Research Topics
| James B AndersonSummaryAffiliation: University of Toronto Country: Canada Publications
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Detail Information
Publications
Gene expression and evolution of antifungal drug resistanceJames B Anderson
Department of Cell and Systems Biology, University of Toronto, 3359 Mississauga Road North, Mississauga, Ontario L5L 1C6, Canada
Antimicrob Agents Chemother 53:1931-6. 2009..In these assays, only the PDR16 deletion strain consistently became extinct both at 32 and at 128 microg/ml FLC. The deletion of PDR16 reduces the capacity of a population to evolve to resistance to FLC...- Antagonism between two mechanisms of antifungal drug resistanceJames B Anderson
Department of Biology, University of Toronto, 3359 Mississauga Road North, Mississauga, Ontario L5L 1C6, Canada
Eukaryot Cell 5:1243-51. 2006..The two independently evolved mechanisms of fluconazole resistance are strongly antagonistic to one another... - Haploidy, diploidy and evolution of antifungal drug resistance in Saccharomyces cerevisiaeJames B Anderson
Department of Botany, University of Toronto, Mississauga, Ontario L5L 1C6, Canada
Genetics 168:1915-23. 2004..These results fit existing theory on the relative abilities of haploids and diploids to adapt and suggest that the ploidy of the fungal pathogen has a strong impact on the evolution of fluconazole resistance... - Mode of selection and experimental evolution of antifungal drug resistance in Saccharomyces cerevisiaeJames B Anderson
Department of Botany, University of Toronto, Mississauga, Ontario L5L 1C6, Canada
Genetics 163:1287-98. 2003..In a variation of experiment 2, haploids showed a higher frequency of resistance than diploids, suggesting that degree of dominance and ploidy are important factors in the evolution of antifungal drug resistance... - Cellular effects and epistasis among three determinants of adaptation in experimental populations of Saccharomyces cerevisiaeLucas S Parreiras
Department of Cell and Systems Biology, University of Toronto, 3359 Mississauga Road North, Mississauga, Ontario, Canada L5L 1C6
Eukaryot Cell 10:1348-56. 2011..These data show how positive and negative epistasis can contribute to adaptation and reproductive isolation... 
Genome-wide investigation of reproductive isolation in experimental lineages and natural species of Neurospora: identifying candidate regions by microarray-based genotyping and mappingJeremy R Dettman
Department of Ecology and Evolutionary Biology, University of Toronto, Mississauga, Ontario, L5L 1C6, Canada
Evolution 64:694-709. 2010..This study demonstrates how advances in high-throughput, genome-wide genotyping can be applied to mapping reproductive isolation genes and speciation research...
Evolution of antifungal-drug resistance: mechanisms and pathogen fitnessJames B Anderson
Department of Botany, 3359 Mississauga Road North, University of Toronto, Mississauga, Ontario, Canada L5L 1C6
Nat Rev Microbiol 3:547-56. 2005..In the search for new strategies to manage drug resistance, measuring the limits of adaptation might reveal methods for trapping fungal pathogens in evolutionary dead ends...- Evolution of drug resistance in Candida albicansLeah E Cowen
Department of Botany, University of Toronto, Mississauga, Ontario, L5L 1C6, Canada
Annu Rev Microbiol 56:139-65. 2002..Predicting the evolution of drug resistance is fundamental to prolonging the efficacy of existing drugs and to strategically developing and deploying novel drugs... - Divergent adaptation promotes reproductive isolation among experimental populations of the filamentous fungus NeurosporaJeremy R Dettman
Department of Ecology and Evolutionary Biology, University of Toronto, Mississauga, ON, L5L 1C6, Canada
BMC Evol Biol 8:35. 2008..We then measured the influence that initial genetic diversity and the direction of selection (parallel versus divergent) had on the evolution of reproductive isolation... - Determinants of divergent adaptation and Dobzhansky-Muller interaction in experimental yeast populationsJames B Anderson
Centre for the Analysis of Genome Function, Department of Cell and Systems Biology, and Department of Ecology and Evolutionary Biology, University of Toronto, Mississauga, Ontario, Canada
Curr Biol 20:1383-8. 2010..This DM interaction is the first reported between experimentally evolved alleles of known genes and shows how reproductive isolation can arise rapidly when divergent selection is strong... - Incipient speciation by divergent adaptation and antagonistic epistasis in yeastJeremy R Dettman
Department of Ecology and Evolutionary Biology, University of Toronto, Mississauga, Ontario, L5L 1C6, Canada
Nature 447:585-8. 2007.... - Marker stability throughout 400 days of in vitro hyphal growth in the filamentous ascomycete, Sclerotinia sclerotiorumLinda M Kohn
Department of Ecology and Evolutionary Biology, University of Toronto, 3359 Mississauga Road North, Mississauga, ON, Canada
Fungal Genet Biol 45:613-7. 2008..This observation has implications for modeling pathogen tolerance or adaptation under conditions of environmental stochasticity, including climate warming... - Population genomics of drug resistance in Candida albicansLeah E Cowen
Department of Botany, University of Toronto, Mississauga, ON, Canada L5L 1C6
Proc Natl Acad Sci U S A 99:9284-9. 2002..The three patterns of gene expression were also identified in fluconazole-resistant clinical isolates, providing further evidence that these patterns represent common programs of adaptation to fluconazole... - Dikaryons of the basidiomycete fungus Schizophyllum commune: evolution in long-term cultureTravis A Clark
Department of Botany, University of Toronto, Mississauga, Ontario L5L 1C6, Canada
Genetics 167:1663-75. 2004..We observed genetic exchange and recombination between the nuclei of several different dikaryons, resulting in genotypic variation in these mitotic cell lineages...