Darryl J Adamko

Summary

Affiliation: University of Alberta
Country: Canada

Publications

  1. ncbi request reprint Investigations of the effects of gender, diurnal variation, and age in human urinary metabolomic profiles
    Carolyn M Slupsky
    Department of Medicine and Magnetic Resonance Diagnostic Centre, University of Alberta, Edmonton, Alberta, Canada
    Anal Chem 79:6995-7004. 2007
  2. doi request reprint Metabolomic biomarkers in a model of asthma exacerbation: urine nuclear magnetic resonance
    Erik J Saude
    Department of Pediatrics, University of Alberta, Alberta, Canada
    Am J Respir Crit Care Med 179:25-34. 2009
  3. ncbi request reprint [A pilot trial on the treatment of gastroesophageal reflux-related cough in infants]
    Darryl J Adamko
    Department of Pediatrics, University of Saskatchewan, Canada
    Zhongguo Dang Dai Er Ke Za Zhi 14:321-7. 2012
  4. doi request reprint The effect of cationic charge on release of eosinophil mediators
    Darryl J Adamko
    Department of Pediatrics, Pulmonary Research Group, University of Alberta, Edmonton, Alberta, Canada
    J Allergy Clin Immunol 122:383-90, 390.e1-4. 2008
  5. ncbi request reprint The induction of eosinophil peroxidase release: improved methods of measurement and stimulation
    Darryl J Adamko
    The Pulmonary Research Group, Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada
    J Immunol Methods 291:101-8. 2004
  6. doi request reprint Rhinovirus has the unique ability to directly activate human T cells in vitro
    Ramses Ilarraza
    Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada
    J Allergy Clin Immunol 131:395-404. 2013
  7. doi request reprint Virus-induced eosinophil mediator release requires antigen-presenting and CD4+ T cells
    Francis Davoine
    Pulmonary Research Group, Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
    J Allergy Clin Immunol 122:69-77, 77.e1-2. 2008
  8. doi request reprint Compound CVT-E002 attenuates allergen-induced airway inflammation and airway hyperresponsiveness, in vivo
    Cory Ebeling
    Pulmonary Research Group, Department of Pediatrics, University of Alberta, Edmonton, AB, Canada
    Mol Nutr Food Res 55:1905-8. 2011
  9. doi request reprint Montelukast inhibits leukotriene stimulation of human dendritic cells in vitro
    Ramses Ilarraza
    Pulmonary Research Group, Departments of Pediatrics, University of Alberta, Edmonton, Alta, Canada
    Int Arch Allergy Immunol 159:422-7. 2012
  10. doi request reprint Metabolomic profiling of asthma: diagnostic utility of urine nuclear magnetic resonance spectroscopy
    Erik J Saude
    Department of Pediatrics, University of Alberta, Magnetic Resonance Diagnostics Centre, Edmonton, Alberta, Canada
    J Allergy Clin Immunol 127:757-64.e1-6. 2011

Collaborators

  • R Moqbel
  • Paige Lacy
  • David Chang
  • Carolyn M Slupsky
  • T J Marrie
  • David Proud
  • Don D Sin
  • S F Paul Man
  • Allan Becker
  • B H Rowe
  • D Y Kunimoto
  • Ramses Ilarraza
  • Francis Davoine
  • Yingqi Wu
  • Christopher Skappak
  • Erik J Saude
  • Cory Ebeling
  • Farnam Ajamian
  • Shana Regush
  • Christopher D Skappak
  • Brian D Sykes
  • Marcelo Marcet-Palacios
  • Peter D Borszcz
  • Po Yin Cheung
  • Sibina Fisher
  • Charlie Tang
  • Caroline Ethier
  • Adrian Sim
  • Lakshmi Puttagunta
  • Lisa Cameron
  • W Tim McGaw
  • Donald Yu
  • John R Gordon
  • Amos Ben-Zvi
  • Kim Cook
  • Ray L Somorjai
  • Brion K Dolenko
  • Taisir Ahmad
  • Idongesit P Obiefuna
  • Min Cao
  • Andy I Kokaji
  • A Dean Befus
  • Jamila Chakir
  • Joo Eun Lee
  • Michel Laviolette
  • Claudine Ferland
  • Dean Befus

