P C Adams

Summary

Affiliation: University of Western Ontario
Country: Canada

Publications

  1. ncbi request reprint HFE mutations in Caucasian participants of the Hemochromatosis and Iron Overload Screening study with serum ferritin level <1000 µg/L
    Paul C Adams
    London Health Services Centre, London, Ontario, Canada
    Can J Gastroenterol 27:390-2. 2013
  2. pmc Probability of C282Y homozygosity decreases as liver transaminase activities increase in participants with hyperferritinemia in the hemochromatosis and iron overload screening study
    Paul C Adams
    Division of Gastroenterology, Department of Medicine, London Health Sciences Center, London, Ontario, Canada
    Hepatology 55:1722-6. 2012
  3. pmc Biological variability of transferrin saturation and unsaturated iron-binding capacity
    Paul C Adams
    Department of Medicine, University Hospital, London, Ontario, Canada
    Am J Med 120:999.e1-7. 2007
  4. ncbi request reprint Comparison of the unsaturated iron-binding capacity with transferrin saturation as a screening test to detect C282Y homozygotes for hemochromatosis in 101,168 participants in the hemochromatosis and iron overload screening (HEIRS) study
    Paul C Adams
    Department of Medicine, London Health Sciences Center, London, Ontario, Canada
    Clin Chem 51:1048-52. 2005
  5. ncbi request reprint Hemochromatosis and iron-overload screening in a racially diverse population
    Paul C Adams
    Department of Medicine, London Health Sciences Centre, London, Ont, Canada
    N Engl J Med 352:1769-78. 2005
  6. ncbi request reprint Screening for haemochromatosis--producing or preventing illness?
    Paul C Adams
    London Health Sciences Centre, London, Ontario, N6A 5A5, Canada
    Lancet 366:269-71. 2005
  7. doi request reprint A diagnostic approach to hyperferritinemia with a non-elevated transferrin saturation
    Paul C Adams
    Department of Medicine, University Hospital, University of Western Ontario, London, Ontario, Canada
    J Hepatol 55:453-8. 2011
  8. ncbi request reprint Hemochromatosis case definition: out of focus?
    Paul C Adams
    University Hospital in London, ON, Canada
    Nat Clin Pract Gastroenterol Hepatol 3:178-9. 2006
  9. ncbi request reprint Liver diseases in the hemochromatosis and iron overload screening study
    Paul C Adams
    Department of Medicine, University Hospital, 339 Windermere Road, London, Ontario, Canada N6A 5A5
    Clin Gastroenterol Hepatol 4:918-23; quiz 807. 2006
  10. doi request reprint How I treat hemochromatosis
    Paul C Adams
    University Hospital, University of Western Ontario, London, ON, Canada
    Blood 116:317-25. 2010

Collaborators

Detail Information

Publications71

  1. ncbi request reprint HFE mutations in Caucasian participants of the Hemochromatosis and Iron Overload Screening study with serum ferritin level <1000 µg/L
    Paul C Adams
    London Health Services Centre, London, Ontario, Canada
    Can J Gastroenterol 27:390-2. 2013
    ..Many patients referred for an elevated serum ferritin level <1000 µg⁄L are advised that they likely have iron overload and hemochromatosis...
  2. pmc Probability of C282Y homozygosity decreases as liver transaminase activities increase in participants with hyperferritinemia in the hemochromatosis and iron overload screening study
    Paul C Adams
    Division of Gastroenterology, Department of Medicine, London Health Sciences Center, London, Ontario, Canada
    Hepatology 55:1722-6. 2012
    ..Mean ALT and AST activities were significantly lower in C282Y homozygotes than nonhomozygotes. The probability of being a C282Y homozygote increased as the ALT and AST activities decreased...
