Aneil F Agrawal

Summary

Affiliation: University of Toronto
Country: Canada

Publications

  1. pmc Similarity selection and the evolution of sex: revisiting the red queen
    Aneil F Agrawal
    Department of Ecology and Evolutionary Biology, University of Toronto, Toronto, Ontario, Canada
    PLoS Biol 4:e265. 2006
  2. pmc Increased transmission of mutations by low-condition females: evidence for condition-dependent DNA repair
    Aneil F Agrawal
    Department of Ecology and Evolutionary Biology, University of Toronto, Toronto, Ontario, Canada
    PLoS Biol 6:e30. 2008
  3. pmc The evolution of plastic recombination
    Aneil F Agrawal
    Department of Zoology, University of British Columbia, Vancouver, Canada
    Genetics 171:803-12. 2005
  4. ncbi Evolution of sex: why do organisms shuffle their genotypes?
    Aneil F Agrawal
    Department of Ecology and Evolutionary Biology, University of Toronto, 25 Harbord Street, Toronto, Ontario, Canada, M5S 3G5
    Curr Biol 16:R696-704. 2006
  5. ncbi Host-parasite coevolution and selection on sex through the effects of segregation
    Aneil F Agrawal
    Department of Ecology and Evolutionary Biology, University of Toronto, 25 Harbord Street, Toronto, Ontario M5S 3G5, Canada
    Am Nat 168:617-29. 2006
  6. pmc Relative effectiveness of mating success and sperm competition at eliminating deleterious mutations in Drosophila melanogaster
    Sean C A Clark
    Department of Ecology and Evolutionary Biology, University of Toronto, Toronto, Ontario, Canada
    PLoS ONE 7:e37351. 2012
  7. doi Variation in the strength and softness of selection on deleterious mutations
    Azadeh Laffafian
    Department of Ecology and Evolutionary Biology, University of Toronto, 25 Willcocks Street, Toronto, Ontario M5S 3B2, Canada
    Evolution 64:3232-41. 2010
  8. doi Selection, epistasis, and parent-of-origin effects on deleterious mutations across environments in Drosophila melanogaster
    Alethea D Wang
    Department of Ecology and Evolutionary Biology, University of Toronto, Toronto, Ontario M5S3B2, Canada
    Am Nat 174:863-74. 2009
  9. doi The effect of deleterious mutations and age on recombination in Drosophila melanogaster
    Katherine Tedman-Aucoin
    Department of Ecology and Evolutionary Biology, University of Toronto, Toronto, ON, M5S 3B2, Canada
    Evolution 66:575-85. 2012
  10. pmc Evidence for elevated mutation rates in low-quality genotypes
    Nathaniel P Sharp
    Department of Ecology and Evolutionary Biology, University of Toronto, Toronto, ON, Canada M5S 3B2
    Proc Natl Acad Sci U S A 109:6142-6. 2012

