E Widjaja

Summary

Affiliation: The Hospital for Sick Children
Country: Canada

Publications

  1. doi request reprint Bilateral white matter abnormality in children with frontal lobe epilepsy
    Elysa Widjaja
    Diagnostic Imaging, Hospital for Sick Children, Toronto, Canada Electronic address
    Epilepsy Res 108:289-94. 2014
  2. doi request reprint Patient and hospital characteristics are associated with cost of hospitalizations in children with epilepsy
    Elysa Widjaja
    Diagnostic Imaging, University of Toronto, Toronto, Canada
    Epilepsy Behav 28:335-42. 2013
  3. pmc Abnormal white matter correlates with neuropsychological impairment in children with localization-related epilepsy
    Elysa Widjaja
    Diagnostic Imaging, Hospital for Sick Children, Toronto, Ontario, Canada
    Epilepsia 54:1065-73. 2013
  4. doi request reprint Diagnostic evaluation in patients with intractable epilepsy and normal findings on MRI: a decision analysis and cost-effectiveness study
    E Widjaja
    Diagnostic Imaging and Division of Neurology, Hospital for Sick Children, Toronto, Ontario, Canada
    AJNR Am J Neuroradiol 34:1004-9, S1-2. 2013
  5. doi request reprint FDG-PET and magnetoencephalography in presurgical workup of children with localization-related nonlesional epilepsy
    Elysa Widjaja
    Diagnostic Imaging, Hospital for Sick Children, Toronto, Ontario, Canada
    Epilepsia 54:691-9. 2013
  6. doi request reprint Impaired default mode network on resting-state FMRI in children with medically refractory epilepsy
    E Widjaja
    Department of Diagnostic Imaging, Hospital for Sick Children, Toronto, Ontario, Canada
    AJNR Am J Neuroradiol 34:552-7. 2013
  7. doi request reprint Abnormal white matter on diffusion tensor imaging in children with new-onset seizures
    E Widjaja
    Diagnostic Imaging, Hospital for Sick Children, Toronto, Canada
    Epilepsy Res 104:105-11. 2013
  8. doi request reprint Diffusion tensor imaging assessment of the epileptogenic zone in children with localization-related epilepsy
    E Widjaja
    Department of Diagnostic Imaging, Hospital for Sick Children, Toronto, Ontario, Canada
    AJNR Am J Neuroradiol 32:1789-94. 2011
  9. doi request reprint Reduced cortical thickness in children with new-onset seizures
    E Widjaja
    Department of Diagnostic Imaging, Hospital for Sick Children, Toronto, Ontario, Canada
    AJNR Am J Neuroradiol 33:673-7. 2012
  10. doi request reprint Abnormal fetal cerebral laminar organization in cobblestone complex as seen on post-mortem MRI and DTI
    Elysa Widjaja
    Department of Diagnostic Imaging, Hospital for Sick Children, 555 University Ave, Toronto, Canada
    Pediatr Radiol 39:860-4. 2009

Detail Information

Publications52

  1. doi request reprint Bilateral white matter abnormality in children with frontal lobe epilepsy
    Elysa Widjaja
    Diagnostic Imaging, Hospital for Sick Children, Toronto, Canada Electronic address
    Epilepsy Res 108:289-94. 2014
    ..032). There was no significant association between FA or MD and clinical seizure parameters. The abnormal WM both ipsilateral and contralateral to seizure focus may be due to seizure activity or abnormal brain development...
  2. doi request reprint Patient and hospital characteristics are associated with cost of hospitalizations in children with epilepsy
    Elysa Widjaja
    Diagnostic Imaging, University of Toronto, Toronto, Canada
    Epilepsy Behav 28:335-42. 2013
    ..We found that the number and cost of hospitalizations in children with epilepsy vary by patient and hospital characteristics. Such findings are essential for informing future health plans and policy decisions on resource allocation. ..
  3. pmc Abnormal white matter correlates with neuropsychological impairment in children with localization-related epilepsy
    Elysa Widjaja
    Diagnostic Imaging, Hospital for Sick Children, Toronto, Ontario, Canada
    Epilepsia 54:1065-73. 2013
    ....
