Jacques Turgeon

Summary

Country: Canada

Publications

  1. ncbi request reprint The pharmacokinetics of ezetimibe
    Chantale Simard
    Universite de Montreal, Quebec
    Can J Clin Pharmacol 10:13A-20A. 2003
  2. doi request reprint Effects of AGTR1 A1166C gene polymorphism in patients with heart failure treated with candesartan
    Simon de Denus
    Faculty of Pharmacy, University of Montreal, Montreal Heart Institute, Montreal, QC, Canada
    Ann Pharmacother 42:925-32. 2008
  3. pmc Understanding clopidogrel efficacy in the presence of cytochrome P450 polymorphism
    Jacques Turgeon
    Faculte de Pharmacie, Universite de Montreal, Montreal, Que
    CMAJ 174:1729. 2006
  4. doi request reprint Lengthening of cardiac repolarization in isolated guinea pigs hearts by sequential or concomitant administration of two IKr blockers
    Raymond Hreiche
    Faculty of Pharmacy, Universite de Montreal, Montreal, Quebec, Canada
    J Pharm Sci 100:2469-81. 2011
  5. doi request reprint Genetic determinants of response to aspirin: appraisal of 4 candidate genes
    Marie Lordkipanidzé
    Faculty of Pharmacy, Universite de Montreal, C P 6128, Succ Centre Ville, Montreal, Quebec, Canada
    Thromb Res 128:47-53. 2011
  6. doi request reprint Week-long high-maintenance dose clopidogrel regimen achieves better platelet aggregation inhibition than a standard loading dose before percutaneous coronary intervention: results of a double-blind, randomized clinical trial
    Thuy Anh Nguyen
    Faculties of Pharmacy, Universite de Montreal, Montreal, Canada
    J Interv Cardiol 22:368-77. 2009
  7. doi request reprint Increased risk of myocardial infarction associated with angiotensin-converting enzyme gene polymorphism is age dependent
    Bettina A Hamelin
    Quebec Heart Institute, Quebec, Canada
    J Clin Pharmacol 51:1286-92. 2011
  8. doi request reprint Association between renal function and CYP3A5 genotype in heart transplant recipients treated with calcineurin inhibitors
    Simon de Denus
    Faculty of Pharmacy, Universite de Montreal, Montreal, Quebec, Canada
    J Heart Lung Transplant 30:326-31. 2011
  9. ncbi request reprint A comparison of six major platelet function tests to determine the prevalence of aspirin resistance in patients with stable coronary artery disease
    Marie Lordkipanidzé
    Faculty of Pharmacy, Universite de Montreal, Montreal, Quebec, Canada
    Eur Heart J 28:1702-8. 2007
  10. doi request reprint Validation of warfarin pharmacogenetic algorithms in clinical practice
    Mélina Marin-Leblanc
    Faculte de Pharmacie, Universite de Montreal, Montreal, Quebec, Canada
    Pharmacogenomics 13:21-9. 2012

