Gustavo Turecki

Summary

Country: Canada

Publications

  1. pmc Dissecting the suicide phenotype: the role of impulsive-aggressive behaviours
    Gustavo Turecki
    McGill Group for Suicide Studies, Douglas Hospital Research Centre, McGill University, Montreal, Que
    J Psychiatry Neurosci 30:398-408. 2005
  2. doi Familial aggregation of suicide explained by cluster B traits: a three-group family study of suicide controlling for major depressive disorder
    Alexander McGirr
    McGill Group for Suicide Studies, Douglas Hospital Research Center, McGill University, Montreal, Que H4H 1R3, Canada
    Am J Psychiatry 166:1124-34. 2009
  3. ncbi Gender and risk factors for suicide: evidence for heterogeneity in predisposing mechanisms in a psychological autopsy study
    Alexander McGirr
    McGill Group for Suicide Studies, Douglas Hospital Research Center, McGill University, Montreal, QC, Canada
    J Clin Psychiatry 67:1612-7. 2006
  4. ncbi Effects of promoter methylation on increased expression of polyamine biosynthetic genes in suicide
    Jeffrey A Gross
    McGill Group for Suicide Studies, Douglas Mental Health University Institute, McGill University, 6875 Boul LaSalle, Verdun, Quebec H4H 1R3, Canada
    J Psychiatr Res 47:513-9. 2013
  5. ncbi Effect of tryptophan hydroxylase-2 gene variants on suicide risk in major depression
    Catalina Lopez de Lara
    McGill Group for Suicide Studies, Douglas Hospital Research Center, Montreal, Canada
    Biol Psychiatry 62:72-80. 2007
  6. doi Profiling brain expression of the spermidine/spermine N1-acetyltransferase 1 (SAT1) gene in suicide
    Timothy A Klempan
    McGill Group for Suicide Studies, Douglas Hospital, McGill University, Montreal, Quebec, Canada
    Am J Med Genet B Neuropsychiatr Genet 150:934-43. 2009
  7. ncbi What is specific to suicide in schizophrenia disorder? Demographic, clinical and behavioural dimensions
    Alexander McGirr
    McGill Group for Suicide Studies, Douglas Hospital Research Center, McGill University, 6875 LaSalle Blvd, Montreal, QC, Canada H4H 1R3
    Schizophr Res 98:217-24. 2008
  8. doi Genome-wide methylation changes in the brains of suicide completers
    Benoit Labonte
    McGill Group for Suicide Studies, Douglas Mental Health University Institute, McGill University, Montreal, USA
    Am J Psychiatry 170:511-20. 2013
  9. pmc Association of polyaminergic loci with anxiety, mood disorders, and attempted suicide
    Laura M Fiori
    McGill Group for Suicide Studies, Douglas Mental Health University Institute, McGill University, Montreal, Quebec, Canada
    PLoS ONE 5:e15146. 2010
  10. doi Childhood trajectories of anxiousness and disruptiveness as predictors of suicide attempts
    Jelena Brezo
    McGill Group for Suicide Studies, Montreal, QC, Canada
    Arch Pediatr Adolesc Med 162:1015-21. 2008

Collaborators

Detail Information

Publications95

  1. pmc Dissecting the suicide phenotype: the role of impulsive-aggressive behaviours
    Gustavo Turecki
    McGill Group for Suicide Studies, Douglas Hospital Research Centre, McGill University, Montreal, Que
    J Psychiatry Neurosci 30:398-408. 2005
    ..On the other hand, not all suicides are associated with impulsive-aggressive behaviors. There is a need to better understand the mechanisms mediating suicide among individuals with no history of impulsive-aggressive behaviors...
  2. doi Familial aggregation of suicide explained by cluster B traits: a three-group family study of suicide controlling for major depressive disorder
    Alexander McGirr
    McGill Group for Suicide Studies, Douglas Hospital Research Center, McGill University, Montreal, Que H4H 1R3, Canada
    Am J Psychiatry 166:1124-34. 2009
    ....
  3. ncbi Gender and risk factors for suicide: evidence for heterogeneity in predisposing mechanisms in a psychological autopsy study
    Alexander McGirr
    McGill Group for Suicide Studies, Douglas Hospital Research Center, McGill University, Montreal, QC, Canada
    J Clin Psychiatry 67:1612-7. 2006
    ..It is unclear whether clinical and behavioral suicide risk factors, identified primarily among men, can be extended to women. We therefore explored sex differences in psychopathology and personality variants among suicide completers...
  4. ncbi Effects of promoter methylation on increased expression of polyamine biosynthetic genes in suicide
    Jeffrey A Gross
    McGill Group for Suicide Studies, Douglas Mental Health University Institute, McGill University, 6875 Boul LaSalle, Verdun, Quebec H4H 1R3, Canada
    J Psychiatr Res 47:513-9. 2013
    ..These findings provide further support for a role for the involvement of epigenetic modifications in the regulation of genes associated with polyamine biosynthesis, and which may contribute to the complexity of suicidal behaviors...
  5. ncbi Effect of tryptophan hydroxylase-2 gene variants on suicide risk in major depression
    Catalina Lopez de Lara
    McGill Group for Suicide Studies, Douglas Hospital Research Center, Montreal, Canada
    Biol Psychiatry 62:72-80. 2007
    ....
