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Species | P C AdamsSummaryAffiliation: University of Western Ontario Country: Canada Publications
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Publications
Probability of C282Y homozygosity decreases as liver transaminase activities increase in participants with hyperferritinemia in the hemochromatosis and iron overload screening studyPaul C Adams
Division of Gastroenterology, Department of Medicine, London Health Sciences Center, London, Ontario, Canada
Hepatology 55:1722-6. 2012..CONCLUSION: Patients with hyperferritinemia are more likely to be C282Y homozygotes if they have normal liver transaminase activities. This paradox could explain the low yields of hemochromatosis screening reported by some liver clinics...
The natural history of untreated HFE-related hemochromatosisPaul C Adams
University Hospital, London, Ont, Canada
Acta Haematol 122:134-9. 2009..These observations are summarized in this review article which raises questions about the need for phlebotomy in all C282Y homozygous patients...- Screening for iron overload: lessons from the hemochromatosis and iron overload screening (HEIRS) studyPaul Adams
Department of Medicine, London Health Sciences Centre, London, Canada
Can J Gastroenterol 23:769-72. 2009..The HEmochromatosis and IRon Overload Screening (HEIRS) Study provided data on a racially, ethnically and geographically diverse cohort of participants in North America screened from primary care populations... 
Haemochromatosis: find them or forget about them?Paul C Adams
Department of Medicine, London Health Sciences Centre, Ontario, Canada
Eur J Gastroenterol Hepatol 16:857-8. 2004..The demonstration of significant liver disease in family members is a strong reminder of the vital importance of pedigree studies when a typical haemochromatosis patient is identified...- Is serum hepcidin causative in hemochromatosis? Novel analysis from a liver transplant with hemochromatosisPaul C Adams
Department of Medicine, University of Western Ontario, London, Ontario
Can J Gastroenterol 22:851-3. 2008..Hepcidin is a circulating hepatic hormone that regulates iron balance. It has been speculated that hepcidin insufficiency or dysregulation may be the primary defect in genetic hemochromatosis... - Serial serum ferritin measurements in untreated HFE C282Y homozygotes in the Hemochromatosis and Iron Overload Screening StudyP C Adams
Department of Medicine, University Hospital, London, Ontario, Canada
Int J Lab Hematol 30:300-5. 2008..6 g, 0.42-7.1, P < 0.05). SF was as likely to decrease as increase in untreated C282Y homozygotes over this relatively brief observation period. Incremental increases in SF are not inevitable in untreated C282Y homozygotes... - Screening in liver disease: report of an AASLD clinical workshopPaul C Adams
London Health Sciences Centre, London, Ontario, Canada
Hepatology 39:1204-12. 2004..Future screening programs require careful planning and implementation to balance the benefits, risks, and cost-effectiveness. This review outlines the concepts of screening and their application to a broad range of liver diseases... - Comparison of the unsaturated iron-binding capacity with transferrin saturation as a screening test to detect C282Y homozygotes for hemochromatosis in 101,168 participants in the hemochromatosis and iron overload screening (HEIRS) studyPaul C Adams
Department of Medicine, London Health Sciences Center, London, Ontario, Canada
Clin Chem 51:1048-52. 2005 - Hemochromatosis and iron-overload screening in a racially diverse populationPaul C Adams
Department of Medicine, London Health Sciences Centre, London, Ont, Canada
N Engl J Med 352:1769-78. 2005..Iron overload and hemochromatosis are common, treatable conditions. HFE genotypes, levels of serum ferritin, transferrin saturation values, and self-reported medical history were studied in a multiethnic primary care population... - Screening for haemochromatosis--producing or preventing illness?Paul C Adams
London Health Sciences Centre, London, Ontario, N6A 5A5, Canada
Lancet 366:269-71. 2005 - HaemochromatosisPaul C Adams
University Hospital, London, ON, Canada
Lancet 370:1855-60. 2007..Phlebotomy therapy improves hepatic fibrosis. Here, we summarise some new findings in haemochromatosis, a disorder first described in 1865... - Biological variability of transferrin saturation and unsaturated iron-binding capacityPaul C Adams
