Margarete K Akens

Summary

Affiliation: University of Toronto
Country: Canada

Publications

  1. doi request reprint Beyond bisphosphonates: photodynamic therapy structurally augments metastatically involved vertebrae and destroys tumor tissue
    Emily Won
    Orthopaedic Biomechanics Laboratory, Division of Orthopaedic Surgery, Sunnybrook Health Sciences Centre, Room UB 19, 2075 Bayview Ave, Toronto, ON M4N 3M5, Canada
    Breast Cancer Res Treat 124:111-9. 2010
  2. pmc Influence of species and anatomical location on chondrocyte expansion
    Margarete K Akens
    Dept of Clinical Studies, University of Guelph, Guelph, Ontario, N1G 2W1, Canada
    BMC Musculoskelet Disord 6:23. 2005
  3. ncbi request reprint Photodynamic therapy of vertebral metastases: evaluating tumor-to-neural tissue uptake of BPD-MA and ALA-PpIX in a murine model of metastatic human breast carcinoma
    Margarete K Akens
    Division of Orthopaedic Surgery, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada
    Photochem Photobiol 83:1034-9. 2007
  4. doi request reprint The benefits of photodynamic therapy on vertebral bone are maintained and enhanced by combination treatment with bisphosphonates and radiation therapy
    Victor C K Lo
    Orthopaedic Biomechanics Laboratory, Sunnybrook Research Institute, UB 55, 2075 Bayview Avenue, Toronto, Ontario, M4N 3M5, Canada
    J Orthop Res 31:1398-405. 2013
  5. doi request reprint Beyond radiation therapy: photodynamic therapy maintains structural integrity of irradiated healthy and metastatically involved vertebrae in a pre-clinical in vivo model
    Victor C K Lo
    Orthopaedic Biomechanics Laboratory, Sunnybrook Research Institute, UB 55, 2075 Bayview Avenue, Toronto, ON M4N 3M5, Canada
    Breast Cancer Res Treat 135:391-401. 2012
  6. doi request reprint Non-destructive evaluation of the effects of combined bisphosphonate and photodynamic therapy on bone strain in metastatic vertebrae using image registration
    Seyed Parsa Hojjat
    Orthopedic Biomechanics Laboratory, Sunnybrook Health Sciences Centre, Toronto, ON, Canada
    Ann Biomed Eng 39:2816-22. 2011
  7. doi request reprint Effects of photodynamic therapy on the structural integrity of vertebral bone
    Emily Won
    Orthopaedic Biomechanics Laboratory, Division of Orthopaedics, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada
    Spine (Phila Pa 1976) 35:272-7. 2010
  8. doi request reprint Defining the therapeutic window of vertebral photodynamic therapy in a murine pre-clinical model of breast cancer metastasis using the photosensitizer BPD-MA (Verteporfin)
    Margarete K Akens
    Division of Orthopaedic Surgery, Sunnybrook Health Science Centre, Room E2 44, 2075 Bayview Ave, Toronto, ON M4N 3M5, Canada
    Breast Cancer Res Treat 119:325-33. 2010
  9. doi request reprint Quantification of the effect of osteolytic metastases on bone strain within whole vertebrae using image registration
    Michael R Hardisty
    Orthopaedic Biomechanics Laboratory, Sunnybrook Health Sciences Centre, 2075 Bayview Ave, Room UB 19, University of Toronto, Toronto, Ontario, Canada
    J Orthop Res 30:1032-9. 2012
  10. ncbi request reprint Evaluation of thiol-modified hyaluronan and elastin-like polypeptide composite augmentation in early-stage disc degeneration: comparing 2 minimally invasive techniques
    Ashley E Leckie
    Orthopaedic Biomechanics Laboratory, Advanced Regenerative Tissue Engineering Centre, Sunnybrook Research Institute, Toronto, Ontario, Canada
    Spine (Phila Pa 1976) 37:E1296-303. 2012

