Philip N Ainslie

Summary

Affiliation: University of British Columbia
Country: Canada

Publications

  1. doi request reprint Breathing and sleep at high altitude
    Philip N Ainslie
    Centre of Heart, Lung and Vascular Health, School of Health and Exercise Sciences, University of British Columbia, Okanagan Campus, British Columbia, Canada Electronic address
    Respir Physiol Neurobiol 188:233-56. 2013
  2. doi request reprint Influence of sympathoexcitation at high altitude on cerebrovascular function and ventilatory control in humans
    P N Ainslie
    Dept of Human Kinetics, School of Health and Exercise Sciences, University of British Columbia, Kelowna, BC, Canada
    J Appl Physiol (1985) 113:1058-67. 2012
  3. pmc The effect of Ventricular Assist Devices on cerebral autoregulation: A preliminary study
    Judith Bellapart
    Department of Intensive Care, Royal Brisbane and Women s Hospital, Butterfield Street, Herston 4029, QLD, Australia
    BMC Anesthesiol 11:4. 2011
  4. doi request reprint Regulation of cerebral blood flow in mammals during chronic hypoxia: a matter of balance
    Philip N Ainslie
    Department of Human Kinetics, Faculty of Health and Social Development, University of British Columbia Okanagan, Kelowna V1V 1V7, Canada
    Exp Physiol 95:251-62. 2010
  5. pmc Cerebral pressure-flow relationship in lowlanders and natives at high altitude
    Jonathan D Smirl
    Centre for Heart, Lung and Vascular Health, School of Health and Exercise Science, University of British Columbia Okanagan, Kelowna, British Columbia, Canada
    J Cereb Blood Flow Metab 34:248-57. 2014
  6. doi request reprint Initial orthostatic hypotension and cerebral blood flow regulation: effect of α1-adrenoreceptor activity
    Nia C S Lewis
    Centre for Heart, Lung and Vascular Health, School of Health and Exercise Sciences, Development, University of British Columbia, Kelowna, British Columbia, Canada
    Am J Physiol Regul Integr Comp Physiol 304:R147-54. 2013
  7. ncbi request reprint Regional changes in brain blood flow during severe passive hyperthermia: effects of PaCO2 and extracranial blood flow
    Anthony R Bain
    Center for Heart, Lung, and Vascular Health, University of British Columbia, Okanagan, British Columbia, Canada
    J Appl Physiol (1985) 115:653-9. 2013
  8. doi request reprint Elevated aerobic fitness sustained throughout the adult lifespan is associated with improved cerebral hemodynamics
    Damian M Bailey
    From the Neurovascular Research Laboratory, University of South Wales, UK D M B, C J M, J V B, D H, K J N the Department of Biomedical Engineering, Toyo University, Kawagoe shi, Saitama, Japan S O and the School of Health and Exercise Sciences, University of British Columbia Okanagan, Kelowna, Canada P N A
    Stroke 44:3235-8. 2013
  9. doi request reprint Dynamic cerebral autoregulation during and following acute hypoxia: role of carbon dioxide
    Jordan S Querido
    Faculty of Medicine, University of British Columbia Vancouver, Vancouver, British Columbia, Canada
    J Appl Physiol (1985) 114:1183-90. 2013
  10. pmc Resting pulmonary haemodynamics and shunting: a comparison of sea-level inhabitants to high altitude Sherpas
    Glen E Foster
    School of Health and Exercise Science, Faculty of Health and Social Development, University of British Columbia Okanagan, 3333 University Way, Kelowna, BC, V1V 1V7 Canada
    J Physiol 592:1397-409. 2014