  3. pmc Biological variability of transferrin saturation and unsaturated iron-binding capacity
    Paul C Adams
    Department of Medicine, University Hospital, London, Ontario, Canada
    Am J Med 120:999.e1-7. 2007
    ..Unsaturated iron-binding capacity has similar performance at lower cost. However, the within-person biological variability of both these tests may limit their ability at commonly used cut points to detect HFE C282Y homozygous patients...
  4. ncbi request reprint Comparison of the unsaturated iron-binding capacity with transferrin saturation as a screening test to detect C282Y homozygotes for hemochromatosis in 101,168 participants in the hemochromatosis and iron overload screening (HEIRS) study
    Paul C Adams
    Department of Medicine, London Health Sciences Center, London, Ontario, Canada
    Clin Chem 51:1048-52. 2005
  5. ncbi request reprint Hemochromatosis and iron-overload screening in a racially diverse population
    Paul C Adams
    Department of Medicine, London Health Sciences Centre, London, Ont, Canada
    N Engl J Med 352:1769-78. 2005
    ..Iron overload and hemochromatosis are common, treatable conditions. HFE genotypes, levels of serum ferritin, transferrin saturation values, and self-reported medical history were studied in a multiethnic primary care population...
  6. ncbi request reprint Screening for haemochromatosis--producing or preventing illness?
    Paul C Adams
    London Health Sciences Centre, London, Ontario, N6A 5A5, Canada
    Lancet 366:269-71. 2005
  7. doi request reprint A diagnostic approach to hyperferritinemia with a non-elevated transferrin saturation
    Paul C Adams
    Department of Medicine, University Hospital, University of Western Ontario, London, Ontario, Canada
    J Hepatol 55:453-8. 2011
    ..Three case studies illustrate common problems in interpreting iron blood tests...
  8. ncbi request reprint Hemochromatosis case definition: out of focus?
    Paul C Adams
    University Hospital in London, ON, Canada
    Nat Clin Pract Gastroenterol Hepatol 3:178-9. 2006
  9. ncbi request reprint Liver diseases in the hemochromatosis and iron overload screening study
    Paul C Adams
    Department of Medicine, University Hospital, 339 Windermere Road, London, Ontario, Canada N6A 5A5
    Clin Gastroenterol Hepatol 4:918-23; quiz 807. 2006
    ..The Hemochromatosis and Iron Overload Screening (HEIRS) Study screened 101,168 primary care participants for iron overload with serum transferrin saturation (TS), ferritin, and C282Y and H63D mutations of the HFE gene...
  10. doi request reprint How I treat hemochromatosis
    Paul C Adams
    University Hospital, University of Western Ontario, London, ON, Canada
    Blood 116:317-25. 2010
    ....
  11. doi request reprint HFE C282Y homozygosity is associated with lower total and low-density lipoprotein cholesterol: The hemochromatosis and iron overload screening study
    Paul C Adams
    Department of Medicine, University Hospital, London, Ontario, Canada
    Circ Cardiovasc Genet 2:34-7. 2009
    ..Relationships between serum lipids, C282Y homozygosity, and serum ferritin have not been well established...
  12. doi request reprint The natural history of untreated HFE-related hemochromatosis
    Paul C Adams
    University Hospital, London, Ont, Canada
    Acta Haematol 122:134-9. 2009
    ..These observations are summarized in this review article which raises questions about the need for phlebotomy in all C282Y homozygous patients...
  13. pmc Screening for iron overload: lessons from the hemochromatosis and iron overload screening (HEIRS) study
    Paul Adams
    Department of Medicine, London Health Sciences Centre, London, Canada
    Can J Gastroenterol 23:769-72. 2009
    ..The HEmochromatosis and IRon Overload Screening (HEIRS) Study provided data on a racially, ethnically and geographically diverse cohort of participants in North America screened from primary care populations...