Department of Medicine, University Hospital, London, Ontario, Canada
Am J Med 120:999.e1-7. 2007..Unsaturated iron-binding capacity has similar performance at lower cost. However, the within-person biological variability of both these tests may limit their ability at commonly used cut points to detect HFE C282Y homozygous patients... - Hemochromatosis case definition: out of focus?Paul C Adams
University Hospital in London, ON, Canada
Nat Clin Pract Gastroenterol Hepatol 3:178-9. 2006 - Expression of ferroportin in hemochromatosis liverPaul C Adams
Department of Medicine, London Health Sciences Centre, University of Western Ontario, London, Ontario, Canada
Blood Cells Mol Dis 31:256-61. 2003..The increase in ferroportin protein without an increase in mRNA is consistent with iron-mediated translational regulation through the 5'IRE in the mRNA... - HFE C282Y homozygosity is associated with lower total and low-density lipoprotein cholesterol: The hemochromatosis and iron overload screening studyPaul C Adams
Department of Medicine, University Hospital, London, Ontario, Canada
Circ Cardiovasc Genet 2:34-7. 2009..Relationships between serum lipids, C282Y homozygosity, and serum ferritin have not been well established... - A diagnostic approach to hyperferritinemia with a non-elevated transferrin saturationPaul C Adams
Department of Medicine, University Hospital, University of Western Ontario, London, Ontario, Canada
J Hepatol 55:453-8. 2011..Three case studies illustrate common problems in interpreting iron blood tests... - Liver diseases in the hemochromatosis and iron overload screening studyPaul C Adams
Department of Medicine, University Hospital, 339 Windermere Road, London, Ontario, Canada N6A 5A5
Clin Gastroenterol Hepatol 4:918-23; quiz 807. 2006..The Hemochromatosis and Iron Overload Screening (HEIRS) Study screened 101,168 primary care participants for iron overload with serum transferrin saturation (TS), ferritin, and C282Y and H63D mutations of the HFE gene... - A primer for predicting risk of disease in HFE-linked hemochromatosisP C Adams
University of Western Ontario, London, Ontario, Canada N6A 5A5
Genet Test 5:311-6. 2001..The risk is highest in men and their C282Y homozygous brothers and significantly lower in homozygous women. Iron overload is uncommon in compound heterozygotes and H63D homozygotes... - Population screening for hemochromatosis--are we finding people with a disease or a biochemical curiosity?Paul C Adams
Department of Medicine, University of Western Ontario, London
Semin Gastrointest Dis 13:89-94. 2002..In this review, the controversial issues surrounding population screening for hemochromatosis are explored in the context of available information from large screening studies... - How I treat hemochromatosisPaul C Adams
University Hospital, University of Western Ontario, London, ON, Canada
Blood 116:317-25. 2010.... - Lessons from liver transplantation: flip, flop, and why?P C Adams
Department of Medicine, London Health Sciences Centre, 339 Windermere Rd, London, Ontario, Canada N6A 5A5
Gut 52:318. 2003 - Genotypic/phenotypic correlations in genetic hemochromatosis: evolution of diagnostic criteriaP C Adams
Department of Medicine, University of Western Ontario, London, Canada
Gastroenterology 114:319-23. 1998..The aim of this study was to reassess the phenotypic diagnostic criteria for hemochromatosis in patients homozygous for the C282Y mutation of the HFE gene... - Population screening for hemochromatosis: a comparison of unbound iron-binding capacity, transferrin saturation, and C282Y genotyping in 5,211 voluntary blood donorsP C Adams
Department of Medicine, University of Western Ontario, London, Ontario, Canada
Hepatology 31:1160-4. 2000..93 (0. 85-1.0, 95% confidence interval), and for TS of 0.83 (0.7-0.95). Screening with UIBC to preselect those for genotyping is a cost-efficient strategy for population screening for hemochromatosis... - Review article: the modern diagnosis and management of haemochromatosisP C Adams
Department of Medicine, University of Western Ontario, London, Ontario, Canada
Aliment Pharmacol Ther 23:1681-91. 2006..However, a growing number of new iron-related genes have been discovered and linked to other iron overload syndromes... - Psychosocial impact of C282Y mutation testing for hemochromatosisT E Power