Collaborators

Detail Information

Publications18

  1. doi request reprint Beyond bisphosphonates: photodynamic therapy structurally augments metastatically involved vertebrae and destroys tumor tissue
    Emily Won
    Orthopaedic Biomechanics Laboratory, Division of Orthopaedic Surgery, Sunnybrook Health Sciences Centre, Room UB 19, 2075 Bayview Ave, Toronto, ON M4N 3M5, Canada
    Breast Cancer Res Treat 124:111-9. 2010
    ..Overall, the ability of PDT to both ablate malignant tissue and improve the structural integrity of vertebral bone motivates its consideration as a local minimally invasive treatment for spinal metastasis secondary to breast cancer...
  2. pmc Influence of species and anatomical location on chondrocyte expansion
    Margarete K Akens
    Dept of Clinical Studies, University of Guelph, Guelph, Ontario, N1G 2W1, Canada
    BMC Musculoskelet Disord 6:23. 2005
    ..The aim of this investigation was to study the effect of species, anatomical location and exogenous growth factors on chondrocyte proliferation in vitro...
  3. ncbi request reprint Photodynamic therapy of vertebral metastases: evaluating tumor-to-neural tissue uptake of BPD-MA and ALA-PpIX in a murine model of metastatic human breast carcinoma
    Margarete K Akens
    Division of Orthopaedic Surgery, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada
    Photochem Photobiol 83:1034-9. 2007
    ..The highest ratio for BPD-MA concentration was found 15 min after injection, which can be recommended for therapy in this model...
  4. doi request reprint The benefits of photodynamic therapy on vertebral bone are maintained and enhanced by combination treatment with bisphosphonates and radiation therapy
    Victor C K Lo
    Orthopaedic Biomechanics Laboratory, Sunnybrook Research Institute, UB 55, 2075 Bayview Avenue, Toronto, Ontario, M4N 3M5, Canada
    J Orthop Res 31:1398-405. 2013
    ..Overall, multimodality treatment demonstrated a sustained positive effect on vertebral structural integrity, motivating PDT as a minimally-invasive adjuvant treatment for spinal metastases...
  5. doi request reprint Beyond radiation therapy: photodynamic therapy maintains structural integrity of irradiated healthy and metastatically involved vertebrae in a pre-clinical in vivo model
    Victor C K Lo
    Orthopaedic Biomechanics Laboratory, Sunnybrook Research Institute, UB 55, 2075 Bayview Avenue, Toronto, ON M4N 3M5, Canada
    Breast Cancer Res Treat 135:391-401. 2012
    ....
  6. doi request reprint Non-destructive evaluation of the effects of combined bisphosphonate and photodynamic therapy on bone strain in metastatic vertebrae using image registration
    Seyed Parsa Hojjat
    Orthopedic Biomechanics Laboratory, Sunnybrook Health Sciences Centre, Toronto, ON, Canada
    Ann Biomed Eng 39:2816-22. 2011
    ..This study demonstrates the application of non-destructive image analysis to quantify the positive mechanical effects of combined BP + PDT treatment in the metastatic spine...
  7. doi request reprint Effects of photodynamic therapy on the structural integrity of vertebral bone
    Emily Won
    Orthopaedic Biomechanics Laboratory, Division of Orthopaedics, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada
    Spine (Phila Pa 1976) 35:272-7. 2010
    ..This study investigates the effects of photodynamic therapy (PDT) on the structural integrity of vertebral bone in healthy rats...
  8. doi request reprint Defining the therapeutic window of vertebral photodynamic therapy in a murine pre-clinical model of breast cancer metastasis using the photosensitizer BPD-MA (Verteporfin)
    Margarete K Akens
    Division of Orthopaedic Surgery, Sunnybrook Health Science Centre, Room E2 44, 2075 Bayview Ave, Toronto, ON M4N 3M5, Canada
    Breast Cancer Res Treat 119:325-33. 2010
    ..Overall, PDT represents an exciting potential new minimally-invasive local, safe and effective therapy in the management of patients with spinal metastases...
  9. doi request reprint Quantification of the effect of osteolytic metastases on bone strain within whole vertebrae using image registration
    Michael R Hardisty
    Orthopaedic Biomechanics Laboratory, Sunnybrook Health Sciences Centre, 2075 Bayview Ave, Room UB 19, University of Toronto, Toronto, Ontario, Canada
