Research Topics
| Neill K J AdhikariSummaryAffiliation: University of Toronto Country: Canada Publications
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Detail Information
Publications
Self-reported symptoms of depression and memory dysfunction in survivors of ARDSNeill K J Adhikari
Department of Critical Care Medicine, Sunnybrook Health Sciences Centre, 2075 Bayview Avenue, Toronto, Ontario, Canada
Chest 135:678-87. 2009..Survivors of ARDS have well documented physical limitations, but psychological effects are less clear. We determined the prevalence of self-reported depression and memory dysfunction in ARDS survivors...
Critical care resources in the Solomon Islands: a cross-sectional surveyMia Westcott
George Institute For Global Health, PO Box M201, Missenden Road Sydney, NSW 2050, Australia
BMC Int Health Hum Rights 12:1. 2012..abstract:..- Stopping randomized trials early for benefit: a protocol of the Study Of Trial Policy Of Interim Truncation-2 (STOPIT-2)Matthias Briel
Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Canada
Trials 10:49. 2009..The aim of STOPIT-2 is to determine the magnitude and determinants of possible bias introduced by stopping RCTs early for benefit... - The use of wireless e-mail to improve healthcare team communicationChris O'Connor
Department of Critical Care Medicine, Room D1 08, Sunnybrook Health Sciences Centre, 2075 Bayview Avenue, Toronto, ON, Canada M4N3M5
J Am Med Inform Assoc 16:705-13. 2009..To assess the impact of using wireless e-mail for clinical communication in an intensive care unit (ICU)... - Self-reported depressive symptoms and memory complaints in survivors five years after ARDSNeill K J Adhikari
Interdepartmental Division of Critical Care, University of Toronto, Toronto, ON, Canada
Chest 140:1484-93. 2011..Survivors of ARDS report depressive symptoms and memory complaints, the prevalence of which after 5 years is unknown... - High-frequency oscillation in adults: a utilization reviewNeill K J Adhikari
Department of Critical Care Medicine and the Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, Toronto, Canada
Crit Care Med 39:2631-44. 2011..Given the uncertain benefits, our objective was to describe contemporary patient selection, high-frequency oscillation utilization, and outcomes... - Consent in critical care trials: a survey of Canadian research ethics boards and critical care researchersMark Duffett
McMaster Children s Hospital, Hamilton, Ontario, Canada
J Crit Care 26:533.e11-22. 2011..We compared the attitudes and beliefs of Canadian research ethics boards (REBs) and intensive care unit researchers toward the use of various consent models for a low-risk randomized controlled trial... 
Epidemiology of acute kidney injury in Canadian critical care units: a prospective cohort studyAyodele Odutayo
Division of Nephrology, Sunnybrook Health Sciences Centre, Toronto, ON, Canada
Can J Anaesth 59:934-42. 2012..We undertook this study to characterize the epidemiology of acute kidney injury (AKI) in Canadian critical care units. We aimed to identify predictors of mortality for patients diagnosed with AKI...- High frequency oscillation in patients with acute lung injury and acute respiratory distress syndrome (ARDS): systematic review and meta-analysisSachin Sud
Critical Care Medicine Program, Interdepartmental Division of Critical Care, University of Toronto, Toronto General Hospital, 585 University Ave, Toronto, ON, Canada, M5G 2N2
BMJ 340:c2327. 2010..To determine clinical and physiological effects of high frequency oscillation compared with conventional ventilation in patients with acute lung injury/acute respiratory distress syndrome (ARDS)... - Prone ventilation reduces mortality in patients with acute respiratory failure and severe hypoxemia: systematic review and meta-analysisSachin Sud
Interdepartmental Division of Critical Care, University of Toronto, Toronto, Canada
Intensive Care Med 36:585-99. 2010..Prone position ventilation for acute hypoxemic respiratory failure (AHRF) improves oxygenation but not survival, except possibly when AHRF is severe... - Worldwide demand for critical careNeill K J Adhikari
Department of Critical Care Medicine, Sunnybrook Health Sciences Centre and Interdepartmental Division of Critical Care, University of Toronto, Toronto, Ontario, Canada
Curr Opin Crit Care 17:620-5. 2011..Interest in the global burden of critical illness is growing, but comprehensive data to describe this burden and the resources available to provide care for critically ill patients are lacking... - Early massive transfusion in trauma patients: Canadian single-centre retrospective cohort studyTushar D Mahambrey
Department of Critical Care Medicine, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada
Can J Anaesth 56:740-50. 2009..To determine associations between red blood cell (RBC) transfusion and early and late clinical outcomes in massively transfused adult trauma patients... - Effect of nitric oxide on oxygenation and mortality in acute lung injury: systematic review and meta-analysisNeill K J Adhikari
Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, Canada