  14. pmc Is serum hepcidin causative in hemochromatosis? Novel analysis from a liver transplant with hemochromatosis
    Paul C Adams
    Department of Medicine, University of Western Ontario, London, Ontario
    Can J Gastroenterol 22:851-3. 2008
    ..Hepcidin is a circulating hepatic hormone that regulates iron balance. It has been speculated that hepcidin insufficiency or dysregulation may be the primary defect in genetic hemochromatosis...
  15. ncbi request reprint Haemochromatosis
    Paul C Adams
    University Hospital, London, ON, Canada
    Lancet 370:1855-60. 2007
    ..Phlebotomy therapy improves hepatic fibrosis. Here, we summarise some new findings in haemochromatosis, a disorder first described in 1865...
  16. ncbi request reprint Haemochromatosis: find them or forget about them?
    Paul C Adams
    Department of Medicine, London Health Sciences Centre, Ontario, Canada
    Eur J Gastroenterol Hepatol 16:857-8. 2004
    ..The demonstration of significant liver disease in family members is a strong reminder of the vital importance of pedigree studies when a typical haemochromatosis patient is identified...
  17. ncbi request reprint Screening in liver disease: report of an AASLD clinical workshop
    Paul C Adams
    London Health Sciences Centre, London, Ontario, Canada
    Hepatology 39:1204-12. 2004
    ..Future screening programs require careful planning and implementation to balance the benefits, risks, and cost-effectiveness. This review outlines the concepts of screening and their application to a broad range of liver diseases...
  18. doi request reprint Serial serum ferritin measurements in untreated HFE C282Y homozygotes in the Hemochromatosis and Iron Overload Screening Study
    P C Adams
    Department of Medicine, University Hospital, London, Ontario, Canada
    Int J Lab Hematol 30:300-5. 2008
    ..6 g, 0.42-7.1, P < 0.05). SF was as likely to decrease as increase in untreated C282Y homozygotes over this relatively brief observation period. Incremental increases in SF are not inevitable in untreated C282Y homozygotes...
  19. ncbi request reprint A primer for predicting risk of disease in HFE-linked hemochromatosis
    P C Adams
    University of Western Ontario, London, Ontario, Canada N6A 5A5
    Genet Test 5:311-6. 2001
    ..The risk is highest in men and their C282Y homozygous brothers and significantly lower in homozygous women. Iron overload is uncommon in compound heterozygotes and H63D homozygotes...
  20. ncbi request reprint Expression of ferroportin in hemochromatosis liver
    Paul C Adams
    Department of Medicine, London Health Sciences Centre, University of Western Ontario, London, Ontario, Canada
    Blood Cells Mol Dis 31:256-61. 2003
    ..The increase in ferroportin protein without an increase in mRNA is consistent with iron-mediated translational regulation through the 5'IRE in the mRNA...
  21. pmc Lessons from liver transplantation: flip, flop, and why?
    P C Adams
    Department of Medicine, London Health Sciences Centre, 339 Windermere Rd, London, Ontario, Canada N6A 5A5
    Gut 52:318. 2003
  22. ncbi request reprint Population screening for hemochromatosis--are we finding people with a disease or a biochemical curiosity?
    Paul C Adams
    Department of Medicine, University of Western Ontario, London
    Semin Gastrointest Dis 13:89-94. 2002
    ..In this review, the controversial issues surrounding population screening for hemochromatosis are explored in the context of available information from large screening studies...
  23. ncbi request reprint Genotypic/phenotypic correlations in genetic hemochromatosis: evolution of diagnostic criteria
    P C Adams
    Department of Medicine, University of Western Ontario, London, Canada
    Gastroenterology 114:319-23. 1998
    ..The aim of this study was to reassess the phenotypic diagnostic criteria for hemochromatosis in patients homozygous for the C282Y mutation of the HFE gene...
