Research Topics
Species | Christopher M AndersonSummaryAffiliation: University of Manitoba Country: Canada Publications
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Publications
Emerging challenges of assigning P2X7 receptor function and immunoreactivity in neuronsChristopher M Anderson
Department of Pharmacology and Therapeutics, University of Manitoba and Division of Neurodegenerative Disorders, St Boniface Hospital Research Center, Winnipeg, Canada R2H 2A6
Trends Neurosci 29:257-62. 2006....
Custom astrocyte-mediated vasomotor responses to neuronal energy demandJillian L LeMaistre
Department of Pharmacology and Therapeutics, University of Manitoba, and Division of Neurodegenerative Disorders, St Boniface Hospital Research Centre, 351 Tache Avenue, Winnipeg, MB R2H2A6, Canada
Genome Biol 10:209. 2009..Astrocytes mediate either constriction or dilation of local brain arterioles in response to synaptic activity. Recent work indicates that the directionality of this response may be dictated by ambient oxygen levels...
Cellular distribution of the neutral amino acid transporter subtype ASCT2 in mouse brainCatherine M Gliddon
Department of Pharmacology and Therapeutics, University of Manitoba, Winnipeg, Manitoba, Canada
J Neurochem 108:372-83. 2009..These results suggest that ASCT2 may be an important neuronal neutral amino acid transporter and highlight a discrepancy between findings of astrocyte ASCT2 function in tissue culture and brain in situ...- Protection of cortical neurons from excitotoxicity by conjugated linoleic acidWaylon T Hunt
Department of Pharmacology and Therapeutics, University of Manitoba, Division of Neurodegenerative Disorders, St Boniface Hospital Research Center, Winnipeg, Manitoba, Canada
J Neurochem 115:123-30. 2010..These results show that CLA is capable of strong neuroprotective effects in glutamate excitotoxicity at concentrations likely achieved by consumption of CLA as a dietary supplement... - Astrocytic poly(ADP-ribose) polymerase-1 activation leads to bioenergetic depletion and inhibition of glutamate uptake capacityKim San Tang
Department of Pharmacology and Therapeutics, University of Manitoba, Winnipeg, Canada
Glia 58:446-57. 2010..Taken together, these experiments showed that PARP-1 activation leads to depletion of the total adenine nucleotide pool in astrocytes and severe reduction in neuroprotective glutamate uptake capacity... - Coactivation of NMDA receptors by glutamate and D-serine induces dilation of isolated middle cerebral arteriesJillian L LeMaistre
Department of Pharmacology and Therapeutics, University of Manitoba, Winnipeg, Manitoba, Canada
J Cereb Blood Flow Metab 32:537-47. 2012..Overall, we conclude that NMDA receptor coactivation by glutamate and D-serine increases lumen diameter in pressurized MCA in an endothelial and eNOS-dependent mechanism... - Vascular and cardiac effects of grape powder in the spontaneously hypertensive ratSijo J Thandapilly
Canadian Centre for Agri Food Research in Health and Medicine, St Boniface Hospital Research Centre, Winnipeg, Manitoba, Canada
Am J Hypertens 25:1070-6. 2012..However, in addition to resveratrol, grapes contain a variety of bioactive polyphenols such as catechins, anthocyanins, and flavonoids. Therefore, we investigated the effects of grape consumption in SHR... - Astrocyte-induced cortical vasodilation is mediated by D-serine and endothelial nitric oxide synthaseJillian L Lemaistre Stobart
Department of Pharmacology and Therapeutics, University of Manitoba, Winnipeg, MB, Canada R3E 0T6
Proc Natl Acad Sci U S A 110:3149-54. 2013..Our results provide evidence that D-serine coactivation of NMDA receptors and endothelial nitric oxide synthase is involved in astrocyte-mediated neurovascular coupling... - Functional and immunocytochemical characterization of D-serine transporters in cortical neuron and astrocyte culturesZongjun Shao
Department of Pharmacology and Therapeutics, University of Manitoba, and Division of Neurodegenerative Disorders, St Boniface Hospital Research Center, Manitoba, Canada
J Neurosci Res 87:2520-30. 2009..Together these findings further our knowledge of the processes that govern D-serine regulation... - Zinc inhibits astrocyte glutamate uptake by activation of poly(ADP-ribose) polymerase-1Sang Won Suh
Department of Neurology, University of California, San Francisco, California, USA
Mol Med 13:344-9. 2007..These findings suggest that release of Zn2+ from neurons during brain insults could induce PARP-1 activation in astrocytes, leading to impaired glutamate uptake and exacerbation of neuronal injury... - Astrocyte glycogen sustains neuronal activity during hypoglycemia: studies with the glycogen phosphorylase inhibitor CP-316,819 ([R-R*,S*]-5-chloro-N-[2-hydroxy-3-(methoxymethylamino)-3-oxo-1-(phenylmethyl)propyl]-1H-indole-2-carboxamide)Sang Won Suh
Department of Neurology, University of California, San Francisco, San Francisco, California, USA
J Pharmacol Exp Ther 321:45-50. 2007..These findings also suggest an approach for forestalling hypoglycemic coma and brain injury in diabetic patients... - ATP-induced ATP release from astrocytesChristopher M Anderson
Department of Neurology, University of California, San Francisco and Department of Veterans Affairs Medical Center, San Francisco, California 94121, USA
J Neurochem 88:246-56. 2004..These findings indicate that astrocytes are capable of ATP-induced ATP release and support a role for regenerative ATP release in glial Ca2+ wave propagation... - Astrocyte-mediated control of cerebral microcirculationChristopher M Anderson
Department of Neurology, University of California-San Francisco, Department of Veterans Affairs Medical Center, San Francisco, CA 94121, USA
Trends Neurosci 26:340-4; author reply 344-5. 2003..This finding represents a breakthrough in our knowledge both of astrocyte function and of the mechanism of activity-dependent cerebral blood flow regulation... - P2X7 receptor-mediated release of excitatory amino acids from astrocytesShumin Duan
Department of Neurology, University of California, San Francisco and Veterans Affairs Medical Center, San Francisco, California 94121, USA
J Neurosci 23:1320-8. 2003..Efflux through P2X7 channels is a previously unrecognized route of ligand-stimulated, nonvesicular astrocyte glutamate release... - Barbiturates induce mitochondrial depolarization and potentiate excitotoxic neuronal deathChristopher M Anderson
Department of Neurology, University of California, San Francisco, USA
J Neurosci 22:9203-9. 2002..Effects of barbiturates on neuronal mitochondria should be considered in experimental and clinical application of these drugs...