Detail Information

Publications19

  1. ncbi request reprint Investigations of the effects of gender, diurnal variation, and age in human urinary metabolomic profiles
    Carolyn M Slupsky
    Department of Medicine and Magnetic Resonance Diagnostic Centre, University of Alberta, Edmonton, Alberta, Canada
    Anal Chem 79:6995-7004. 2007
    ..The mechanisms by which these differences arise will be key to the discovery of new diagnostic tests and new understandings of the mechanism of disease...
  2. doi request reprint Metabolomic biomarkers in a model of asthma exacerbation: urine nuclear magnetic resonance
    Erik J Saude
    Department of Pediatrics, University of Alberta, Alberta, Canada
    Am J Respir Crit Care Med 179:25-34. 2009
    ....
  3. ncbi request reprint [A pilot trial on the treatment of gastroesophageal reflux-related cough in infants]
    Darryl J Adamko
    Department of Pediatrics, University of Saskatchewan, Canada
    Zhongguo Dang Dai Er Ke Za Zhi 14:321-7. 2012
    ..Second, in a randomized placebo-controlled fashion, we determined whether treatment of GER with bethanacol and omeprazole could improve these respiratory symptoms...
  4. doi request reprint The effect of cationic charge on release of eosinophil mediators
    Darryl J Adamko
    Department of Pediatrics, Pulmonary Research Group, University of Alberta, Edmonton, Alberta, Canada
    J Allergy Clin Immunol 122:383-90, 390.e1-4. 2008
    ..Although the role of cytokines in cell activation is well established, the presence of cationic-charged tissue can also be an important factor in inflammatory cell function...
  5. ncbi request reprint The induction of eosinophil peroxidase release: improved methods of measurement and stimulation
    Darryl J Adamko
    The Pulmonary Research Group, Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada
    J Immunol Methods 291:101-8. 2004
    ..Finally, using this technique, we have been able to demonstrate secretory IgA (s-IgA)-induced release of EPO. By using OPD, we have developed a more sensitive and specific method to analyze the release of extracellular EPO...
  6. doi request reprint Rhinovirus has the unique ability to directly activate human T cells in vitro
    Ramses Ilarraza
    Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada
    J Allergy Clin Immunol 131:395-404. 2013
    ..These findings suggested that antigen presentation was important for T-cell activation...
  7. doi request reprint Virus-induced eosinophil mediator release requires antigen-presenting and CD4+ T cells
    Francis Davoine
    Pulmonary Research Group, Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
    J Allergy Clin Immunol 122:69-77, 77.e1-2. 2008
    ..We hypothesize that human eosinophils respond to viruses, although only after interaction with T cells...
  8. doi request reprint Compound CVT-E002 attenuates allergen-induced airway inflammation and airway hyperresponsiveness, in vivo
    Cory Ebeling
    Pulmonary Research Group, Department of Pediatrics, University of Alberta, Edmonton, AB, Canada
    Mol Nutr Food Res 55:1905-8. 2011
    ..This correlated with an increased presence of interferon-γ in the lung, and also increased regulatory T cells and IL-10. The ability of CVT-E002 to induce regulatory T-cell development was also seen in human in vitro co-cultures...
  9. doi request reprint Montelukast inhibits leukotriene stimulation of human dendritic cells in vitro
    Ramses Ilarraza
    Pulmonary Research Group, Departments of Pediatrics, University of Alberta, Edmonton, Alta, Canada
    Int Arch Allergy Immunol 159:422-7. 2012
    ..We also studied the effect of LTC(4) in the context of response to an airway virus (respiratory syncytial virus, RSV)...
  10. doi request reprint Metabolomic profiling of asthma: diagnostic utility of urine nuclear magnetic resonance spectroscopy
    Erik J Saude
    Department of Pediatrics, University of Alberta, Magnetic Resonance Diagnostics Centre, Edmonton, Alberta, Canada
    J Allergy Clin Immunol 127:757-64.e1-6. 2011