BMJ 334:779. 2007.... - Critical care and the global burden of critical illness in adultsNeill K J Adhikari
Interdepartmental Division of Critical Care, University of Toronto and Department of Critical Care Medicine, Sunnybrook Health Sciences Centre, Toronto, ON, Canada
Lancet 376:1339-46. 2010.... - High-frequency ventilation versus conventional ventilation for treatment of acute lung injury and acute respiratory distress syndromeSachin Sud
Division of Critical Care, Department of Medicine, Trillium Health Center, University of Toronto, Mississauga, Canada
Cochrane Database Syst Rev 2:CD004085. 2013..This review was originally published in 2004 and was updated in 2011... - Timing the initiation of renal replacement therapy for acute kidney injury in Canadian intensive care units: a multicentre observational studyEdward Clark
Kidney Research Centre, Ottawa Hospital Research Institute, University of Ottawa, Ottawa, ON, Canada
Can J Anaesth 59:861-70. 2012..Defining current practice is necessary to design interventional trials. We describe the current Canadian practice regarding the timing of RRT initiation for AKI... - The design and interpretation of pilot trials in clinical research in critical careDonald M Arnold
Department of Medicine, McMaster University, Hamilton, Ontario, Canada
Crit Care Med 37:S69-74. 2009..The objective of this review is to highlight the importance of randomized pilot trials and to describe key features of their design and interpretation using examples from critical care... - Electronic prescribing in an ambulatory care setting: a cluster randomized trialKatie N Dainty
St Michael s Hospital, Toronto, ON, Canada
J Eval Clin Pract 18:761-7. 2012..Medication errors resulting in preventable adverse drug events most commonly occur at the ordering stage. Electronic prescribing may prevent such errors but its impact has not been rigorously evaluated... - Quality of professional society guidelines and consensus conference statements in critical careTasnim Sinuff
Department of Critical Care Medicine, Sunnybrook Health Sciences Centre, and Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, Ontario, Canada
Crit Care Med 36:1049-58. 2008..To examine the quality of professional society critical care guidelines and consensus statements... - Pressure and volume limited ventilation for the ventilatory management of patients with acute lung injury: a systematic review and meta-analysisKaren E A Burns
Interdepartmental Division of Critical Care, University of Toronto, Toronto, Canada
PLoS ONE 6:e14623. 2011..We conducted a systematic review and meta-analysis of randomized controlled trials (RCTs) comparing pressure and volume-limited (PVL) ventilation strategies with more traditional mechanical ventilation in adults with ALI and ARDS... - Abstract reporting in randomized clinical trials of acute lung injury: an audit and assessment of a quality of reporting scoreKaren E A Burns
Graduate Program in Health Research Methodology, McMaster University, Hamilton, Ontario, Canada
Crit Care Med 33:1937-45. 2005..Checklists may aid authors and editors in prioritizing important criteria for inclusion in RCT abstracts... - Stopping randomized trials early for benefit and estimation of treatment effects: systematic review and meta-regression analysisDirk Bassler
Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada
JAMA 303:1180-7. 2010..Theory and simulation suggest that randomized controlled trials (RCTs) stopped early for benefit (truncated RCTs) systematically overestimate treatment effects for the outcome that precipitated early stopping... - Noninvasive ventilation for acute respiratory failure near the end of lifeTasnim Sinuff
Department of Critical Care Medicine, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada
Crit Care Med 36:789-94. 2008.... - Has mortality from acute respiratory distress syndrome decreased over time?: A systematic reviewJason Phua
F R C P C, Toronto Western Hospital, 399 Bathurst Street, 2MCL 411M, Toronto, ON M5T 2S8, Canada
Am J Respir Crit Care Med 179:220-7. 2009..It is commonly stated that mortality from acute respiratory distress syndrome (ARDS) and acute lung injury (ALI) is decreasing... - Mortality predictions in the intensive care unit: comparing physicians with scoring systemsTasnim Sinuff
Department of Critical Care Medicine, Sunnybrook and Women's College Health Sciences Centre, Toronto, Ontario, Canada
Crit Care Med 34:878-85. 2006..The overall accuracy of both predictions of patient mortality was moderate, implying limited usefulness of outcome prediction in the first 24 hrs for clinical decision making... - A multifaceted intervention for quality improvement in a network of intensive care units: a cluster randomized trialDamon C Scales
Interdepartmental Division of Critical Care, University of Toronto, Toronto, ON, Canada
JAMA 305:363-72. 2011..Evidence-based practices improve intensive care unit (ICU) outcomes, but eligible patients may not receive them. Community hospitals treat most critically ill patients but may have few resources dedicated to quality improvement... - Medical admission order sets to improve deep vein thrombosis prophylaxis rates and other outcomesChris O'Connor