  4. doi request reprint Diagnostic evaluation in patients with intractable epilepsy and normal findings on MRI: a decision analysis and cost-effectiveness study
    E Widjaja
    Diagnostic Imaging and Division of Neurology, Hospital for Sick Children, Toronto, Ontario, Canada
    AJNR Am J Neuroradiol 34:1004-9, S1-2. 2013
    ..The aim of this study was to determine the cost-effective diagnostic strategy that will identify the epileptogenic zone in patients with suspected focal intractable epilepsy and normal MR imaging findings by using decision analysis...
  5. doi request reprint FDG-PET and magnetoencephalography in presurgical workup of children with localization-related nonlesional epilepsy
    Elysa Widjaja
    Diagnostic Imaging, Hospital for Sick Children, Toronto, Ontario, Canada
    Epilepsia 54:691-9. 2013
    ....
  6. doi request reprint Impaired default mode network on resting-state FMRI in children with medically refractory epilepsy
    E Widjaja
    Department of Diagnostic Imaging, Hospital for Sick Children, Toronto, Ontario, Canada
    AJNR Am J Neuroradiol 34:552-7. 2013
    ..However, little is known about the DMN in children with medically refractory epilepsy. The aim was to determine whether there was a difference in the DMN in children with medically refractory epilepsy relative to controls...
  7. doi request reprint Abnormal white matter on diffusion tensor imaging in children with new-onset seizures
    E Widjaja
    Diagnostic Imaging, Hospital for Sick Children, Toronto, Canada
    Epilepsy Res 104:105-11. 2013
    ..The findings indicate that impaired WM integrity with abnormal myelin and axons is present in children with new-onset seizures...
  8. doi request reprint Diffusion tensor imaging assessment of the epileptogenic zone in children with localization-related epilepsy
    E Widjaja
    Department of Diagnostic Imaging, Hospital for Sick Children, Toronto, Ontario, Canada
    AJNR Am J Neuroradiol 32:1789-94. 2011
    ....
  9. doi request reprint Reduced cortical thickness in children with new-onset seizures
    E Widjaja
    Department of Diagnostic Imaging, Hospital for Sick Children, Toronto, Ontario, Canada
    AJNR Am J Neuroradiol 33:673-7. 2012
    ..Our aim was to evaluate hippocampal and thalamic volumes and lobar cortical thickness of children with new-onset seizures...
  10. doi request reprint Abnormal fetal cerebral laminar organization in cobblestone complex as seen on post-mortem MRI and DTI
    Elysa Widjaja
    Department of Diagnostic Imaging, Hospital for Sick Children, 555 University Ave, Toronto, Canada
    Pediatr Radiol 39:860-4. 2009
    ....
  11. doi request reprint Subcortical alterations in tissue microstructure adjacent to focal cortical dysplasia: detection at diffusion-tensor MR imaging by using magnetoencephalographic dipole cluster localization
    Elysa Widjaja
    Department of Diagnostic Imaging, Division of Neurology, Hospital for Sick Children, 555 University Ave, Toronto, ON, Canada
    Radiology 251:206-15. 2009
    ....
  12. doi request reprint Alteration of diffusion tensor parameters in postmortem brain
    Elysa Widjaja
    Diagnostic Imaging, Hospital for Sick Children, Toronto, Canada
    Magn Reson Imaging 27:865-70. 2009
    ..However, trace and eigenvalues decreased markedly within the first few hours postmortem. Therefore trace and eigenvalues obtained from ex vivo studies cannot be extrapolated to in vivo studies...
  13. doi request reprint Effects of gradient encoding and number of signal averages on fractional anisotropy and fiber density index in vivo at 1.5 tesla
    E Widjaja
    Diagnostic Imaging, Hospital for Sick Children, Toronto, Ontario, Canada
    Acta Radiol 50:106-13. 2009
    ..Tensor estimation can be improved by increasing the number of gradient directions (NGD) or increasing the number of signal averages (NSA), but at a cost of increased scan time...
  14. doi request reprint Alteration of human fetal subplate layer and intermediate zone during normal development on MR and diffusion tensor imaging
    E Widjaja
    Diagnostic Imaging, Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, Canada
    AJNR Am J Neuroradiol 31:1091-9. 2010
    ....
