Marina Afanasyeva

Summary

Affiliation: University of Calgary
Country: Canada

Publications

  1. ncbi Novel model of constrictive pericarditis associated with autoimmune heart disease in interferon-gamma-knockout mice
    Marina Afanasyeva
    Department of Pathology, Johns Hopkins Medical Intitutions, Baltimore, MD, USA
    Circulation 110:2910-7. 2004
  2. pmc Interleukin-13 protects against experimental autoimmune myocarditis by regulating macrophage differentiation
    Daniela Cihakova
    Johns Hopkins University, Department of Pathology, Division of Immunology, Ross 648, 720 Rutland Ave, Baltimore, MD 21205, USA
    Am J Pathol 172:1195-208. 2008
  3. pmc Impaired up-regulation of CD25 on CD4+ T cells in IFN-gamma knockout mice is associated with progression of myocarditis to heart failure
    Marina Afanasyeva
    Department of Pathology, The Johns Hopkins Medical Institutions, 720 Rutland Avenue, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 102:180-5. 2005
  4. pmc Quantitative analysis of myocardial inflammation by flow cytometry in murine autoimmune myocarditis: correlation with cardiac function
    Marina Afanasyeva
    Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    Am J Pathol 164:807-15. 2004
  5. ncbi Animal models for autoimmune myocarditis and autoimmune thyroiditis
    Daniela Cihakova
    Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Methods Mol Med 102:175-93. 2004
  6. ncbi Thyroid-specific expression of IFN-gamma limits experimental autoimmune thyroiditis by suppressing lymphocyte activation in cervical lymph nodes
    Jobert G Barin
    Department of Pathology, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA
    J Immunol 170:5523-9. 2003
  7. ncbi Cutting edge: a critical role for IL-10 in induction of nasal tolerance in experimental autoimmune myocarditis
    Ziya Kaya
    Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA
    J Immunol 168:1552-6. 2002
  8. pmc Cardiomyopathy is linked to complement activation
    Marina Afanasyeva
    W Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    Am J Pathol 161:351-7. 2002
  9. ncbi Autoimmune myocarditis: cellular mediators of cardiac dysfunction
    Marina Afanasyeva
    Cardiovascular Research Group, Faculty of Medicine, University of Calgary, Canada
    Autoimmun Rev 3:476-86. 2004
  10. ncbi Conductance catheter-based assessment of arterial input impedance, arterial function, and ventricular-vascular interaction in mice
    Patrick Segers
    Hydraulics Laboratory, Institute Biomedical Technology, Ghent University, Gent, Belgium
    Am J Physiol Heart Circ Physiol 288:H1157-64. 2005

Detail Information

Publications10

  1. ncbi Novel model of constrictive pericarditis associated with autoimmune heart disease in interferon-gamma-knockout mice
    Marina Afanasyeva
    Department of Pathology, Johns Hopkins Medical Intitutions, Baltimore, MD, USA
    Circulation 110:2910-7. 2004
    ..Constrictive pericarditis represents a serious hemodynamic syndrome that may lead to heart failure. Studies of its pathophysiological mechanisms have been impeded by the lack of an animal model...
  2. pmc Interleukin-13 protects against experimental autoimmune myocarditis by regulating macrophage differentiation
    Daniela Cihakova
    Johns Hopkins University, Department of Pathology, Division of Immunology, Ross 648, 720 Rutland Ave, Baltimore, MD 21205, USA
    Am J Pathol 172:1195-208. 2008
    ..IL-13 KO mice had increased caspase-1 activation, leading to increased production of both IL-1beta and IL-18. Therefore, IL-13 protects against myocarditis by modulating monocyte/macrophage populations and by regulating their function...
  3. pmc Impaired up-regulation of CD25 on CD4+ T cells in IFN-gamma knockout mice is associated with progression of myocarditis to heart failure
    Marina Afanasyeva
    Department of Pathology, The Johns Hopkins Medical Institutions, 720 Rutland Avenue, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 102:180-5. 2005
    ..An exaggerated inflammatory response in IFN-gamma KO mice causes cardiac dysfunction, leading to dilated cardiomyopathy and heart failure...
  4. pmc Quantitative analysis of myocardial inflammation by flow cytometry in murine autoimmune myocarditis: correlation with cardiac function
    Marina Afanasyeva
    Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    Am J Pathol 164:807-15. 2004
    ....
  5. ncbi Animal models for autoimmune myocarditis and autoimmune thyroiditis
    Daniela Cihakova
    Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Methods Mol Med 102:175-93. 2004
    ..H2h4 mice. These mice express the H-2A(k) allele on an NOD genetic background and develop spontaneous thyroiditis, which is exacerbated with dietary iodine...
  6. ncbi Thyroid-specific expression of IFN-gamma limits experimental autoimmune thyroiditis by suppressing lymphocyte activation in cervical lymph nodes
    Jobert G Barin
    Department of Pathology, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA
    J Immunol 170:5523-9. 2003
    ..The study supports a disease-limiting role of IFN-gamma in autoimmune thyroiditis. Furthermore, it provides the first evidence that local IFN-gamma activity in the thyroid is sufficient for disease suppression...
  7. ncbi Cutting edge: a critical role for IL-10 in induction of nasal tolerance in experimental autoimmune myocarditis
    Ziya Kaya
    Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA
    J Immunol 168:1552-6. 2002
    ..This study implicates IL-10 in the induction of nasal tolerance and in limiting inflammation later during the disease process...
  8. pmc Cardiomyopathy is linked to complement activation
    Marina Afanasyeva
    W Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    Am J Pathol 161:351-7. 2002
  9. ncbi Autoimmune myocarditis: cellular mediators of cardiac dysfunction
    Marina Afanasyeva
    Cardiovascular Research Group, Faculty of Medicine, University of Calgary, Canada
    Autoimmun Rev 3:476-86. 2004
    ..EAM provides insights into the role of the immune system in the development of dilated cardiomyopathy (DCM) and heart failure and may serve as a general paradigm for autoimmune organ-specific tissue damage...
  10. ncbi Conductance catheter-based assessment of arterial input impedance, arterial function, and ventricular-vascular interaction in mice
    Patrick Segers
    Hydraulics Laboratory, Institute Biomedical Technology, Ghent University, Gent, Belgium
    Am J Physiol Heart Circ Physiol 288:H1157-64. 2005
    ..We obtained an anticipated response of Z(in) and arterial function parameters following VCO and AOO, demonstrating the sensitivity of the measuring technique to induced physiological alterations in murine hemodynamics...