Collaborators

Detail Information

Publications26

  1. doi request reprint Breathing and sleep at high altitude
    Philip N Ainslie
    Centre of Heart, Lung and Vascular Health, School of Health and Exercise Sciences, University of British Columbia, Okanagan Campus, British Columbia, Canada Electronic address
    Respir Physiol Neurobiol 188:233-56. 2013
    ..Finally, we suggest avenues for future research, and discuss implications for understanding sleep pathology...
  2. doi request reprint Influence of sympathoexcitation at high altitude on cerebrovascular function and ventilatory control in humans
    P N Ainslie
    Dept of Human Kinetics, School of Health and Exercise Sciences, University of British Columbia, Kelowna, BC, Canada
    J Appl Physiol (1985) 113:1058-67. 2012
    ..These findings have implications for our understanding of CBF function in the context of pathologies associated with sympathoexcitation and hypoxemia...
  3. pmc The effect of Ventricular Assist Devices on cerebral autoregulation: A preliminary study
    Judith Bellapart
    Department of Intensive Care, Royal Brisbane and Women s Hospital, Butterfield Street, Herston 4029, QLD, Australia
    BMC Anesthesiol 11:4. 2011
    ..abstract:..
  4. doi request reprint Regulation of cerebral blood flow in mammals during chronic hypoxia: a matter of balance
    Philip N Ainslie
    Department of Human Kinetics, Faculty of Health and Social Development, University of British Columbia Okanagan, Kelowna V1V 1V7, Canada
    Exp Physiol 95:251-62. 2010
    ..The associated implications of these hypoxia-induced integrative alterations for the regulation of CBF are discussed, and future avenues for research are proposed...
  5. pmc Cerebral pressure-flow relationship in lowlanders and natives at high altitude
    Jonathan D Smirl
    Centre for Heart, Lung and Vascular Health, School of Health and Exercise Science, University of British Columbia Okanagan, Kelowna, British Columbia, Canada
    J Cereb Blood Flow Metab 34:248-57. 2014
    ..Our findings indicate that spontaneous changes in TFA metrics do not necessarily reflect physiologically important alterations in the capacity of the brain to regulate BP. ..
  6. doi request reprint Initial orthostatic hypotension and cerebral blood flow regulation: effect of α1-adrenoreceptor activity
    Nia C S Lewis
    Centre for Heart, Lung and Vascular Health, School of Health and Exercise Sciences, Development, University of British Columbia, Kelowna, British Columbia, Canada
    Am J Physiol Regul Integr Comp Physiol 304:R147-54. 2013
    ..Although the development of IOH is not influenced by the α(1)-adrenergic receptor pathway, this pathway is critical in the recovery from IOH to prevent cerebral hypoperfusion and ultimately syncope...
  7. ncbi request reprint Regional changes in brain blood flow during severe passive hyperthermia: effects of PaCO2 and extracranial blood flow
    Anthony R Bain
    Center for Heart, Lung, and Vascular Health, University of British Columbia, Okanagan, British Columbia, Canada
    J Appl Physiol (1985) 115:653-9. 2013
    ....
  8. doi request reprint Elevated aerobic fitness sustained throughout the adult lifespan is associated with improved cerebral hemodynamics
    Damian M Bailey
    From the Neurovascular Research Laboratory, University of South Wales, UK D M B, C J M, J V B, D H, K J N the Department of Biomedical Engineering, Toyo University, Kawagoe shi, Saitama, Japan S O and the School of Health and Exercise Sciences, University of British Columbia Okanagan, Kelowna, Canada P N A
    Stroke 44:3235-8. 2013
    ..The present study examined to what extent cerebral hemodynamics are improved when training is sustained throughout the adult lifespan...
  9. doi request reprint Dynamic cerebral autoregulation during and following acute hypoxia: role of carbon dioxide
    Jordan S Querido
    Faculty of Medicine, University of British Columbia Vancouver, Vancouver, British Columbia, Canada
    J Appl Physiol (1985) 114:1183-90. 2013
    ..05). Our results demonstrate that dCA impairment in isocapnic hypoxia can be prevented with hypocapnia, and highlight the integrated nature of hypoxic cerebrovascular control, which is under strong CO2 influence...