Department of Medicine, Trillium Health Centre, Mississauga, Ontario, Canada
J Hosp Med 4:81-9. 2009..The value of order sets for clinical decision support has not been established... - A guide for the design and conduct of self-administered surveys of cliniciansKaren E A Burns
Interdepartmental Division of Critical Care, University of Toronto, and Keenan Research Centre and the Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, Ont
CMAJ 179:245-52. 2008 - Pay for performance in the intensive care unit--opportunity or threat?Kristina Khanduja
Department of Anaesthesia, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada
Crit Care Med 37:852-8. 2009..Our objective was to describe these programs and their potential implementation in intensive care units (ICUs)... - Utility and safety of draining pleural effusions in mechanically ventilated patients: a systematic review and meta-analysisEwan C Goligher
Interdepartmental Division of Critical Care, Mount Sinai Hospital and the University Health Network, University of Toronto, 600 University Avenue, Toronto, Ontario M5G 1X5, Canada
Crit Care 15:R46. 2011..Pleural effusions are frequently drained in mechanically ventilated patients but the benefits and risks of this procedure are not well established... - Use of non-invasive ventilation to wean critically ill adults off invasive ventilation: meta-analysis and systematic reviewKaren E A Burns
Interdepartmental Division of Critical Care, St Michael s Hospital, Toronto, ON, Canada M5B 1W8
BMJ 338:b1574. 2009..To summarise the evidence for early extubation with immediate application of non-invasive ventilation compared with continued invasive weaning on important outcomes in intubated adults with respiratory failure... - Effect of mechanical ventilation in the prone position on clinical outcomes in patients with acute hypoxemic respiratory failure: a systematic review and meta-analysisSachin Sud
Interdepartmental Division of Critical Care, University of Toronto, Faculty of Science, Toronto, Ont
CMAJ 178:1153-61. 2008..We sought to determine the effect of mechanical ventilation in the prone position on mortality, oxygenation, duration of ventilation and adverse events in patients with acute hypoxemic respiratory failure... - Does intensive insulin therapy really reduce mortality in critically ill surgical patients? A reanalysis of meta-analytic dataJan O Friedrich
Interdepartmental Division of Critical Care and Department of Medicine, University of Toronto, R, Fraser Elliot Building, 3rd Floor, South Wing, 3S 805, 190 Elizabeth Street, Toronto, Ontario, Canada
Crit Care 14:324. 2010..Further insights may come from individual patient data meta-analyses or from future large multicenter RCTs in more narrowly defined subgroups of surgical patients... - Survey of information technology in Intensive Care Units in Ontario, CanadaStephen E Lapinsky
Intensive Care Unit, Mount Sinai Hospital, Toronto, Canada
BMC Med Inform Decis Mak 8:5. 2008..We surveyed ICUs in the province of Ontario, Canada, to determine the availability, implementation and variability of information systems... - The ratio of means method as an alternative to mean differences for analyzing continuous outcome variables in meta-analysis: a simulation studyJan O Friedrich
Department of Medicine, University of Toronto, Toronto, Canada
BMC Med Res Methodol 8:32. 2008..SMD and RoM allow pooling of outcomes expressed in different units and comparisons of effect sizes across interventions, but RoM interpretation does not require knowledge of the pooled SD, a quantity generally unknown to clinicians... - Implementation of a research awareness program in the critical care unit: effects on families and cliniciansCraig Dale
Trauma, Emergency and Critical Care Program, Sunnybrook Health Sciences Centre, Toronto, ON, Canada
Intensive Crit Care Nurs 26:69-74. 2010..Successful conduct of research studies in the critically ill requires communication with families, substitute decision-makers and clinicians... - Clinical review: critical care in the global context--disparities in burden of illness, access, and economicsRobert A Fowler
Department of Medicine, Sunnybrook Health Sciences Centre, 2075 Bayview Avenue, Room D478, Toronto, ON, Canada M4N 3M5
Crit Care 12:225. 2008.... - Update in critical care 2007Robert A Fowler
Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, Ontario, Canada
Am J Respir Crit Care Med 177:808-19. 2008 - Randomized trials stopped early for benefit: a systematic reviewVictor M Montori
Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada
JAMA 294:2203-9. 2005..These findings suggest clinicians should view the results of such trials with skepticism... - Prophylactic magnesium for improving neurologic outcome after aneurysmal subarachnoid hemorrhage: systematic review and meta-analysisEyal Golan
Department of Medicine, University Health Network, Toronto, Ontario, Canada M5T 2S8
J Crit Care 28:173-81. 2013..Neurologic disability is common after aneurysmal subarachnoid hemorrhage (aSAH). Our objective was to systematically review the prophylactic use of magnesium to improve neurologic outcomes in these patients... - Rosiglitazone: can meta-analysis accurately estimate excess cardiovascular risk given the available data? Re-analysis of randomized trials using various methodologic approachesJan O Friedrich