Department of Psychology, University of Western Ontario, London, Canada
Genet Test 5:107-10. 2001..Genetic testing for hemochromatosis is well accepted and should not be discouraged on the basis of potential adverse psychosocial effects... - Long-term survival analysis in hereditary hemochromatosisP C Adams
Department of Medicine, University of Western Ontario, London, Canada
Gastroenterology 101:368-72. 1991..The presence of cirrhosis significantly increases mortality and is the major clinical factor affecting survival... - Is there a threshold of hepatic iron concentration that leads to cirrhosis in C282Y hemochromatosis?P C Adams
London Health Sciences Centre, University of Western Ontario, Canada
Am J Gastroenterol 96:567-9. 2001..The objective of this study was to determine if a threshold for hepatic iron concentration leads to the development of cirrhosis in C282Y hemochromatosis... - Natural history of C282Y homozygotes for hemochromatosisJohn P Wojcik
Department of Medicine, University of Western Ontario, London, Canada
Can J Gastroenterol 16:297-302. 2002..To study the clinical outcomes of subjects who are homozygous for the C282Y mutation of the hemochromatosis gene... - A nomogram to predict C282Y hemochromatosisJerry S McGrath
Department of Medicine, London Health Sciences Centre, Ontario, Canada
J Lab Clin Med 140:6-8. 2002..9-8.1). This approach allows the clinician to predict the probability of a patient's being a C282Y homozygote over a wide range of ferritin and transferrin saturation values instead of above a particular threshold... - Factors affecting glucose tolerance in hereditary hemochromatosisI M Hramiak
Department of Medicine, University of Western Ontario, London
Clin Invest Med 20:110-8. 1997..These mechanisms include decreased beta-cell secretion of insulin due to iron overload, insulin resistance and genetic factors... - Screening for hemochromatosis and iron overload: satisfaction with results notification and understanding of mailed results in unaffected participants of the HEIRS studyHelen F Harrison
Department of Medicine, London Health Sciences Centre, London, Ontario, Canada
Genet Test 12:491-500. 2008.... - Natural history of the C282Y homozygote for the hemochromatosis gene (HFE) with a normal serum ferritin levelCory Yamashita
Department of Medicine, London Health Sciences Centre, 339 Windermere Road, London, Ontario, Canada N6A 5A5
Clin Gastroenterol Hepatol 1:388-91. 2003..The long-term prognosis, rate of iron accumulation, and surveillance guidelines for these individuals are unknown... - Rate of iron reaccumulation following iron depletion in hereditary hemochromatosis. Implications for venesection therapyP C Adams
Department of Medicine, University Hospital, University of Western Ontario, London, Canada
J Clin Gastroenterol 16:207-10. 1993..Annual monitoring of body iron stores with reinstitution of weekly venesection when the serum ferritin exceeds the upper limit of normal was a safe alternative to long-term maintenance venesection... - Assessment of silent liver fibrosis in hemochromatosis C282Y homozygotes with normal transaminase levelsMelanie Beaton
Department of Medicine, University Hospital, London, Ontario, Canada
Clin Gastroenterol Hepatol 6:713-4. 2008..The objective of this study was to assess the degree of liver injury in referred C282Y homozygotes who underwent elective liver biopsy and had serum AST and ALT levels < 40 IU/L... - Prognostic factors and survival in patients with hereditary hemochromatosis and cirrhosisMelanie D Beaton
Department of Gastroenterology, University of Western Ontario, London, Ontario
Can J Gastroenterol 20:257-60. 2006..Early diagnosis and treatment of hereditary hemochromatosis by preventing the development of cirrhosis may reduce the incidence of hepatocellular carcinoma in the future... - Heme-oxygenase-mediated iron accumulation in the liverZia A Khan
Department of Pathology, University of Western Ontario, London, Canada
Can J Physiol Pharmacol 82:448-56. 2004..Our data provides evidence of increased HO activity as an important pro-oxidant mechanism leading to iron accumulation in the liver... - Hemochromatosis patients as voluntary blood donorsTara E Power
Department of Psychology, University of Western Ontario, London, Canada
Can J Gastroenterol 18:393-6. 2004.... - Hemochromatosis. Common genes, uncommon illness?Helen Harrison