Detail Information

Publications34

  1. pmc Similarity selection and the evolution of sex: revisiting the red queen
    Aneil F Agrawal
    Department of Ecology and Evolutionary Biology, University of Toronto, Toronto, Ontario, Canada
    PLoS Biol 4:e265. 2006
    ..Though parasites alone may not provide a complete explanation for sex, the results presented here expand the potential for parasites to contribute to the maintenance of sex rather than act against it...
  2. pmc Increased transmission of mutations by low-condition females: evidence for condition-dependent DNA repair
    Aneil F Agrawal
    Department of Ecology and Evolutionary Biology, University of Toronto, Toronto, Ontario, Canada
    PLoS Biol 6:e30. 2008
    ..A separate experiment provided no support for an alternative hypothesis based on sperm selection...
  3. pmc The evolution of plastic recombination
    Aneil F Agrawal
    Department of Zoology, University of British Columbia, Vancouver, Canada
    Genetics 171:803-12. 2005
    ..In contrast, the evolution of plastic recombination in diploids is much more restricted. Selection on plasticity requires the ability to detect DNA damage or cis-trans effects as may occur through maternal effects on fitness...
  4. ncbi Evolution of sex: why do organisms shuffle their genotypes?
    Aneil F Agrawal
    Department of Ecology and Evolutionary Biology, University of Toronto, 25 Harbord Street, Toronto, Ontario, Canada, M5S 3G5
    Curr Biol 16:R696-704. 2006
    ..Ultimately, we need to identify which evolutionary forces--for example, selection, genetic drift, migration--are responsible for building the associations affected by sex...
  5. ncbi Host-parasite coevolution and selection on sex through the effects of segregation
    Aneil F Agrawal
    Department of Ecology and Evolutionary Biology, University of Toronto, 25 Harbord Street, Toronto, Ontario M5S 3G5, Canada
    Am Nat 168:617-29. 2006
    ..In cases where segregation and recombination act in opposite directions, we found that the effects of segregation dominate as an evolutionary force acting on sex in diploids...
  6. pmc Relative effectiveness of mating success and sperm competition at eliminating deleterious mutations in Drosophila melanogaster
    Sean C A Clark
    Department of Ecology and Evolutionary Biology, University of Toronto, Toronto, Ontario, Canada
    PLoS ONE 7:e37351. 2012
    ..Establishing whether the various stages of sexual selection affect deleterious mutations differently, and to what extent, remains an important issue to resolve...
  7. doi Variation in the strength and softness of selection on deleterious mutations
    Azadeh Laffafian
    Department of Ecology and Evolutionary Biology, University of Toronto, 25 Willcocks Street, Toronto, Ontario M5S 3B2, Canada
    Evolution 64:3232-41. 2010
    ..A model is presented showing that the sensitivities of mutants and wild types to local competitors differentially affect equilibrium mutation frequency and measures of load...
  8. doi Selection, epistasis, and parent-of-origin effects on deleterious mutations across environments in Drosophila melanogaster
    Alethea D Wang
    Department of Ecology and Evolutionary Biology, University of Toronto, Toronto, Ontario M5S3B2, Canada
    Am Nat 174:863-74. 2009
    ..e., epistasis becomes more positive). In addition, we find a high incidence of indirect genetic effects whereby the strength of selection against the alleles carried by offspring is dependent on the genotypes of their parents...
  9. doi The effect of deleterious mutations and age on recombination in Drosophila melanogaster
    Katherine Tedman-Aucoin
    Department of Ecology and Evolutionary Biology, University of Toronto, Toronto, ON, M5S 3B2, Canada
    Evolution 66:575-85. 2012
    ..The differences among genotypes or among age classes are large enough to add substantial noise to genetic mapping experiments that do not consider these sources of variation...
  10. pmc Evidence for elevated mutation rates in low-quality genotypes
    Nathaniel P Sharp
    Department of Ecology and Evolutionary Biology, University of Toronto, Toronto, ON, Canada M5S 3B2
    Proc Natl Acad Sci U S A 109:6142-6. 2012
    ..Positive mutational feedback could affect human health by increasing the rate of germline mutation, and possibly somatic mutation, in individuals of poor health because of genetic or environmental stress...
  11. pmc The evolution of sex is favoured during adaptation to new environments
    Lutz Becks
    Department of Ecology and Evolutionary Biology, University of Toronto, Toronto, Ontario, Canada
    PLoS Biol 10:e1001317. 2012
    ..This "long-term advantage" builds over multiple generations, eventually resulting in higher fitness of sexual types...
  12. doi Differences between selection on sex versus recombination in red queen models with diploid hosts
