Research Topics
| Ayub AkbariSummaryAffiliation: University of Ottawa Country: Canada Publications
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Detail Information
Publications
Change in appropriate referrals to nephrologists after the introduction of automatic reporting of the estimated glomerular filtration rateAyub Akbari
Department of Medicine, Ottawa Hospital Research Institute, University of Ottawa, Ottawa, Ontario
CMAJ 184:E269-76. 2012..We hypothesized that such reporting, along with an ad hoc educational component for primary care physicians, would increase the number of appropriate referrals...
Reference intervals for anion gap and strong ion difference in pregnancy: a pilot studyAyub Akbari
Department of Medicine, University of Ottawa, Ottawa, Ontario, Canada
Hypertens Pregnancy 26:111-9. 2007..Acid-base status and electrolyte levels change in normal pregnancy. We hypothesized that these physiological changes affect both anion gap and strong ion difference (SID)...- Detection of chronic kidney disease with laboratory reporting of estimated glomerular filtration rate and an educational programAyub Akbari
Department of Medicine, University of Ottawa, Ontario, Canada
Arch Intern Med 164:1788-92. 2004..We hypothesized that laboratory reporting of estimated glomerular filtration rate (GFR) accompanied with an educational intervention would improve recognition of chronic kidney disease (CKD)... 
Effect of clinical variables and immunosuppression on serum cystatin C and beta-trace protein in kidney transplant recipientsChristine A White
Department of Medicine, Division of Nephrology, Queen s University, Kingston, Canada
Am J Kidney Dis 54:922-30. 2009..The aim of this study is to examine the independent effect of various clinical parameters on serum concentrations of creatinine, cystatin C, and BTP in kidney transplant recipients...- Chronic kidney disease stage in renal transplantation classification using cystatin C and creatinine-based equationsChristine White
Division of Nephrology, Queen s University, Kingston, Ontario, Canada
Nephrol Dial Transplant 22:3013-20. 2007..However, creatinine-based equations are inaccurate in RTRs leading to frequent CKD stage misclassification. It is not known whether the classification of CKD stage would be improved using a cystatin C-based estimate of GFR... - Estimating GFR using serum beta trace protein: accuracy and validation in kidney transplant and pediatric populationsChristine A White
Division of Nephrology, Department of Medicine, Queen s University, Kingston, Ontario, Canada
Kidney Int 76:784-91. 2009..These results were an improvement compared to the MDRD and Schwartz equations, both of which had high median bias and reduced accuracy. The updated Schwartz equation also performed well... - A novel equation to estimate glomerular filtration rate using beta-trace proteinChristine A White
Division of Nephrology, Department of Medicine, Queen s University, Kingston, Canada
Clin Chem 53:1965-8. 2007..The utility of BTP has been limited by the lack of an equation to translate BTP into an estimate of GFR. The objectives of this study were to develop a BTP-based GFR estimation equation... - Cystatin-C and beta trace protein as markers of renal function in pregnancyAyub Akbari
Kidney Research Centre, Ottawa, Ontario, Canada
BJOG 112:575-8. 2005..27 for 1/Cys-C vs CrCl). CONCLUSION: These data demonstrate that despite claims to the contrary, Cys-C is a poor marker of GFR during pregnancy. Similarly, BTP shows little promise... - Estimating glomerular filtration rate in kidney transplantation: a comparison between serum creatinine and cystatin C-based methodsChristine White
Division of Nephrology, Department of Medicine, University of Ottawa, Ottawa, Ontario, Canada
J Am Soc Nephrol 16:3763-70. 2005..Further prospective studies with repetitive measurement of cystatin C are needed to determine whether cystatin C-based estimates of GFR will be sufficiently accurate to monitor long-term allograft function... - Reporting of the estimated glomerular filtration rate was associated with increased use of angiotensin-converting enzyme inhibitors and angiotensin-II receptor blockers in CKDArsh K Jain