  6. doi Profiling brain expression of the spermidine/spermine N1-acetyltransferase 1 (SAT1) gene in suicide
    Timothy A Klempan
    McGill Group for Suicide Studies, Douglas Hospital, McGill University, Montreal, Quebec, Canada
    Am J Med Genet B Neuropsychiatr Genet 150:934-43. 2009
    ....
  7. ncbi What is specific to suicide in schizophrenia disorder? Demographic, clinical and behavioural dimensions
    Alexander McGirr
    McGill Group for Suicide Studies, Douglas Hospital Research Center, McGill University, 6875 LaSalle Blvd, Montreal, QC, Canada H4H 1R3
    Schizophr Res 98:217-24. 2008
    ..It remains to be better understood what differentiates schizophrenic from non-schizophrenic suicides and whether or not these two groups share a common suicide liability...
  8. doi Genome-wide methylation changes in the brains of suicide completers
    Benoit Labonte
    McGill Group for Suicide Studies, Douglas Mental Health University Institute, McGill University, Montreal, USA
    Am J Psychiatry 170:511-20. 2013
    ..The authors used a genome-wide approach to investigate the extent of DNA methylation alterations in the brains of suicide completers...
  9. pmc Association of polyaminergic loci with anxiety, mood disorders, and attempted suicide
    Laura M Fiori
    McGill Group for Suicide Studies, Douglas Mental Health University Institute, McGill University, Montreal, Quebec, Canada
    PLoS ONE 5:e15146. 2010
    ..Studies have identified associations between genetic variants in spermidine/spermine N1-acetyltransferase (SAT1) and both anxiety and suicide, and several polymorphisms appear to play important roles in determining gene expression...
  10. doi Childhood trajectories of anxiousness and disruptiveness as predictors of suicide attempts
    Jelena Brezo
    McGill Group for Suicide Studies, Montreal, QC, Canada
    Arch Pediatr Adolesc Med 162:1015-21. 2008
    ..To investigate the association of childhood trajectories of anxiousness and disruptiveness with suicide attempts in early adulthood...
  11. ncbi Natural history of suicidal behaviors in a population-based sample of young adults
    Jelena Brezo
    McGill Group for Suicide Studies, Douglas Hospital Research Center, Montreal, Canada
    Psychol Med 37:1563-74. 2007
    ..In this study, we examined the natural histories of several suicidal behaviors and investigated two conceptual models of suicidality (dimensional and categorical) in the context of adolescent and adult-onset suicide attempts...
  12. doi Recent and lifetime utilization of health care services by children and adolescent suicide victims: a case-control study
    Johanne Renaud
    Depressive Disorders Program, and the McGill Group for Suicide Studies, Douglas Mental Health University Institute, McGill University, Montreal, Quebec, Canada H4H 1R3
    J Affect Disord 117:168-73. 2009
    ....
  13. pmc H3K4 tri-methylation in synapsin genes leads to different expression patterns in bipolar disorder and major depression
    Cristiana Cruceanu
    McGill Group for Suicide Studies, Douglas Mental Health University Institute, McGill University, Montreal, QC, Canada
    Int J Neuropsychopharmacol 16:289-99. 2013
    ..Our findings suggest that synapsin dysregulation in mood disorders is mediated in part by epigenetic regulatory mechanisms...
  14. ncbi Identifying correlates of suicide attempts in suicidal ideators: a population-based study
    Jelena Brezo
    McGill Group for Suicide Studies, Douglas Hospital Research Center, Montreal, Canada
    Psychol Med 37:1551-62. 2007
    ..Identification of factors that distinguish between ideators who act on their suicidal thoughts from those who do not is an important clinical and research objective...
  15. doi Genetic and epigenetic influences on expression of spermine synthase and spermine oxidase in suicide completers
    Laura M Fiori
    McGill Group for Suicide Studies, Douglas Mental Health University Institute, McGill University, Montreal, Quebec, Canada
    Int J Neuropsychopharmacol 13:725-36. 2010
    ....
  16. ncbi Risk factors for suicide completion in major depression: a case-control study of impulsive and aggressive behaviors in men
    A Dumais
    McGill Group for Suicide Studies, Douglas Hospital, McGill University, 6875 LaSalle Blvd, Montreal, Que H4H 1R3, Canada
    Am J Psychiatry 162:2116-24. 2005
    ..With a case-control design, a comparison of the level of impulsive and aggressive behaviors and the prevalence of associated psychopathology was carried out with control for the presence of primary psychopathology...
  17. doi Global gene expression profiling of the polyamine system in suicide completers
    Laura M Fiori
    McGill Group for Suicide Studies, Douglas Mental Health University Institute, McGill University, Montreal, Quebec, Canada
    Int J Neuropsychopharmacol 14:595-605. 2011
    ..This study provides a broader view of the nature and extent of the dysregulation of the polyamine system in suicide, and highlights the importance of this system in the neurobiology of suicide...
  18. doi High-resolution capillary gas chromatography in combination with mass spectrometry for quantification of three major polyamines in postmortem brain cortex
    Gary Gang Chen
    McGill Group for Suicide Studies, Douglas Mental Health University Institute, McGill University, Montreal, QC, Canada
    Methods Mol Biol 720:427-36. 2011
    ....