Collaborators

Detail Information

Publications21

  1. ncbi request reprint The pharmacokinetics of ezetimibe
    Chantale Simard
    Universite de Montreal, Quebec
    Can J Clin Pharmacol 10:13A-20A. 2003
    ..5- to 2-fold. So far, no drug interaction study has been associated with major changes in either the pharmokinetics of ezetimibe or coadministered drugs...
  2. doi request reprint Effects of AGTR1 A1166C gene polymorphism in patients with heart failure treated with candesartan
    Simon de Denus
    Faculty of Pharmacy, University of Montreal, Montreal Heart Institute, Montreal, QC, Canada
    Ann Pharmacother 42:925-32. 2008
    ..It is currently impossible to determine which patient will benefit from the addition of an ARB...
  3. pmc Understanding clopidogrel efficacy in the presence of cytochrome P450 polymorphism
    Jacques Turgeon
    Faculte de Pharmacie, Universite de Montreal, Montreal, Que
    CMAJ 174:1729. 2006
  4. doi request reprint Lengthening of cardiac repolarization in isolated guinea pigs hearts by sequential or concomitant administration of two IKr blockers
    Raymond Hreiche
    Faculty of Pharmacy, Universite de Montreal, Montreal, Quebec, Canada
    J Pharm Sci 100:2469-81. 2011
    ..Furthermore, order of administration of two I(Kr) blockers together may be an important factor in drug-induced long QT syndrome...
  5. doi request reprint Genetic determinants of response to aspirin: appraisal of 4 candidate genes
    Marie Lordkipanidzé
    Faculty of Pharmacy, Universite de Montreal, C P 6128, Succ Centre Ville, Montreal, Quebec, Canada
    Thromb Res 128:47-53. 2011
    ....
  6. doi request reprint Week-long high-maintenance dose clopidogrel regimen achieves better platelet aggregation inhibition than a standard loading dose before percutaneous coronary intervention: results of a double-blind, randomized clinical trial
    Thuy Anh Nguyen
    Faculties of Pharmacy, Universite de Montreal, Montreal, Canada
    J Interv Cardiol 22:368-77. 2009
    ..This study evaluated the effect on platelet aggregation of four different dosing regimens of clopidogrel given before elective PCI in a randomized, prospective, double-blind, and placebo-controlled design...
  7. doi request reprint Increased risk of myocardial infarction associated with angiotensin-converting enzyme gene polymorphism is age dependent
    Bettina A Hamelin
    Quebec Heart Institute, Quebec, Canada
    J Clin Pharmacol 51:1286-92. 2011
    ..05). Similar observations were obtained versus the healthy elderly men (P < .05). The ACE-I/D polymorphism seems to be a genetic risk factor for MI in young men and becomes an important modulator of MI risk at a young age...
  8. doi request reprint Association between renal function and CYP3A5 genotype in heart transplant recipients treated with calcineurin inhibitors
    Simon de Denus
    Faculty of Pharmacy, Universite de Montreal, Montreal, Quebec, Canada
    J Heart Lung Transplant 30:326-31. 2011
    ..The aim of this study was to evaluate the association between polymorphisms of the genes encoding these proteins and the long-term renal function of heart transplant recipients treated with calcineurin inhibitors...
  9. ncbi request reprint A comparison of six major platelet function tests to determine the prevalence of aspirin resistance in patients with stable coronary artery disease
    Marie Lordkipanidzé
    Faculty of Pharmacy, Universite de Montreal, Montreal, Quebec, Canada
    Eur Heart J 28:1702-8. 2007
    ..We sought to compare the results obtained from six major platelet function tests in the assessment of the prevalence of aspirin resistance in patients with stable coronary artery disease...
  10. doi request reprint Validation of warfarin pharmacogenetic algorithms in clinical practice
    Mélina Marin-Leblanc
    Faculte de Pharmacie, Universite de Montreal, Montreal, Quebec, Canada
    Pharmacogenomics 13:21-9. 2012
    ..Michaud et al., Wadelius et al. and the International Warfarin Pharmacogenetics Consortium algorithm...
  11. doi request reprint An evaluation of pharmacists' expectations towards pharmacogenomics
    Simon de Denus
    Universite de Montreal, Montreal, Canada
    Pharmacogenomics 14:165-75. 2013
    ..However, little is known about the opinions of pharmacists towards pharmacogenomics or their willingness to integrate this new field in their practice...