Department of Medicine, University of Toronto, Toronto, Canada
BMC Res Notes 2:5. 2009..The objective of this study was to assess the robustness of the rosiglitazone results by using alternative reasonable methodologic approaches and by analyzing additional related outcomes... - Ratio of geometric means to analyze continuous outcomes in meta-analysis: comparison to mean differences and ratio of arithmetic means using empiric data and simulationJan O Friedrich
Department of Medicine, University of Toronto, Toronto, Canada
Stat Med 31:1857-86. 2012.... - Previous cultures are not clinically useful for guiding empiric antibiotics in suspected ventilator-associated pneumonia: secondary analysis from a randomized trialKevin M Sanders
Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, Ontario, Canada M5T 2S8
J Crit Care 23:58-63. 2008..To examine the predictive validity of prior cultures at predicting the microorganism isolated at the time of suspicion of ventilator-associated pneumonia (VAP)... - Legislative barriers to outpatient e-prescribing in a randomized trialSherman Quan
Department of Medicine, Sunnybrook Health Sciences Centre, Toronto, Ontario
Healthc Q 10:106-10, 112. 2007.... - Outcomes of interfacility critical care adult patient transport: a systematic reviewEddy Fan
Interdepartmental Division of Critical Care Medicine, University of Toronto, 399 Bathurst Street, F2-150, Toronto, Ontario, M5T 2S8, Canada
Crit Care 10:R6. 2006..Further study is required to define the risks and benefits of interfacility transfer in this patient population. Such information is important for the planning and allocation of resources related to transporting critically ill adults... - Real-time automated paging and decision support for critical laboratory abnormalitiesEdward Etchells
Centre for Patient Safety, University of Toronto, 2075 Bayview Avenue, Toronto, Ontario, Canada
BMJ Qual Saf 20:924-30. 2011..For patients with critical laboratory abnormalities, timely clinical alerts with decision support could improve management and reduce adverse events... - Ratio of means for analyzing continuous outcomes in meta-analysis performed as well as mean difference methodsJan O Friedrich
Department of Medicine, University of Toronto, Toronto, Ontario, Canada
J Clin Epidemiol 64:556-64. 2011..Ratio of means (RoM) is an alternative effect measure that performs comparably in simulation. We compared treatment effects and heterogeneity for RoM, MD, and SMD using empiric data... - Drotrecogin alfa (activated): does current evidence support treatment for any patients with severe sepsis?Jan O Friedrich
Interdepartmental Division of Critical Care, University of Toronto, Toronto, Ontario, Canada
Crit Care 10:145. 2006..Consequently, further randomised trials of this agent in prospectively defined high-risk patients are required to clarify its role in the management of severe sepsis... - High-dose renal replacement therapy for acute kidney injury: Systematic review and meta-analysisRyan Van Wert
Department of Medicine, University of Toronto, Toronto, Canada
Crit Care Med 38:1360-9. 2010..To determine the effect of renal replacement therapy dose on mortality and dialysis dependence in patients with acute kidney injury... - Inclusion of zero total event trials in meta-analyses maintains analytic consistency and incorporates all available dataJan O Friedrich
Interdepartmental Division of Critical Care, University of Toronto, Toronto, Canada
BMC Med Res Methodol 7:5. 2007..This study examined the influence of such trials on pooled treatment effects... - Routine chest x-rays in intensive care units: a systematic review and meta-analysisAnusoumya Ganapathy
Department of Critical Care Medicine, Sunnybrook Health Sciences Centre, 2075 Bayview Avenue, Toronto ON M4N 3M5, Canada
Crit Care 16:R68. 2012..Chest x-rays (CXRs) are the most frequent radiological tests performed in the intensive care unit (ICU). However, the utility of performing daily routine CXRs is unclear... - The evolution of intensive care unit performance assessmentMarius Terblanche
Department of Critical Care Medicine, B 702 Sunnybrook and Women s College Health Science Centre, Toronto, Ontario, Canada M4N 3M5
J Crit Care 21:19-22. 2006..Successful performance assessment requires the quantification of relevant indexes of performance. Although these indexes are increasingly being developed, it will be some time before widely recognized, validated systems are available... - Maintaining allocation concealment: following your SNOSEDamon C Scales
Interdepartmental Division of Critical Care, University of Toronto, Ontario, Canada
J Crit Care 20:191-3. 2005 - Bilevel noninvasive positive pressure ventilation for acute respiratory failure: survey of Ontario practiceKaren E A Burns
Division of Critical Care Medicine, University of Western Ontario, London, Ontario, Canada
Crit Care Med 33:1477-83. 2005..Some factors associated with variation in NIV use may be suitable targets for utilization improvement interventions...