Stephane Angers

Summary

Affiliation: University of Toronto
Country: Canada

Publications

  1. pmc KIF14 negatively regulates Rap1a-Radil signaling during breast cancer progression
    Syed M Ahmed
    Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, Faculty of Medicine, University of Toronto, Toronto, Ontario M5S 1A1, Canada
    J Cell Biol 199:951-67. 2012
  2. ncbi request reprint [The tumor suppressor gene WTX, mutated in Wilms tumours, is a member of the beta-catenin destruction complex]
    Stephane Angers
    Chaire de Recherche du Canada en Architecture Fonctionnelle des Complexes de Signalisation, Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, M5S 3M2 Canada
    Med Sci (Paris) 23:1025-7. 2007
  3. ncbi request reprint Proximal events in Wnt signal transduction
    Stephane Angers
    Leslie Dan Faculty of Pharmacy and the Department of Biochemistry, University of Toronto, Ontario, M5S 3M2, Canada
    Nat Rev Mol Cell Biol 10:468-77. 2009
  4. doi request reprint Gli proteins in development and disease
    Chi chung Hui
    Program in Developmental and Stem Cell Biology, Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada
    Annu Rev Cell Dev Biol 27:513-37. 2011
  5. pmc Calcium-sensing receptor modulates cell adhesion and migration via integrins
    Sujeenthar Tharmalingam
    Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario M5S 3M2, Canada
    J Biol Chem 286:40922-33. 2011
  6. pmc Mink1 regulates β-catenin-independent Wnt signaling via Prickle phosphorylation
    Avais M Daulat
    Department of Pharmaceutical Sciences, University of Toronto, Toronto, Canada
    Mol Cell Biol 32:173-85. 2012
  7. pmc Inhibition of tankyrases induces Axin stabilization and blocks Wnt signalling in breast cancer cells
    Renyue Bao
    Department of Biochemistry, Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario, Canada
    PLoS ONE 7:e48670. 2012
  8. pmc G protein betagamma subunits regulate cell adhesion through Rap1a and its effector Radil
    Syed M Ahmed
    Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario M5S 3M2, Canada
    J Biol Chem 285:6538-51. 2010
  9. pmc The ubiquitin-specific protease USP34 regulates axin stability and Wnt/β-catenin signaling
    Tony T H Lui
    Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, 144 College Street, Toronto, M5S 3M2 Ontario, Canada
    Mol Cell Biol 31:2053-65. 2011
  10. doi request reprint A novel assay for measurement of membrane-protein surface expression using a β-lactamase
    Vincent M Lam
    Department of Pharmacology and Toxicology, University of Toronto, Toronto, Ontario, Canada
    Traffic 14:778-84. 2013

Collaborators

Detail Information

Publications13

  1. pmc KIF14 negatively regulates Rap1a-Radil signaling during breast cancer progression
    Syed M Ahmed
    Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, Faculty of Medicine, University of Toronto, Toronto, Ontario M5S 1A1, Canada
    J Cell Biol 199:951-67. 2012
    ....
  2. ncbi request reprint [The tumor suppressor gene WTX, mutated in Wilms tumours, is a member of the beta-catenin destruction complex]
    Stephane Angers
    Chaire de Recherche du Canada en Architecture Fonctionnelle des Complexes de Signalisation, Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, M5S 3M2 Canada
    Med Sci (Paris) 23:1025-7. 2007
  3. ncbi request reprint Proximal events in Wnt signal transduction
    Stephane Angers
    Leslie Dan Faculty of Pharmacy and the Department of Biochemistry, University of Toronto, Ontario, M5S 3M2, Canada
    Nat Rev Mol Cell Biol 10:468-77. 2009
    ..This leads to changes in cell movement and polarity and to the antagonism of the beta-catenin pathway...
  4. doi request reprint Gli proteins in development and disease
    Chi chung Hui
    Program in Developmental and Stem Cell Biology, Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada
    Annu Rev Cell Dev Biol 27:513-37. 2011
    ..In this review, we describe the regulation of Gli proteins during development and discuss possible mechanisms for their abnormal activation during tumorigenesis...
  5. pmc Calcium-sensing receptor modulates cell adhesion and migration via integrins
    Sujeenthar Tharmalingam
    Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario M5S 3M2, Canada
    J Biol Chem 286:40922-33. 2011
    ..The significance of this interaction is further highlighted by studies implicating the CaSR in cancer metastasis, axonal growth, and stem cell attachment, functions that rely on integrin-mediated cell adhesion...
  6. pmc Mink1 regulates β-catenin-independent Wnt signaling via Prickle phosphorylation
    Avais M Daulat
    Department of Pharmaceutical Sciences, University of Toronto, Toronto, Canada
    Mol Cell Biol 32:173-85. 2012
    ..Our results provide a link between Mink and the Vangl-Prickle complex and highlight the importance of Prickle phosphorylation and endosomal trafficking for its function during Wnt-PCP signaling...
  7. pmc Inhibition of tankyrases induces Axin stabilization and blocks Wnt signalling in breast cancer cells
    Renyue Bao
    Department of Biochemistry, Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario, Canada
    PLoS ONE 7:e48670. 2012
    ..These results indicate that stabilization of Axin by inhibition of tankyrases alone, may not be an effective means to block tumor cell growth and that combinatorial therapeutic approaches should be considered...
  8. pmc G protein betagamma subunits regulate cell adhesion through Rap1a and its effector Radil
    Syed M Ahmed
    Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario M5S 3M2, Canada
    J Biol Chem 285:6538-51. 2010
    ..These results add to the molecular understanding of how G protein-coupled receptors impinge on cell adhesion and suggest that the Gbetagamma x Rap1 x Radil complex plays important roles in this process...
  9. pmc The ubiquitin-specific protease USP34 regulates axin stability and Wnt/β-catenin signaling
    Tony T H Lui
    Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, 144 College Street, Toronto, M5S 3M2 Ontario, Canada
    Mol Cell Biol 31:2053-65. 2011
    ..Given the numerous human diseases exhibiting spurious Wnt pathway activation, the development of USP34 inhibitors may offer a novel therapeutic opportunity...
  10. doi request reprint A novel assay for measurement of membrane-protein surface expression using a β-lactamase
    Vincent M Lam
    Department of Pharmacology and Toxicology, University of Toronto, Toronto, Ontario, Canada
    Traffic 14:778-84. 2013
    ..Considering its simplicity and low cost, this assay could become a standard technique in the measurement of protein surface expression...
  11. doi request reprint Tandem affinity purification and identification of heterotrimeric g protein-associated proteins
    Syed M Ahmed
    Department of Pharmaceutical Sciences and Biochemistry, Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, ON, Canada
    Methods Mol Biol 756:357-70. 2011
    ..This approach is predicated on the establishment of mammalian cell lines constitutively or inducibly expressing affinity-tagged versions of Gβγ or wild-type and constitutively active Gα subunits, respectively...
  12. doi request reprint Ptk7 promotes non-canonical Wnt/PCP-mediated morphogenesis and inhibits Wnt/β-catenin-dependent cell fate decisions during vertebrate development
    Madeline Hayes
    Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto, ON, M5G 1X8, Canada
    Development 140:1807-18. 2013
    ....
  13. doi request reprint Emerging non-canonical functions for heterotrimeric G proteins in cellular signaling
    Syed M Ahmed
    Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, ON, Canada
    J Recept Signal Transduct Res 33:177-83. 2013
    ..This review highlights some examples of recently identified interacting proteins and summarizes how they functionally connect heterotrimeric G proteins to previously underappreciated cellular roles...