Jacques J Tremblay
Tremblay J, Robert N. Role of nuclear receptors in INSL3 gene transcription in Leydig cells. Ann N Y Acad Sci. 2005;1061:183-9 pubmed
..Thus, the human INSL3 promoter constitutes a novel target for the orphan nuclear receptor Nur77. ..
Abdou H, Bergeron F, Tremblay J. A cell-autonomous molecular cascade initiated by AMP-activated protein kinase represses steroidogenesis. Mol Cell Biol. 2014;34:4257-71 pubmed publisher
..Our data identify AMPK as a molecular rheostat that actively represses steroid hormone biosynthesis to preserve cellular energy homeostasis and prevent excess steroid production. ..
Moisan V, Bomgardner D, Tremblay J. Expression of the Ladybird-like homeobox 2 transcription factor in the developing mouse testis and epididymis. BMC Dev Biol. 2008;8:22 pubmed publisher
..Altogether, our data suggest that the homeoprotein Lbx2 might be involved in the regulation of male reproductive system development and cell differentiation as well as in male epididymal segmentation. ..
Mendoza Villarroel R, Di Luoffo M, Camiré E, Giner X, Brousseau C, Tremblay J. The INSL3 gene is a direct target for the orphan nuclear receptor, COUP-TFII, in Leydig cells. J Mol Endocrinol. 2014;53:43-55 pubmed publisher
Mendoza Villarroel R, Robert N, Martin L, Brousseau C, Tremblay J. The nuclear receptor NR2F2 activates star expression and steroidogenesis in mouse MA-10 and MLTC-1 Leydig cells. Biol Reprod. 2014;91:26 pubmed publisher
..These data identify an essential role for the nuclear receptor NR2F2 as a direct activator of Star gene expression in Leydig cells, and thus in the control of steroid hormone biosynthesis. ..