London Health Sciences Centre, London, Ont
Can Fam Physician 48:1326-33. 2002..To increase family physicians' awareness of the prevalence of hemochromatosis and to suggest strategies for diagnosis and management of hemochromatosis with the goal of decreasing the development of associated life-threatening conditions... - The diversity of liver diseases among outpatient referrals for an elevated serum ferritinKaren Wong
Department of Medicine, Division of Gastroenterology, University of Western Ontario, London, Canada
Can J Gastroenterol 20:467-70. 2006..CONCLUSION: HFE-linked hemochromatosis accounted for less than one-half of the diagnoses in an outpatient population referred for elevated ferritin, suggesting a need to search further for an alternate cause... - Psychosocial impact of genetic testing for hemochromatosis in the HEIRS Study: a comparison of participants recruited in Canada and in the United StatesTara E Power
London Ontario Health Sciences Center, London, Ontario, Canada
Genet Test 11:55-64. 2007..S. individuals, although fewer Canadians may experience a negative response to such testing... - HemochromatosisPaul C Adams
Department of Medicine, University of Western Ontario, London Health Sciences Centre, University Campus, P.O. Box 5339, London, Ontario N6A 5A5, Canada
Clin Liver Dis 8:735-53, vii. 2004..The discovery of the gene has led to a genetic blood test useful in the diagnosis of hemochromatosis. Treatment by phlebotomy is simple and efficient and can prevent the development of cirrhosis, leading to a normal life expectancy... - Phenotype variation in C282Y homozygotes for the hemochromatosis geneAdriana Lazarescu
Department of Medicine, University of Western Ontario, London, Ontario, Canada
Clin Gastroenterol Hepatol 3:1043-6. 2005..In addition, these results support the hypothesis that other genes contribute to the variance in serum ferritin concentration among C282Y homozygotes... - Glucose-induced regulation of novel iron transporters in vascular endothelial cell dysfunctionZia A Khan
Department of Pathology, University of Western Ontario, London, Canada
Free Radic Res 39:1203-10. 2005..In conclusion, our study suggests that glucose-induced alteration of iron transporters may arbitrate iron accumulation and oxidative stress in endothelial cells... - Variation in physician reimbursement for endoscopy across CanadaL S Roth
University of Western Ontario, London Health Sciences Centre, London, Canada
Can J Gastroenterol 23:503-5. 2009..Fees are set provincially, and the consistency with regard to compensation for colonoscopy and gastroscopy across the provinces has yet to be established... - Induction versus noninduction antiviral therapy for chronic hepatitis C virus in patients with congenital coagulation disorders: a Canadian multicentre trialA Chatterjee
University of Toronto University Health Network, Toronto Western Hospital, 399 Bathurst Street, Toronto, Ontario, Canada
Can J Gastroenterol 21:91-5. 2007..The present study compared induction therapy with interferon-alpha (IFN-alpha)-2b with standard IFN-alpha2b therapy. Pegylated IFN was not available at the time that the study was initiated... - A Canadian multicenter retrospective study evaluating transjugular liver biopsy in patients with congenital bleeding disorders and hepatitis C: is it safe and useful?Jennifer L Shin
Department of Medicine at University Health Network, University of Toronto, Toronto, Ontario, Canada
Am J Hematol 78:85-93. 2005..We conclude that this procedure can be safely performed on an outpatient basis. The diagnosis of cirrhosis and/or portal hypertension was made in a substantial proportion of individuals (26%), all of whom had asymptomatic liver disease... - Time to endoscopy and outcomes in upper gastrointestinal bleedingN Sarin
University of Western Ontario, London, Canada
Can J Gastroenterol 23:489-93. 2009..The present retrospective review of endoscopies performed at a large teaching hospital assessed the timing of endoscopy with respect to the morbidity and mortality of UGIB... - The myths and realities of hemochromatosisMelanie D Beaton
Department of Medicine, London Health Sciences Centre, 339 Windermere Road, London, Ontario, Canada
