canada
    Am Heart J 152:277-84. 2006
    ....
  73. doi request reprint Usefulness of the QRS score as a strong prognostic marker in patients discharged after undergoing primary percutaneous coronary intervention for ST-segment elevation myocardial infarction
    Michael C Tjandrawidjaja
    University of Alberta, Edmonton, Canada
    Am J Cardiol 106:630-4. 2010
    ..24, HR for death/CHF/shock 2.93, 95% CI 1.84 to 4.67). In conclusion, infarct size as estimated by QRS scoring at hospital discharge is an independent and prognostically relevant metric in patients with STEMI undergoing primary PCI...
  74. doi request reprint Prior coronary artery bypass graft patients with ST-segment elevation myocardial infarction treated with primary percutaneous coronary intervention
    Robert C Welsh
    University of Alberta, Edmonton, Alberta, Canada
    JACC Cardiovasc Interv 3:343-51. 2010
    ..We sought to compare outcomes in ST-segment elevation myocardial infarction (STEMI) patients undergoing primary percutaneous coronary intervention (PCI) with or without previous coronary artery bypass grafts (CABG)...
  75. ncbi request reprint Compromised atrial coronary anatomy is associated with atrial arrhythmias and atrioventricular block complicating acute myocardial infarction
    Michael C Tjandrawidjaja
    Department of Medicine, University of Alberta, Edmonton, Alberta, Canada T6G 2H7
    J Electrocardiol 38:271-8. 2005
    ..The relevance of the atrial coronary anatomy in the pathogenesis of atrial arrhythmias and atrioventricular (AV) block complicating acute myocardial infarction (AMI) remains unclear...
  76. ncbi request reprint Effects of socioeconomic status on mortality after acute myocardial infarction
    Wei Ching Chang
    University of Alberta, Edmonton, Alberta, Canada
    Am J Med 120:33-9. 2007
    ..To assess the effects of socioeconomic status on mortality in patients with acute myocardial infarction...
  77. ncbi request reprint International differences in evolution of early discharge after acute myocardial infarction
    Padma Kaul
    University of Alberta, Edmonton, Alberta, Canada
    Lancet 363:511-7. 2004
    ..We aimed to identify the extent to which countries have taken advantage of the opportunity for early discharge...
  78. ncbi request reprint Short- and long-term risk stratification in acute coronary syndromes: the added value of quantitative ST-segment depression and multiple biomarkers
    Cynthia M Westerhout
    University of Alberta, Edmonton, Canada
    J Am Coll Cardiol 48:939-47. 2006
    ..The purpose of this study was to develop 30-day and 1-year risk stratification models for non-ST-segment elevation acute coronary syndrome (NSTE-ACS) patients that incorporate quantitative ST-segment depression and novel biomarkers...
  79. doi request reprint Acute heart failure in the emergency department: short and long-term outcomes of elderly patients with heart failure
    Justin A Ezekowitz
    Division of Cardiology, Department of Medicine University of Alberta, Canada
    Eur J Heart Fail 10:308-14. 2008
    ..We examined discharge rates, and whether outcomes, including mortality, differed based on admission status in AHF...
  80. pmc Assessment of activity status and survival according to the Canadian Cardiovascular Society angina classification
    Padma Kaul
    Division of Cardiology, University of Alberta, Edmonton, Alberta T6G 2M8, Canada
    Can J Cardiol 25:e225-31. 2009
    ..Despite its widespread use, limited data on the validity of the Canadian Cardiovascular Society angina (CCSA) classification relative to other measures of functional status have been reported...
  81. ncbi request reprint Long-term mortality of patients with acute myocardial infarction in the United States and Canada: comparison of patients enrolled in Global Utilization of Streptokinase and t-PA for Occluded Coronary Arteries (GUSTO)-I
    Padma Kaul
    University of Alberta, 7221 Aberhart Center I, 8440 112 St, Edmonton, AB T6G 2B7, Canada
    Circulation 110:1754-60. 2004
    ..4%, adjusted P=0.02). We sought to determine whether Canadian-US differences in practice patterns in GUSTO-I had an impact on 5-year mortality...