  24. ncbi request reprint Population screening for hemochromatosis: a comparison of unbound iron-binding capacity, transferrin saturation, and C282Y genotyping in 5,211 voluntary blood donors
    P C Adams
    Department of Medicine, University of Western Ontario, London, Ontario, Canada
    Hepatology 31:1160-4. 2000
    ..93 (0. 85-1.0, 95% confidence interval), and for TS of 0.83 (0.7-0.95). Screening with UIBC to preselect those for genotyping is a cost-efficient strategy for population screening for hemochromatosis...
  25. ncbi request reprint Review article: the modern diagnosis and management of haemochromatosis
    P C Adams
    Department of Medicine, University of Western Ontario, London, Ontario, Canada
    Aliment Pharmacol Ther 23:1681-91. 2006
    ..However, a growing number of new iron-related genes have been discovered and linked to other iron overload syndromes...
  26. ncbi request reprint Psychosocial impact of C282Y mutation testing for hemochromatosis
    T E Power
    Department of Psychology, University of Western Ontario, London, Canada
    Genet Test 5:107-10. 2001
    ..Genetic testing for hemochromatosis is well accepted and should not be discouraged on the basis of potential adverse psychosocial effects...
  27. ncbi request reprint Long-term survival analysis in hereditary hemochromatosis
    P C Adams
    Department of Medicine, University of Western Ontario, London, Canada
    Gastroenterology 101:368-72. 1991
    ..The presence of cirrhosis significantly increases mortality and is the major clinical factor affecting survival...
  28. ncbi request reprint Is there a threshold of hepatic iron concentration that leads to cirrhosis in C282Y hemochromatosis?
    P C Adams
    London Health Sciences Centre, University of Western Ontario, Canada
    Am J Gastroenterol 96:567-9. 2001
    ..The objective of this study was to determine if a threshold for hepatic iron concentration leads to the development of cirrhosis in C282Y hemochromatosis...
  29. ncbi request reprint A nomogram to predict C282Y hemochromatosis
    Jerry S McGrath
    Department of Medicine, London Health Sciences Centre, Ontario, Canada
    J Lab Clin Med 140:6-8. 2002
    ..9-8.1). This approach allows the clinician to predict the probability of a patient's being a C282Y homozygote over a wide range of ferritin and transferrin saturation values instead of above a particular threshold...
  30. ncbi request reprint Natural history of C282Y homozygotes for hemochromatosis
    John P Wojcik
    Department of Medicine, University of Western Ontario, London, Canada
    Can J Gastroenterol 16:297-302. 2002
    ..To study the clinical outcomes of subjects who are homozygous for the C282Y mutation of the hemochromatosis gene...
  31. ncbi request reprint Factors affecting glucose tolerance in hereditary hemochromatosis
    I M Hramiak
    Department of Medicine, University of Western Ontario, London
    Clin Invest Med 20:110-8. 1997
    ..These mechanisms include decreased beta-cell secretion of insulin due to iron overload, insulin resistance and genetic factors...
  32. ncbi request reprint Natural history of the C282Y homozygote for the hemochromatosis gene (HFE) with a normal serum ferritin level
    Cory Yamashita
    Department of Medicine, London Health Sciences Centre, 339 Windermere Road, London, Ontario, Canada N6A 5A5
    Clin Gastroenterol Hepatol 1:388-91. 2003
    ..The long-term prognosis, rate of iron accumulation, and surveillance guidelines for these individuals are unknown...
  33. doi request reprint Screening for hemochromatosis and iron overload: satisfaction with results notification and understanding of mailed results in unaffected participants of the HEIRS study
    Helen F Harrison
    Department of Medicine, London Health Sciences Centre, London, Ontario, Canada
    Genet Test 12:491-500. 2008
    ....
  34. ncbi request reprint Rate of iron reaccumulation following iron depletion in hereditary hemochromatosis. Implications for venesection therapy
    P C Adams
    Department of Medicine, University Hospital, University of Western Ontario, London, Canada
    J Clin Gastroenterol 16:207-10. 1993
    ..Annual monitoring of body iron stores with reinstitution of weekly venesection when the serum ferritin exceeds the upper limit of normal was a safe alternative to long-term maintenance venesection...
