James B Anderson

Summary

Affiliation: University of Toronto
Country: Canada

Publications

  1. pmc Gene expression and evolution of antifungal drug resistance
    James B Anderson
    Department of Cell and Systems Biology, University of Toronto, 3359 Mississauga Road North, Mississauga, Ontario L5L 1C6, Canada
    Antimicrob Agents Chemother 53:1931-6. 2009
  2. pmc Antagonism between two mechanisms of antifungal drug resistance
    James B Anderson
    Department of Biology, University of Toronto, 3359 Mississauga Road North, Mississauga, Ontario L5L 1C6, Canada
    Eukaryot Cell 5:1243-51. 2006
  3. pmc Haploidy, diploidy and evolution of antifungal drug resistance in Saccharomyces cerevisiae
    James B Anderson
    Department of Botany, University of Toronto, Mississauga, Ontario L5L 1C6, Canada
    Genetics 168:1915-23. 2004
  4. pmc Mode of selection and experimental evolution of antifungal drug resistance in Saccharomyces cerevisiae
    James B Anderson
    Department of Botany, University of Toronto, Mississauga, Ontario L5L 1C6, Canada
    Genetics 163:1287-98. 2003
  5. pmc Cellular effects and epistasis among three determinants of adaptation in experimental populations of Saccharomyces cerevisiae
    Lucas S Parreiras
    Department of Cell and Systems Biology, University of Toronto, 3359 Mississauga Road North, Mississauga, Ontario, Canada L5L 1C6
    Eukaryot Cell 10:1348-56. 2011
  6. doi request reprint Genome-wide investigation of reproductive isolation in experimental lineages and natural species of Neurospora: identifying candidate regions by microarray-based genotyping and mapping
    Jeremy R Dettman
    Department of Ecology and Evolutionary Biology, University of Toronto, Mississauga, Ontario, L5L 1C6, Canada
    Evolution 64:694-709. 2010
  7. ncbi request reprint Evolution of antifungal-drug resistance: mechanisms and pathogen fitness
    James B Anderson
    Department of Botany, 3359 Mississauga Road North, University of Toronto, Mississauga, Ontario, Canada L5L 1C6
    Nat Rev Microbiol 3:547-56. 2005
  8. ncbi request reprint Evolution of drug resistance in Candida albicans
    Leah E Cowen
    Department of Botany, University of Toronto, Mississauga, Ontario, L5L 1C6, Canada
    Annu Rev Microbiol 56:139-65. 2002
  9. pmc Divergent adaptation promotes reproductive isolation among experimental populations of the filamentous fungus Neurospora
    Jeremy R Dettman
    Department of Ecology and Evolutionary Biology, University of Toronto, Mississauga, ON, L5L 1C6, Canada
    BMC Evol Biol 8:35. 2008
  10. pmc Determinants of divergent adaptation and Dobzhansky-Muller interaction in experimental yeast populations
    James B Anderson
    Centre for the Analysis of Genome Function, Department of Cell and Systems Biology, and Department of Ecology and Evolutionary Biology, University of Toronto, Mississauga, Ontario, Canada
    Curr Biol 20:1383-8. 2010