  12. pmc Metabolic activity and mRNA levels of human cardiac CYP450s involved in drug metabolism
    Veronique Michaud
    Research Centre of the University of Montreal Hospital Centre CRCHUM, Centre Hospitalier de l Université de Montréal and Faculty of Pharmacy, Universite de Montreal, Montreal, Quebec, Canada
    PLoS ONE 5:e15666. 2010
    ..The overall objective of our study was to determine in a large cohort of samples, mRNA levels and CYP450 activity expressed in the human heart...
  13. doi request reprint Prevalence and risk of potential cytochrome P450-mediated drug-drug interactions in older hospitalized patients with polypharmacy
    Julie Doan
    Sir Mortimer B Davis Jewish General Hospital, Faculty of Pharmacy, Universite de Montreal, Montreal, Quebec, Canada
    Ann Pharmacother 47:324-32. 2013
    ..As rates of polypharmacy rise and medication regimens become more complex, the risk of potential cytochrome P450 (CYP)-mediated drug-drug interactions (DDIs) is a growing clinical concern for older adults...
  14. doi request reprint Performance of different population pharmacokinetic algorithms
    Philippe Colucci
    Faculte de Pharmacie, University of Montreal, Montreal, Canada
    Ther Drug Monit 33:583-91. 2011
    ..This increased interest has given rise to additional algorithms...
  15. doi request reprint Gender-related differences in drug-induced prolongation of cardiac repolarization in prepubertal guinea pigs
    Raymond Hreiche
    Faculty of Pharmacy, Universite de Montreal, Montreal, Quebec, Canada
    J Cardiovasc Pharmacol Ther 14:28-37. 2009
    ....
  16. pmc Assessing drug distribution in tissues expressing P-glycoprotein through physiologically based pharmacokinetic modeling: model structure and parameters determination
    Frederique Fenneteau
    Faculte de Pharmacie, Universite de Montreal, Montreal, Quebec, Canada
    Theor Biol Med Model 6:2. 2009
    ..This work aims to improve our understanding of the impact of P-gp activity modulation on tissue distribution of P-gp substrate...
  17. pmc Ten renin-angiotensin system-related gene polymorphisms in maximally treated Canadian Caucasian patients with heart failure
    Marcin Zakrzewski-Jakubiak
    Universite de Montreal, Montreal, Canada
    Br J Clin Pharmacol 65:742-51. 2008
    ..It is also acknowledged that the genotype frequency of certain gene polymorphisms varies across different ethnic groups and that a difference in gene polymorphism frequencies between healthy and heart failure patients seems to exist...
  18. ncbi request reprint Inhibitory effects of propafenone on the pharmacokinetics of caffeine in humans
    Veronique Michaud
    Faculty of Pharmacy, Universite de Montreal, Montreal, Quebec, Canada
    Ther Drug Monit 28:779-83. 2006
    ..Caffeine has intrinsic proarrhythmic effects; thus, its coadministration with an antiarrhythmic agent such as propafenone should be used with caution, especially in patients with poor CYP2D6 activity...
  19. doi request reprint Drug-induced long QT syndrome in women: review of current evidence and remaining gaps
    Raymond Hreiche
    Faculty of Pharmacy, Université de Montréal and Research Center, CHUM, Montreal, Quebec, Canada
    Gend Med 5:124-35. 2008
    ..This major cardiac adverse effect may lead to malignant polymorphic ventricular tachycardias, termed torsades de pointes, which may degenerate into ventricular fibrillation and cause sudden death...
  20. pmc The influence of CYP2D6 phenotype on the clinical response of nebivolol in patients with essential hypertension
    Jean Lefebvre
    Hypertension Research Unit, CHUL Research Center, Faculty of Pharmacy, Laval University, Quebec, Canada
    Br J Clin Pharmacol 63:575-82. 2007
    ..The metabolism of the third-generation beta(1)-receptor antagonist nebivolol has been shown to be highly dependent on cytochrome P450 2D6 enzymatic activity in preclinical studies...
  21. ncbi request reprint Effects of ciprofloxacin on the stereoselective disposition of mexiletine in man
    Line Labbe
    Quebec Heart Institute, Hopital Laval, Ste Foy, Quebec G1V 4G5, Canada
    Ther Drug Monit 26:492-8. 2004
    ..Nevertheless, results obtained in this study suggest that no major drug interaction is to be expected during the concomitant administration of ciprofloxacin and mexiletine in patients...