London Kidney Chemical Research Unit, Division of Nephrology, Department of Medicine, London Health Science Center, University of Western Ontario, London, Canada
Kidney Int 81:1248-53. 2012..Thus, eGFR reporting contributes to improved, guideline-appropriate care of older patients with CKD... - Serum creatinine is an inadequate screening test for renal failure in elderly patientsPeter J Swedko
Division of Nephrology, The Ottawa Hospital, Riverside Campus, 1967 Riverside Dr, Ottawa, Ontario, Canada K1H 7W9
Arch Intern Med 163:356-60. 2003..CONCLUSION: Serum creatinine is a poor screening test for renal failure in elderly patients, leading to marked underinvestigation and underrecognition of renal failure in this population... - Quality of cardiovascular disease care in Ontario, Canada: missed opportunities for prevention - a cross sectional studyClare Liddy
C, T, Lamont Primary Health Care Research Centre, Bruyère Research Institute, Ottawa, ON, Canada
BMC Cardiovasc Disord 12:74. 2012..abstract:.. - Spot urine protein measurements: are these accurate in kidney transplant recipients?Ayub Akbari
Division of Nephrology, Department of Medicine, University of Ottawa, Ottawa, Ontario, Canada
Transplantation 94:389-95. 2012..Aside from tests of correlation, there has been little evaluation of these measurements in kidney transplantation... - Estimating glomerular filtration rate in kidney transplantation: is the new chronic kidney disease epidemiology collaboration equation any better?Christine A White
Division of Nephrology, Department of Medicine, Queen s University, Kingston, Ontario, Canada
Clin Chem 56:474-7. 2010..The performance of the new equation for kidney transplant recipients (KTRs) is unknown... - Use of kidney function end points in kidney transplant trials: a systematic reviewChristine A White
Division of Nephrology, Department of Medicine, Queen s University, Kingston, Ontario, Canada
Am J Kidney Dis 56:1140-57. 2010..The frequency and type of kidney function end points used are unknown... - Chronic kidney disease management: comparison between renal transplant recipients and nontransplant patients with chronic kidney diseaseAyub Akbari
Division of Nephrology, Department of Medicine, University of Ottawa, Ottawa, Ont, Canada
Nephron Clin Pract 107:c7-13. 2007..It is not known how the management of CKD in RTR differs from that of patients with native CKD. This study compares the management of complications related to CKD between RTR and patients with native CKD... - Beta-trace protein, cystatin C, beta(2)-microglobulin, and creatinine compared for detecting impaired glomerular filtration rates in childrenGuido Filler
Departments of Pediatrics, Children's Hospital of Eastern Ontario, Ottawa, Ontario, K1H 8L1 Canada
Clin Chem 48:729-36. 2002..CONCLUSIONS: BTP is superior to serum creatinine and an alternative for Cys-C to detect mildly reduced GFR in children, but it is not better than the Schwartz GFR estimate... - The estimation, measurement, and relevance of the glomerular filtration rate in stage 5 chronic kidney diseaseChristine A White
Division of Nephrology, Department of Medicine, Queen s University, Kingston, Kingston, Ontario, Canada
Semin Dial 24:540-9. 2011..This review will focus on the methods available to quantify GFR in stage 5 CKD and their use in both clinical and research settings... - The impact of interlaboratory differences in cystatin C assay measurement on glomerular filtration rate estimationChristine A White
Division of Nephrology, Department of Medicine, Queen s University, Kingston, Ontario, Canada
Clin J Am Soc Nephrol 6:2150-6. 2011..This study was designed to examine the differences in CysC and GFR estimation (eGFR) using Siemens' nephelometric immunoassay and the Mayo Clinic equation. The ability of the eGFRs to predict measured GFR was also examined... - Performance of creatinine-based estimates of GFR in kidney transplant recipients: a systematic reviewChristine A White
Department of Medicine, Division of Nephrology, Queen s University, Kingston, Ottawa, Ontario, Canada
Am J Kidney Dis 51:1005-15. 2008..The performance of these equations in kidney transplant recipients is unclear, with conflicting results between studies... - The effect of pentoxifylline on proteinuria in diabetic kidney disease: a meta-analysisBrendan B McCormick
