Chris Metcalfe

Summary

Affiliation: Trent University
Country: Canada

Publications

  1. ncbi request reprint A fragmentation study of a flavone triglycoside, kaempferol-3-O-robinoside-7-O-rhamnoside
    Raymond E March
    Water Quality Centre, Trent University, Peterborough, Ontario K9J 7B8, Canada
    Rapid Commun Mass Spectrom 18:931-4. 2004
  2. doi request reprint Monitoring for contaminants of emerging concern in drinking water using POCIS passive samplers
    Chris Metcalfe
    Water Quality Centre, Trent University, Peterborough, ON K9J 7B8, Canada
    Environ Sci Process Impacts 16:473-81. 2014
  3. doi request reprint A multi-assay screening approach for assessment of endocrine-active contaminants in wastewater effluent samples
    Chris D Metcalfe
    Environmental and Resource Studies, Trent University, Peterborough, ON, K9J 7B8, Canada
    Sci Total Environ 454:132-40. 2013
  4. doi request reprint Contaminants in the coastal karst aquifer system along the Caribbean coast of the Yucatan Peninsula, Mexico
    Chris D Metcalfe
    Worsfold Water Quality Centre, Trent University, Peterborough, ON, Canada
    Environ Pollut 159:991-7. 2011
  5. doi request reprint Illicit drugs in Canadian municipal wastewater and estimates of community drug use
    Chris Metcalfe
    Worsfold Water Quality Centre, Trent University, 1600 West Bank Drive Peterborough, ON, K9J 7B8, Canada
    Environ Pollut 158:3179-85. 2010
  6. doi request reprint Antidepressants and their metabolites in municipal wastewater, and downstream exposure in an urban watershed
    Chris D Metcalfe
    Worsfold Water Quality Center, Environmental and Resource Studies, Trent University, 1600 West Bank Drive, Peterborough, Ontario K9J7B8, Canada
    Environ Toxicol Chem 29:79-89. 2010
  7. ncbi request reprint Intra- and inter-species differences in persistent organic contaminants in the blubber of blue whales and humpback whales from the Gulf of St. Lawrence, Canada
    Chris Metcalfe
    Water Quality Centre, Trent University, Ontario K9J 7B8, Peterborough, Canada
    Mar Environ Res 57:245-60. 2004
  8. ncbi request reprint Distribution of acidic and neutral drugs in surface waters near sewage treatment plants in the lower Great Lakes, Canada
    Chris D Metcalfe
    Water Quality Centre, Trent University, Peterborough, Ontario K9J 7B8, Canada
    Environ Toxicol Chem 22:2881-9. 2003
  9. ncbi request reprint Estrogenic potency of chemicals detected in sewage treatment plant effluents as determined by in vivo assays with Japanese medaka (Oryzias latipes)
    C D Metcalfe
    Environmental and Resource Studies Program, Trent University, Peterborough, Ontario K9J 7B8, Canada
    Environ Toxicol Chem 20:297-308. 2001
  10. ncbi request reprint Occurrence of neutral and acidic drugs in the effluents of Canadian sewage treatment plants
    Chris D Metcalfe
    Water Quality Centre, Trent University, Peterborough, Ontario, Canada K9J 7B8
    Environ Toxicol Chem 22:2872-80. 2003

Collaborators

Detail Information

Publications46

  1. ncbi request reprint A fragmentation study of a flavone triglycoside, kaempferol-3-O-robinoside-7-O-rhamnoside
    Raymond E March
    Water Quality Centre, Trent University, Peterborough, Ontario K9J 7B8, Canada
    Rapid Commun Mass Spectrom 18:931-4. 2004
    ..radical anion fragments by loss of the rhamnose glycan residue to yield the radical anion Y(7)[Y(3,0)-H](-.) (m/z 284) and by scission to yield [Y(7)-H][Y(3,0)--H](-) (m/z 283). A fragmentation mechanism has been proposed...
  2. doi request reprint Monitoring for contaminants of emerging concern in drinking water using POCIS passive samplers
    Chris Metcalfe
    Water Quality Centre, Trent University, Peterborough, ON K9J 7B8, Canada
    Environ Sci Process Impacts 16:473-81. 2014
    ..CECs in treated drinking water were present at low ng L(-1) concentrations, which are not considered to be a threat to human health. ..
