C Thomas G Appleton

Summary

Affiliation: University of Western Ontario
Country: Canada

Publications

  1. ncbi Forced mobilization accelerates pathogenesis: characterization of a preclinical surgical model of osteoarthritis
    C Thomas G Appleton
    CIHR Group in Skeletal Development and Remodeling, Schulich School of Medicine and Dentistry, The University of Western Ontario, London, Ontario, N6A 5C1, Canada
    Arthritis Res Ther 9:R13. 2007
  2. ncbi Molecular and histological analysis of a new rat model of experimental knee osteoarthritis
    C Thomas G Appleton
    CIHR Group in Skeletal Development and Remodeling, The University of Western Ontario, London, Ontario, Canada
    Ann N Y Acad Sci 1117:165-74. 2007
  3. ncbi Transforming growth factor alpha suppression of articular chondrocyte phenotype and Sox9 expression in a rat model of osteoarthritis
    C Thomas G Appleton
    University of Western Ontario, London, Ontario, Canada
    Arthritis Rheum 56:3693-705. 2007
  4. ncbi Rho/ROCK and MEK/ERK activation by transforming growth factor-alpha induces articular cartilage degradation
    C Thomas G Appleton
    CIHR Group in Skeletal Development and Remodeling, London, ON, Canada
    Lab Invest 90:20-30. 2010
  5. ncbi Regulator of G-protein signaling (RGS) proteins differentially control chondrocyte differentiation
    C Thomas G Appleton
    CIHR Group in Skeletal Development and Remodeling, Ontario, London, Ontario, Canada
    J Cell Physiol 207:735-45. 2006
  6. ncbi Transforming growth factor-alpha induces endothelin receptor A expression in osteoarthritis
    Shirine E Usmani
    Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, The University of Western Ontario, London, Ontario, Canada, N6A 5C1
    J Orthop Res 30:1391-7. 2012
  7. ncbi Vascular smooth muscle cells as a valvular interstitial cell surrogate in heart valve tissue engineering
    Andrew J E Appleton
    Department of Anatomy and Cell Biology, The Schulich School of Medicine and Dentistry, The University of Western Ontario, London, Canada
    Tissue Eng Part A 15:3889-97. 2009
  8. ncbi Microarray analyses of gene expression during chondrocyte differentiation identifies novel regulators of hypertrophy
    Claudine G James
    CIHR Group in Skeletal Development and Remodeling, University of Western Ontario, London, Ontario N6A 5C1, Canada
    Mol Biol Cell 16:5316-33. 2005

Collaborators

Detail Information

Publications8

  1. ncbi Forced mobilization accelerates pathogenesis: characterization of a preclinical surgical model of osteoarthritis
    C Thomas G Appleton
    CIHR Group in Skeletal Development and Remodeling, Schulich School of Medicine and Dentistry, The University of Western Ontario, London, Ontario, N6A 5C1, Canada
    Arthritis Res Ther 9:R13. 2007
    ..The time course of OA progression can be modulated through the use of forced mobilization...
  2. ncbi Molecular and histological analysis of a new rat model of experimental knee osteoarthritis
    C Thomas G Appleton
    CIHR Group in Skeletal Development and Remodeling, The University of Western Ontario, London, Ontario, Canada
    Ann N Y Acad Sci 1117:165-74. 2007
    ..Identified candidate genes including genes involved in chemokine, endothelin, and transforming growth factor-alpha signaling are discussed in the context of articular cartilage degeneration in early OA...
  3. ncbi Transforming growth factor alpha suppression of articular chondrocyte phenotype and Sox9 expression in a rat model of osteoarthritis
    C Thomas G Appleton
    University of Western Ontario, London, Ontario, Canada
    Arthritis Rheum 56:3693-705. 2007
    ..To define the roles of transforming growth factor alpha (TGFalpha) in cartilage degradation...
  4. ncbi Rho/ROCK and MEK/ERK activation by transforming growth factor-alpha induces articular cartilage degradation
    C Thomas G Appleton
    CIHR Group in Skeletal Development and Remodeling, London, ON, Canada
    Lab Invest 90:20-30. 2010
    ..These data suggest that TGFalpha is a strong stimulator of cartilage degradation and that Rho/ROCK and MEK/ERK signaling have critical roles in mediating these effects...
  5. ncbi Regulator of G-protein signaling (RGS) proteins differentially control chondrocyte differentiation
    C Thomas G Appleton
    CIHR Group in Skeletal Development and Remodeling, Ontario, London, Ontario, Canada
    J Cell Physiol 207:735-45. 2006
    ..The identification of Rgs genes as novel regulators of chondrogenesis will contribute to a better understanding of both normal cartilage development and the etiology of chondrodysplasias and osteoarthritis...
  6. ncbi Transforming growth factor-alpha induces endothelin receptor A expression in osteoarthritis
    Shirine E Usmani
    Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, The University of Western Ontario, London, Ontario, Canada, N6A 5C1
    J Orthop Res 30:1391-7. 2012
    ..Thus, TGFα may be a therapeutic target upstream of ET(A)R in OA...
  7. ncbi Vascular smooth muscle cells as a valvular interstitial cell surrogate in heart valve tissue engineering
    Andrew J E Appleton
    Department of Anatomy and Cell Biology, The Schulich School of Medicine and Dentistry, The University of Western Ontario, London, Canada
    Tissue Eng Part A 15:3889-97. 2009
    ....
  8. ncbi Microarray analyses of gene expression during chondrocyte differentiation identifies novel regulators of hypertrophy
    Claudine G James
    CIHR Group in Skeletal Development and Remodeling, University of Western Ontario, London, Ontario N6A 5C1, Canada
    Mol Biol Cell 16:5316-33. 2005
    ..Collectively, these analyses provide novel information on the temporal expression of molecules regulating endochondral bone development...