P R Albert

Summary

Affiliation: University of Ottawa
Country: Canada

Publications

  1. ncbi request reprint Diacylglycerol and ceramide formation induced by dopamine D2S receptors via Gbeta gamma -subunits in Balb/c-3T3 cells
    Gele Liu
    Ottawa Health Research Institute Neuroscience, University of Ottawa, Canada K1H 8M5
    Am J Physiol Cell Physiol 284:C640-8. 2003
  2. ncbi request reprint The mental retardation gene CC2D1A/Freud-1 encodes a long isoform that binds conserved DNA elements to repress gene transcription
    Anastasia Rogaeva
    Ottawa Health Research Institute Neuroscience, and Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, ON, Canada
    Eur J Neurosci 26:965-74. 2007
  3. ncbi request reprint Cell-type specific induction of tryptophan hydroxylase-2 transcription by calcium mobilization
    Federico Remes Lenicov
    Ottawa Health Research Institute Neuroscience, University of Ottawa, Ottawa, Ontario, Canada
    J Neurochem 103:2047-57. 2007
  4. pmc The neurobiology of depression--revisiting the serotonin hypothesis. II. Genetic, epigenetic and clinical studies
    Paul R Albert
    Ottawa Hospital Research Institute Neuroscience, University of Ottawa, Ottawa, Ontario, Canada
    Philos Trans R Soc Lond B Biol Sci 368:20120535. 2013
  5. pmc Transcriptional regulation of the 5-HT1A receptor: implications for mental illness
    Paul R Albert
    Ottawa Hospital Research Institute Neuroscience, University of Ottawa, 451 Smyth Road, Ottawa, ON, Canada, K1H 8M5
    Philos Trans R Soc Lond B Biol Sci 367:2402-15. 2012
  6. pmc Transcriptional dysregulation of 5-HT1A autoreceptors in mental illness
    Paul R Albert
    Ottawa Hospital Research Institute Neuroscience, University of Ottawa, 451 Smyth Road, Ottawa, Ontario, K1H 8M5, Canada
    Mol Brain 4:21. 2011
  7. ncbi request reprint A putative alpha-helical G beta gamma-coupling domain in the second intracellular loop of the 5-HT1A receptor
    P R Albert
    Department of Medicine, University of Ottawa, Canada
    Ann N Y Acad Sci 861:146-61. 1998
  8. ncbi request reprint G protein preferences for dopamine D2 inhibition of prolactin secretion and DNA synthesis in GH4 pituitary cells
    Paul R Albert
    Ottawa Health Research Institute, Department of Neuroscience, University of Ottawa, Ottawa, Canada K1H 8M5
    Mol Endocrinol 16:1903-11. 2002
  9. ncbi request reprint G protein specificity: traffic direction required
    Paul R Albert
    Ottawa Health Research Institute, Neuroscience, University of Ottawa, 451 Smyth Road, K1H 8M5, Ottawa, ON, Canada
    Cell Signal 14:407-18. 2002
  10. ncbi request reprint Constitutive G(i2)-dependent activation of adenylyl cyclase type II by the 5-HT1A receptor. Inhibition by anxiolytic partial agonists
    P R Albert
    Neuroscience Research Institute, Department of Medicine, University of Ottawa, Ottawa, Canada K1H 8M5
    J Biol Chem 274:35469-74. 1999

Collaborators

  • A Kiss
  • N Herrmann
  • D S Park
  • K Helin
  • F Cecconi
  • Bryan Roth
  • A Fortin
  • Behzad Banihashemi
  • Neena Kushwaha
  • Mireille Daigle
  • Anastasia Rogaeva
  • Helen Mao
  • Sylvie Lemonde
  • Houman Nafisi
  • Ariel M Wilson
  • Irit Itzhaki Van-Ham
  • Gele Liu
  • Stephen J Morris
  • Abdallah Al-Hakim
  • Xianliang Rui
  • W Swardfager
  • Benoit Laliberte
  • Margaret Czesak
  • Federico Remes Lenicov
  • Caroline Nunn
  • Xiao Ming Ou
  • Peter Chidiac
  • Liliane Robillard
  • Bernard P Schimmer
  • Jennivine Tsao
  • Mohammad H Ghahremani
  • X M Ou
  • M Daigle
  • P Shammi
  • S Marzolini
  • P I Oh
  • M Saleem
  • K L Lanctot
  • Yi Yuen Zhou
  • Tera M Mosher
  • Kirsten X Jacobsen
  • Hamed Jafar-Nejad
  • Naghmeh Sajedi
  • Miles Berger
  • Shannon C Harwood
  • Laurence H Tecott
  • Qingshi Zhao
  • Pavel D Hrdina
  • Christopher D Bown
  • Lisheng Du
  • Gustavo Turecki
  • David Bakish
  • Ajoy Basak
  • Adolfo Sequeira
  • N Kushwaha
  • J M Storring

