Joan Allalunis-Turner

Summary

Affiliation: University of Alberta
Country: Canada

Publications

  1. ncbi request reprint mtDNA mutations in invasive cervix tumors: a retrospective analysis
    Joan Allalunis-Turner
    Department of Oncology, University of Alberta, Edmonton, AB, Canada
    Cancer Lett 243:193-201. 2006
  2. pmc Hypoxic regulation of cytoglobin and neuroglobin expression in human normal and tumor tissues
    Marwan Emara
    Department of Oncology, University of Alberta, Cross Cancer Institute, 11560 University of Alberta, Edmonton, Alberta, T6G 1Z2, Canada
    Cancer Cell Int 10:33. 2010
  3. ncbi request reprint ADC response to radiation therapy correlates with induced changes in radiosensitivity
    Matthew P Larocque
    Department of Medical Physics, Cross Cancer Institute, 11560 University Avenue, Edmonton, Alberta T6G 1Z2, Canada
    Med Phys 37:3855-61. 2010
  4. pmc Notch signaling as a therapeutic target for breast cancer treatment?
    Jianxun Han
    Department of Oncology, University of Alberta, Cross Cancer Institute, Edmonton, Canada
    Breast Cancer Res 13:210. 2011
  5. ncbi request reprint Knockdown of cytoglobin expression sensitizes human glioma cells to radiation and oxidative stress
    Jingye Fang
    Department of Oncology, University of Alberta, Edmonton, Alberta, Canada
    Radiat Res 176:198-207. 2011
  6. doi request reprint Characterization and comparison of protein complexes initiated by the intracellular domain of individual Notch paralogs
    Jianxun Han
    Department of Oncology, University of Alberta, Cross Cancer Institute, Edmonton, Alberta, Canada T6G 1Z2
    Biochem Biophys Res Commun 407:479-85. 2011
  7. pmc The cytotoxicity of gamma-secretase inhibitor I to breast cancer cells is mediated by proteasome inhibition, not by gamma-secretase inhibition
    Jianxun Han
    Department of Oncology, University of Alberta, Cross Cancer Institute, 11560 University Avenue, Edmonton, Alberta, Canada T6G 1Z2
    Breast Cancer Res 11:R57. 2009
  8. pmc Mutation in mitochondrial complex I ND6 subunit is associated with defective response to hypoxia in human glioma cells
    Carrie DeHaan
    Department of Oncology, University of Alberta, and Cross Cancer Institute, 11560 University Avenue, Edmonton, Alberta, Canada T6G 1Z2
    Mol Cancer 3:19. 2004
  9. doi request reprint Monitoring T2 and ADC at 9.4 T following fractionated external beam radiation therapy in a mouse model
    Matthew P Larocque
    Department of Medical Physics, Cross Cancer Institute, 11560 University Avenue, Edmonton, Alberta T6G 1Z2, Canada
    Phys Med Biol 55:1381-93. 2010
  10. ncbi request reprint Quantitative analysis reveals asynchronous and more than DSB-associated histone H2AX phosphorylation after exposure to ionizing radiation
    Jianxun Han
    Department of Oncology, University of Alberta, Cross Cancer Institute, Edmonton, Alberta T6G 1Z2, Canada
    Radiat Res 165:283-92. 2006

Collaborators

  • Michael J Hendzel
  • Jianxun Han
  • Carrie DeHaan
  • Feridoun Karimi-Busheri
  • Marilyn L Clarke
  • Matthew P Larocque
  • Marwan Emara
  • Jingye Fang
  • Alasdair Syme
  • B Gino Fallone
  • Sebastien Bonnet
  • Ivy Ma
  • A Robert Turner
  • Keith Wachowicz
  • Atiyah Yahya
  • Nicole Salloum
  • Kyoko Hashimoto
  • Gary D Lopaschuk
  • Stephen L Archer
  • Lakshmi Puttagunta
  • Alois Haromy
  • Miguel A Andrade
  • Christopher J Porter
  • Sandra Bonnet
  • Evangelos D Michelakis
  • Christopher T Lee
  • Bernard Thebaud
  • Christian Beaulieu
  • Gwyneth Harry
  • Richard Thompson