  35. doi request reprint Assessment of silent liver fibrosis in hemochromatosis C282Y homozygotes with normal transaminase levels
    Melanie Beaton
    Department of Medicine, University Hospital, London, Ontario, Canada
    Clin Gastroenterol Hepatol 6:713-4. 2008
    ..The objective of this study was to assess the degree of liver injury in referred C282Y homozygotes who underwent elective liver biopsy and had serum AST and ALT levels < 40 IU/L...
  36. pmc Prognostic factors and survival in patients with hereditary hemochromatosis and cirrhosis
    Melanie D Beaton
    Department of Gastroenterology, University of Western Ontario, London, Ontario
    Can J Gastroenterol 20:257-60. 2006
    ..Less is known about the outcome of cirrhotic hereditary hemochromatosis patients. The present study evaluated the survival of patients with hereditary hemochromatosis and cirrhosis...
  37. pmc Hemochromatosis. Common genes, uncommon illness?
    Helen Harrison
    London Health Sciences Centre, London, Ont
    Can Fam Physician 48:1326-33. 2002
    ..To increase family physicians' awareness of the prevalence of hemochromatosis and to suggest strategies for diagnosis and management of hemochromatosis with the goal of decreasing the development of associated life-threatening conditions...
  38. ncbi request reprint Heme-oxygenase-mediated iron accumulation in the liver
    Zia A Khan
    Department of Pathology, University of Western Ontario, London, Canada
    Can J Physiol Pharmacol 82:448-56. 2004
    ..Our data provides evidence of increased HO activity as an important pro-oxidant mechanism leading to iron accumulation in the liver...
  39. pmc The diversity of liver diseases among outpatient referrals for an elevated serum ferritin
    Karen Wong
    Department of Medicine, Division of Gastroenterology, University of Western Ontario, London, Canada
    Can J Gastroenterol 20:467-70. 2006
    ..The aim of the present study was to examine the diversity of liver diseases in outpatients referred because of elevated serum ferritin...
  40. ncbi request reprint Hemochromatosis patients as voluntary blood donors
    Tara E Power
    Department of Psychology, University of Western Ontario, London, Canada
    Can J Gastroenterol 18:393-6. 2004
    ....
  41. ncbi request reprint Psychosocial impact of genetic testing for hemochromatosis in the HEIRS Study: a comparison of participants recruited in Canada and in the United States
    Tara E Power
    London Ontario Health Sciences Center, London, Ontario, Canada
    Genet Test 11:55-64. 2007
    ..S. individuals, although fewer Canadians may experience a negative response to such testing...
  42. ncbi request reprint Phenotype variation in C282Y homozygotes for the hemochromatosis gene
    Adriana Lazarescu
    Department of Medicine, University of Western Ontario, London, Ontario, Canada
    Clin Gastroenterol Hepatol 3:1043-6. 2005
    ..However, approximately 50% of women and 20% of men do not have an increase in serum ferritin level. This study assessed factors, genetic and otherwise, that may modify biochemical expression in C282Y homozygotes...
  43. ncbi request reprint Hemochromatosis
    Paul C Adams
    Department of Medicine, University of Western Ontario, London Health Sciences Centre, University Campus, P O Box 5339, London, Ontario N6A 5A5, Canada
    Clin Liver Dis 8:735-53, vii. 2004
    ..The discovery of the gene has led to a genetic blood test useful in the diagnosis of hemochromatosis. Treatment by phlebotomy is simple and efficient and can prevent the development of cirrhosis, leading to a normal life expectancy...
  44. ncbi request reprint Glucose-induced regulation of novel iron transporters in vascular endothelial cell dysfunction
    Zia A Khan
    Department of Pathology, University of Western Ontario, London, Canada
    Free Radic Res 39:1203-10. 2005
    ..In conclusion, our study suggests that glucose-induced alteration of iron transporters may arbitrate iron accumulation and oxidative stress in endothelial cells...