Can J Gastroenterol 21:101-4. 2007..Genetic testing is widely available and particularly useful in family studies. Hemochromatosis can be readily diagnosed and treated. The purpose of the present review is to address the medical myths and misconceptions of hemochromatosis... - Thyroid-stimulating hormone and free thyroxine levels in persons with HFE C282Y homozygosity, a common hemochromatosis genotype: the HEIRS studyJames C Barton
Southern Iron Disorders Center, 2022 Brookwood Medical Center Drive, Birmingham, AL 35209, USA
Thyroid 18:831-8. 2008..We evaluated thyroid-stimulating hormone (TSH) and free thyroxine (T4) in white participants of the primary care-based Hemochromatosis and Iron Overload Screening (HEIRS) Study... - Hemochromatosis (HFE) gene splice site mutation IVS5+1 G/A in North American Vietnamese with and without phenotypic evidence of iron overloadMichael Steiner
Institute of Clinical Chemistry and Laboratory Medicine, University of Rostock, Rostock, Germany
Transl Res 149:92-5. 2007..32% for cases and 2.04% for controls (P>0.5). This finding suggests that the HFE IVS5+1 G/A splice site mutation is not the major explanation for unexpectedly high prevalence of TS and SF in North American Asians... - Geographic and racial/ethnic differences in HFE mutation frequencies in the Hemochromatosis and Iron Overload Screening (HEIRS) StudyRonald T Acton
Department of Microbiology, University of Alabama at Birmingham 35209 0005, USA
Ethn Dis 16:815-21. 2006..To assess geographic differences in the frequencies of HFE C282Y and H63D genotypes in six racial/ethnic groups recruited in the Hemochromatosis and Iron Overload Screening (HEIRS) Study... - A diagnostic approach to hemochromatosisAnthony S Tavill
Case Western Reserve School of Medicine and Cleveland Clinic, Ohio, USA
Can J Gastroenterol 20:535-40. 2006..The authors offer a stepwise, diagnostic algorithm based on current evidence-based data, that they regard as most cost-effective. An early diagnosis can lead to phlebotomy therapy to prevent the development of cirrhosis... - Mixture models of serum iron measures in population screening for hemochromatosis and iron overloadChristine E McLaren
Epidemiology Division, Department of Medicine, University of California, Irvine, CA 92697, USA
Transl Res 148:196-206. 2006..It was concluded that mixture modeling of phenotypic data may provide a clinical guide for screening with gender-specific thresholds to identify potential samples for genetic testing... - Hemochromatosis and Iron Overload Screening (HEIRS) study design for an evaluation of 100,000 primary care-based adultsChristine E McLaren
Epidemiology Division, College of Medicine, University of California, Irvine 92697, USA
Am J Med Sci 325:53-62. 2003..Participants are recruited from 5 Field Centers. Laboratory testing and data management and analysis are performed in a Central Laboratory and Coordinating Center, respectively... - Relationships of serum ferritin, transferrin saturation, and HFE mutations and self-reported diabetes in the Hemochromatosis and Iron Overload Screening (HEIRS) studyRonald T Acton
Department of Microbiology, University of Alabama at Birmingham, 1530 3rd Ave South, Birmingham, AL 35294 0005, USA
Diabetes Care 29:2084-9. 2006.... - HFE C282Y homozygotes have reduced low-density lipoprotein cholesterol: the Atherosclerosis Risk in Communities (ARIC) StudyJames S Pankow
Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, Minn 55454, USA
Transl Res 152:3-10. 2008..Reduced LDL in C282Y homozygotes may be because of effects of excess iron on cholesterol metabolism and lipoprotein formation in the liver... - Accuracy of family history of hemochromatosis or iron overload: the hemochromatosis and iron overload screening studyRonald T Acton
Department of Microbiology, University of Alabama at Birmingham, Birmingham, Alabama 35209 0005, USA
Clin Gastroenterol Hepatol 6:934-8. 2008..Background &.. - Association of ferroportin Q248H polymorphism with elevated levels of serum ferritin in African Americans in the Hemochromatosis and Iron Overload Screening (HEIRS) StudyCharles A Rivers
Departments of Microbiology, Medicine, and Epidemiology and International Health, University of Alabama at Birmingham, Birmingham, AL 35294, USA