Detail Information

Publications30

  1. ncbi request reprint Diacylglycerol and ceramide formation induced by dopamine D2S receptors via Gbeta gamma -subunits in Balb/c-3T3 cells
    Gele Liu
    Ottawa Health Research Institute Neuroscience, University of Ottawa, Canada K1H 8M5
    Am J Physiol Cell Physiol 284:C640-8. 2003
    ..Both D2 agonists and ceramide specifically induced mitogen-activated protein kinase (ERK1/2), suggesting that ceramide mediates a novel pathway of D2S-induced ERK1/2 activation, leading to cell growth...
  2. ncbi request reprint The mental retardation gene CC2D1A/Freud-1 encodes a long isoform that binds conserved DNA elements to repress gene transcription
    Anastasia Rogaeva
    Ottawa Health Research Institute Neuroscience, and Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, ON, Canada
    Eur J Neurosci 26:965-74. 2007
    ..Disruption of transcriptional regulation by mutation of Freud-1 may play a role in abnormal brain function leading to mental retardation...
  3. ncbi request reprint Cell-type specific induction of tryptophan hydroxylase-2 transcription by calcium mobilization
    Federico Remes Lenicov
    Ottawa Health Research Institute Neuroscience, University of Ottawa, Ottawa, Ontario, Canada
    J Neurochem 103:2047-57. 2007
    ..These results are the first to identify calcium-mediated regulation of the proximal TPH2 promoter as critical for cell-specific TPH2 expression...
  4. pmc The neurobiology of depression--revisiting the serotonin hypothesis. II. Genetic, epigenetic and clinical studies
    Paul R Albert
    Ottawa Hospital Research Institute Neuroscience, University of Ottawa, Ottawa, Ontario, Canada
    Philos Trans R Soc Lond B Biol Sci 368:20120535. 2013
    ....
  5. pmc Transcriptional regulation of the 5-HT1A receptor: implications for mental illness
    Paul R Albert
    Ottawa Hospital Research Institute Neuroscience, University of Ottawa, 451 Smyth Road, Ottawa, ON, Canada, K1H 8M5
    Philos Trans R Soc Lond B Biol Sci 367:2402-15. 2012
    ..Targeted therapeutics to inhibit 5-HT(1A) autoreceptor expression and induce 5-HT(1A) heteroreceptor expression may ameliorate treatment of anxiety and major depression...
  6. pmc Transcriptional dysregulation of 5-HT1A autoreceptors in mental illness
    Paul R Albert
    Ottawa Hospital Research Institute Neuroscience, University of Ottawa, 451 Smyth Road, Ottawa, Ontario, K1H 8M5, Canada
    Mol Brain 4:21. 2011
    ....
  7. ncbi request reprint A putative alpha-helical G beta gamma-coupling domain in the second intracellular loop of the 5-HT1A receptor
    P R Albert
    Department of Medicine, University of Ottawa, Canada
    Ann N Y Acad Sci 861:146-61. 1998
    ..If confirmed in other receptors, these results support a general model in which activated receptor and G beta gamma subunits remain associated to interact with effectors in a receptor-specific manner...
  8. ncbi request reprint G protein preferences for dopamine D2 inhibition of prolactin secretion and DNA synthesis in GH4 pituitary cells
    Paul R Albert
    Ottawa Health Research Institute, Department of Neuroscience, University of Ottawa, Ottawa, Canada K1H 8M5
    Mol Endocrinol 16:1903-11. 2002
    ..These results demonstrate distinct receptor-G protein preferences for inhibition of TRH-induced PRL secretion and DNA synthesis...
  9. ncbi request reprint G protein specificity: traffic direction required
    Paul R Albert
    Ottawa Health Research Institute, Neuroscience, University of Ottawa, 451 Smyth Road, K1H 8M5, Ottawa, ON, Canada
    Cell Signal 14:407-18. 2002
    ..By identifying G protein specificity for individual receptor signaling pathways, ligands targeted to disrupt individual pathways of a given receptor could be developed...
  10. ncbi request reprint Constitutive G(i2)-dependent activation of adenylyl cyclase type II by the 5-HT1A receptor. Inhibition by anxiolytic partial agonists
    P R Albert
    Neuroscience Research Institute, Department of Medicine, University of Ottawa, Ottawa, Canada K1H 8M5
    J Biol Chem 274:35469-74. 1999
    ..g. buspirone and flesinoxan) but was not altered by full agonists or antagonists. Thus, anxiolytic activity may involve inhibition of spontaneous 5-HT1A receptor activity...
  11. ncbi request reprint Receptor signaling and structure: insights from serotonin-1 receptors
    P R Albert
    Ottawa Health Research Institute, 451 Smyth Road, University of Ottawa, Ottawa, Canada K1H 8M5