  45. pmc Variation in physician reimbursement for endoscopy across Canada
    L S Roth
    University of Western Ontario, London Health Sciences Centre, London, Canada
    Can J Gastroenterol 23:503-5. 2009
    ..Fees are set provincially, and the consistency with regard to compensation for colonoscopy and gastroscopy across the provinces has yet to be established...
  46. pmc Induction versus noninduction antiviral therapy for chronic hepatitis C virus in patients with congenital coagulation disorders: a Canadian multicentre trial
    A Chatterjee
    University of Toronto University Health Network, Toronto Western Hospital, 399 Bathurst Street, Toronto, Ontario, Canada
    Can J Gastroenterol 21:91-5. 2007
    ..The present study compared induction therapy with interferon-alpha (IFN-alpha)-2b with standard IFN-alpha2b therapy. Pegylated IFN was not available at the time that the study was initiated...
  47. ncbi request reprint A Canadian multicenter retrospective study evaluating transjugular liver biopsy in patients with congenital bleeding disorders and hepatitis C: is it safe and useful?
    Jennifer L Shin
    Department of Medicine at University Health Network, University of Toronto, Toronto, Ontario, Canada
    Am J Hematol 78:85-93. 2005
    ..We conclude that this procedure can be safely performed on an outpatient basis. The diagnosis of cirrhosis and/or portal hypertension was made in a substantial proportion of individuals (26%), all of whom had asymptomatic liver disease...
  48. pmc Time to endoscopy and outcomes in upper gastrointestinal bleeding
    N Sarin
    University of Western Ontario, London, Canada
    Can J Gastroenterol 23:489-93. 2009
    ..The present retrospective review of endoscopies performed at a large teaching hospital assessed the timing of endoscopy with respect to the morbidity and mortality of UGIB...
  49. pmc The myths and realities of hemochromatosis
    Melanie D Beaton
    Department of Medicine, London Health Sciences Centre, 339 Windermere Road, London, Ontario, Canada
    Can J Gastroenterol 21:101-4. 2007
    ..Genetic testing is widely available and particularly useful in family studies. Hemochromatosis can be readily diagnosed and treated. The purpose of the present review is to address the medical myths and misconceptions of hemochromatosis...
  50. pmc Association of ferroportin Q248H polymorphism with elevated levels of serum ferritin in African Americans in the Hemochromatosis and Iron Overload Screening (HEIRS) Study
    Charles A Rivers
    Departments of Microbiology, Medicine, and Epidemiology and International Health, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Blood Cells Mol Dis 38:247-52. 2007
    ..012). There were no significant differences in Q248H frequencies in men and women control participants. We conclude that the frequency of the FPN1 Q248H polymorphism is greater in AA men with elevated SF than in those with normal SF...
  51. ncbi request reprint Hemochromatosis (HFE) gene splice site mutation IVS5+1 G/A in North American Vietnamese with and without phenotypic evidence of iron overload
    Michael Steiner
    Institute of Clinical Chemistry and Laboratory Medicine, University of Rostock, Rostock, Germany
    Transl Res 149:92-5. 2007
    ..32% for cases and 2.04% for controls (P>0.5). This finding suggests that the HFE IVS5+1 G/A splice site mutation is not the major explanation for unexpectedly high prevalence of TS and SF in North American Asians...
  52. pmc A diagnostic approach to hemochromatosis
    Anthony S Tavill
    Case Western Reserve School of Medicine and Cleveland Clinic, Ohio, USA
    Can J Gastroenterol 20:535-40. 2006
    ..The authors offer a stepwise, diagnostic algorithm based on current evidence-based data, that they regard as most cost-effective. An early diagnosis can lead to phlebotomy therapy to prevent the development of cirrhosis...