  19. ncbi Gender-specific suicide risk factors: a case-control study of individuals with major depressive disorder
    Ioana Mioara Dalca
    McGill University, McGill Group for Suicide Studies, Douglas Hospital, Montreal, Quebec, Canada
    J Clin Psychiatry 74:1209-16. 2013
    ..In this study, we aimed to investigate clinical and behavioral risk factors for suicide among female depressed patients and compare them to similar factors among male depressed patients...
  20. ncbi Is violent method of suicide a behavioral marker of lifetime aggression?
    Alexandre Dumais
    McGill Group for Suicide Studies, Douglas Hospital, McGill University, 6875 LaSalle Blvd, Montreal, Quebec H4H 1R3, Canada
    Am J Psychiatry 162:1375-8. 2005
    ..The main purpose of this study was to investigate whether the method of suicide is a valid behavioral marker of a lifetime history of aggression...
  21. doi Differential glucocorticoid receptor exon 1(B), 1(C), and 1(H) expression and methylation in suicide completers with a history of childhood abuse
    Benoit Labonte
    McGill Group for Suicide Studies, McGill University, Montreal, Quebec, Canada
    Biol Psychiatry 72:41-8. 2012
    ..The abuse-related decrease in hGR expression associates with increased DNA methylation of the promoter of the hGR(1F) variant in the hippocampus...
  22. pmc Broad and narrow personality traits as markers of one-time and repeated suicide attempts: a population-based study
    Jelena Brezo
    McGill Group for Suicide Studies, Douglas Hospital Research Center, Montreal, Canada
    BMC Psychiatry 8:15. 2008
    ..One approach may be to examine whether narrow, i.e., lower-order personality traits may be more useful than their underlying, broad personality trait dimensions...
  23. ncbi The effect of genetic variation of the serotonin 1B receptor gene on impulsive aggressive behavior and suicide
    Hana Zouk
    McGill Group for Suicide Studies, Douglas Hospital Research Center, McGill University, Montreal, Canada
    Am J Med Genet B Neuropsychiatr Genet 144:996-1002. 2007
    ..The A-161T locus, which seems to impact 5-HT1B transcription, could play a role in suicide predisposition by means of mediating impulsive-aggressive behaviors...
  24. pmc Implication of synapse-related genes in bipolar disorder by linkage and gene expression analyses
    Catalina Lopez de Lara
    Department of Psychiatry, McGill University, Montreal, QC, Canada
    Int J Neuropsychopharmacol 13:1397-410. 2010
    ..Further studies are warranted to demonstrate the functional role of these genes in BD...
  25. ncbi An examination of DSM-IV borderline personality disorder symptoms and risk for death by suicide: a psychological autopsy study
    Alexander McGirr
    University of Toronto, Toronto, Ontario McGill Group for Suicide Studies, Douglas Hospital Research Centre, McGill University, Montreal, Quebec
    Can J Psychiatry 54:87-92. 2009
    ....
  26. ncbi Course of major depressive disorder and suicide outcome: a psychological autopsy study
    Alexander McGirr
    McGill Group for Suicide Studies, Douglas Hospital Research Center, McGill University, Montreal, Quebec, Canada
    J Clin Psychiatry 69:966-70. 2008
    ..By considering the number of MDEs among representative suicides, we aimed to further investigate the relationship between suicide outcome and the course of major depressive disorder...
  27. doi Obsessive-compulsive personality disorder and suicidal behavior: evidence for a positive association in a sample of depressed patients
    Gabriel Diaconu
    The McGill Group for Suicide Studies, Douglas Hospital Research Centre, McGill University, Montreal, Quebec, Canada
    J Clin Psychiatry 70:1551-6. 2009
    ..To explore the association between obsessive-compulsive personality disorder (OCPD) and suicidal behavior...
  28. pmc Evidence of altered polyamine concentrations in cerebral cortex of suicide completers
    Gary Gang Chen
    Douglas Mental Health University Institute, McGill University, Montreal, Quebec, Canada
    Neuropsychopharmacology 35:1477-84. 2010
    ....
  29. ncbi Investigation of completed suicide and genes involved in cholesterol metabolism
    Aleksandra Lalovic
    McGill Group for Suicide Studies, Douglas Hospital Research Centre, 6875 LaSalle Blvd, Verdun, Quebec, Canada H4H 1R3
    J Affect Disord 79:25-32. 2004
    ..Given that genes control many aspects of cholesterol biosynthesis and metabolism, one approach through which to explore the putative association between low cholesterol and suicide is through genetic studies...
  30. ncbi Current psychiatric morbidity, aggression/impulsivity, and personality dimensions in child and adolescent suicide: a case-control study
    Johanne Renaud
    Depressive Disorders Program, and the McGill Group for Suicide Studies, Douglas Mental Health University Institute, McGill University, Montreal, Quebec, Canada H4H 1R3
    J Affect Disord 105:221-8. 2008
    ..The present study was designed to evaluate psychiatric risk factors for child and adolescent suicide, and to determine the association between impulsive-aggressive and other personality traits, and suicide completion in this population...