  82. doi request reprint Declining in-hospital mortality and increasing heart failure incidence in elderly patients with first myocardial infarction
    Justin A Ezekowitz
    Division of Cardiology, University of Alberta, Edmonton, Alberta, Canada
    J Am Coll Cardiol 53:13-20. 2009
    ..The purpose of this study was to examine the long-term incidence of heart failure (HF) in elderly patients with myocardial infarction (MI)...
  83. ncbi request reprint Electrocardiographic left ventricular hypertrophy in GUSTO IV ACS: an important risk marker of mortality in women
    Cynthia M Westerhout
    Canadian VIGOUR Centre Research Group, 214 Heritage Medical Research Centre, University of Alberta, Edmonton, Alberta, Canada T6G 2S2
    Eur Heart J 28:2064-9. 2007
    ..To examine the association of left ventricular hypertrophy (LVH) on admission electrocardiography with adverse outcomes in acute coronary syndrome (ACS) patients...
  84. doi request reprint Predicting chronic left ventricular dysfunction 90 days after ST-segment elevation myocardial infarction: An Assessment of Pexelizumab in Acute Myocardial Infarction (APEX-AMI) Substudy
    Justin A Ezekowitz
    University of Alberta and the Canadian VIGOUR Center, Edmonton, Alberta, Canada
    Am Heart J 160:272-8. 2010
    ....
  85. ncbi request reprint No prognostic significance of chronic infection with Chlamydia pneumoniae in acute coronary syndromes: insights from the Global Utilization of Strategies to Open Occluded Arteries IV Acute Coronary Syndromes trial
    Cynthia M Westerhout
    Heritage Medical Research Centre, University of Alberta, Edmonton, Alberta, Canada T6G 2S2
    Am Heart J 154:306-12. 2007
    ....
  86. pmc Differences in admission rates and outcomes between men and women presenting to emergency departments with coronary syndromes
    Padma Kaul
    Division of Cardiology, Department of Medicine, and the Canadian VIGOUR Centre, University of Alberta, Edmonton, Alta
    CMAJ 177:1193-9. 2007
    ..We sought to examine sex-related differences at an earlier point in care--presentation to the emergency department...
  87. doi request reprint Patient and informal caregivers' knowledge of heart failure: necessary but insufficient for effective self-care
    Alexander M Clark
    Faculty of Nursing, Level 3 CSB, University of Alberta, Edmonton, AB, Canada T6R 2R6
    Eur J Heart Fail 11:617-21. 2009
    ..We aimed to examine the individual and contextual factors perceived by patients and their informal caregivers' to influence their willingness and capacity to undertake effective HF self-care...
  88. ncbi request reprint Meta-analysis: beta-blocker dose, heart rate reduction, and death in patients with heart failure
    Finlay A McAlister
    University of Alberta Hospital, 2F1 21 Walter Mackenzie Health Sciences Centre, 8440 112 Street, Edmonton, Alberta, Canada
    Ann Intern Med 150:784-94. 2009
    ..Guidelines recommend that patients with heart failure receive beta-blockers in doses used in the trials that have proven their efficacy. Although the adverse effects of beta-blockade are dose-related, it is unclear whether the benefits are...
  89. doi request reprint Better outcomes for patients treated at hospitals that participate in clinical trials
    Sumit R Majumdar
    Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
    Arch Intern Med 168:657-62. 2008
    ....
  90. ncbi request reprint Insights into the change in brain natriuretic peptide after ST-elevation myocardial infarction (STEMI): why should it be better than baseline?
    Justin A Ezekowitz
    2C2 Cardiology UAH, University of Alberta, 8440 112 Street, Edmonton, AB T6G 2B7, Canada
    Can J Physiol Pharmacol 85:173-8. 2007
    ..This likely reflects the variability in NT-proBNP at presentation and the ability to integrate subsequent important physiologic sequelae of STEMI such as reperfusion and infarct size...
  91. ncbi request reprint Renal insufficiency and heart failure: prognostic and therapeutic implications from a prospective cohort study
    Finlay A McAlister
    Division of General Internal Medicine, University of Alberta, Edmonton, Canada
    Circulation 109:1004-9. 2004
    ..The prevalence, prognostic import, and impact of renal insufficiency on the benefits of ACE inhibitors and beta-blockers in community-dwelling patients with heart failure are uncertain...