    Trends Endocrinol Metab 12:453-60. 2001
    ..Structural determination of 5-HT1 receptor and G-protein domains that mediate G-protein-specific coupling and desensitization could lead to the development of highly selective ligands that directly regulate receptor-G-protein coupling...
  12. ncbi request reprint Heterodimerization of mineralocorticoid and glucocorticoid receptors at a novel negative response element of the 5-HT1A receptor gene
    X M Ou
    Neuroscience Research Institute, University of Ottawa, Ottawa, Ontario K1H 8M5, Canada
    J Biol Chem 276:14299-307. 2001
    ..These data represent the first identification of an nMRE/GRE and indicate that heterodimerization of MR and GR mediates direct corticosteroid-induced transrepression of the 5-HT1A receptor promoter...
  13. ncbi request reprint Dopamine-D2S receptor inhibition of calcium influx, adenylyl cyclase, and mitogen-activated protein kinase in pituitary cells: distinct Galpha and Gbetagamma requirements
    Behzad Banihashemi
    Ottawa Health Research Institute, Neuroscience, Department of Medicine, University of Ottawa, Ottawa, Ontario, Canada K1H 8M5
    Mol Endocrinol 16:2393-404. 2002
    ....
  14. ncbi request reprint Homology cloning of cDNA or genomic DNA
    P R Albert
    University of Ottawa, Ottawa, Canada
    Curr Protoc Neurosci . 2001
    ..This unit describes conditions that have been used to clone and identify novel genes and cDNA clones using low-stringency hybridization of known probes to membranes that contain libraries of bacterial or bacteriophage DNA...
  15. doi request reprint GAP1(IP4BP)/RASA3 mediates Galphai-induced inhibition of mitogen-activated protein kinase
    Houman Nafisi
    Ottawa Health Research Institute Neuroscience, Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa K1H 8M5, Canada
    J Biol Chem 283:35908-17. 2008
    ..Our results provide a novel mechanism for dopamine D2S-induced inhibition of ERK1/2 and indicate that RASA3 links Galphai proteins to inhibit Gq-induced Ras/ERK1/2 activation...
  16. ncbi request reprint Differential signaling of dopamine-D2S and -D2L receptors to inhibit ERK1/2 phosphorylation
    Irit Itzhaki Van-Ham
    Department of Medicine, University of Ottawa, Ottawa, Ontario, Canada
    J Neurochem 102:1796-804. 2007
    ..In conclusion, the D(2)S and D(2)L receptors differ in inhibitory signaling to ERK1/2 due to specific residues in the D(2)L receptor alternatively spliced domain, which may account for differences in their function in vivo...
  17. ncbi request reprint Growth hormone-induced diacylglycerol and ceramide formation via Galpha i3 and Gbeta gamma in GH4 pituitary cells. Potentiation by dopamine-D2 receptor activation
    Gele Liu
    Ottawa Health Research Institute, Neuroscience 451 Smyth Road, Room 2464, University of Ottawa, Canada K1H 8M5
    J Biol Chem 277:48427-33. 2002
    ..We conclude that in GH(4) pituitary cells, GH induces formation of DAG/ceramide via a novel Galpha(i)3/Gbetagamma-dependent pathway. This novel pathway suggests a mechanism for autocrine feedback regulation by GH of pituitary function...
  18. doi request reprint Brain derived neurotrophic factor, cardiopulmonary fitness and cognition in patients with coronary artery disease
    W Swardfager
    Neuropsychopharmacology Research Group, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada
    Brain Behav Immun 25:1264-71. 2011
    ..To assess serum brain derived neurotrophic factor (BDNF) concentrations as a correlate of cardiopulmonary fitness and as a predictor of cognitive performance in subjects with coronary artery disease (CAD)...
  19. pmc APAF1 is a key transcriptional target for p53 in the regulation of neuronal cell death
    A Fortin
    Ottawa Health Research Institute - Neuroscience, University of Ottawa, Ottawa, Ontario K1H-8M5, Canada
    J Cell Biol 155:207-16. 2001
    ..Together, these results demonstrate that Apaf1 is a key transcriptional target for p53 that plays a pivotal role in the regulation of apoptosis after neuronal injury...
  20. ncbi request reprint Coupling of 5-HT1A autoreceptors to inhibition of mitogen-activated protein kinase activation via G beta gamma subunit signaling
    Neena Kushwaha
    Ottawa Health Research Institute Neurosciences and Department of Cellular and Molecular Medicine, University of Ottawa, 451 Smyth Road, Ottawa, Ontario, Canada K1H 8M5
    Eur J Neurosci 21:721-32. 2005