    ..The ability to diagnose and monitor asthma on the basis of noninvasive measurements of airway cellular dysfunction is difficult in the typical clinical setting...
  11. doi request reprint Human dendritic cells promote an antiviral immune response when stimulated by CVT-E002
    Ramses Ilarraza
    Department of Pediatrics, University of Alberta, Edmonton, AB, Canada
    J Pharm Pharmacol 63:670-8. 2011
    ..We hypothesized that the mechanism for this antiviral effect could be through modulation of dendritic cells leading to enhanced T-cell activation...
  12. doi request reprint The metabolomics of asthma: novel diagnostic potential
    Darryl J Adamko
    Department of Pediatrics, University of Alberta, Edmonton, AB, Canada
    Chest 141:1295-302. 2012
    ..The pattern of metabolites becomes the diagnostic representing the disease. This article outlines the more recent work that has been done to develop the metabolomic profile of asthma...
  13. ncbi request reprint Interleukin-12 inhibits eosinophil degranulation and migration but does not promote eosinophil apoptosis
    Francis Davoine
    Pulmonary Research Group, Department of Medicine, University of Alberta, Edmonton, Canada
    Int Arch Allergy Immunol 140:277-84. 2006
    ..We postulated that IL-12 directly modulates eosinophil functions and has the capacity to regulate eosinophil degranulation, migration and survival, in vitro...
  14. pmc Identifying hypoxia in a newborn piglet model using urinary NMR metabolomic profiling
    Christopher Skappak
    Department of Pediatrics, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada
    PLoS ONE 8:e65035. 2013
    ..This was better than using physiologic measures alone. Metabolomic profiling of urine has potential for identifying neonates that have undergone episodes of hypoxia...
  15. ncbi request reprint Human lymphocytes express the transcriptional regulator, Wilms tumor 1: the role of WT1 in mediating nitric oxide-dependent repression of lymphocyte proliferation
    Marcelo Marcet-Palacios
    Pulmonary Research Group, Department of Medicine, 550A Heritage Medical Research Centre, University of Alberta, Edmonton, Alta, Canada
    Biochem Biophys Res Commun 363:283-7. 2007
    ..We conclude that WT1 might be an important component of the NO-dependent regulation of T lymphocyte proliferation and potential function...
  16. ncbi request reprint Effects of clarithromycin on inflammatory cell mediator release and survival
    Peter D Borszcz
    Pulmonary Research Group, Department of Medicine, University of Alberta, Edmonton, Canada
    Chemotherapy 51:206-10. 2005
    ..The mode of anti-inflammatory effects of clarithromycin on inflammatory cells is not well understood. We hypothesized that clarithromycin inhibits inflammatory cell mediator release and survival...
  17. pmc Eosinophils in human oral squamous carcinoma; role of prostaglandin D2
    Francis Davoine
    Pulmonary Research Group, University of Alberta, 559 Heritage Medical Research Centre, Edmonton, Alberta T6G 2S2, Canada
    J Inflamm (Lond) 10:4. 2013
    ..Our data suggest that OSC-derived PGD2 may play an important role via CRTH2 (the PGD2 receptor on eosinophils) in eosinophil recruitment and subsequent anti-tumor activity through the action of eosinophil cationic proteins...
  18. doi request reprint Pneumococcal pneumonia: potential for diagnosis through a urinary metabolic profile
    Carolyn M Slupsky
    Department of Medicine, Magnetic Resonance Diagnostic Centre, University of Alberta, Edmonton, Alberta, Canada
    J Proteome Res 8:5550-8. 2009
    ..These data demonstrate that urinary metabolomic profiles may be useful for the effective diagnosis of CAP...
  19. ncbi request reprint CD8+ T lymphocytes in viral hyperreactivity and M2 muscarinic receptor dysfunction
    Darryl J Adamko
    Department of Environmental Health Sciences, School of Hygiene and Public Health, Johns Hopkins University, Baltimore, Maryland 21224, USA
    Am J Respir Crit Care Med 167:550-6. 2003
    ..In contrast, CD8+ T cells are not necessary for virus-induced hyperreactivity and M2R dysfunction in nonsensitized guinea pigs...