  31. ncbi Risk factors for suicide completion in borderline personality disorder: a case-control study of cluster B comorbidity and impulsive aggression
    Alexander McGirr
    McGill Group for Suicide Studies, Douglas Hospital Research Center, Montreal, Canada
    J Clin Psychiatry 68:721-9. 2007
    ..Using a case-control design, this study investigated clinical and behavioral risk factors for suicide completion in borderline personality disorder...
  32. ncbi STin2 variant and family history of suicide as significant predictors of suicide completion in major depression
    Catalina Lopez de Lara
    McGill Group for Suicide Studies, Douglas Hospital Research Center, Montreal, Quebec H4H 1R3, Canada
    Biol Psychiatry 59:114-20. 2006
    ..Serotonergic alterations have been observed in suicide and depression and impulsive-aggressive behaviors. Therefore, we aimed to identify predictors of suicide, considering genetic variation at the serotonin transporter (5-HTT) gene...
  33. pmc Global brain gene expression analysis links glutamatergic and GABAergic alterations to suicide and major depression
    Adolfo Sequeira
    McGill Group for Suicide Studies, Douglas Mental Health University Institute, McGill University, Montreal, Quebec, Canada
    PLoS ONE 4:e6585. 2009
    ..In this study we investigated brain regions that are known to be implicated in the neurobiology of suicide and major depression are likely to represent valid global molecular alterations...
  34. ncbi Family-based exome-sequencing approach identifies rare susceptibility variants for lithium-responsive bipolar disorder
    Cristiana Cruceanu
    a Department of Human Genetics, McGill University, Montreal, QC, Canada
    Genome 56:634-40. 2013
    ..By focusing on rare variants in a familial cohort, we hope to explain a significant portion of the missing heritability in BD, as well as to narrow our current insight on the key biochemical pathways implicated in this complex disorder. ..
  35. doi Analysis of oxysterols and cholesterol in prefrontal cortex of suicides
    Erika Freemantle
    Department of Human Genetics, McGill University, Montreal, QC, Canada
    Int J Neuropsychopharmacol 16:1241-9. 2013
    ....
  36. pmc Risk of bleeding associated with combined use of selective serotonin reuptake inhibitors and antiplatelet therapy following acute myocardial infarction
    Christopher Labos
    Department of Medicine, McGill University, Montreal, Que
    CMAJ 183:1835-43. 2011
    ..Use of either treatment may increase the risk of bleeding. We assessed the risk of bleeding among patients taking both medications following acute myocardial infarction...
  37. ncbi An examination of DSM-IV depressive symptoms and risk for suicide completion in major depressive disorder: a psychological autopsy study
    Alexander McGirr
    McGill Group for Suicide Studies, Douglas Hospital Research Center, McGill University, 6875 LaSalle Blvd, Montreal, QC, Canada H4H 1R3
    J Affect Disord 97:203-9. 2007
    ....
  38. doi Identification and characterization of spermidine/spermine N1-acetyltransferase promoter variants in suicide completers
    Laura M Fiori
    McGill Group for Suicide Studies, Douglas Mental Health University Institute, McGill University, Montreal, Quebec, Canada
    Biol Psychiatry 66:460-7. 2009
    ....
  39. doi A deletion in tropomyosin-related kinase B and the development of human anxiety
    Carl Ernst
    McGill Group for Suicide Studies, McGill University, Montreal, QC, Canada
    Biol Psychiatry 69:604-7. 2011
    ..The tropomyosin-related kinase B (TrkB)/brain-derived neurotrophic factor system has been associated with psychiatric disorders, and animal models of defects in this system suggest that it might have a particular role in anxiety...
  40. ncbi Sexual orientation and gender identity in youth suicide victims: an exploratory study
    Johanne Renaud
    Department of Psychiatry, McGill University, Montreal, Quebec
    Can J Psychiatry 55:29-34. 2010
    ..Our study was designed to explore additional outcome variables of a suicide case-control study to determine the association between sexual orientation and gender identity in suicide completion in children and adolescents...
  41. ncbi Characterization of impulsivity in suicide completers: clinical, behavioral and psychosocial dimensions
    Hana Zouk
    McGill Group for Suicide Studies, Douglas Hospital Research Center, McGill University, Montreal, QC, Canada
    J Affect Disord 92:195-204. 2006
    ..Yet, not all suicides are highly impulsive. We aimed to better understand clinical, behavioral and psychosocial correlates of the association between suicide and impulsive behavior...
  42. pmc Lithium response and genetic variation in the CREB family of genes
    Firoza Mamdani
    McGill Group for Suicide Studies Depressive Disorders Group, Douglas Hospital, Research Centre, McGill University, Montreal, Quebec, Canada
    Am J Med Genet B Neuropsychiatr Genet 147:500-4. 2008
    ..Following correction for multiple testing, our results suggest that the CREB1-1H SNP (G/A change, P < 0.002) and the CREB1-7H SNP (T/C change, P < 0.002) may be associated with BD and/or lithium response...
  43. pmc Regulation of a truncated form of tropomyosin-related kinase B (TrkB) by Hsa-miR-185* in frontal cortex of suicide completers
    Gilles Maussion
    McGill Group for Suicide Studies, Douglas Hospital Research Institute, McGill University, Montreal, Quebec, Canada
    PLoS ONE 7:e39301. 2012
    ..Previous studies indicate that downregulation of TrkB-T1 in frontal cortex may be involved in neurobiological processes underlying suicide...
