Affiliation: University of Saskatchewan
Alaverdashvili M, Hackett M, Pickering I, Paterson P. Laminar-specific distribution of zinc: evidence for presence of layer IV in forelimb motor cortex in the rat. Neuroimage. 2014;103:502-10 pubmed publisher
..The finding is also critical for future investigation of the biochemical mechanisms through which therapeutic interventions can enhance neural plasticity, particularly through Zn dependent pathways. ..
Alaverdashvili M, Paterson P, Bradley M. Laser system refinements to reduce variability in infarct size in the rat photothrombotic stroke model. J Neurosci Methods. 2015;247:58-66 pubmed publisher
..Continuous monitoring and control of laser beam intensity is critical for ensuring consistent infarct size. ..
Alaverdashvili M, Li X, Paterson P. Protein-Energy Malnutrition Causes Deficits in Motor Function in Adult Male Rats. J Nutr. 2015;145:2503-11 pubmed publisher
..This model can be used in combination with disease models of sensorimotor deficits to examine the interactions between nutritional status, other treatments, and disease progression. ..
Alaverdashvili M, Caine S, Li X, Hackett M, Bradley M, Nichol H, et al
. Protein-Energy Malnutrition Exacerbates Stroke-Induced Forelimb Abnormalities and Dampens Neuroinflammation. Transl Stroke Res. 2018;9:622-630 pubmed publisher
..05). The LP diet altered the cortical Zn, Ca, and Cl signatures (P < 0.05). Our data suggest that proactive treatment of pre-existing PEM could be essential for optimal post-stroke recovery. ..
Alaverdashvili M, Paterson P. Mapping the dynamics of cortical neuroplasticity of skilled motor learning using micro X-ray fluorescence and histofluorescence imaging of zinc in the rat. Behav Brain Res. 2017;318:52-60 pubmed publisher
..Nanoscopic XFI could be explored in future as a means of imaging these subtle physiological changes. ..
Alaverdashvili M, Hackett M, Caine S, Paterson P. Parallel changes in cortical neuron biochemistry and motor function in protein-energy malnourished adult rats. Neuroimage. 2017;149:275-284 pubmed publisher
..The findings of this study provide a mechanism by which PEM, if not treated, could exacerbate the course of various neurological disorders and diminish treatment efficacy. ..