Research Topics
| Aneil F AgrawalSummaryAffiliation: University of Toronto Country: Canada Publications
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Detail Information
Publications
Similarity selection and the evolution of sex: revisiting the red queenAneil F Agrawal
Department of Ecology and Evolutionary Biology, University of Toronto, Toronto, Ontario, Canada
PLoS Biol 4:e265. 2006..Though parasites alone may not provide a complete explanation for sex, the results presented here expand the potential for parasites to contribute to the maintenance of sex rather than act against it...
Host-parasite coevolution and selection on sex through the effects of segregationAneil F Agrawal
Department of Ecology and Evolutionary Biology, University of Toronto, 25 Harbord Street, Toronto, Ontario M5S 3G5, Canada
Am Nat 168:617-29. 2006..In cases where segregation and recombination act in opposite directions, we found that the effects of segregation dominate as an evolutionary force acting on sex in diploids...- The evolution of plastic recombinationAneil F Agrawal
Department of Zoology, University of British Columbia, Vancouver, Canada
Genetics 171:803-12. 2005..In contrast, the evolution of plastic recombination in diploids is much more restricted. Selection on plasticity requires the ability to detect DNA damage or cis-trans effects as may occur through maternal effects on fitness... - Increased transmission of mutations by low-condition females: evidence for condition-dependent DNA repairAneil F Agrawal
Department of Ecology and Evolutionary Biology, University of Toronto, Toronto, Ontario, Canada
PLoS Biol 6:e30. 2008..A separate experiment provided no support for an alternative hypothesis based on sperm selection... - Evolution of sex: why do organisms shuffle their genotypes?Aneil F Agrawal
Department of Ecology and Evolutionary Biology, University of Toronto, 25 Harbord Street, Toronto, Ontario, Canada, M5S 3G5
Curr Biol 16:R696-704. 2006..Ultimately, we need to identify which evolutionary forces--for example, selection, genetic drift, migration--are responsible for building the associations affected by sex... - The evolution of sex is favoured during adaptation to new environmentsLutz Becks
Department of Ecology and Evolutionary Biology, University of Toronto, Toronto, Ontario, Canada
PLoS Biol 10:e1001317. 2012..This "long-term advantage" builds over multiple generations, eventually resulting in higher fitness of sexual types... 
Differences between selection on sex versus recombination in red queen models with diploid hostsAneil F Agrawal
Department of Ecology and Evolutionary Biology, University of Toronto, Toronto, Ontario, Canada
Evolution 63:2131-41. 2009..These results strongly indicate that Red Queen models focusing exclusively on the effects of recombination cannot be used to infer the type of selection on sex that is generated by parasites on diploid hosts...- Spatial heterogeneity and the evolution of sex in diploidsAneil F Agrawal
Department of Ecology and Evolutionary Biology, University of Toronto, Toronto, Ontario, Canada
Am Nat 174:S54-70. 2009..I find that inbreeding affects the evolution of sex through segregation, not recombination. Several suggestions for empirical experiments are given... - Relative effectiveness of mating success and sperm competition at eliminating deleterious mutations in Drosophila melanogasterSean C A Clark
Department of Ecology and Evolutionary Biology, University of Toronto, Toronto, Ontario, Canada
PLoS ONE 7:e37351. 2012..Establishing whether the various stages of sexual selection affect deleterious mutations differently, and to what extent, remains an important issue to resolve... - Evidence for elevated mutation rates in low-quality genotypesNathaniel P Sharp
Department of Ecology and Evolutionary Biology, University of Toronto, Toronto, ON, Canada M5S 3B2
Proc Natl Acad Sci U S A 109:6142-6. 2012..Positive mutational feedback could affect human health by increasing the rate of germline mutation, and possibly somatic mutation, in individuals of poor health because of genetic or environmental stress... - Sexual selection and the random union of gametes: testing for a correlation in fitness between mates in Drosophila melanogasterNathaniel P Sharp
Department of Ecology and Evolutionary Biology, University of Toronto, 25 Willcocks Street, Toronto, Ontario M5S 3B2, Canada
Am Nat 174:613-22. 2009..We find evidence for positive assortative mating among virgins but no evidence of assortative mating using the more complete measure of reproduction... - Selection, epistasis, and parent-of-origin effects on deleterious mutations across environments in Drosophila melanogasterAlethea D Wang
Department of Ecology and Evolutionary Biology, University of Toronto, Toronto, Ontario M5S3B2, Canada
Am Nat 174:863-74. 2009..e., epistasis becomes more positive). In addition, we find a high incidence of indirect genetic effects whereby the strength of selection against the alleles carried by offspring is dependent on the genotypes of their parents... - Variation in the strength and softness of selection on deleterious mutationsAzadeh Laffafian
Department of Ecology and Evolutionary Biology, University of Toronto, 25 Willcocks Street, Toronto, Ontario M5S 3B2, Canada
Evolution 64:3232-41. 2010..A model is presented showing that the sensitivities of mutants and wild types to local competitors differentially affect equilibrium mutation frequency and measures of load... - Ecological determinants of mutation load and inbreeding depression in subdivided populationsAneil F Agrawal
Department of Ecology and Evolutionary Biology, University of Toronto, Toronto, Ontario M5S 3B2, Canada
Am Nat 176:111-22. 2010..The same conditions that increase mutation load also increase inbreeding depression... - Assortative mating for fitness and the evolution of recombinationAlistair Blachford
Department of Zoology, University of British Columbia, 6270 University Boulevard, Vancouver, British Columbia V6T 1Z4, Canada