  44. doi Levels of aggressiveness are higher among alcohol-related suicides: results from a psychological autopsy study
    Eduardo Chachamovich
    McGill Group for Suicide Studies, Department of Psychiatry, McGill University, 6875 LaSalle Blvd, Montreal, Quebec, Canada H4H 1R3
    Alcohol 46:529-36. 2012
    ..Apart from substance-related diagnoses, AUD and non-AUD suicides have comparable Axis I psychiatric diagnoses and familial transmission of suicidal behavior...
  45. pmc Dysregulation of the sympathetic nervous system, hypothalamic-pituitary-adrenal axis and executive function in individuals at risk for suicide
    Alexander McGirr
    McGill Group for Suicide Studies, Douglas Hospital Research Centre, McGill University, 6875 LaSalle Blvd, Montreal, QC H4H1R3
    J Psychiatry Neurosci 35:399-408. 2010
    ..We investigated stress reactivity of the autonomic nervous system and the HPA axis in suicide predisposition and characterized the effect of this dysregulation on neuropsychologic function...
  46. doi Altered expression of lipid metabolism and immune response genes in the frontal cortex of suicide completers
    Aleksandra Lalovic
    McGill Group for Suicide Studies, Douglas Mental Health University Institute, McGill University, Verdun, Quebec, Canada
    J Affect Disord 120:24-31. 2010
    ....
  47. doi Suicide and gambling: psychopathology and treatment-seeking
    Monique Seguin
    Université du Québec en Outaouais, Department of Psychology, McGill Group for Suicide Studies, Douglas Hospital, McGill University, Montreal, Quebec, Canada
    Psychol Addict Behav 24:541-7. 2010
    ..Lower service utilization associated with PG suicides argues in favor of stepping up detection, engagement in care and treatment with respect to problem gambling, especially when comorbidity is present...
  48. pmc Response to treatment in bipolar disorder
    Cristiana Cruceanu
    McGill Group for Suicide Studies, Douglas Hospital, McGill University, Montreal, Quebec, Canada
    Curr Opin Psychiatry 24:24-8. 2011
    ....
  49. doi Personal and family history of suicidal behaviour is associated with lower peripheral cortisol in depressed outpatients
    Alexander McGirr
    McGill Group for Suicide Studies, Douglas Mental Health University Institute, McGill University, Montreal, Canada University of Toronto, Faculty of Medicine, Toronto, Canada
    J Affect Disord 131:368-73. 2011
    ..In this study, we aimed to characterize the relationship between plasma cortisol and an increased risk for suicide, as defined by family history...
  50. ncbi Epigenetic regulation of spermidine/spermine N1-acetyltransferase (SAT1) in suicide
    Laura M Fiori
    McGill Group for Suicide Studies, Douglas Mental Health University Institute, McGill University, Montreal, Quebec, Canada
    J Psychiatr Res 45:1229-35. 2011
    ....
  51. pmc Age and haplotype variations within FADS1 interact and associate with alterations in fatty acid composition in human male cortical brain tissue
    Erika Freemantle
    Department of Genetics, McGill University, Montreal, Quebec, Canada
    PLoS ONE 7:e42696. 2012
    ..The contribution to alterations of FAs within the brain by local synthesis is still a matter of debate. Thus, the impact of genetic variants in FADS genes on gene expression and brain FA levels is an important avenue to investigate...
  52. doi Cholesterol and phospholipids in frontal cortex and synaptosomes of suicide completers: relationship with endosomal lipid trafficking genes
    Erika Freemantle
    Department of Human Genetics, McGill University, Montreal, QC, Canada
    J Psychiatr Res 47:272-9. 2013
    ..The results of this study suggest an altered PL content mediated by LIPA expression in violent suicides in the prefrontal cortex, which would have important consequences for inhibitory neurotransmission...
  53. pmc Conserved epigenetic sensitivity to early life experience in the rat and human hippocampus
    Matthew Suderman
    Sackler Program for Epigenetics and Developmental Psychobiology at McGill University, Department of Pharmacology and Therapeutics, McGill University, Montreal, QC, Canada
    Proc Natl Acad Sci U S A 109:17266-72. 2012
    ..These results provide support for an analogous cross-species epigenetic regulatory response at the level of the genomic region to early life experience...
  54. pmc Synapsin II is involved in the molecular pathway of lithium treatment in bipolar disorder
    Cristiana Cruceanu
    McGill Group for Suicide Studies, Douglas Mental Health University Institute, McGill University, Montreal, Quebec, Canada
    PLoS ONE 7:e32680. 2012
    ..In both in vitro models, we found SYN2 to be modulated by the presence of Li. By focusing on Li-responsive BD we have identified a potential mechanism for Li response in some patients...
  55. pmc Fatty acid composition in postmortem brains of people who completed suicide
    Aleksandra Lalovic
    McGill Group for Suicide Studies, Douglas Hospital Research Centre, Verdun, QC, Canada
    J Psychiatry Neurosci 32:363-70. 2007
    ....