  3. doi request reprint A multi-assay screening approach for assessment of endocrine-active contaminants in wastewater effluent samples
    Chris D Metcalfe
    Environmental and Resource Studies, Trent University, Peterborough, ON, K9J 7B8, Canada
    Sci Total Environ 454:132-40. 2013
    ..Overall, these data indicate that a step-wise approach is feasible using a combination of in vitro testing and instrumental analysis to monitor for EDCs in wastewater and other environmental matrixes...
  4. doi request reprint Contaminants in the coastal karst aquifer system along the Caribbean coast of the Yucatan Peninsula, Mexico
    Chris D Metcalfe
    Worsfold Water Quality Centre, Trent University, Peterborough, ON, Canada
    Environ Pollut 159:991-7. 2011
    ..Prevention and mitigation measures are needed to ensure that expanding development does not impact the marine environment and human health, thus damaging the tourism-based economy of the region...
  5. doi request reprint Illicit drugs in Canadian municipal wastewater and estimates of community drug use
    Chris Metcalfe
    Worsfold Water Quality Centre, Trent University, 1600 West Bank Drive Peterborough, ON, K9J 7B8, Canada
    Environ Pollut 158:3179-85. 2010
    ..The community consumption estimate for ecstasy in the present study is far below published estimates of the prevalence of ecstasy use among the Canadian population, which may be due to only occasional use of ecstasy...
  6. doi request reprint Antidepressants and their metabolites in municipal wastewater, and downstream exposure in an urban watershed
    Chris D Metcalfe
    Worsfold Water Quality Center, Environmental and Resource Studies, Trent University, 1600 West Bank Drive, Peterborough, Ontario K9J7B8, Canada
    Environ Toxicol Chem 29:79-89. 2010
    ..The present study illustrates that data are needed on the distribution in the aquatic environment of both the parent compound and the biologically active metabolites of pharmaceuticals...
  7. ncbi request reprint Intra- and inter-species differences in persistent organic contaminants in the blubber of blue whales and humpback whales from the Gulf of St. Lawrence, Canada
    Chris Metcalfe
    Water Quality Centre, Trent University, Ontario K9J 7B8, Peterborough, Canada
    Mar Environ Res 57:245-60. 2004
    ..These may reflect differences in the diet of the two species, since fish comprise a large part of the diet of humpback whales and blue whales feed exclusively on euphausiid crustaceans (i.e. krill)...
  8. ncbi request reprint Distribution of acidic and neutral drugs in surface waters near sewage treatment plants in the lower Great Lakes, Canada
    Chris D Metcalfe
    Water Quality Centre, Trent University, Peterborough, Ontario K9J 7B8, Canada
    Environ Toxicol Chem 22:2881-9. 2003
    ..For the first time, the lipid regulating drug atorvastatin was detected in samples of STP effluent and surface water...
  9. ncbi request reprint Estrogenic potency of chemicals detected in sewage treatment plant effluents as determined by in vivo assays with Japanese medaka (Oryzias latipes)
    C D Metcalfe
    Environmental and Resource Studies Program, Trent University, Peterborough, Ontario K9J 7B8, Canada
    Environ Toxicol Chem 20:297-308. 2001
    ....
  10. ncbi request reprint Occurrence of neutral and acidic drugs in the effluents of Canadian sewage treatment plants
    Chris D Metcalfe
    Water Quality Centre, Trent University, Peterborough, Ontario, Canada K9J 7B8
    Environ Toxicol Chem 22:2872-80. 2003
    ..The rates of elimination of ibuprofen and naproxen appeared to be elevated in STPs with hydraulic retention times for sewage greater than 12 h...
  11. ncbi request reprint Occurrence of antimicrobials in the final effluents of wastewater treatment plants in Canada
    Xiu Sheng Miao
    Water Quality Centre, Trent University, Peterborough, Ontario, K9J 7B8 Canada
    Environ Sci Technol 38:3533-41. 2004
    ..The concentrations of antimicrobials detected in WWTP final effluents did not exceed 1 microg/L; levels that are unlikely to affect the growth and survival of aquatic organisms...