  10. pmc Resting pulmonary haemodynamics and shunting: a comparison of sea-level inhabitants to high altitude Sherpas
    Glen E Foster
    School of Health and Exercise Science, Faculty of Health and Social Development, University of British Columbia Okanagan, 3333 University Way, Kelowna, BC, V1V 1V7 Canada
    J Physiol 592:1397-409. 2014
    ..Despite elevated pulmonary pressures and profound hypoxaemia, IPAVA blood flow in all subjects at HA was lower than expected compared to acute normobaric hypoxia...
  11. doi request reprint Stability of cerebral metabolism and substrate availability in humans during hypoxia and hyperoxia
    Philip N Ainslie
    School of Health and Exercise Sciences, University of British Columbia, British Columbia, Canada
    Clin Sci (Lond) 126:661-70. 2014
    ..As such, cerebral metabolism is still supported almost exclusively by carbohydrate oxidation during severe levels of hypoxaemia. ..
  12. pmc Regional neurovascular coupling and cognitive performance in those with low blood pressure secondary to high-level spinal cord injury: improved by alpha-1 agonist midodrine hydrochloride
    Aaron A Phillips
    1 Cardiovascular Physiology and Rehabilitation Laboratory, Physical Activity Promotion and Chronic Disease Prevention Unit, University of British Columbia, Vancouver, British Columbia, Canada 2 Experimental Medicine Program, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada 3 Centre for Heart, Lung and Vascular Health, School of Health and Exercise Sciences, Faculty of Health and Social Development, University of British Columbia Okanagan, Kelowna, British Columbia, Canada 4 International Collaboration on Repair Discoveries ICORD, Department of Medicine, Division of Physical Medicine and Rehabilitation, University of British Columbia, and GF Strong Rehabilitation Centre, Vancouver Coastal Health, Vancouver, British Columbia, Canada
    J Cereb Blood Flow Metab 34:794-801. 2014
    ..05). Improvements in BP were related to improved cognitive function in those with SCI (r(2)=0.52; P<0.05). Impaired NVC, secondary to low BP, may partially mediate reduced cognitive function in individuals with high-level SCI. ..
  13. doi request reprint Maintained cerebrovascular function during post-exercise hypotension
    Christopher K Willie
    Centre for Heart, Lung and Vascular Health, School of Health and Exercise Sciences, University of British Columbia, 3333 University Way, Okanagan, Kelowna, BC, Canada
    Eur J Appl Physiol 113:1597-604. 2013
    ..05). These data indicate that cerebrovascular regulation remains intact following a moderate bout of aerobic exercise...
  14. doi request reprint Cerebrovascular reactivity and dynamic autoregulation in tetraplegia
    Luke C Wilson
    Department of Physiology, University of British Columbia Okanagan, Kelowna, BC V1X, Canada
    Am J Physiol Regul Integr Comp Physiol 298:R1035-42. 2010
    ..Changes are evident in coherence at baseline and MCAv PI during baseline and hypercapnic states in chronic Tetra, which may be indicative of cerebrovascular adaptation...
  15. ncbi request reprint Influence of posture on the regulation of cerebral perfusion
    Jinelle C Geinas
    School of Health and Exercises Sciences, Faculty of Health and Social Development, University of British Columbia, Okanagan Campus, BC, Canada
    Aviat Space Environ Med 83:751-7. 2012
    ..Posture has a major influence on cerebral blood flow (CBF). Unlike head-up tilt (HUT), less is known about how CBF is regulated during head-down tilt (HDT). We hypothesized that CBF would be elevated during HDT and decreased during HUT...
  16. ncbi request reprint Increased central arterial stiffness explains baroreflex dysfunction in spinal cord injury
    Aaron A Phillips
    1 Cardiovascular Physiology and Rehabilitation Laboratory, Physical Activity Promotion and Chronic Disease Prevention Unit, University of British Columbia, Vancouver, Canada
    J Neurotrauma 31:1122-8. 2014