  56. doi Dysfunction of astrocyte connexins 30 and 43 in dorsal lateral prefrontal cortex of suicide completers
    Carl Ernst
    McGill Group for Suicide Studies, McGill University, Montreal, Quebec, Canada
    Biol Psychiatry 70:312-9. 2011
    ..Although it is known that particular neurobiological processes underlie suicidal ideation and behavior, there still remains limited knowledge about the specific factors involved...
  57. ncbi Implication of SSAT by gene expression and genetic variation in suicide and major depression
    Adolfo Sequeira
    McGill Group for Suicide Studies, Douglas Hospital, McGill University, Montreal, Quebec, Canada
    Arch Gen Psychiatry 63:35-48. 2006
    ..A large body of evidence suggests that predisposition to suicide, an important public health problem, is mediated to a certain extent by neurobiological factors...
  58. doi Family history of suicidal behavior predicts impulsive-aggressive behavior levels in psychiatric outpatients
    Gabriel Diaconu
    McGill Group for Suicide Studies, Douglas Hospital Research Centre, McGill University, Montreal, Quebec, Canada
    J Affect Disord 113:172-8. 2009
    ..Our aim was to investigate the association between family history of suicidal behavior, and expressions of impulsivity and aggressive behavior, in a clinical population...
  59. ncbi Seasonal differences in psychopathology of male suicide completers
    Caroline D Kim
    McGill Group for Suicide Studies, Douglas Hospital Research Centre, McGill University, Montreal, Canada
    Compr Psychiatry 45:333-9. 2004
    ..These findings indicate that assessment of suicide risk may need to include consideration of possible seasonal effects, depending on psychopathology...
  60. pmc Suicide and no axis I psychopathology
    Carl Ernst
    McGill Group for Suicide Studies, Douglas Hospital Research Centre, McGill University, Montreal, Canada
    BMC Psychiatry 4:7. 2004
    ..To better understand this issue, we studied suicide completers without an axis I diagnosis and compared them, on measures of psychopathology other than axis I, to normal controls and suicide cases with axis I psychopathology...
  61. doi Association of the SAT1 in/del polymorphism with suicide completion
    Laura M Fiori
    McGill Group for Suicide Studies, Douglas Mental Health University Institute, McGill University, Montreal, Quebec, Canada
    Am J Med Genet B Neuropsychiatr Genet 153:825-9. 2010
    ..These results add support for a role of SAT1 in conferring a risk for suicide completion, in particular in the context of depressive disorders...
  62. ncbi The relationship of impulsive aggressiveness to suicidality and other depression-linked behaviors
    Alexander McGirr
    McGill Group for Suicide Studies, Douglas Hospital Research Center, McGill University, 6875 LaSalle Boulevard, Montreal, Quebec H4H 1R3, Canada
    Curr Psychiatry Rep 9:460-6. 2007
    ..However, not all suicides are associated with impulsive-aggressive behaviors, and we need to better understand vulnerability to suicide among non-impulsive-aggressive suicide...
  63. ncbi Alpha 2A adrenergic receptor gene and suicide
    Adolfo Sequeira
    McGill Group for Suicide Studies, Douglas Hospital, McGill University, 6875 LaSalle Blvd, Verdun, QC, Canada H4H 1R3
    Psychiatry Res 125:87-93. 2004
    ..These results are preliminary. If confirmed, they suggest that variation at the alpha(2A) adrenergic receptor gene may play a role in a small proportion of suicide cases...
  64. ncbi [Which are the recent clinical findings regarding the association between depression and suicide?]
    Eduardo Chachamovich
    McGill Group for Suicide Studies, Department of Psychiatry, McGill University, Montreal, Canada
    Rev Bras Psiquiatr 31:S18-25. 2009
    ..The present paper aims to briefly review the recent findings regarding the suicide-related clinical features of depression. Moreover, strategies for suicide prevention were also reviewed...
  65. pmc No association between the PREP gene and lithium responsive bipolar disorder
    Firoza Mamdani
    Douglas Hospital Research Centre, McGill University, Montreal, Quebec, Canada
    BMC Psychiatry 7:9. 2007
    ....
  66. doi Predicting suicide attempts in young adults with histories of childhood abuse
    Jelena Brezo
    McGill Group for Suicide Studies, Douglas Hospital Research Center, Montreal, Quebec, Canada
    Br J Psychiatry 193:134-9. 2008
    ..Although childhood abuse is an important correlate of suicidality, not all individuals who were abused as children attempt suicide...
  67. doi Effects of histone modifications on increased expression of polyamine biosynthetic genes in suicide
    Laura M Fiori
    McGill Group for Suicide Studies, Douglas Mental Health University Institute, McGill University, Verdun, Quebec, Canada
    Int J Neuropsychopharmacol 15:1161-6. 2012
    ..Overall, our findings indicate that the H3K4me3 modification plays an important role in the regulation of polyamine biosynthesis, and that this mechanism may be involved in the neurobiology of suicide...
  68. pmc Astrocytic hypertrophy in anterior cingulate white matter of depressed suicides
    Susana G Torres-Platas
    McGill Group for Suicide Studies, Department of Neurology and Neurosurgery, Douglas Mental Health University Institute, McGill University, Verdun, Quebec, Canada
    Neuropsychopharmacology 36:2650-8. 2011
    ..The presence of hypertrophic astrocytes in BA24 white matter is consistent with reports suggesting white matter alterations in depression, and provides further support to the neuroinflammatory theory of depression...