  12. ncbi request reprint Release of persistent organic contaminants from carcasses of Lake Ontario Chinook salmon (Oncorhynchus tshawytscha)
    Shaun O'Toole
    Water Quality Centre, Trent University, Peterborough, ON K9J 7B8, Canada
    Environ Pollut 140:102-13. 2006
    ..Based upon the concentrations of contaminants in the salmon tissues, approximately 75 g of total PCBs and 35 g of total DDT compounds would be transported annually into the Credit River from this source...
  13. ncbi request reprint Presence of nonylphenol ethoxylate surfactants in a watershed in central Mexico and removal from domestic sewage in a treatment wetland
    Marco A Belmont
    Environmental and Resource Studies Program, Trent University, Peterborough, Ontario K9J 7B8, Canada
    Environ Toxicol Chem 25:29-35. 2006
    ..These data indicate that construction of low-cost and technologically simple treatment wetlands may be one solution to reducing the impacts of contaminants from domestic sewage in developing countries, such as Mexico...
  14. ncbi request reprint Fate of synthetic musks in a domestic wastewater treatment plant and in an agricultural field amended with biosolids
    Jian jun Yang
    Water Quality Center, Trent University, 1600 West Bank Drive, Peterborough, Ontario, Canada K9J 7B8
    Sci Total Environ 363:149-65. 2006
    ..0 and 1.3 mug/kg, respectively, but concentrations declined relatively rapidly over the next 6 weeks, post-application...
  15. ncbi request reprint Feminization of female leukophore-free strain of Japanese medaka (Oryzias latipes) exposed to 17beta-estradiol
    Gordon C Balch
    Environmental and Resource Studies, Trent University, Peterborough, Ontario K9J 7B8, Canada
    Environ Toxicol Chem 23:2763-8. 2004
    ..The FLFII strain is an excellent teleost model for detecting feminization or masculinization of fish, and automated methods can be used for rapid analysis of the genotypic sex of FLFII medaka...
  16. ncbi request reprint Carbamazepine and its metabolites in wastewater and in biosolids in a municipal wastewater treatment plant
    Xiu Sheng Miao
    Water Quality Centre, Trent University, Peterborough, Ontario K91 7B8, Canada
    Environ Sci Technol 39:7469-75. 2005
    ..The calculated daily inputs into the WWTP are somewhat less than the inputs of 192 g estimated from Canadian annual sales data for CBZ...
  17. ncbi request reprint Alterations to gonadal development and reproductive success in Japanese medaka (Oryzias latipes) exposed to 17alpha-ethinylestradiol
    Gordon C Balch
    Environmental and Resource Studies Program, Trent University, Peterborough, Ontario K9J 7B8, Canada
    Environ Toxicol Chem 23:782-91. 2004
    ..However, it is clear that concentrations of endocrine disrupting chemicals (EDCs) that cause gonadal intersex are sufficient to reduce reproductive performance...
  18. pmc Endocrine disruption and altered gonadal development in white perch (Morone americana) from the lower Great Lakes region
    Richard J Kavanagh
    Environmental and Resource Studies, Trent University, 1600 West Bank Drive, Peterborough, Ontario K9J 7B8, Canada
    Environ Health Perspect 112:898-902. 2004
    ..These observations indicate that male white perch are exposed to estrogenic endocrine-disrupting substances that may be responsible for the induction of gonadal intersex...
  19. doi request reprint Uptake and depuration of the anti-depressant fluoxetine by the Japanese medaka (Oryzias latipes)
    Gordon Paterson
    Worsfold Water Quality Centre, Trent University, Peterborough, Ontario, Canada
    Chemosphere 74:125-30. 2008
    ..These results indicate longer persistence and greater potential for the bioaccumulation of fluoxetine and norfluoxetine in fish tissues than would be predicted from prior half life estimates derived using mammalian species...
  20. doi request reprint Waterborne fluoxetine disrupts the reproductive axis in sexually mature male goldfish, Carassius auratus
    Jan A Mennigen
    Centre for Advances Research in Environmental Genomics, Department of Biology, University of Ottawa, Ontario, Canada
    Aquat Toxicol 100:354-64. 2010
    ..This study demonstrates that FLX disrupts reproductive physiology of male fish at environmentally relevant concentrations, and potential mechanisms are discussed...
