Laura T Arbour
Affiliation: University of Victoria
- The current state of birth outcome and birth defect surveillance in northern regions of the worldLaura Arbour
University of British Columbia, Department of Medical Genetics, Island Medical Program, Victoria, BC V8P 5C2, Canada
Int J Circumpolar Health 68:443-58. 2009..The aim of this review is to catalogue existing and developing birth outcome and birth defect surveillance within and around the geographic jurisdiction of the International Union of Circumpolar Health (IUCH)...
- Causes and risk factors for infant mortality in Nunavut, Canada 1999-2011Sorcha A Collins
Department of Medical Genetics, University of British Columbia Island Medical Program, University of Victoria, PO Box 1700 STN CSC, Victoria, BC, V8W 2Y2, Canada
BMC Pediatr 12:190. 2012..Nunavut has the largest Inuit population in Canada, a population which has been identified as having high rates of Sudden Infant Death Syndrome (SIDS) and infant deaths due to infections...
- Rates of congenital anomalies and other adverse birth outcomes in an offspring cohort of registered nurses from British Columbia, CanadaLaura T Arbour
Department of Medical Genetics, Island Medical Program, Faculty of Medicine, University of British Columbia, Victoria, BC
Can J Public Health 101:230-4. 2010....
- A KCNQ1 V205M missense mutation causes a high rate of long QT syndrome in a First Nations community of northern British Columbia: a community-based approach to understanding the impactLaura Arbour
Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia, Canada
Genet Med 10:545-50. 2008..Hereditary long QT syndrome is named for a prolonged QT interval reflecting predisposition to ventricular arrhythmias and sudden death. A high rate in a remote, northern Canadian First Nations community was brought to attention...
- Autoimmune liver disease and the Canadian First Nations Aboriginal Communities of British Columbia's Pacific NorthwestEric M Yoshida
Department of Medicine, University of British Columbia, Vancouver, Canada
World J Gastroenterol 12:3625-7. 2006..Evidence suggesting that autoimmune hepatitis is also more likely amongst BC's First Nations communities is also presented...
- Heavy smoking during pregnancy as a marker for other risk factors of adverse birth outcomes: a population-based study in British Columbia, CanadaAnders C Erickson
Division of Medical Sciences, University of Victoria, Medical Science Bld, Victoria, B C, Canada
BMC Public Health 12:102. 2012..Our goal was to determine whether number of cigarettes smoked could identify those in greatest need for comprehensive intervention programs to improve outcomes...
- Characteristics of primary biliary cirrhosis in British Columbia's First Nations populationLaura Arbour
Department of Genetics, University of British Columbia, 4500 Oak Street, Vancouver, BC, Canada V6H 3N1
Can J Gastroenterol 19:305-10. 2005..For the purpose of the present report, 28 symptomatic cases were ascertained separately and reviewed in a clinical study to delineate the features of this population...
- Maternal smoking at first prenatal visit as a marker of risk for adverse pregnancy outcomes in the Qikiqtaaluk (Baffin) RegionKate Mehaffey
Faculty of Medicine, UBC Aboriginal Family Practice program, Vancouver, British Columbia, Canada
Rural Remote Health 10:1484. 2010..Nunavut also has the highest rates of preterm birth and low birth weight infants in Canada. The present study assessed whether the number of cigarettes smoked per day, as recorded in the first trimester, influenced birth outcomes...
- Retrospective review of pediatric and adult autoimmune hepatitis in two quaternary care centres in British Columbia: increased prevalence seen in British Columbia's First Nations communityHenry V Chung
Department of Medicine, University of British Columbia, Vancouver, Canada
Can J Gastroenterol 21:565-8. 2007..The researchers hypothesized that this community may also be at increased risk for autoimmune hepatitis (AIH)...
- The mystery of primary biliary cirrhosis in British Columbia's First Nations peopleLaura Arbour
University of British Columbia, Department of Medical Genetics, Vancouver, Canada
Int J Circumpolar Health 63:185-8. 2004..9% of the population of BC is of FN descent, 25% of those requiring transplantation for PBC were of FN descent. From this, it can be calculated that PBC is about 8 times more common than in the non-native population...
- Changes in frequencies of select congenital anomalies since the onset of folic acid fortification in a Canadian birth defect registryKimberly A Godwin
UBC Department of Medical Genetics, Children s and Women s Health Centre, Vancouver, BC
Can J Public Health 99:271-5. 2008..Fortification of grain products with folic acid has been shown to significantly reduce the occurrence of neural tube defects (NTDs) in Canada and elsewhere. However, the impact on non-NTD anomalies has not been well studied...
- The development of a comprehensive maternal-child health information system for Nunavut-Nutaqqavut (Our Children)Samantha Lauson
UBC Department of Medical Genetics, Victoria, Canada
Int J Circumpolar Health 70:363-72. 2011..Public health and community efforts are needed to understand and improve outcomes...
- Characterization of a new X-linked mental retardation syndrome with microcephaly, cortical malformation, and thin habitusChristèle du Souich
Rare Disease Foundation, Vancouver, British Columbia, Canada
Am J Med Genet A 149:2469-78. 2009..This combination of features is unreported and distinct from Lujan-Fryns syndrome, Snyder-Robinson syndrome, and zinc finger DHHC domain-containing 9-associated MR. We propose the name of this new syndrome to be CK syndrome...
- DNA on loan: issues to consider when carrying out genetic research with aboriginal families and communitiesLaura Arbour
University of British Columbia, Vancouver, Canada
Community Genet 9:153-60. 2006..This paper will explore practical ways of maintaining a respectful research relationship when genetics research with aboriginal people is undertaken...
- Spina bifida, folate metabolism, and dietary folate intake in a Northern Canadian aboriginal populationLaura Arbour
Department of Human Genetics, School of Dietetics and Human Nutrition, McGill University Montreal, Quebec Canada
Int J Circumpolar Health 61:341-51. 2002..Furthermore, there is a high frequency of spina bifida in the Cree of the region. It was hypothesized that genetically altered folate metabolism as well as low folate intake contributes to the high frequency of spina bifida...
- Mutations in the gene encoding capillary morphogenesis protein 2 cause juvenile hyaline fibromatosis and infantile systemic hyalinosisSandra Hanks
Section of Cancer Genetics, Institute of Cancer Research, Sutton, Surrey, United Kingdom
Am J Hum Genet 73:791-800. 2003..These data (1) demonstrate that JHF and ISH are allelic conditions and (2) implicate perturbation of basement-membrane matrix assembly as the cause of the characteristic perivascular hyaline deposition seen in these conditions...
- The gene for juvenile hyaline fibromatosis maps to chromosome 4q21Nazneen Rahman
Section of Cancer Genetics, Institute of Cancer Research, Surrey, United Kingdom
Am J Hum Genet 71:975-80. 2002..5). Meiotic recombinants place the gene for JHF within a 7-cM interval bounded by D4S2393 and D4S395...