  92. ncbi request reprint Impact of different patterns of invasive care on quality of life outcomes in patients with non-ST elevation acute coronary syndrome: results from the GUSTO-IIb Canada-United States substudy
    Padma Kaul
    University of Alberta, Edmonton
    Can J Cardiol 20:760-6. 2004
    ....
  93. ncbi request reprint Aspirin use and outcomes in a community-based cohort of 7352 patients discharged after first hospitalization for heart failure
    Finlay A McAlister
    Division of General Internal Medicine, University of Alberta, Edmonton, Canada
    Circulation 113:2572-8. 2006
    ....
  94. ncbi request reprint How many patients with heart failure are eligible for cardiac resynchronization? Insights from two prospective cohorts
    Finlay A McAlister
    The Division of General Internal Medicine, 2E3 24 Walter Mackenzie Health Sciences Centre, University of Alberta, 8440 112 Street, Edmonton, Alberta T6G 2R7, Canada
    Eur Heart J 27:323-9. 2006
    ..To determine what proportion of patients with heart failure are eligible for cardiac resynchronization therapy (CRT)...
  95. ncbi request reprint Optimizing use of revascularization and clinical outcomes in ST-elevation myocardial infarction: insights from the GUSTO-V trial
    Padma Kaul
    University of Alberta, 7, 226 Aberhart Center I, Edmonton, Alberta, Canada T6G 2J3
    Eur Heart J 27:1198-206. 2006
    ..To examine the relative contribution of system and patient level factors to the variation in international revascularization rates, and their impact on mortality outcomes...
  96. ncbi request reprint Economic analysis of the Assessment of the Safety and Efficacy of a New Thrombolytic Regimen (ASSENT-3) study: costs of reperfusion strategies in acute myocardial infarction
    Padma Kaul
    Department of Medicine, Duke Clinical Research Institute, Durham, NC, USA
    Am Heart J 149:637-44. 2005
    ....
  97. ncbi request reprint The interaction among sex, hemoglobin and outcomes in a specialty heart failure clinic
    Justin A Ezekowitz
    Division of Cardiology, University of Alberta, Edmonton, Alberta T6G 2H7
    Can J Cardiol 21:165-71. 2005
    ..Accordingly, the relationship among sex, anemia and outcomes in CHF was analyzed...
  98. ncbi request reprint A systematic review of randomized trials of disease management programs in heart failure
    F A McAlister
    Divisions of General Internal Medicine, University of Alberta Hospital, Edmonton, Canada
    Am J Med 110:378-84. 2001
    ..Data on mortality are inconclusive. Further studies are needed to establish the incremental benefits of the different elements of these programs...
  99. ncbi request reprint Therapeutic exercise for individuals with heart failure: special attention to older women with heart failure
    M J Haykowsky
    Faculty of Rehabilitation Medicine, Division of Cardiology, University of Alberta, Edmonton, Alberta, Canada
    J Card Fail 10:165-73. 2004
    ....
  100. ncbi request reprint Endothelial nitric oxide synthase increases in left atria of dogs with pacing-induced heart failure
    F H Khadour
    Department of Pharmacology, Cardiovascular Research Group, University of Alberta, Edmonton, Alberta, Canada T6G 2S2
    Am J Physiol 275:H1971-8. 1998
    ..Ca2+-independent NOS activity was undetectable in any cardiac tissue. The specific upregulation of eNOS in the left atria suggests that NO production may be enhanced to counterbalance hypertrophy that develops during pacing-induced CHF...
  101. ncbi request reprint Mortality at 1 year with combination platelet glycoprotein IIb/IIIa inhibition and reduced-dose fibrinolytic therapy vs conventional fibrinolytic therapy for acute myocardial infarction: GUSTO V randomized trial
    A Michael Lincoff
    Department of Cardiovascular Medicine, Cleveland Clinic Foundation, 9500 Euclid Ave, Cleveland, OH 44195, USA
    JAMA 288:2130-5. 2002
    ..Rates of nonfatal ischemic complications were significantly diminished...