Detail Information

Publications13

  1. ncbi request reprint mtDNA mutations in invasive cervix tumors: a retrospective analysis
    Joan Allalunis-Turner
    Department of Oncology, University of Alberta, Edmonton, AB, Canada
    Cancer Lett 243:193-201. 2006
    ..003). These results suggest that multiple mtDNA mutations are an independent marker of poor prognosis, and that prospective clinical trials that incorporate analysis of mitochondrial genetic alterations in cervix cancer are warranted...
  2. pmc Hypoxic regulation of cytoglobin and neuroglobin expression in human normal and tumor tissues
    Marwan Emara
    Department of Oncology, University of Alberta, Cross Cancer Institute, 11560 University of Alberta, Edmonton, Alberta, T6G 1Z2, Canada
    Cancer Cell Int 10:33. 2010
    ..Immunoreactivity of carbonic anhydrase IX (CA IX), a hypoxia-inducible metalloenzyme that catalyzes the hydration of CO2 to bicarbonate, was used as an endogenous marker of hypoxia...
  3. ncbi request reprint ADC response to radiation therapy correlates with induced changes in radiosensitivity
    Matthew P Larocque
    Department of Medical Physics, Cross Cancer Institute, 11560 University Avenue, Edmonton, Alberta T6G 1Z2, Canada
    Med Phys 37:3855-61. 2010
    ..Magnetic resonance imaging was used to compare the responses of human glioma tumor xenografts to a single fraction of radiation, where a change in radiosensitivity was induced by use of a suture-based ligature...
  4. pmc Notch signaling as a therapeutic target for breast cancer treatment?
    Jianxun Han
    Department of Oncology, University of Alberta, Cross Cancer Institute, Edmonton, Canada
    Breast Cancer Res 13:210. 2011
    ....
  5. ncbi request reprint Knockdown of cytoglobin expression sensitizes human glioma cells to radiation and oxidative stress
    Jingye Fang
    Department of Oncology, University of Alberta, Edmonton, Alberta, Canada
    Radiat Res 176:198-207. 2011
    ..These finding suggest that modulating cytoglobin levels may be a promising treatment strategy for sensitizing human glioma cells to oxidative stress that is induced by ionizing radiation, certain chemotherapies and ischemia-reperfusion...
  6. doi request reprint Characterization and comparison of protein complexes initiated by the intracellular domain of individual Notch paralogs
    Jianxun Han
    Department of Oncology, University of Alberta, Cross Cancer Institute, Edmonton, Alberta, Canada T6G 1Z2
    Biochem Biophys Res Commun 407:479-85. 2011
    ..These results help to explain the dose-dependent and paralog-specific activities of NICD. These results are informative for the development of new reagents to block Notch signaling for therapeutic benefit...
  7. pmc The cytotoxicity of gamma-secretase inhibitor I to breast cancer cells is mediated by proteasome inhibition, not by gamma-secretase inhibition
    Jianxun Han
    Department of Oncology, University of Alberta, Cross Cancer Institute, 11560 University Avenue, Edmonton, Alberta, Canada T6G 1Z2
    Breast Cancer Res 11:R57. 2009
    ....
  8. pmc Mutation in mitochondrial complex I ND6 subunit is associated with defective response to hypoxia in human glioma cells
    Carrie DeHaan
    Department of Oncology, University of Alberta, and Cross Cancer Institute, 11560 University Avenue, Edmonton, Alberta, Canada T6G 1Z2
    Mol Cancer 3:19. 2004
    ....
  9. doi request reprint Monitoring T2 and ADC at 9.4 T following fractionated external beam radiation therapy in a mouse model
    Matthew P Larocque
    Department of Medical Physics, Cross Cancer Institute, 11560 University Avenue, Edmonton, Alberta T6G 1Z2, Canada
    Phys Med Biol 55:1381-93. 2010
    ..3 days after the last fraction of treatment. These results further the understanding of the temporal evolution of T2 and ADC during fractionated radiotherapy and support their potential use as time-sensitive biomarkers for tumor response...
  10. ncbi request reprint Quantitative analysis reveals asynchronous and more than DSB-associated histone H2AX phosphorylation after exposure to ionizing radiation
    Jianxun Han
    Department of Oncology, University of Alberta, Cross Cancer Institute, Edmonton, Alberta T6G 1Z2, Canada
    Radiat Res 165:283-92. 2006
    ..In addition, we found that increased histone H2AX phosphorylation also occurred outside of DSB sites after exposure to ionizing radiation. The function of this DSB-unassociated phosphorylation is not known...
  11. doi request reprint Expression and hypoxic up-regulation of neuroglobin in human glioblastoma cells
    Marwan Emara
    Department of Oncology, University of Alberta, Cross Cancer Institute, 11560 University Avenue, Edmonton, Alberta, T6G 1Z2, Canada
    Mol Oncol 3:45-53. 2009
    ..Our finding of hypoxic up-regulation of neuroglobin in human glioblastoma cells may provide insight into how tumor cells adapt to and survive in hypoxic microenvironments...
  12. ncbi request reprint Human polynucleotide kinase participates in repair of DNA double-strand breaks by nonhomologous end joining but not homologous recombination
    Feridoun Karimi-Busheri
    Department of Experimental Oncology, Cross Cancer Institute, University of Alberta, 11560 University Avenue, Edmonton, Alberta, Canada
    Cancer Res 67:6619-25. 2007
    ..We also provide evidence that the action of hPNK in the repair of camptothecin-induced topoisomerase 1 "dead-end" complexes is independent of DNA-PKcs and that hPNK is not involved in the nucleotide excision repair pathway...
  13. ncbi request reprint A mitochondria-K+ channel axis is suppressed in cancer and its normalization promotes apoptosis and inhibits cancer growth
    Sebastien Bonnet
    Pulmonary Hypertension Program and Vascular Biology Group, Department of Physiology, University of Alberta, Edmonton, AB T6G 2B7, Canada
    Cancer Cell 11:37-51. 2007
    ..Molecular inhibition of PDK2 by siRNA mimics DCA. The mitochondria-NFAT-Kv axis and PDK are important therapeutic targets in cancer; the orally available DCA is a promising selective anticancer agent...