  69. doi The neurodevelopmental origins of suicidal behavior
    Gustavo Turecki
    McGill Group for Suicide Studies, Department of Psychiatry, McGill University, Montreal, Canada
    Trends Neurosci 35:14-23. 2012
    ....
  70. ncbi Genetic association studies of neurotensin gene and restless legs syndrome in French Canadians
    Lan Xiong
    Center for the Study of Brain Diseases, CHUM Research Center Notre Dame Hospital, University of Montreal, Bureau Y 3616 2, 1560, rue Sherbrooke Est, Montreal, Que, Canada H2L 4MI
    Sleep Med 9:273-82. 2008
    ..The purpose of the current study is to further explore the NTS gene for potential functional variant(s) in its entire genomic and potential regulatory regions and their possible association with RLS symptoms...
  71. doi Current trends in the assessment and somatic treatment of resistant/refractory major depression: an overview
    Marcelo T Berlim
    Depressive Disorders Program, and the McGill Group for Suicide Studies, Douglas Mental Health University Institute, McGill University, Montreal, Quebec, Canada
    Ann Med 40:149-59. 2008
    ....
  72. ncbi Definition, assessment, and staging of treatment-resistant refractory major depression: a review of current concepts and methods
    Marcelo T Berlim
    Depressive Disorders Program, Douglas Hospital Research Centre, McGill University, Montreal, Quebec
    Can J Psychiatry 52:46-54. 2007
    ..Our paper aims to summarize the current medical literature on the conceptual and methodologic issues involved in the definition, assessment, and staging of TRD...
  73. ncbi Personality traits as correlates of suicide attempts and suicidal ideation in young adults
    Jelena Brezo
    McGill Group for Suicide Studies, Douglas Hospital Research Center, Montreal, Canada
    Psychol Med 36:191-202. 2006
    ..Adults in their twenties appear to be at high risk for suicidal behaviors (SBs) and there is substantial evidence suggesting that certain personality traits may increase individual vulnerability to suicide...
  74. ncbi Cholesterol content in brains of suicide completers
    Aleksandra Lalovic
    McGill Group for Suicide Studies, Douglas Hospital Research Centre, McGill University, Verdun, Quebec, Canada
    Int J Neuropsychopharmacol 10:159-66. 2007
    ....
  75. ncbi Characterization of QKI gene expression, genetics, and epigenetics in suicide victims with major depressive disorder
    Timothy A Klempan
    McGill Group for Suicide Studies, Douglas Hospital, McGill University, Montreal, Quebec, Canada
    Biol Psychiatry 66:824-31. 2009
    ..We examined the brain expression and genetic/epigenetic regulation of QKI, an oligodendrocyte-specific RNA binding protein important for cell development and myelination...
  76. doi Suicide neurobiology
    Carl Ernst
    McGill Group for Suicide Studies, McGill University, Montreal, Quebec, Canada
    Prog Neurobiol 89:315-33. 2009
    ....
  77. ncbi Cholesterol metabolism and suicidality in Smith-Lemli-Opitz syndrome carriers
    Aleksandra Lalovic
    McGill Group for Suicide Studies, Douglas Hospital Research Centre, 6875 LaSalle Blvd, Verdun, Quebec H4H 1R3, Canada
    Am J Psychiatry 161:2123-6. 2004
    ..This population has a partial deficiency in 7-dehydrocholesterol reductase (DHCR7), the enzyme that catalyzes the last step in cholesterol biosynthesis...
  78. ncbi Confirmation of region-specific patterns of gene expression in the human brain
    Carl Ernst
    McGill Group for Suicide Studies, McGill University, Montreal, QC, Canada
    Neurogenetics 8:219-24. 2007
    ....
  79. ncbi Wolfram syndrome and suicide: Evidence for a role of WFS1 in suicidal and impulsive behavior
    Adolfo Sequeira
    McGill Group for Suicide Studies, Douglas Hospital, McGill University, Montreal, Canada
    Am J Med Genet B Neuropsychiatr Genet 119:108-13. 2003
    ..However, these findings are preliminary and should be confirmed in independent samples...
  80. pmc Brain serotonin synthesis in adult males characterized by physical aggression during childhood: a 21-year longitudinal study
    Linda Booij
    Department of Psychiatry, McGill University, Montreal, Canada
    PLoS ONE 5:e11255. 2010
    ..It remains unclear though whether low 5-HT mediates the behavior or instead reflects a pre-existing vulnerability trait...
  81. ncbi Risks of suicide and poisoning among elderly patients prescribed selective serotonin reuptake inhibitors: a retrospective cohort study
    Elham Rahme
    Department of Medicine, McGill University, Montreal, Quebec, Canada
    J Clin Psychiatry 69:349-57. 2008
    ..Risks of suicide death and of poisoning were compared during periods of SSRI treatment versus periods without any antidepressant treatment among elderly patients...
  82. doi A quantitative GC-MS method for three major polyamines in postmortem brain cortex
    Gary G Chen
    McGill Group for Suicide Studies, Douglas Hospital, McGill University, Montreal, Quebec, Canada
    J Mass Spectrom 44:1203-10. 2009
    ..The method allows the quantitation of PUT down to 10 ng/g and SPD and SPM down to 100 and 1000 ng/g, respectively of wet tissue...