  53. ncbi request reprint Geographic and racial/ethnic differences in HFE mutation frequencies in the Hemochromatosis and Iron Overload Screening (HEIRS) Study
    Ronald T Acton
    Department of Microbiology, University of Alabama at Birmingham 35209 0005, USA
    Ethn Dis 16:815-21. 2006
    ..To assess geographic differences in the frequencies of HFE C282Y and H63D genotypes in six racial/ethnic groups recruited in the Hemochromatosis and Iron Overload Screening (HEIRS) Study...
  54. ncbi request reprint Mixture models of serum iron measures in population screening for hemochromatosis and iron overload
    Christine E McLaren
    Epidemiology Division, Department of Medicine, University of California, Irvine, CA 92697, USA
    Transl Res 148:196-206. 2006
    ..It was concluded that mixture modeling of phenotypic data may provide a clinical guide for screening with gender-specific thresholds to identify potential samples for genetic testing...
  55. ncbi request reprint Relationships of serum ferritin, transferrin saturation, and HFE mutations and self-reported diabetes in the Hemochromatosis and Iron Overload Screening (HEIRS) study
    Ronald T Acton
    Department of Microbiology, University of Alabama at Birmingham, 1530 3rd Ave South, Birmingham, AL 35294 0005, USA
    Diabetes Care 29:2084-9. 2006
    ....
  56. ncbi request reprint Initial screening transferrin saturation values, serum ferritin concentrations, and HFE genotypes in whites and blacks in the Hemochromatosis and Iron Overload Screening Study
    James C Barton
    Southern Iron Disorders Center, Birmingham, Alabama 35209, USA
    Genet Test 9:231-41. 2005
    ..Possible explanations for differences in TfSat and SF in whites and blacks and pertinence to the detection of hemochromatosis, iron overload, and other disorders with similar phenotypes are discussed...
  57. ncbi request reprint Hemochromatosis and Iron Overload Screening (HEIRS) study design for an evaluation of 100,000 primary care-based adults
    Christine E McLaren
    Epidemiology Division, College of Medicine, University of California, Irvine 92697, USA
    Am J Med Sci 325:53-62. 2003
    ..Participants are recruited from 5 Field Centers. Laboratory testing and data management and analysis are performed in a Central Laboratory and Coordinating Center, respectively...
  58. pmc Characteristics of participants with self-reported hemochromatosis or iron overload at HEIRS study initial screening
    James C Barton
    Southern Iron Disorders Center, Birmingham, Alabama, USA
    Am J Hematol 83:126-32. 2008
    ..Previous H/IO reports in some participants could be explained by treatment that induced iron depletion before initial screening, misdiagnosis, or participant misunderstanding of their physician or the initial screening questionnaire...
  59. pmc Thyroid-stimulating hormone and free thyroxine levels in persons with HFE C282Y homozygosity, a common hemochromatosis genotype: the HEIRS study
    James C Barton
    Southern Iron Disorders Center, 2022 Brookwood Medical Center Drive, Birmingham, AL 35209, USA
    Thyroid 18:831-8. 2008
    ..We evaluated thyroid-stimulating hormone (TSH) and free thyroxine (T4) in white participants of the primary care-based Hemochromatosis and Iron Overload Screening (HEIRS) Study...
  60. pmc HFE C282Y homozygotes have reduced low-density lipoprotein cholesterol: the Atherosclerosis Risk in Communities (ARIC) Study
    James S Pankow
    Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, Minn 55454, USA
    Transl Res 152:3-10. 2008
    ..Reduced LDL in C282Y homozygotes may be because of effects of excess iron on cholesterol metabolism and lipoprotein formation in the liver...
  61. ncbi request reprint Genetic screening for iron overload: No evidence of discrimination at 1 year
    Mark A Hall
    Wake Forest University Medical School, Department of Public Health Sciences, 2000 West 1st Street, Winston Salem, NC 27157 1063, USA
    J Fam Pract 56:829-34. 2007
    ..This study measured the extent of insurance and employment problems associated with population screening for hereditary hemochromatosis and iron overload...