  21. ncbi request reprint Effects of the antiandrogens, vinclozolin and cyproterone acetate on gonadal development in the Japanese medaka (Oryzias latipes)
    Yiannis Kiparissis
    Environmental and Resource Studies, Trent University, Peterborough, Ont, Canada K9J 7B8
    Aquat Toxicol 63:391-403. 2003
    ..The results of this study indicate that antiandrogens have the potential to alter testicular development and gametogenesis in fish. However, research is needed to determine the mechanisms by which antiandrogens affect fish...
  22. ncbi request reprint Poor elemental food quality reduces the toxicity of fluoxetine on Daphnia magna
    Laura K Hansen
    Department of Biology, Trent University, Peterborough, Ontario, Canada
    Aquat Toxicol 86:99-103. 2008
    ..Nevertheless, these results demonstrate the need to consider elemental food quality in ecotoxicological testing protocols that are aimed at evaluating the risks of exposure to chemicals in the aquatic environment...
  23. ncbi request reprint Analysis of paroxetine, fluoxetine and norfluoxetine in fish tissues using pressurized liquid extraction, mixed mode solid phase extraction cleanup and liquid chromatography-tandem mass spectrometry
    Shaogang Chu
    Worsfold Water Quality Center, Trent University, Peterborough, Ontario K9J 7B8, Canada
    J Chromatogr A 1163:112-8. 2007
    ..These analyses showed that the three analytes were present in fish tissues at concentrations up to approximately 1 microg/kg wet weight...
  24. ncbi request reprint Simultaneous determination of triclocarban and triclosan in municipal biosolids by liquid chromatography tandem mass spectrometry
    Shaogang Chu
    Worsfold Water Quality Center, Trent University, Peterborough, Ontario, Canada
    J Chromatogr A 1164:212-8. 2007
    ..62 to 11.55 microg/g dry weight for triclosan, and from 2.17 to 5.97 microg/g dry weight for triclocarban...
  25. doi request reprint Detecting the transport of toxic pesticides from golf courses into watersheds in the Precambrian Shield region of Ontario, Canada
    Tracy L Metcalfe
    Worsfold Water Quality Centre, Trent University, Peterborough, Ontario K9J 7B8, Canada
    Environ Toxicol Chem 27:811-8. 2008
    ..Overall, these data indicate that some pesticides applied to golf courses in the Precambrian Shield of central Ontario may have the potential to cause toxic impacts to aquatic organisms in adjacent watersheds...
  26. pmc Effects of the isoflavones genistein and equol on the gonadal development of Japanese medaka Oryzias latipes
    Yiannis Kiparissis
    Environmental and Resource Studies, Trent University, Peterborough, Ontario, Canada
    Environ Health Perspect 111:1158-63. 2003
    ..This laboratory study indicates that isoflavone compounds should be considered candidate estrogenic compounds that may be involved in the alteration of sexual development in feral fish populations...
  27. ncbi request reprint Determination of carbamazepine and its metabolites in aqueous samples using liquid chromatography-electrospray tandem mass spectrometry
    Xiu Sheng Miao
    Water Quality Centre, Trent University, Peterborough, Ontario K9J 7B8, Canada
    Anal Chem 75:3731-8. 2003
    ..To our knowledge, this is the first report on the simultaneous determination of carbamazepine and its metabolites in environmental samples...
  28. ncbi request reprint Determination of pharmaceuticals in aqueous samples using positive and negative voltage switching microbore liquid chromatography/electrospray ionization tandem mass spectrometry
    Xiu Sheng Miao
    Water Quality Centre, Trent University, Peterborough, Ontario K9J 7B8, Canada
    J Mass Spectrom 38:27-34. 2003
    ..Atorvastatin was detected in a sewage treatment plant final effluent...
  29. ncbi request reprint Developmental effects in Japanese medaka (Oryzias latipes) exposed to nonylphenol ethoxylates and their degradation products
    Gordon Balch
    Environmental and Resource Studies Program, Trent University, 1600 West Bank Drive, Peterborough, Ont, Canada K9J 7B8
    Chemosphere 62:1214-23. 2006
    ..NP1EO is very weakly estrogenic at concentrations that are an order of magnitude higher than the lowest observed effect concentration for nonylphenol...