Blood Cells Mol Dis 38:247-52. 2007..012). There were no significant differences in Q248H frequencies in men and women control participants. We conclude that the frequency of the FPN1 Q248H polymorphism is greater in AA men with elevated SF than in those with normal SF... - Determinants and characteristics of mean corpuscular volume and hemoglobin concentration in white HFE C282Y homozygotes in the hemochromatosis and iron overload screening studyChristine E McLaren
Department of Epidemiology, University of California, Irvine, California 92697, USA
Am J Hematol 82:898-905. 2007..2 g/dL higher in women with C282Y/C282Y than in controls. Greater mean MCV in C282Y homozygosity reflects increased mean TfSat and mean SF in men and women; an additional effect of genotype on MCV and Hb was detected in women... - African Americans at risk for increased iron stores or liver diseaseFitzroy W Dawkins
Division of Hematology Oncology, Department of Medicine, Howard University, Washington, DC, USA
Am J Med 120:734.e1-9. 2007.... - Characteristics of participants with self-reported hemochromatosis or iron overload at HEIRS study initial screeningJames C Barton
Southern Iron Disorders Center, Birmingham, Alabama, USA
Am J Hematol 83:126-32. 2008..Previous H/IO reports in some participants could be explained by treatment that induced iron depletion before initial screening, misdiagnosis, or participant misunderstanding of their physician or the initial screening questionnaire... - Genetic screening for iron overload: No evidence of discrimination at 1 yearMark A Hall
Wake Forest University Medical School, Department of Public Health Sciences, 2000 West 1st Street, Winston Salem, NC 27157 1063, USA
J Fam Pract 56:829-34. 2007..This study measured the extent of insurance and employment problems associated with population screening for hereditary hemochromatosis and iron overload... - HFE C282Y homozygotes aged 25-29 years at HEIRS Study initial screeningJames C Barton
Southern Iron Disorders Center, Birmingham, Alabama, USA
Genet Test 11:269-75. 2007..Screening using an elevated TfSat criterion would fail to detect some C282Y homozygotes aged 25-29 years... - Results communication and patient education after screening for possible hemochromatosis and iron overload: experience from the HEIRS Study of a large ethnically and linguistically diverse groupAnn P Walker
Division of Human Genetics, Department of Pediatrics, University of California, Irvine, Orange, California 92868 3298, USA
Genet Med 9:778-91. 2007.... - Initial screening transferrin saturation values, serum ferritin concentrations, and HFE genotypes in whites and blacks in the Hemochromatosis and Iron Overload Screening StudyJames C Barton
Southern Iron Disorders Center, Birmingham, Alabama 35209, USA
Genet Test 9:231-41. 2005..Possible explanations for differences in TfSat and SF in whites and blacks and pertinence to the detection of hemochromatosis, iron overload, and other disorders with similar phenotypes are discussed... - Serum ferritin concentrations and body iron stores in a multicenter, multiethnic primary-care populationVictor R Gordeuk
Department of Medicine and Center for Sickle Cell Disease, Howard University, Washington, District of Columbia 20060, USA
Am J Hematol 83:618-26. 2008..Serum ferritin >900 microg/L in male C282Y homozygotes is predictive of moderately increased iron stores... - Bivariate mixture modeling of transferrin saturation and serum ferritin concentration in Asians, African Americans, Hispanics, and whites in the Hemochromatosis and Iron Overload Screening (HEIRS) StudyChristine E McLaren
Department of Epidemiology, University of California, Irvine, California, USA
Transl Res 151:97-109. 2008..This approach can identify populations in which hereditary or acquired factors influence metabolism measurement... - Randomized controlled trial of total immunosuppression withdrawal in liver transplant recipients: role of ursodeoxycholic acidNimer Assy
Section of Hepatology, University of Manitoba, Winnipeg, Manitoba Canada, and Liver Unit, Sieff Hospital, Safed, Israel
Transplantation 83:1571-6. 2007..There are two goals, to determine: 1) whether TIW is frequently associated with rejection; and 2) whether UDCA decreases the risk of liver disease (both rejection and recurrence) after TIW... - Serum ferritin and transferrin saturation in Asians and Pacific IslandersEmily L Harris
Kaiser Permanente Center for Health Research, Portland, OR Honolulu, HI, USA
Arch Intern Med 167:722-6. 2007.... - A chat on fat in liverChristopher Day
Can J Gastroenterol 20:461-2. 2006