    Aneil F Agrawal
    Department of Ecology and Evolutionary Biology, University of Toronto, Toronto, Ontario, Canada
    Evolution 63:2131-41. 2009
    ..These results strongly indicate that Red Queen models focusing exclusively on the effects of recombination cannot be used to infer the type of selection on sex that is generated by parasites on diploid hosts...
  13. doi Spatial heterogeneity and the evolution of sex in diploids
    Aneil F Agrawal
    Department of Ecology and Evolutionary Biology, University of Toronto, Toronto, Ontario, Canada
    Am Nat 174:S54-70. 2009
    ..I find that inbreeding affects the evolution of sex through segregation, not recombination. Several suggestions for empirical experiments are given...
  14. doi The effects of selective history and environmental heterogeneity on inbreeding depression in experimental populations of Drosophila melanogaster
    Tristan A F Long
    Department of Ecology and Evolutionary Biology, University of Toronto, Toronto, Ontario M5S 3B2, Canada
    Am Nat 181:532-44. 2013
    ..Though both of these factors are significant predictors of inbreeding depression in our study, there is an effect of assay environment on inbreeding depression that cannot be explained by either stress or CV...
  15. pmc DNA repair pathway choice is influenced by the health of Drosophila melanogaster
    Alethea D Wang
    Department of Ecology and Evolutionary Biology, University of Toronto, Toronto, ON, M5S 3B2, Canada
    Genetics 192:361-70. 2012
    ..Finally, we observe that the effect of larval diet on adult repair increases as flies age, indicating that developmental differences early in life can have long-lasting consequences...
  16. ncbi Sexual selection and the random union of gametes: testing for a correlation in fitness between mates in Drosophila melanogaster
    Nathaniel P Sharp
    Department of Ecology and Evolutionary Biology, University of Toronto, 25 Willcocks Street, Toronto, Ontario M5S 3B2, Canada
    Am Nat 174:613-22. 2009
    ..We find evidence for positive assortative mating among virgins but no evidence of assortative mating using the more complete measure of reproduction...
  17. ncbi The condition dependency of fitness in males and females: the fitness consequences of juvenile diet assessed in environments differing in key adult resources
    Andrea E Zikovitz
    Department of Ecology and Evolutionary Biology, University of Toronto, 25 Willcocks Street, Toronto, Ontario, Canada
    Evolution 67:2849-60. 2013
    ..Instead, this manipulation increased selection on males, suggesting that this environmental factor indirectly affects selection on males via their interaction with females. ..
  18. doi Male-biased fitness effects of spontaneous mutations in Drosophila melanogaster
    Nathaniel P Sharp
    Department of Ecology and Evolutionary Biology, University of Toronto, Toronto, Ontario M5S 3B2, Canada
    Evolution 67:1189-95. 2013
    ..This pattern is expected to reduce the mutation load of sexual females and promote the maintenance of sexual reproduction...
  19. ncbi Assortative mating for fitness and the evolution of recombination
    Alistair Blachford
    Department of Zoology, University of British Columbia, 6270 University Boulevard, Vancouver, British Columbia V6T 1Z4, Canada
    Evolution 60:1337-43. 2006
    ....
  20. doi Environmental duress and epistasis: how does stress affect the strength of selection on new mutations?
    Aneil F Agrawal
    Department of Ecology and Evolutionary Biology, University of Toronto, 25 Willcocks Street, Toronto, ON, Canada M5S 3B2
    Trends Ecol Evol 25:450-8. 2010
    ..We reject the notion that stress typically increases selection. Instead, we find that different types of stresses affect selection differently, though the underlying mechanisms are, as yet, unclear in most cases...
  21. doi Ecological determinants of mutation load and inbreeding depression in subdivided populations
    Aneil F Agrawal
    Department of Ecology and Evolutionary Biology, University of Toronto, Toronto, Ontario M5S 3B2, Canada
    Am Nat 176:111-22. 2010
    ..The same conditions that increase mutation load also increase inbreeding depression...
  22. doi Sensitivity of the distribution of mutational fitness effects to environment, genetic background, and adaptedness: a case study with Drosophila
    Alethea D Wang
    Department of Ecology and Evolutionary Biology, University of Toronto, Toronto, Ontario, Canada
    Evolution 68:840-53. 2014
    ..Contrary to predictions of fitness landscape theory, the match between genetic background and assay environment (i.e., adaptedness) had little effect on f(s). ..
  23. doi The effect of sexual selection on offspring fitness depends on the nature of genetic variation
    Tristan A F Long
    Department of Ecology and Evolutionary Biology, University of Toronto, Toronto, ON M5S 3B2, Canada