  15. doi request reprint Diffusion tensor imaging identifies changes in normal-appearing white matter within the epileptogenic zone in tuberous sclerosis complex
    Elysa Widjaja
    Diagnostic Imaging, Hospital for Sick Children, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada
    Epilepsy Res 89:246-53. 2010
    ..To evaluate diffusion tensor imaging (DTI) indices of (i) cortical tubers and (ii) normal-appearing subcortical white matter adjacent to cortical tubers within the epileptogenic zone and non-epileptogenic zone...
  16. doi request reprint Longitudinal brain volumes in children with intractable partial seizures
    Elysa Widjaja
    Diagnostic Imaging, Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada
    Pediatr Neurol 42:315-9. 2010
    ....
  17. doi request reprint Corroboration of normal and abnormal fetal cerebral lamination on postmortem MR imaging with postmortem examination
    E Widjaja
    Department of Diagnostic Imaging, Hospital for Sick Children, Toronto, Ontario, Canada
    AJNR Am J Neuroradiol 31:1987-93. 2010
    ..Our aim was to compare postmortem MR imaging assessment of normal and abnormal fetal cerebral lamination on T1- and T2-weighted images with histopathology...
  18. doi request reprint Cost-effectiveness of pediatric epilepsy surgery compared to medical treatment in children with intractable epilepsy
    Elysa Widjaja
    Diagnostic Imaging, The Hospital for Sick Children, Canada
    Epilepsy Res 94:61-8. 2011
    ..We evaluated the cost-effectiveness of epilepsy surgery compared to medical treatment in children with intractable epilepsy...
  19. doi request reprint Widespread cortical thinning in children with frontal lobe epilepsy
    Elysa Widjaja
    Diagnostic Imaging, Hospital for Sick Children, Toronto, Ontario, Canada
    Epilepsia 52:1685-91. 2011
    ..The aim of this study was to identify regions of reduced cortical thickness in children with intractable FLE...
  20. doi request reprint Characteristics of MEG and MRI between Taylor's focal cortical dysplasia (type II) and other cortical dysplasia: surgical outcome after complete resection of MEG spike source and MR lesion in pediatric cortical dysplasia
    Elysa Widjaja
    Diagnostic Imaging, The Hospital for Sick Children, Ontario, Canada
    Epilepsy Res 82:147-55. 2008
    ..The aims of this study were to determine whether MRI and magnetoencephalography (MEG) could distinguish between these two groups and to evaluate surgical outcomes...
  21. ncbi request reprint Post-mortem MRI of the foetal spine and spinal cord
    E Widjaja
    Academic Section of Radiology, Sheffield Children s Hospital, Sheffield, UK
    Clin Radiol 61:679-85. 2006
    ..To compare the findings of post-mortem magnetic resonance imaging (MRI) of the foetal spine with autopsy with a view to using post-mortem MRI as an alternative or adjunct to autopsy, particularly in foetal and neonatal cases...
  22. doi request reprint Advances in neuroimaging in patients with epilepsy
    Elysa Widjaja
    Department of Diagnostic Imaging, Hospital for Sick Children, Toronto, Ontario, Canada
    Neurosurg Focus 25:E3. 2008
    ..In addition to MR imaging, magnetoencephalography and nuclear medicine studies such as PET and SPECT scanning may be used to lateralize seizure focus when clinical, electrophysiological, and structural MR imaging findings are discordant...
  23. ncbi request reprint Evaluation of subcortical white matter and deep white matter tracts in malformations of cortical development
    Elysa Widjaja
    Diagnostic Imaging, Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, Canada
    Epilepsia 48:1460-9. 2007
    ..The purpose was to investigate (1) the microstructural changes in subcortical white matter adjacent to malformations of cortical development (MCD) and (2) the deep white matter tracts using diffusion tensor imaging (DTI)...
  24. ncbi request reprint Diffusion tensor imaging of midline posterior fossa malformations
    Elysa Widjaja
    Diagnostic Imaging, Hospital for Sick Children, Toronto, ON, Canada
    Pediatr Radiol 36:510-7. 2006
    ..However, these studies have focused mainly on malformations involving the supratentorial compartments. There is a paucity of data on diffusion tensor imaging of posterior fossa malformations...