    ..55; p<0.05), but not in able-bodied persons. Normalizing BP did not improve BRS or CCA stiffness. This study clearly shows that reduced BRS is closely related to increased arterial stiffness in the population with SCI. ..
  17. doi request reprint Regulation of cerebral blood flow after spinal cord injury
    Aaron A Phillips
    Cardiovascular Physiology and Rehabilitation Laboratory, University of British Columbia, Vancouver, Canada
    J Neurotrauma 30:1551-63. 2013
    ....
  18. pmc Conduit artery structure and function in lowlanders and native highlanders: relationships with oxidative stress and role of sympathoexcitation
    Nia C S Lewis
    Centre for Heart, Lung and Vascular Health, University of British Columbia, Okanagan Campus, School of Health and Exercise Sciences 111 Health Science Centre 1088 Discovery Avenue, Kelowna, British Columbia, Canada
    J Physiol 592:1009-24. 2014
    ..Although a lifetime of high-altitude exposure neither intensifies nor attenuates the impairments seen with short-term exposure, chronic high-altitude exposure appears to be associated with arterial remodelling...
  19. pmc Perturbed and spontaneous regional cerebral blood flow responses to changes in blood pressure after high-level spinal cord injury: the effect of midodrine
    Aaron A Phillips
    Cardiovascular Physiology and Rehabilitation Laboratory, Physical Activity Promotion and Chronic Disease Prevention Unit, University of British Columbia, Vancouver, British Columbia, Canada
    J Appl Physiol (1985) 116:645-53. 2014
    ..4 ± 2% decline; P < 0.05), and a 59% improvement in orthostatic tolerance (P < 0.01). The vertebrobasilar region may be particularly susceptible to hypoperfusion in SCI, leading to increased orthostatic intolerance...
  20. doi request reprint The effect of time-of-day and sympathetic α1-blockade on orthostatic tolerance
    Nina C S Lewis
    School of Health and Exercise Sciences, Faculty of Health and Social Development, University of British Columbia, Okanagan Campus, Kelowna, British Columbia, Canada
    Chronobiol Int 29:882-90. 2012
    ..04). These findings highlight an important role of α(1)-sympathetic vasoconstrictor activity in acutely regulating blood pressure and offsetting syncope, especially in the early morning...
  21. ncbi request reprint Effect of acute hypoxia on regional cerebral blood flow: effect of sympathetic nerve activity
    Nia C S Lewis
    Centre for Heart, Lung and Vascular Health, University of British Columbia, Kelowna, British Columbia, Canada
    J Appl Physiol (1985) 116:1189-96. 2014
    ....
  22. pmc Integrative regulation of human brain blood flow
    Christopher K Willie
    Centre for Heart, Lung and Vascular Health, School of Health and Exercise Sciences, University of British Columbia Okanagan, Kelowna, British Columbia, Canada V1V 1V7
    J Physiol 592:841-59. 2014
    ..Finally, we summarize the state of our knowledge with respect to these areas, outline important gaps in the literature and suggest avenues for future research. ..
  23. pmc Influence of age on syncope following prolonged exercise: differential responses but similar orthostatic intolerance
    Carissa Murrell
    Department of Human Kinetics, University of British Columbia Okanagan, Kelowna, Canada
    J Physiol 587:5959-69. 2009
    ..The similar MCAv at pre-syncope indicates there is an age-independent critical cerebral blood flow threshold at which syncope occurs...
  24. doi request reprint Influence of changes in blood pressure on cerebral perfusion and oxygenation
    Samuel J E Lucas
    Department of Physiology, University of Otago, Dunedin, New Zealand
    Hypertension 55:698-705. 2010
    ..Thus, a finite slope of the plateau region does not necessarily imply a defective CA. Moreover, with progressive hypotension and hypertension there are differential changes in cerebral oxygenation and MCAv(mean)...
  25. ncbi request reprint Influence of indomethacin on ventilatory and cerebrovascular responsiveness to CO2 and breathing stability: the influence of PCO2 gradients
    Jui Lin Fan
    Department of Physiology, Otago School of Medical Science, University of Otago, Dunedin, New Zealand
    Am J Physiol Regul Integr Comp Physiol 298:R1648-58. 2010
    ....