S M H Alibhai

..Further insight into adverse effects of ADT and strategies to minimize these adverse effects await data from ongoing studies...

..Conflicting data in both areas have led to controversy and confusion. Here, we review published data in an attempt to clarify those issues...

..These results provide a foundation for a randomized trial to better understand the impact of exercise during IC on clinically important outcomes...

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..Although radical prostatectomy (RP) is associated with greater 30-day mortality in older men, the magnitude of the excess risk in older age groups compared with younger ones has not been well characterized...

..Receiving IC does not appear to lead to worse QOL or functional status than more palliative approaches. This information may aid treatment discussions in older patients with AML...

..This prospective longitudinal study evaluated the effect of androgen deprivation therapy (ADT) on objective and self-reported physical function...

..Comorbidity is an important consideration in oncology practice, particularly among older patients. Although a variety of comorbidity indices have been employed in research studies, it is unclear whether any one index is preferred...

..We determined whether hospital or surgeon volumes impacted various short-term surgical complications...

..To evaluate the effects of androgen-deprivation therapy (ADT) on cognitive function in men with nonmetastatic prostate cancer (PC)...

..One study suggested that androgen deprivation therapy may also be associated with nonfragility fractures in older men. Whether other clinical risk factors independently increase the risk of fractures is not certain...

..Few population-based studies have reported on the rates of major short-term complications that lead to hospitalization after radiotherapy...

..CONCLUSION Continuous ADT use for at least 6 months in older men is associated with an increased risk of diabetes and fragility fracture but not AMI or sudden cardiac death...

..Although cognitive function was not generally related to sex hormone levels in older men, there may be a weak association with working memory. These results may help guide future studies...

..To determine the current practice of clinicians in the diagnosis and management of osteoporosis among men taking androgen deprivation therapy (ADT), because ADT leads to decreased bone mineral density (BMD) and fractures...

..We estimated life expectancy (LE) and quality-adjusted life expectancy (QALE) associated with available treatments for localized prostate cancer in men aged >/= 65 years, adjusting for Gleason score, patient preferences, and comorbidity...

..Previous studies have evaluated the influence of age and comorbidity, but to the authors' knowledge not RLE, on actual treatment decisions...

..This information may aid discussions with patients about treatment...

..Acute myeloid leukemia (AML) is associated with a poor prognosis, particularly in older patients. To the authors' knowledge, few population-based studies of AML treatment patterns and outcomes exist to date...

..To investigate the association of age with prostate cancer stage and grade, as the latter factors at the time of diagnosis influence management and prognosis, with some studies suggesting that they may change as a function of patient age...

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..Screening tools to detect malnutrition are highlighted, and nonpharmacologic and pharmacologic strategies to minimize or reverse weight loss in older adults are discussed...

..Prior studies have suggested an increased risk of short-term complications among older men who underwent radical prostatectomy, but these studies did not adjust for comorbidity...

..To describe anticipated health-related quality of life (HRQL) for different hypothetical strategies of febrile neutropenia (FN) management in adult cancer patients...

..Our objective was to evaluate the current level of evidence before supporting widespread adoption of outpatient management for this population...

..Compared to younger adults, older adults tolerate intensive chemotherapy quite well from QOL and physical function perspectives...

..We compared physical and cognitive function, and quality of life in a cross-sectional study of 57 patients receiving androgen deprivation therapy for nonmetastatic prostate cancer and 51 healthy age matched controls...

..quot; Life expectancy estimates are strongly associated with treatment choice. The appropriateness of the 10-year rule remains to be determined...

..Many of these patients with at least moderate-grade disease may benefit from potentially curative therapy (radical prostatectomy or radiotherapy)...

..v. management are associated with higher anticipated health-related quality of life, although the most commonly preferred strategy was inpatient care. This data may help with determining more cost-effective strategies for paediatric FN...

..However, most tumors in this study were clinically diagnosed rather than screen-detected. Further randomized trials examining the treatment of screen-detected, localized prostate cancer are needed; several are currently underway...

..Persistent improvements were found in participants' balance, strength, functional mobility, and fear of falling. Patient satisfaction with the program was high. Challenges faced in program implementation are also highlighted...

..Early introduction of aggressive treatment protocols in adult centers may have negated differences in outcomes among AYA patients by site of care...

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..Because bladder cancer is the most expensive malignancy to treat per patient, decisions regarding the optimal treatment strategy should consider costs...

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..To assess the predictive validity of the Triage Risk Stratification Tool (TRST) to identify return to the emergency department (ED) or hospitalization in a multicenter patient sample...

..Complete nephroureterectomy is the standard of care, and increasing evidence has shown that a suboptimal surgical technique is associated with an adverse prognosis...

..Cytokines, biomarkers of inflammation, may moderate both health outcomes, but published data are limited. We looked at the role of cytokines in modulating QOL and fatigue in an older AML population...

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..Study Type - Health Economic (multiway sensitivity analyses) Level of Evidence 2b...

..Benefits of prophylactic hematopoietic colony-stimulating factors (CSFs) in adults and children receiving cancer chemotherapy or undergoing stem-cell transplantation (SCT) are unclear...

..The majority of patients preferred a passive or collaborative decision-making role. Almost half the patients did not know their estimated 6-month prognosis, and 17% felt it was 90% or better...

..We estimated life expectancy (LE) and quality-adjusted life expectancy (QALE) for both of these treatments for men and women of different ages and comorbidity levels...

..The effect of communication barriers on outcomes of care in the inpatient setting requires further exploration, particularly for selected conditions in which length of stay is significantly prolonged...

..Health-related quality of life is a key issue in prostate cancer (PC) management. The authors summarized published utilities for common health-related quality of life outcomes of PC and determined how methodological factors affect them...