  83. pmc Psychiatric diagnoses in 3275 suicides: a meta-analysis
    Geneviève Arsenault-Lapierre
    McGill Group for Suicide Studies, Douglas Hospital Research Centre, Department of Psychiatry, McGill University, Montreal, Canada
    BMC Psychiatry 4:37. 2004
    ..This study provides overall rates of total and specific psychiatric disorders in suicide completers and presents evidence supporting gender and geographic differences in their relative proportion...
  84. doi The genetics of suicide: a critical review of molecular studies
    Jelena Brezo
    Department of Psychiatry, McGill Group for Suicide Studies, 6875 La Salle Boulevard, Montreal, Quebec, H4H 1R3, Canada
    Psychiatr Clin North Am 31:179-203. 2008
    ....
  85. ncbi Mutational analysis of neurotensin in familial restless legs syndrome
    Alex Desautels
    Centre d Etude du Sommeil, Hôpital du Sacré Coeur de Montréal and Centre de recherche en sciences neurologiques, Universite de Montreal, Quebec, Canada
    Mov Disord 19:90-4. 2004
    ..Based on these results, it is unlikely that NTS is the gene responsible for RLS in chromosome 12-linked families...
  86. ncbi Impaired repression at a 5-hydroxytryptamine 1A receptor gene polymorphism associated with major depression and suicide
    Sylvie Lemonde
    Ottawa Health Research Institute Neuroscience, University of Ottawa, Department of Medicine, Ottawa, Canada, K1H 8M5
    J Neurosci 23:8788-99. 2003
    ..We suggest a novel transcriptional model in which the G(-1019) allele derepresses 5-HT1A autoreceptor expression to reduce serotonergic neurotransmission, predisposing to depression and suicide...
  87. pmc Promoter-wide hypermethylation of the ribosomal RNA gene promoter in the suicide brain
    Patrick O McGowan
    Department of Psychiatry, Douglas Mental Health University Institute, Montreal, Quebec, Canada
    PLoS ONE 3:e2085. 2008
    ..rRNA genes, that encode ribosomal RNA, are the backbone of the protein synthesis machinery and levels of rRNA gene promoter methylation determine rRNA transcription...
  88. ncbi Molecular characterization of suicide by microarray analysis
    Fuad G Gwadry
    G BioChem Solutions, Verdun, Canada
    Am J Med Genet C Semin Med Genet 133:48-56. 2005
    ..Microarray expression studies and related platforms are promising tools to gain better insight into the neurobiology of suicide...
  89. ncbi Suicide: a neurobiological point of view
    Tim Klempan
    Rev Bras Psiquiatr 27:172-3. 2005
  90. ncbi Completed suicides in a youth centres population
    Johanne Renaud
    Universite de Montreal, Montreal, Quebec
    Can J Psychiatry 50:690-4. 2005
    ..More than one-third had received services from youth centres (YCs) at some point. This study sought to characterize a sample of those youths to improve services for this at-risk population...
  91. pmc Increased tryptophan hydroxylase immunoreactivity in the dorsal raphe nucleus of alcohol-dependent, depressed suicide subjects is restricted to the dorsal subnucleus
    Willy L Bonkale
    Department of Psychiatry and Behavioral Science, Neuropsychiatry Research Program, Texas A and M University System HSC, Texas 76504, USA
    Synapse 60:81-5. 2006
    ..Our results indicate that abnormalities in 5-HT biosynthesis in the brain of depressed alcoholic suicide subjects are restricted within distinct regions of the DR...
  92. ncbi Dopamine beta-hydroxylase (DBH) gene and schizophrenia phenotypic variability: a genetic association study
    Kenji Yamamoto
    Douglas Hospital Research Centre 6875 Boulevard LaSalle, Verdun H4H 1R3, Canada
    Am J Med Genet B Neuropsychiatr Genet 117:33-8. 2003
    ..These results suggest that the DBH gene is not a causative factor in schizophrenia but that it may be a modulator of psychotic symptoms, severity of the disorder and therapeutic response to neuroleptic drugs...
  93. pmc Psychiatric services utilization in completed suicides of a youth centres population
    Johanne Renaud
    Department of Child and Adolescent Psychiatry, CHU Mère Enfant Sainte Justine, 3175 Cote Sainte Catherine, Universite de Montreal, Montreal, Canada
    BMC Psychiatry 6:36. 2006
    ..This is the second of two papers on YCs population, the first paper having shown that the rate of psychopathology was higher in the YCs population compared to the general adolescent population...
  94. ncbi Suicide cases in New Brunswick from April 2002 to May 2003: the importance of better recognizing substance and mood disorder comorbidity
    Monique Seguin
    Department of Psychology, Université du Québec en Outaouais, Gatineau
    Can J Psychiatry 51:581-6. 2006
    ..To investigate all suicide cases that occurred in New Brunswick in the 14 months spanning April 1, 2002, to May 31, 2003, to determine 6-month and lifetime prevalence rates of psychopathology in the deceased...
  95. ncbi Life trajectories and burden of adversity: mapping the developmental profiles of suicide mortality
    Monique Seguin
    Department of Psychologyu, Université du Québec en Outaouais, Canada
    Psychol Med 37:1575-83. 2007
    ....