Division of Nephrology, Kidney Research Center, Ottawa Health Research Institute, Ottawa, Ontario, Canada
Am J Kidney Dis 52:454-63. 2008..Pentoxifylline is a potential therapeutic agent for diabetic kidney disease because it has anti-inflammatory, antifibrotic, and hemorheological properties... - Combination therapy with an angiotensin receptor blocker and an ACE inhibitor in proteinuric renal disease: a systematic review of the efficacy and safety dataMartin MacKinnon
Department of Medicine, Division of Nephrology, University of Ottawa, Ottawa, Ontario, Canada
Am J Kidney Dis 48:8-20. 2006..Additional trials with longer follow-up are needed to determine whether the decrease in proteinuria will result in significant preservation of renal function... - When laboratories report estimated glomerular filtration rates in addition to serum creatinines, nephrology consults increaseArsh K Jain
Division of Nephrology, Department of Medicine, University of Western Ontario, London, Ontario, Canada
Kidney Int 76:318-23. 2009..However, it remains to be seen whether the routine reporting of eGFR results in improved treatment and outcomes for those with chronic kidney disease... - Angiotensin-converting enzyme inhibitors and angiotensin receptor blockers in peritoneal dialysis: systematic review and meta-analysis of randomized controlled trialsAyub Akbari
Department of Medicine, University of Ottawa, Ottawa, Ontario, Canada
Perit Dial Int 29:554-61. 2009..Angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) are widely used in clinical practice. The safety and efficacy of these agents in peritoneal dialysis (PD) patients are unclear... - The Cockcroft-Gault formula should not be used in childrenGuido Filler
Department of Pediatrics, Children s Hospital of Eastern Ontario, University of Ottawa, Ottawa, Canada
Kidney Int 67:2321-4. 2005..Although designed for adults, the Cockcroft-Gault formula was recently proposed for use in children > or =13 years of age... - Measured creatinine clearance from timed urine collections substantially overestimates glomerular filtration rate in patients with liver cirrhosis: a systematic review and individual patient meta-analysisNormand L Proulx
Department of Medicine, University of Western Ontario, London, Ontario N6A 4G5, Canada
Nephrol Dial Transplant 20:1617-22. 2005..The objective of this study was to review the accuracy of measured creatinine clearance (MCrCl) from timed urine collections for estimating true GFR... - Feasibility of providing nephrology services to remote communities with videoconferencingManon Campbell
Division of Nephrology, Department of Medicine, Ottawa Hospital, Ottawa, ON K1H 7W9, Canada
J Telemed Telecare 18:13-6. 2012..The analysis of staff hours worked showed almost no increase following the introduction of telemedicine. Telemedicine is therefore feasible for follow-up care of remote chronic kidney disease patients... - Pregnancy outcomes in women with chronic kidney disease: a systematic reviewImmaculate F Nevis
Department of Medicine, University of Western Ontario, London, Ontario, Canada
Clin J Am Soc Nephrol 6:2587-98. 2011..Pregnant women with chronic kidney disease (CKD) are at risk of adverse maternal and fetal outcomes. We conducted a systematic review of observational studies that described this risk... - Improved delivery of cardiovascular care (IDOCC) through outreach facilitation: study protocol and implementation details of a cluster randomized controlled trial in primary careClare Liddy
C, T, Lamont Primary Health Care Research Centre, Elisabeth Bruyere Research Institute, Ottawa, Ontario, Canada
Implement Sci 6:110. 2011..abstract:.. - Zopiclone-induced acute interstitial nephritisNaser Hussain
Department of Medicine, University of Ottawa, Ottawa, Ontario, Canada
Am J Kidney Dis 41:E17. 2003..Kidney biopsy results showed acute interstitial nephritis with a prominent eosinophilic infiltrate in the interstitium. He recovered his renal function after stopping the medication and receiving corticosteroids... - Cystatin C and residual renal function in patients on peritoneal dialysisAtul Mulay
Am J Kidney Dis 52:194-5; author reply 195-6. 2008