    Curr Biol 22:204-8. 2012
    ..Consequently, studies based on laboratory populations, cultured for prolonged periods under homogeneous conditions, may provide a skewed perspective on the relationship between sexual and natural selection...
  24. doi Estimating nonlinear selection gradients using quadratic regression coefficients: double or nothing?
    John R Stinchcombe
    Department of Ecology and Evolutionary Biology, and Centre for the Analysis of Genome Evolution and Function, University of Toronto, Toronto, ON M5S 3B2, Canada
    Evolution 62:2435-40. 2008
    ..Proper treatment of quadratic regression coefficients is necessary for estimation of fitness surfaces and contour plots, canonical analysis of the gamma matrix, and modeling the evolution of populations on an adaptive landscape...
  25. doi Mating density and the strength of sexual selection against deleterious alleles in Drosophila melanogaster
    Nathaniel P Sharp
    Department of Ecology and Evolutionary Biology, University of Toronto, 25 Harbord Street, Toronto, ON, Canada, M5S 3G5
    Evolution 62:857-67. 2008
    ..In most cases, sexual selection is as strong or stronger than these other forms of selection...
  26. doi Condition-dependence of the sexually dimorphic transcriptome in Drosophila melanogaster
    Minyoung J Wyman
    Department of Ecology and Evolutionary Biology, University of Toronto, Toronto, Ontario, M5S 3B2, Canada
    Evolution 64:1836-48. 2010
    ..Our results demonstrate that through condition-dependence, early life experience has dramatic effects on sexual dimorphism in the adult transcriptome...
  27. doi Higher rates of sex evolve in spatially heterogeneous environments
    Lutz Becks
    Department of Ecology and Evolutionary Biology, University of Toronto, Toronto, Ontario M5S 3B2, Canada
    Nature 468:89-92. 2010
    ..Counter to some alternative theories for the evolution of sex, there is no evidence that genetic drift plays any part in the evolution of sex in these populations...
  28. pmc Temporal variation in selection accelerates mutational decay by Muller's ratchet
    Alison M Wardlaw
    Department of Ecology and Evolutionary Biology, University of Toronto, Toronto, Ontario M5S 3B2, Canada
    Genetics 191:907-16. 2012
    ..Our finding that temporal autocorrelation in selection dramatically increases ratchet rate and rate of fitness decline may help to explain the paucity of asexual taxa...
  29. pmc Inferences about the distribution of dominance drawn from yeast gene knockout data
    Aneil F Agrawal
    Department of Ecology and Evolutionary Biology, University of Toronto, Toronto, Ontario M5S 3B2, Canada
    Genetics 187:553-66. 2011
    ....
  30. pmc The evolutionary dynamics of operon distributions in eukaryote genomes
    Asher D Cutter
    Department of Ecology and Evolutionary Biology, Centre for the Analysis of Genome Evolution and Function, University of Toronto, Toronto, Ontario M5S 3B2, Canada
    Genetics 185:685-93. 2010
    ..This theory, and applications to C. elegans and Ciona, motivates several new and testable hypotheses about eukaryote operon evolution...
  31. doi The effect of pathogens on selection against deleterious mutations in Drosophila melanogaster
    Jadene A Young
    Department of Ecology and Evolutionary Biology, University of Toronto, Toronto, ON, Canada, M5S 3B2
    J Evol Biol 22:2125-9. 2009
    ..We found that mutations tended to become more deleterious in the presence of disease. This increase in the average selection was primarily due to three genes with the remainder showing little evidence of change...
  32. ncbi Purging the genome with sexual selection: reducing mutation load through selection on males
    Michael C Whitlock
    Department of Zoology, University of British Columbia, Vancouver, BC V6T 1Z4 Canada
    Evolution 63:569-82. 2009
    ..Several lines of enquiry are suggested to better fill large gaps in our understanding of sexual selection and its effect on genetic load...
  33. pmc How much do genetic covariances alter the rate of adaptation?
    Aneil F Agrawal
    Department of Ecology and Evolutionary Biology, University of Toronto, 25 Willcocks Street, Toronto, Ontario, Canada M5S 3B2
    Proc Biol Sci 276:1183-91. 2009
    ..We also discuss how our metric can be used to identify traits or suites of traits whose genetic covariances to other traits have a particularly large impact on the rate of adaptation...
  34. pmc Modelling infection as a two-step process combining gene-for-gene and matching-allele genetics
    Aneil F Agrawal
    Department of Biology, Indiana University, Bloomington, IN 47405 3700, USA
    Proc Biol Sci 270:323-34. 2003
    ..The magnitude of the cost that switched the dynamics from GFG dominated to MA dominated depended on the genetic architecture of defence (i.e. the number of GFG and MA loci)...