    J Orthop Res 30:1032-9. 2012
    ....
  10. ncbi request reprint Evaluation of thiol-modified hyaluronan and elastin-like polypeptide composite augmentation in early-stage disc degeneration: comparing 2 minimally invasive techniques
    Ashley E Leckie
    Orthopaedic Biomechanics Laboratory, Advanced Regenerative Tissue Engineering Centre, Sunnybrook Research Institute, Toronto, Ontario, Canada
    Spine (Phila Pa 1976) 37:E1296-303. 2012
    ..An in vitro biomechanical and imaging study generated from an in vivo porcine model of early stage degenerative disc disease was used to evaluate mechanical property restoration, comparing 2 minimally invasive injection techniques...
  11. pmc Hierarchical model of fibrillar collagen organization for interpreting the second-order susceptibility tensors in biological tissue
    Adam E Tuer
    Department of Physics, University of Toronto, Toronto, Ontario, Canada
    Biophys J 103:2093-105. 2012
    ..From the P-SHG parameters of vertebrae tissue, a three-dimensional reconstruction of lamellae of intervertebral disk is presented...
  12. doi request reprint Evaluating the effects of mixed osteolytic/osteoblastic metastasis on vertebral bone quality in a new rat model
    Lisa Wise-Milestone
    Orthopaedic Biomechanics Laboratory, Sunnybrook Research Institute, UB 19, 2075 Bayview Avenue, Toronto, Ontario, Canada M4N 3M5
    J Orthop Res 30:817-23. 2012
    ..Bone quality resulting from these lesions consisted of decreased structural properties, but without a significant impact on mechanical integrity...
  13. doi request reprint Evaluation of a bipolar-cooled radiofrequency device for ablation of bone metastases: preclinical assessment in porcine vertebrae
    Padina S Pezeshki
    Institute of Biomaterials and Biomedical Engineering, University of Toronto, Rosebrugh Building, 164 College Street, Room 407, Toronto, ON M5S 3G9, Canada Sunnybrook Research Institute, 2075 Bayview Ave, Room S611, Toronto, ON M4N 3M5, Canada
    Spine J 14:361-70. 2014
    ..New bipolar-cooled radiofrequency (BCRF) may generate larger controlled lesions without the same degree of risk to adjacent structures...
  14. doi request reprint Biodistribution and pharmacokinetic studies of a porphyrin dimer photosensitizer (Oxdime) by fluorescence imaging and spectroscopy in mice bearing xenograft tumors
    Mamta Khurana
    Department of Medical Biophysics, University of Toronto Ontario Cancer Institute, Toronto, ON
    Photochem Photobiol 88:1531-8. 2012
    ..Significant quantities accumulated in the tumor, indicating that this PDT sensitizer may be promising for cancer treatment...
  15. doi request reprint Assessment of photobleaching during endoscopic autofluorescence imaging of the lower GI tract
    Alexandre Douplik
    Ontario Cancer Institute, Princess Margaret Hospital, University Health Network, Toronto, ON, Canada
    Lasers Surg Med 42:224-31. 2010
    ....
  16. doi request reprint In vitro and in vivo evaluation of ferric-hyaluronate implants for delivery of amikacin sulfate to the tarsocrural joint of horses
    Nicola C Cribb
    Department of Clinical Studies, Ontario Veterinary College, University of Guelph, Guelph, ON, Canada
    Vet Surg 38:498-505. 2009
    ..To assess the antimicrobial elution characteristics, toxicity, and antimicrobial activity of amikacin-impregnated ferric-hyaluronate implants (AI-FeHAI) for amikacin delivery to the tarsocrural joint of horses...
  17. ncbi request reprint In vivo study of the inflammatory modulating effects of low-level laser therapy on iNOS expression using bioluminescence imaging
    Yumi Moriyama
    Ontario Cancer Institute, Princess Margaret Hospital, Toronto, Ontario, Canada
    Photochem Photobiol 81:1351-5. 2005
    ..Histological analysis was also performed and demonstrated the presence of fewer inflammatory cells in the synovial joints of mice irradiated with 635 nm compared with nonirradiated knee joints...
  18. pmc An experimental animal model of aseptic loosening of hip prostheses in sheep to study early biochemical changes at the interface membrane
    Alexander O El-Warrak
    Musculoskeletal Research Unit, Dept of Veterinary Surgery, University of Zurich, Winterthurerstr, 260, 8057 Zurich, Switzerland
    BMC Musculoskelet Disord 5:7. 2004
    ....