Detail Information

Publications14

  1. pmc Gene expression and evolution of antifungal drug resistance
    James B Anderson
    Department of Cell and Systems Biology, University of Toronto, 3359 Mississauga Road North, Mississauga, Ontario L5L 1C6, Canada
    Antimicrob Agents Chemother 53:1931-6. 2009
    ..In these assays, only the PDR16 deletion strain consistently became extinct both at 32 and at 128 microg/ml FLC. The deletion of PDR16 reduces the capacity of a population to evolve to resistance to FLC...
  2. pmc Antagonism between two mechanisms of antifungal drug resistance
    James B Anderson
    Department of Biology, University of Toronto, 3359 Mississauga Road North, Mississauga, Ontario L5L 1C6, Canada
    Eukaryot Cell 5:1243-51. 2006
    ..The two independently evolved mechanisms of fluconazole resistance are strongly antagonistic to one another...
  3. pmc Haploidy, diploidy and evolution of antifungal drug resistance in Saccharomyces cerevisiae
    James B Anderson
    Department of Botany, University of Toronto, Mississauga, Ontario L5L 1C6, Canada
    Genetics 168:1915-23. 2004
    ..These results fit existing theory on the relative abilities of haploids and diploids to adapt and suggest that the ploidy of the fungal pathogen has a strong impact on the evolution of fluconazole resistance...
  4. pmc Mode of selection and experimental evolution of antifungal drug resistance in Saccharomyces cerevisiae
    James B Anderson
    Department of Botany, University of Toronto, Mississauga, Ontario L5L 1C6, Canada
    Genetics 163:1287-98. 2003
    ..In a variation of experiment 2, haploids showed a higher frequency of resistance than diploids, suggesting that degree of dominance and ploidy are important factors in the evolution of antifungal drug resistance...
  5. pmc Cellular effects and epistasis among three determinants of adaptation in experimental populations of Saccharomyces cerevisiae
    Lucas S Parreiras
    Department of Cell and Systems Biology, University of Toronto, 3359 Mississauga Road North, Mississauga, Ontario, Canada L5L 1C6
    Eukaryot Cell 10:1348-56. 2011
    ..These data show how positive and negative epistasis can contribute to adaptation and reproductive isolation...
  6. doi request reprint Genome-wide investigation of reproductive isolation in experimental lineages and natural species of Neurospora: identifying candidate regions by microarray-based genotyping and mapping
    Jeremy R Dettman
    Department of Ecology and Evolutionary Biology, University of Toronto, Mississauga, Ontario, L5L 1C6, Canada
    Evolution 64:694-709. 2010
    ..This study demonstrates how advances in high-throughput, genome-wide genotyping can be applied to mapping reproductive isolation genes and speciation research...
  7. ncbi request reprint Evolution of antifungal-drug resistance: mechanisms and pathogen fitness
    James B Anderson
    Department of Botany, 3359 Mississauga Road North, University of Toronto, Mississauga, Ontario, Canada L5L 1C6
    Nat Rev Microbiol 3:547-56. 2005
    ..In the search for new strategies to manage drug resistance, measuring the limits of adaptation might reveal methods for trapping fungal pathogens in evolutionary dead ends...
  8. ncbi request reprint Evolution of drug resistance in Candida albicans
    Leah E Cowen
    Department of Botany, University of Toronto, Mississauga, Ontario, L5L 1C6, Canada
    Annu Rev Microbiol 56:139-65. 2002
    ..Predicting the evolution of drug resistance is fundamental to prolonging the efficacy of existing drugs and to strategically developing and deploying novel drugs...
  9. pmc Divergent adaptation promotes reproductive isolation among experimental populations of the filamentous fungus Neurospora
    Jeremy R Dettman
    Department of Ecology and Evolutionary Biology, University of Toronto, Mississauga, ON, L5L 1C6, Canada
    BMC Evol Biol 8:35. 2008
    ..We then measured the influence that initial genetic diversity and the direction of selection (parallel versus divergent) had on the evolution of reproductive isolation...
  10. pmc Determinants of divergent adaptation and Dobzhansky-Muller interaction in experimental yeast populations
    James B Anderson
    Centre for the Analysis of Genome Function, Department of Cell and Systems Biology, and Department of Ecology and Evolutionary Biology, University of Toronto, Mississauga, Ontario, Canada
    Curr Biol 20:1383-8. 2010
    ..This DM interaction is the first reported between experimentally evolved alleles of known genes and shows how reproductive isolation can arise rapidly when divergent selection is strong...
  11. ncbi request reprint Incipient speciation by divergent adaptation and antagonistic epistasis in yeast
    Jeremy R Dettman
    Department of Ecology and Evolutionary Biology, University of Toronto, Mississauga, Ontario, L5L 1C6, Canada
    Nature 447:585-8. 2007
    ....
  12. ncbi request reprint Marker stability throughout 400 days of in vitro hyphal growth in the filamentous ascomycete, Sclerotinia sclerotiorum
    Linda M Kohn
    Department of Ecology and Evolutionary Biology, University of Toronto, 3359 Mississauga Road North, Mississauga, ON, Canada
    Fungal Genet Biol 45:613-7. 2008
    ..This observation has implications for modeling pathogen tolerance or adaptation under conditions of environmental stochasticity, including climate warming...
  13. pmc Population genomics of drug resistance in Candida albicans
    Leah E Cowen
    Department of Botany, University of Toronto, Mississauga, ON, Canada L5L 1C6
    Proc Natl Acad Sci U S A 99:9284-9. 2002
    ..The three patterns of gene expression were also identified in fluconazole-resistant clinical isolates, providing further evidence that these patterns represent common programs of adaptation to fluconazole...
  14. pmc Dikaryons of the basidiomycete fungus Schizophyllum commune: evolution in long-term culture
    Travis A Clark
    Department of Botany, University of Toronto, Mississauga, Ontario L5L 1C6, Canada
    Genetics 167:1663-75. 2004
    ..We observed genetic exchange and recombination between the nuclei of several different dikaryons, resulting in genotypic variation in these mitotic cell lineages...