  25. ncbi request reprint White matter abnormalities in children with idiopathic developmental delay
    E Widjaja
    Diagnostic Imaging, Hospital for Sick Children, Toronto, Ontario, Canada
    Acta Radiol 49:589-95. 2008
    ..The underlying cause of developmental delay (DD) often remains unclear despite extensive clinical examination and investigations. Interference in normal development of the brain may result in DD...
  26. ncbi request reprint Normal fetal lumbar spine on postmortem MR imaging
    E Widjaja
    Academic Section of Radiology, University of Sheffield, Sheffield, United Kingdom
    AJNR Am J Neuroradiol 27:553-9. 2006
    ..The aim of this study is to describe the MR imaging appearances of normal development of the fetal spine at different gestational ages...
  27. ncbi request reprint 2D time-of-flight MR venography in neonates: anatomy and pitfalls
    E Widjaja
    Diagnostic Imaging, Hospital for Sick Children, Toronto, Ontario, Canada
    AJNR Am J Neuroradiol 27:1913-8. 2006
    ..The aim of this retrospective study is to evaluate the presence of flow gaps in venous sinuses in neonates on 2D time-of-flight (TOF) MR venography (MRV)...
  28. doi request reprint Wavelets and fuzzy relational classifiers: a novel diffusion-weighted image analysis system for pediatric metabolic brain diseases
    S Zarei Mahmoodabadi
    Diagnostic Imaging Department, The Hospital for Sick Children, Toronto, Canada
    Comput Methods Programs Biomed 103:74-86. 2011
    ..A sensitivity and specificity of 60% and 93.33%, respectively, in detecting metabolic brain diseases have been achieved...
  29. doi request reprint Abnormal axial diffusivity in the deep gray nuclei and dorsal brain stem in infantile spasm treated with vigabatrin
    G N Simao
    Department of Diagnostic Imaging, Hospital for Sick Children, Toronto, Ontario, Canada
    AJNR Am J Neuroradiol 32:199-203. 2011
    ..The findings suggest that axonal changes play a greater role in the observed abnormal signal intensity, with lesser contribution from myelin changes...
  30. ncbi request reprint Involvement of the anterior lobe of the cerebellar vermis in perinatal profound hypoxia
    D J A Connolly
    Department of Radiology, Sheffield Children s Hospital, Sheffield, England
    AJNR Am J Neuroradiol 28:16-9. 2007
    ..We tested the hypothesis that this sign was associated with other signs of significant perinatal hypoxic damage...
  31. doi request reprint PCA-SGA implementation in classification and disease specific feature extraction of the brain MRS signals
    S Zarei Mahmoodabadi
    Department of Electrical Engineering at Ryerson University, Toronto, ON, Canada
    Conf Proc IEEE Eng Med Biol Soc 2008:3526-9. 2008
    ..The PCA-SGA implementation received the specificity of 89.91%. The SGA was able to achieve the sensitivity of 84.84% and positive predictivity of 88.46% in extracting disease specific MRS signal features...
  32. ncbi request reprint Magnetic resonance perfusion imaging in malformations of cortical development
    E Widjaja
    Academic Section of Radiology, University of Sheffield, Sheffield, United Kingdom
    Acta Radiol 48:907-17. 2007
    ..Malformations of cortical development vary in neuronal maturity and level of functioning...
  33. doi request reprint Localization of epileptic foci in children with intractable epilepsy secondary to multiple cortical tubers by using synthetic aperture magnetometry kurtosis
    Ichiro Sugiyama
    Divisions of Neurology, The Hospital for Sick Children, University of Toronto, Ontario, Canada
    J Neurosurg Pediatr 4:515-22. 2009
    ..To evaluate the efficacy of the SAM(g2) method, the authors applied it to readings obtained in children with intractable epilepsy secondary to tuberous sclerosis complex (TSC), and compared them to localizations obtained with ECDs...