Evolution 60:1337-43. 2006.... - Environmental duress and epistasis: how does stress affect the strength of selection on new mutations?Aneil F Agrawal
Department of Ecology and Evolutionary Biology, University of Toronto, 25 Willcocks Street, Toronto, ON, Canada M5S 3B2
Trends Ecol Evol 25:450-8. 2010..We reject the notion that stress typically increases selection. Instead, we find that different types of stresses affect selection differently, though the underlying mechanisms are, as yet, unclear in most cases... - The effect of sexual selection on offspring fitness depends on the nature of genetic variationTristan A F Long
Department of Ecology and Evolutionary Biology, University of Toronto, Toronto, ON M5S 3B2, Canada
Curr Biol 22:204-8. 2012..Consequently, studies based on laboratory populations, cultured for prolonged periods under homogeneous conditions, may provide a skewed perspective on the relationship between sexual and natural selection... - The effect of deleterious mutations and age on recombination in Drosophila melanogasterKatherine Tedman-Aucoin
Department of Ecology and Evolutionary Biology, University of Toronto, Toronto, ON, M5S 3B2, Canada
Evolution 66:575-85. 2012..The differences among genotypes or among age classes are large enough to add substantial noise to genetic mapping experiments that do not consider these sources of variation... - Condition-dependence of the sexually dimorphic transcriptome in Drosophila melanogasterMinyoung J Wyman
Department of Ecology and Evolutionary Biology, University of Toronto, Toronto, Ontario, M5S 3B2, Canada
Evolution 64:1836-48. 2010..Our results demonstrate that through condition-dependence, early life experience has dramatic effects on sexual dimorphism in the adult transcriptome... - Mating density and the strength of sexual selection against deleterious alleles in Drosophila melanogasterNathaniel P Sharp
Department of Ecology and Evolutionary Biology, University of Toronto, 25 Harbord Street, Toronto, ON, Canada, M5S 3G5
Evolution 62:857-67. 2008..In most cases, sexual selection is as strong or stronger than these other forms of selection... - Higher rates of sex evolve in spatially heterogeneous environmentsLutz Becks
Department of Ecology and Evolutionary Biology, University of Toronto, Toronto, Ontario M5S 3B2, Canada
Nature 468:89-92. 2010..Counter to some alternative theories for the evolution of sex, there is no evidence that genetic drift plays any part in the evolution of sex in these populations... - Estimating nonlinear selection gradients using quadratic regression coefficients: double or nothing?John R Stinchcombe
Department of Ecology and Evolutionary Biology, and Centre for the Analysis of Genome Evolution and Function, University of Toronto, Toronto, ON M5S 3B2, Canada
Evolution 62:2435-40. 2008..Proper treatment of quadratic regression coefficients is necessary for estimation of fitness surfaces and contour plots, canonical analysis of the gamma matrix, and modeling the evolution of populations on an adaptive landscape... - Temporal variation in selection accelerates mutational decay by Muller's ratchetAlison M Wardlaw
Department of Ecology and Evolutionary Biology, University of Toronto, Toronto, Ontario M5S 3B2, Canada
Genetics 191:907-16. 2012..Our finding that temporal autocorrelation in selection dramatically increases ratchet rate and rate of fitness decline may help to explain the paucity of asexual taxa... - DNA repair pathway choice is influenced by the health of Drosophila melanogasterAlethea D Wang
Department of Ecology and Evolutionary Biology, University of Toronto, Toronto, ON, M5S 3B2, Canada
Genetics 192:361-70. 2012..Finally, we observe that the effect of larval diet on adult repair increases as flies age, indicating that developmental differences early in life can have long-lasting consequences... - Inferences about the distribution of dominance drawn from yeast gene knockout dataAneil F Agrawal
Department of Ecology and Evolutionary Biology, University of Toronto, Toronto, Ontario M5S 3B2, Canada
Genetics 187:553-66. 2011.... - The evolutionary dynamics of operon distributions in eukaryote genomesAsher D Cutter
Department of Ecology and Evolutionary Biology, Centre for the Analysis of Genome Evolution and Function, University of Toronto, Toronto, Ontario M5S 3B2, Canada
Genetics 185:685-93. 2010..This theory, and applications to C. elegans and Ciona, motivates several new and testable hypotheses about eukaryote operon evolution... - The effect of pathogens on selection against deleterious mutations in Drosophila melanogasterJadene A Young
Department of Ecology and Evolutionary Biology, University of Toronto, Toronto, ON, Canada, M5S 3B2
J Evol Biol 22:2125-9. 2009..We found that mutations tended to become more deleterious in the presence of disease. This increase in the average selection was primarily due to three genes with the remainder showing little evidence of change... - Purging the genome with sexual selection: reducing mutation load through selection on malesMichael C Whitlock
Department of Zoology, University of British Columbia, Vancouver, BC V6T 1Z4 Canada
Evolution 63:569-82. 2009..Several lines of enquiry are suggested to better fill large gaps in our understanding of sexual selection and its effect on genetic load... - How much do genetic covariances alter the rate of adaptation?Aneil F Agrawal
Department of Ecology and Evolutionary Biology, University of Toronto, 25 Willcocks Street, Toronto, Ontario, Canada M5S 3B2
Proc Biol Sci 276:1183-91. 2009..We also discuss how our metric can be used to identify traits or suites of traits whose genetic covariances to other traits have a particularly large impact on the rate of adaptation... - Modelling infection as a two-step process combining gene-for-gene and matching-allele geneticsAneil F Agrawal
Department of Biology, Indiana University, Bloomington, IN 47405 3700, USA
Proc Biol Sci 270:323-34. 2003..The magnitude of the cost that switched the dynamics from GFG dominated to MA dominated depended on the genetic architecture of defence (i.e. the number of GFG and MA loci)...