  30. ncbi request reprint Analysis of acrylamide in water using a coevaporation preparative step and isotope dilution liquid chromatography tandem mass spectrometry
    Shaogang Chu
    Worsfold Water Quality Center, Trent University, Peterborough, Ontario, K9J 7B8, Canada
    Anal Chem 79:5093-6. 2007
    ..e., sludge) had been applied. Concentrations of acrylamide in these samples ranged from <LOQ to 0.16 microg/L...
  31. ncbi request reprint Inhibition of metamorphosis in tadpoles of Xenopus laevis exposed to polybrominated diphenyl ethers (PBDEs)
    Gordon C Balch
    Environmental and Resource Studies Program, Trent University, 1600 West Bank Drive, Peterborough, Ont, Canada
    Chemosphere 64:328-38. 2006
    ....
  32. ncbi request reprint Determination of cholesterol-lowering statin drugs in aqueous samples using liquid chromatography-electrospray ionization tandem mass spectrometry
    Xiu Sheng Miao
    Water Quality Center, Trent University, 3720 Nassau Mills Road, Peterborough, ON K9J 7B8, Canada
    J Chromatogr A 998:133-41. 2003
    ..All of the statins were detected in an untreated sewage sample at 4-117 ng/l and in a treated sewage sample at 1-59 ng/1; but only atorvastatin was detected in a surface water sample at 1 ng/l...
  33. doi request reprint Sampling in the Great Lakes for pharmaceuticals, personal care products, and endocrine-disrupting substances using the passive polar organic chemical integrative sampler
    Hongxia Li
    Worsfold Water Quality Centre, Trent University, 1600 West Bank Drive, Peterborough, Ontario K9J 7B8, Canada
    Environ Toxicol Chem 29:751-62. 2010
    ....
  34. ncbi request reprint Analysis of acidic drugs in the effluents of sewage treatment plants using liquid chromatography-electrospray ionization tandem mass spectrometry
    Xiu Sheng Miao
    Water Quality Centre, Trent University, Peterborough, Ont, Canada
    J Chromatogr A 952:139-47. 2002
    ..The method was applied to the quantitative analysis of acidic drugs in the effluents from three Canadian STPs, in which bezafibrate, diclofenac, fenoprofen, gemfibrozil, ibuprofen, indomethacin and naproxen were detected...
  35. doi request reprint Characterizing and compensating for matrix effects using atmospheric pressure chemical ionization liquid chromatography-tandem mass spectrometry: analysis of neutral pharmaceuticals in municipal wastewater
    Xiaoming Zhao
    Worsfold Water Quality Centre, Trent University, Peterborough, Ontario, Canada
    Anal Chem 80:2010-7. 2008
    ..Isotope-labeled compounds corrected for these overestimates that occurred as a result of interferences from the sample matrix...
  36. ncbi request reprint Electrospray ionization mass spectrometry of ginsenosides
    Xiu Sheng Miao
    Water Quality Centre, Trent University, Peterborough, Ontario K9J 7B8, Canada
    J Mass Spectrom 37:495-506. 2002
    ..Adduct ions [M + 2AcO + Na](-), [M + AcO](-), [M - CH(2)O + AcO](-), [M + 2AcO](2-), [M - H + AcO](2-) and [M - 2H](2-) were observed at low cone voltage (15-30 V) only...
  37. ncbi request reprint Fragmentation study of salinomycin and monensin A antibiotics using electrospray quadrupole time-of-flight mass spectrometry
    Xiu Sheng Miao
    Water Quality Centre, Trent University, Peterborough, ON K9J 7B8, Canada
    Rapid Commun Mass Spectrom 17:149-54. 2003
    ..Both type A (containing the terminal carboxyl group) and type F (containing the terminal hydroxyl group) fragment ions were observed in the product ion mass spectra of sodium adduct ions of salinomycin and monensin A...
  38. ncbi request reprint Increased kidney, liver, and testicular cell death after chronic exposure to 17alpha-ethinylestradiol in medaka (Oryzias latipes)
    Lynn P Weber
    Department of Veterinary Biomedical Sciences, University of Saskatchewan, Saskatoon, Saskatchewan S7N 5B4, Canada
    Environ Toxicol Chem 23:792-7. 2004
    ..These results suggest that chronic exposure to EE2 in medaka is hepatotoxic and nephrotoxic in both sexes, whereas gonadal toxicity is specific to males...
