C Thomas G Appleton

Summary

Affiliation: University of Western Ontario
Country: Canada

Publications

  1. pmc Forced mobilization accelerates pathogenesis: characterization of a preclinical surgical model of osteoarthritis
    C Thomas G Appleton
    CIHR Group in Skeletal Development and Remodeling, Schulich School of Medicine and Dentistry, The University of Western Ontario, London, Ontario, N6A 5C1, Canada
    Arthritis Res Ther 9:R13. 2007
  2. ncbi request reprint Molecular and histological analysis of a new rat model of experimental knee osteoarthritis
    C Thomas G Appleton
    CIHR Group in Skeletal Development and Remodeling, The University of Western Ontario, London, Ontario, Canada
    Ann N Y Acad Sci 1117:165-74. 2007
  3. ncbi request reprint Transforming growth factor alpha suppression of articular chondrocyte phenotype and Sox9 expression in a rat model of osteoarthritis
    C Thomas G Appleton
    University of Western Ontario, London, Ontario, Canada
    Arthritis Rheum 56:3693-705. 2007
  4. doi request reprint Rho/ROCK and MEK/ERK activation by transforming growth factor-alpha induces articular cartilage degradation
    C Thomas G Appleton
    CIHR Group in Skeletal Development and Remodeling, London, ON, Canada
    Lab Invest 90:20-30. 2010
  5. ncbi request reprint Regulator of G-protein signaling (RGS) proteins differentially control chondrocyte differentiation
    C Thomas G Appleton
    CIHR Group in Skeletal Development and Remodeling, Ontario, London, Ontario, Canada
    J Cell Physiol 207:735-45. 2006
  6. doi request reprint Transforming growth factor-alpha induces endothelin receptor A expression in osteoarthritis
    Shirine E Usmani
    Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, The University of Western Ontario, London, Ontario, Canada, N6A 5C1
    J Orthop Res 30:1391-7. 2012
  7. doi request reprint Vascular smooth muscle cells as a valvular interstitial cell surrogate in heart valve tissue engineering
    Andrew J E Appleton
    Department of Anatomy and Cell Biology, The Schulich School of Medicine and Dentistry, The University of Western Ontario, London, Canada
    Tissue Eng Part A 15:3889-97. 2009
  8. pmc Microarray analyses of gene expression during chondrocyte differentiation identifies novel regulators of hypertrophy
    Claudine G James
    CIHR Group in Skeletal Development and Remodeling, University of Western Ontario, London, Ontario N6A 5C1, Canada
    Mol Biol Cell 16:5316-33. 2005

Collaborators

Detail Information

Publications8

  1. pmc Forced mobilization accelerates pathogenesis: characterization of a preclinical surgical model of osteoarthritis
    C Thomas G Appleton
    CIHR Group in Skeletal Development and Remodeling, Schulich School of Medicine and Dentistry, The University of Western Ontario, London, Ontario, N6A 5C1, Canada
    Arthritis Res Ther 9:R13. 2007
    ..The time course of OA progression can be modulated through the use of forced mobilization...
  2. ncbi request reprint Molecular and histological analysis of a new rat model of experimental knee osteoarthritis
    C Thomas G Appleton
    CIHR Group in Skeletal Development and Remodeling, The University of Western Ontario, London, Ontario, Canada
    Ann N Y Acad Sci 1117:165-74. 2007
    ..Identified candidate genes including genes involved in chemokine, endothelin, and transforming growth factor-alpha signaling are discussed in the context of articular cartilage degeneration in early OA...
  3. ncbi request reprint Transforming growth factor alpha suppression of articular chondrocyte phenotype and Sox9 expression in a rat model of osteoarthritis
    C Thomas G Appleton
    University of Western Ontario, London, Ontario, Canada
    Arthritis Rheum 56:3693-705. 2007
    ..To define the roles of transforming growth factor alpha (TGFalpha) in cartilage degradation...
  4. doi request reprint Rho/ROCK and MEK/ERK activation by transforming growth factor-alpha induces articular cartilage degradation
    C Thomas G Appleton
    CIHR Group in Skeletal Development and Remodeling, London, ON, Canada
    Lab Invest 90:20-30. 2010
    ..These data suggest that TGFalpha is a strong stimulator of cartilage degradation and that Rho/ROCK and MEK/ERK signaling have critical roles in mediating these effects...
  5. ncbi request reprint Regulator of G-protein signaling (RGS) proteins differentially control chondrocyte differentiation
    C Thomas G Appleton
    CIHR Group in Skeletal Development and Remodeling, Ontario, London, Ontario, Canada
    J Cell Physiol 207:735-45. 2006
    ..The identification of Rgs genes as novel regulators of chondrogenesis will contribute to a better understanding of both normal cartilage development and the etiology of chondrodysplasias and osteoarthritis...
  6. doi request reprint Transforming growth factor-alpha induces endothelin receptor A expression in osteoarthritis
    Shirine E Usmani
    Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, The University of Western Ontario, London, Ontario, Canada, N6A 5C1
    J Orthop Res 30:1391-7. 2012
    ..Thus, TGFα may be a therapeutic target upstream of ET(A)R in OA...
  7. doi request reprint Vascular smooth muscle cells as a valvular interstitial cell surrogate in heart valve tissue engineering
    Andrew J E Appleton
    Department of Anatomy and Cell Biology, The Schulich School of Medicine and Dentistry, The University of Western Ontario, London, Canada
    Tissue Eng Part A 15:3889-97. 2009
    ....
  8. pmc Microarray analyses of gene expression during chondrocyte differentiation identifies novel regulators of hypertrophy
    Claudine G James
    CIHR Group in Skeletal Development and Remodeling, University of Western Ontario, London, Ontario N6A 5C1, Canada
    Mol Biol Cell 16:5316-33. 2005
    ..Collectively, these analyses provide novel information on the temporal expression of molecules regulating endochondral bone development...