M Alda

Summary

Affiliation: University of Ottawa
Country: Canada

Publications

  1. ncbi Bipolar disorder: from families to genes
    M Alda
    Department of Psychiatry, University of Ottawa, Ontario
    Can J Psychiatry 42:378-87. 1997
  2. ncbi Autosomal recessive inheritance of affective disorders in families of responders to lithium prophylaxis?
    M Alda
    Department of Psychiatry, University of Ottawa, Canada
    J Affect Disord 44:153-7. 1997
  3. ncbi Association and linkage studies of CRH and PENK genes in bipolar disorder: a collaborative IGSLI study
    M Alda
    Department of Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada
    Am J Med Genet 96:178-81. 2000
  4. ncbi MN blood groups and bipolar disorder: evidence of genotypic association and Hardy-Weinberg disequilibrium
    M Alda
    Department of Psychiatry, University of Ottawa, Ontario, Canada
    Biol Psychiatry 44:361-3. 1998
  5. ncbi Anticipation in bipolar affective disorder: is age at onset a valid criterion?
    M Alda
    Department of Psychiatry, Dalhousie University, Nova Scotia, Canada
    Am J Med Genet 96:804-7. 2000
  6. ncbi Is lithium response related to G(s)alpha levels in transformed lymphoblasts from subjects with bipolar disorder?
    M Alda
    Department of Psychiatry, Dalhousie University, Halifax, Canada
    J Affect Disord 65:117-22. 2001
  7. ncbi Protective effect of pregnancy in women with lithium-responsive bipolar disorder
    P Grof
    Department of Psychiatry, University of Ottawa, Ottawa, Canada
    J Affect Disord 61:31-9. 2000
  8. ncbi Lack of association between the hSKCa3 channel gene CAG polymorphism and schizophrenia
    R Joober
    Montreal General Hospital Research Institute, Department of Psychiatry, McGill University, Quebec, Canada
    Am J Med Genet 88:154-7. 1999
  9. ncbi Genetic factors and treatment of mood disorders
    M Alda
    Department of Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada
    Bipolar Disord 3:318-24. 2001
  10. ncbi Measures of attention and hyperactivity symptoms in a high-risk sample of children of bipolar parents
    A Duffy
    Dalhousie University, Department of Psychiatry, Halifax, Nova Scotia, Canada
    J Affect Disord 67:159-65. 2001

Detail Information

Publications11

  1. ncbi Bipolar disorder: from families to genes
    M Alda
    Department of Psychiatry, University of Ottawa, Ontario
    Can J Psychiatry 42:378-87. 1997
    ..Genetic factors are known to contribute to the etiology of bipolar illness, but the actual genetic mechanisms remain to be clarified...
  2. ncbi Autosomal recessive inheritance of affective disorders in families of responders to lithium prophylaxis?
    M Alda
    Department of Psychiatry, University of Ottawa, Canada
    J Affect Disord 44:153-7. 1997
    ..66 in females) fitted the data best. On the other hand, X-chromosome and polygenic models could be rejected. The finding of a major-gene effect represents a specific hypothesis that can be tested by molecular genetic techniques...
  3. ncbi Association and linkage studies of CRH and PENK genes in bipolar disorder: a collaborative IGSLI study
    M Alda
    Department of Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada
    Am J Med Genet 96:178-81. 2000
    ..In conclusion, our study does not support the hypothesis that genes coding for CRH or PENK contribute to the genetic susceptibility to bipolar disorder. Am. J. Med. Genet. (Neuropsychiatr. Genet.) 96:178-181, 2000...
  4. ncbi MN blood groups and bipolar disorder: evidence of genotypic association and Hardy-Weinberg disequilibrium
    M Alda
    Department of Psychiatry, University of Ottawa, Ontario, Canada
    Biol Psychiatry 44:361-3. 1998
    ..01). CONCLUSIONS: These results suggest a possible locus on chromosome 4 (4q28-q31.1) associated with genetic susceptibility to bipolar illness...
  5. ncbi Anticipation in bipolar affective disorder: is age at onset a valid criterion?
    M Alda
    Department of Psychiatry, Dalhousie University, Nova Scotia, Canada
    Am J Med Genet 96:804-7. 2000
    ..This suggests that age at onset alone may not be a sufficient criterion of anticipation. Am. J. Med. Genet. (Neuropsychiatr. Genet.) 96:804-807, 2000...
  6. ncbi Is lithium response related to G(s)alpha levels in transformed lymphoblasts from subjects with bipolar disorder?
    M Alda
    Department of Psychiatry, Dalhousie University, Halifax, Canada
    J Affect Disord 65:117-22. 2001
    ..Long-term lithium administration blunts G-protein coupled cAMP signaling and may regulate G(s)alpha levels...
  7. ncbi Protective effect of pregnancy in women with lithium-responsive bipolar disorder
    P Grof
    Department of Psychiatry, University of Ottawa, Ottawa, Canada
    J Affect Disord 61:31-9. 2000
    ..Our retrospective study statistically examines the clinical course of 28 women with RDC typical bipolar disorder, type I, who became pregnant prior to receiving successful lithium prophylaxis...
  8. ncbi Lack of association between the hSKCa3 channel gene CAG polymorphism and schizophrenia
    R Joober
    Montreal General Hospital Research Institute, Department of Psychiatry, McGill University, Quebec, Canada
    Am J Med Genet 88:154-7. 1999
    ..In addition, hSKCa3 was mapped to chromosome 1. Our results do not support the involvement of this particular CAG repeat-containing gene in schizophrenia...
  9. ncbi Genetic factors and treatment of mood disorders
    M Alda
    Department of Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada
    Bipolar Disord 3:318-24. 2001
    ..This paper reviews the pharmacogenetics of mood disorders...
  10. ncbi Measures of attention and hyperactivity symptoms in a high-risk sample of children of bipolar parents
    A Duffy
    Dalhousie University, Department of Psychiatry, Halifax, Nova Scotia, Canada
    J Affect Disord 67:159-65. 2001
    ..CONCLUSIONS: In this high-risk population, subjective difficulty with attention appeared to be state-dependent, associated with the degree of subjective distress related to an underlying psychiatric illness...
  11. ncbi TPH and suicidal behavior: a study in suicide completers
    G Turecki
    Douglas Hospital Research Institute, Department of Psychiatry, McGill University, Verdun, Quebec, Canada
    Mol Psychiatry 6:98-102. 2001
    ..These and other results continue to point to the substantial role that the gene that codes for TPH may play in the neurobiology of suicidal behavior...