  62. ncbi request reprint HFE C282Y homozygotes aged 25-29 years at HEIRS Study initial screening
    James C Barton
    Southern Iron Disorders Center, Birmingham, Alabama, USA
    Genet Test 11:269-75. 2007
    ..Screening using an elevated TfSat criterion would fail to detect some C282Y homozygotes aged 25-29 years...
  63. ncbi request reprint African Americans at risk for increased iron stores or liver disease
    Fitzroy W Dawkins
    Division of Hematology Oncology, Department of Medicine, Howard University, Washington, DC, USA
    Am J Med 120:734.e1-9. 2007
    ....
  64. ncbi request reprint Results communication and patient education after screening for possible hemochromatosis and iron overload: experience from the HEIRS Study of a large ethnically and linguistically diverse group
    Ann P Walker
    Division of Human Genetics, Department of Pediatrics, University of California, Irvine, Orange, California 92868 3298, USA
    Genet Med 9:778-91. 2007
    ....
  65. ncbi request reprint Determinants and characteristics of mean corpuscular volume and hemoglobin concentration in white HFE C282Y homozygotes in the hemochromatosis and iron overload screening study
    Christine E McLaren
    Department of Epidemiology, University of California, Irvine, California 92697, USA
    Am J Hematol 82:898-905. 2007
    ..2 g/dL higher in women with C282Y/C282Y than in controls. Greater mean MCV in C282Y homozygosity reflects increased mean TfSat and mean SF in men and women; an additional effect of genotype on MCV and Hb was detected in women...
  66. pmc Bivariate mixture modeling of transferrin saturation and serum ferritin concentration in Asians, African Americans, Hispanics, and whites in the Hemochromatosis and Iron Overload Screening (HEIRS) Study
    Christine E McLaren
    Department of Epidemiology, University of California, Irvine, California, USA
    Transl Res 151:97-109. 2008
    ..This approach can identify populations in which hereditary or acquired factors influence metabolism measurement...
  67. pmc Accuracy of family history of hemochromatosis or iron overload: the hemochromatosis and iron overload screening study
    Ronald T Acton
    Department of Microbiology, University of Alabama at Birmingham, Birmingham, Alabama 35209 0005, USA
    Clin Gastroenterol Hepatol 6:934-8. 2008
    ..The aim of this study was to assess the analytic validity of self-reported family history of hemochromatosis or iron overload...
  68. pmc Serum ferritin concentrations and body iron stores in a multicenter, multiethnic primary-care population
    Victor R Gordeuk
    Department of Medicine and Center for Sickle Cell Disease, Howard University, Washington, District of Columbia 20060, USA
    Am J Hematol 83:618-26. 2008
    ..Serum ferritin >900 microg/L in male C282Y homozygotes is predictive of moderately increased iron stores...
  69. ncbi request reprint Randomized controlled trial of total immunosuppression withdrawal in liver transplant recipients: role of ursodeoxycholic acid
    Nimer Assy
    Section of Hepatology, University of Manitoba, Winnipeg, Manitoba Canada, and Liver Unit, Sieff Hospital, Safed, Israel
    Transplantation 83:1571-6. 2007
    ..There are two goals, to determine: 1) whether TIW is frequently associated with rejection; and 2) whether UDCA decreases the risk of liver disease (both rejection and recurrence) after TIW...
  70. pmc A chat on fat in liver
    Christopher Day
    Can J Gastroenterol 20:461-2. 2006
  71. ncbi request reprint Serum ferritin and transferrin saturation in Asians and Pacific Islanders
    Emily L Harris
    Kaiser Permanente Center for Health Research, Portland, OR Honolulu, HI, USA
    Arch Intern Med 167:722-6. 2007
    ....