  39. ncbi request reprint Seasonality effects on pharmaceuticals and s-triazine herbicides in wastewater effluent and surface water from the Canadian side of the upper Detroit River
    Wen Yi Hua
    Great Lakes Institute for Environmental Research, University of Windsor, 2990 Riverside Drive West, Windsor, Ontario N9B 3P4, Canada
    Environ Toxicol Chem 25:2356-65. 2006
    ..Detroit River surface water concentrations of carbamazepine, cotinine, and atrazine may present a health concern to aquatic wildlife and to humans via the consumption of drinking water...
  40. ncbi request reprint Changes in persistent contaminant concentration and CYP1A1 protein expression in biopsy samples from northern bottlenose whales, Hyperoodon ampullatus, following the onset of nearby oil and gas development
    Sascha K Hooker
    Department of Biology, Dalhousie University, Halifax, Nova Scotia B3H 4J1, Canada
    Environ Pollut 152:205-16. 2008
    ..Concentrations were higher in whales from The Gully than from the Davis Strait, with significant increases in 4,4'-DDE and trans-nonachlor in 2002-2003 relative to 1996-1997...
  41. ncbi request reprint Pharmaceutical compounds in wastewater: wetland treatment as a potential solution
    John R White
    Institute, Louisiana State University, Baton Rouge, LA 70803, USA
    ScientificWorldJournal 6:1731-6. 2006
    ..There is a need to document the degree to which various pharmaceutical compounds are removed in full-scale treatment wetlands, as there is a paucity of data on overall pharmaceutical removal rates...
  42. ncbi request reprint Residues of persistent organochlorine contaminants in southern elephant seals (Mirounga leonina) from Elephant Island, Antarctica
    Kleber C Miranda-Filho
    Programa de Pós Graduação em Oceanografia Biológica, Fundacao Universidade Federal do Rio Grande, Av Itália km 8, 96 201 900 Rio Grande RS, Brazil
    Environ Sci Technol 41:3829-35. 2007
    ..Data showed that concentrations of contaminants generally increased from pups < juveniles < adults and suggested that pups accumulated contaminants through transfer from the mother seals via transplacental and lactational routes...
  43. ncbi request reprint Decreased apoptosis in the forebrain of adult male medaka (Oryzias latipes) after aqueous exposure to ethinylestradiol
    Elizabeth A Stokes
    Department of Biology, Georgia State University, MSC 8L0389, 33 Gilmer St SE, Unit 8, Atlanta 30303 3088, USA
    Comp Biochem Physiol C Toxicol Pharmacol 138:163-7. 2004
    ..Thus, when examining the effects of EDCs on natural populations, data from a variety of tissues should be examined and the interpretation of any effects should include consideration of tissue-specific processes...
  44. ncbi request reprint Increased cellular apoptosis after chronic aqueous exposure to nonylphenol and quercetin in adult medaka (Oryzias latipes)
    Lynn P Weber
    Department of Zoology, Oklahoma State University, 430 Life Sciences West, Stillwater, OK 74078, USA
    Comp Biochem Physiol C Toxicol Pharmacol 131:51-9. 2002
    ..These results suggest that nonylphenol caused testicular degeneration via increased testicular cell apoptosis, while quercetin may be ovotoxic via increased follicular atresia...
  45. doi request reprint Runoff of pharmaceuticals and personal care products following application of biosolids to an agricultural field
    Edward Topp
    Agriculture and Agri Food Canada, London, Canada ON N5V 4T3
    Sci Total Environ 396:52-9. 2008
    ..Overall, this study showed that injection of biosolids slurry below the soil surface could effectively eliminate surface runoff of PPCPs...
  46. ncbi request reprint A teleost in vitro reporter gene assay to screen for agonists of the peroxisome proliferator-activated receptors
    Gele Liu
    Centre for Advanced Research in Environmental Genomics and Department of Biology, University of Ottawa, Ottawa, Ontario K1N 6N5, Canada
    Environ Toxicol Chem 24:2260-6. 2005
    ..This in vitro reporter gene assay shows promise as a rapid and sensitive technique for screening environmental samples for PPAR-active substances...