  34. ncbi request reprint Preserved structural integrity of white matter adjacent to low-grade tumors
    Daniel Nilsson
    Diagnostic Imaging, Hospital for Sick Children, 555 University Avenue, Toronto, ON M5G 1X8, Canada
    Childs Nerv Syst 24:313-20. 2008
    ..We hypothesized that the structural integrity of the adjacent WM tracts would be preserved in these slow-growing tumors...
  35. ncbi request reprint Midline "brain in brain": an unusual variant of holoprosencephaly with anterior prosomeric cortical dysplasia
    E Widjaja
    Division of Neuroradiology, Hospital for Sick Children, Toronto, Ontario, Canada
    Childs Nerv Syst 23:437-42. 2007
    ..We report three cases of brain malformation presenting with a midline mass of dysplastic cortex that we have termed "brain in brain" malformation...
  36. ncbi request reprint Misrepresentation of surface rendering of pediatric brain malformations performed following spatial normalization
    L I Wallis
    Academic Unit of Radiology, Royal Hallamshire Hospital, Sheffield, UK
    Acta Radiol 47:1094-9. 2006
    ..To evaluate the effects of spatial normalization on volume rendering in cases of pediatric brain malformation...
  37. doi request reprint Diffusion tensor tractography detection of functional pathway for the spread of epileptiform activity between temporal lobe and Rolandic region
    Ratan D Bhardwaj
    Division of Neurosurgery, Department of Surgery, The Hospital for Sick Children, Suite 2608 12 Yonge Street, Toronto, ON, Canada
    Childs Nerv Syst 26:185-90. 2010
    ..The aim of the study was to assess the connectivity between magnetoencephalographic (MEG) dipoles in the temporal lobe and Rolandic region in children with temporal lobe epilepsy using diffusion tensor imaging (DTI) tractography...
  38. ncbi request reprint MR imaging of patients with localisation-related seizures: initial experience at 3.0T and relevance to the NICE guidelines
    P D Griffiths
    Section of Radiology, University of Sheffield, Sheffield, UK
    Clin Radiol 60:1090-9. 2005
    ..Although MR is acknowledged to be a reliable way of detecting pathology in people with epilepsy there is a dearth of information studying the health economics of imaging epilepsy in relation to patient management and outcomes...
  39. doi request reprint Diffusion tensor imaging of commissural and projection white matter in tuberous sclerosis complex and correlation with tuber load
    G Simao
    Diagnostic Imaging, Hospital for Sick Children, Toronto, Ontario, Canada
    AJNR Am J Neuroradiol 31:1273-7. 2010
    ..The aim of this study was to evaluate DTI changes in the corpus callosum and internal capsules and to correlate the DTI changes with cortical/subcortical tuber load...
  40. ncbi request reprint Presurgical localization of primary motor cortex in pediatric patients with brain lesions by the use of spatially filtered magnetoencephalography
    William Gaetz
    Department of Diagnostic Imaging, Hospital for Sick Children, Toronto, Canada
    Neurosurgery 64:ons177-85; discussion ons186. 2009
    ....
  41. doi request reprint MRI of childhood epilepsy due to inborn errors of metabolism
    Bejoy Thomas
    Department of Diagnostic Imaging, The Hospital for Sick Children, 555 University Ave, Toronto, ON M5G 1X8, Canada
    AJR Am J Roentgenol 194:W367-74. 2010
    ..The purpose of this pictorial essay is to classify epilepsy syndromes due to inborn errors of metabolism according to age at onset and type of seizure and to show the MRI features of many of the syndromes...
  42. doi request reprint Brain and bone abnormalities of thanatophoric dwarfism
    Elka Miller
    Department of Diagnostic Imaging, Hospital for Sick Children, Toronto, ON, Canada
    AJR Am J Roentgenol 192:48-51. 2009
    ..The purpose of this article is to present the imaging findings of skeletal and brain abnormalities in thanatophoric dwarfism, a lethal form of dysplastic dwarfism...
  43. doi request reprint Interictal epileptogenic fast oscillations on neonatal and infantile EEGs in hemimegalencephaly
    Madoka Yamazaki
    Division of Neurology, The Hospital for Sick Children, Toronto, ON, Canada
    Epilepsy Res 83:198-206. 2009
    ..Hemimegalencephaly is an epileptic encephalopathy which presents during the neonatal period. Our aims are to analyze interictal fast oscillations and EEG patterns in neonates and infants with hemimegalencephaly...