    ..Thus, the i2-domain of the 5-HT1A autoreceptor is crucial for coupling to G beta gamma subunits and their subsequent responses (e.g. calcium mobilization and inhibition of MAPK activity)...
  21. doi request reprint TNFAIP8: a new effector for Galpha(i) coupling to reduce cell death and induce cell transformation
    Benoit Laliberte
    Ottawa Hospital Research Institute Neuroscience, University of Ottawa, Ottawa, ON, Canada
    J Cell Physiol 225:865-74. 2010
    ..The data suggest that Gαi-TNFAIP8-mediated rescue of pre-oncogenic cells enhances progression to oncogenic transformation, providing a selective target to inhibit cellular transformation...
  22. ncbi request reprint RGS17/RGSZ2, a novel regulator of Gi/o, Gz, and Gq signaling
    Helen Mao
    Department of Neuroscience, Ottawa Health Research Institute, University of Ottawa, Ottawa, Ontario K1H 8M5, Canada
    J Biol Chem 279:26314-22. 2004
    ..Differences observed between in vitro GAP assays and whole-cell signaling suggest additional determinants of the G-protein specificity of RGS GAP effects that could include receptors and effectors...
  23. ncbi request reprint Impaired repression at a 5-hydroxytryptamine 1A receptor gene polymorphism associated with major depression and suicide
    Sylvie Lemonde
    Ottawa Health Research Institute Neuroscience, University of Ottawa, Department of Medicine, Ottawa, Canada, K1H 8M5
    J Neurosci 23:8788-99. 2003
    ..We suggest a novel transcriptional model in which the G(-1019) allele derepresses 5-HT1A autoreceptor expression to reduce serotonergic neurotransmission, predisposing to depression and suicide...
  24. ncbi request reprint Differential desensitization of dopamine D2 receptor isoforms by protein kinase C: the importance of receptor phosphorylation and pseudosubstrate sites
    Stephen J Morris
    Ottawa Health Research Institute Neuroscience, University of Ottawa, 451 Smyth Road, Ottawa, Canada K1H 8M5
    Eur J Pharmacol 577:44-53. 2007
    ..Thus the relative location of phosphorylation and pseudosubstrate sites provides an important determinant substrate sensitivity to PKC...
  25. ncbi request reprint Differential repression by freud-1/CC2D1A at a polymorphic site in the dopamine-D2 receptor gene
    Anastasia Rogaeva
    Ottawa Health Research Institute Neuroscience and Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario K1H 8M5, Canada
    J Biol Chem 282:20897-905. 2007
    ..Allele-specific regulation of DRD2 expression by Freud-1 may possibly associate with psychiatric disorders or mental retardation...
  26. ncbi request reprint Molecular determinants in the second intracellular loop of the 5-hydroxytryptamine-1A receptor for G-protein coupling
    Neena Kushwaha
    Ottawa Health Research Institute Neuroscience, and Department of Cellular and Molecular Medicine, University of Ottawa, 451 Smyth Road, Ottawa, Ontario, Canada, K1H 8M5
    Mol Pharmacol 69:1518-26. 2006
    ..Thus, the 5-HT1A receptor Ci2 domain determines Gbetagamma specificity and stabilizes Galphai-mediated signaling...
  27. ncbi request reprint RGS17/RGSZ2 and the RZ/A family of regulators of G-protein signaling
    Caroline Nunn
    Department of Physiology and Pharmacology, University of Western Ontario, London, Ont, Canada, N6A 5C1
    Semin Cell Dev Biol 17:390-9. 2006
    ..The tissue and brain distribution, and the evolving understanding of the roles of this family of RGS proteins in receptor signaling and brain function are highlighted...
  28. ncbi request reprint Forskolin-resistant Y1 adrenal cell mutants are deficient in adenylyl cyclase type 4
    Abdallah Al-Hakim
    Department of Pharmacology, University of Toronto, Toronto, Ont, Canada M5G 1L6
    Mol Cell Endocrinol 214:155-65. 2004
    ..Taken together, these observations indicate that AC-4 deficiency is a hallmark of the forskolin-resistant phenotype of these mutants and suggest that AC-4 is an important target of forskolin action in the Y1 adrenal cell line...
  29. ncbi request reprint Expression of adenylyl cyclase-4 (AC-4) in Y1 and forskolin-resistant adrenal cells
    Xianliang Rui
    Banting and Best Department of Medical Research, University of Toronto, 112 College Street, Toronto, Ont, Canada M5G 1L6
    Mol Cell Endocrinol 215:101-8. 2004
    ....
  30. ncbi request reprint Dopamine-D2-mediated inhibition of TRH-induced PLC activation in pituitary cells-direct or indirect?
    Paul R Albert
    Endocrinology 143:744-6. 2002