  44. doi request reprint Bilateral diffusion tensor abnormalities of temporal lobe and cingulate gyrus white matter in children with temporal lobe epilepsy
    Daniel Nilsson
    Department of Diagnostic Imaging at The Hospital for Sick Children, Toronto, Ontario, Canada
    Epilepsy Res 81:128-35. 2008
    ..The aim of this study was to investigate interictal changes in the temporal lobe white matter (TLWM) and cingulate gyrus white matter (CGWM) of children with TLE using DTI...
  45. doi request reprint Corpus callosotomy in children and the disconnection syndromes: a review
    Andrew Jea
    Division of Neurosurgery, Department of Surgery, Hospital for Sick Children, University of Toronto Faculty of Medicine, Suite 1503, 555 University Avenue, Toronto, Ontario, Canada M5G 1X8
    Childs Nerv Syst 24:685-92. 2008
    ..In addition, most published case reports and case series of corpus callosotomy seldom report neurological deficits. We sought to categorize these deficits based on surgical anatomy...
  46. doi request reprint Neurosurgical management of intractable rolandic epilepsy in children: role of resection in eloquent cortex. Clinical article
    Mony Benifla
    Divisions of Neurosurgery, The Hospital for Sick Children, The University of Toronto, Ontario, Canada
    J Neurosurg Pediatr 4:199-216. 2009
    ..The authors undertook this study to review their experience with cortical resections in the rolandic region in children with intractable epilepsy...
  47. ncbi request reprint The old and the new: supratentorial MR findings in Chiari II malformation
    Elka Miller
    Division of Neuroradiology, Diagnostic Imaging, The Hospital for Sick Children, Toronto, Canada
    Childs Nerv Syst 24:563-75. 2008
    ..The objective of this study was to use magnetic resonance imaging to develop an improved morphological understanding of the abnormalities of the forebrain in Chiari II malformation...
  48. doi request reprint Vigabatrin-associated reversible MRI signal changes in patients with infantile spasms
    Aphrodite Dracopoulos
    Department of Ophthalmology and Vision Sciences, The Hospital for Sick Children, Toronto, Ontario, Canada
    Epilepsia 51:1297-304. 2010
    ..To evaluate the magnetic resonance imaging (MRI) of pediatric patients with infantile spasms (IS) treated with vigabatrin (VGB) in order to investigate whether VGB affects the brain...
  49. doi request reprint Occipital lobe injury and cortical visual outcomes after neonatal hypoglycemia
    Emily W Y Tam
    Department of Pediatrics, Division of Neonatology, Hospital for Sick Children, 555 University Ave, Toronto, Ontario M5G 1X8, Canada
    Pediatrics 122:507-12. 2008
    ..The purpose of this study was to determine whether hypoglycemic injury, as indicated by diffusion restriction in the occipital lobes, correlated with visual evoked potentials and long-term cortical visual dysfunction...
  50. ncbi request reprint Imaging the fetal spine using in utero MR: diagnostic accuracy and impact on management
    Paul D Griffiths
    Academic Unit of Radiology, Royal Hallamshire Hospital, University of Sheffield, Glossop Road, Sheffield, S10 2JF, UK
    Pediatr Radiol 36:927-33. 2006
    ..In-utero MR imaging (iuMR) has entered the clinical arena during the last decade. It is used mainly for imaging fetal brain abnormalities...
  51. pmc In utero magnetic resonance imaging for brain and spinal abnormalities in fetuses
    Paul D Griffiths
    Academic Unit of Radiology, University of Sheffield, Royal Hallamshire Hospital, Sheffield S10 2JF
    BMJ 331:562-5. 2005
  52. ncbi request reprint Proton MR spectroscopy of polymicrogyria and heterotopia
    Elysa Widjaja
    Department of Radiology, Royal Hallamshire Hospital, Sheffield, England
    AJNR Am J Neuroradiol 24:2077-81. 2003
    ..The aim of this study was to determine the MR spectroscopic characteristics of polymicrogyria and heterotopia compared with those of normal frontal lobe white matter...