Sheila Weitzman

Summary

Affiliation: The Hospital for Sick Children
Country: Canada

Publications

  1. ncbi request reprint Langerhans cell histiocytosis: update for the pediatrician
    Sheila Weitzman
    Division of Pediatric Hematology Oncology, The Hospital for Sick Children, Toronto and University of Toronto, Toronto, Canada
    Curr Opin Pediatr 20:23-9. 2008
  2. ncbi request reprint Uncommon histiocytic disorders: the non-Langerhans cell histiocytoses
    Sheila Weitzman
    Department of Pediatrics, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada
    Pediatr Blood Cancer 45:256-64. 2005
  3. doi request reprint Approach to hemophagocytic syndromes
    Sheila Weitzman
    Division of Hematology Oncology, The Hospital for Sick Children, Toronto, ON, Canada
    Hematology Am Soc Hematol Educ Program 2011:178-83. 2011
  4. ncbi request reprint Complementary and alternative (CAM) dietary therapies for cancer
    Sheila Weitzman
    The Division of Hematology Oncology, The Hospital for Sick Children, Toronto, Ontario, Canada
    Pediatr Blood Cancer 50:494-7; discussion 498. 2008
  5. ncbi request reprint 2'-Chlorodeoxyadenosine (2-CdA) as salvage therapy for Langerhans cell histiocytosis (LCH). results of the LCH-S-98 protocol of the Histiocyte Society
    Sheila Weitzman
    Division of Hematology Oncology, The Hospital for Sick Children, Toronto, Ontario, Canada
    Pediatr Blood Cancer 53:1271-6. 2009
  6. ncbi request reprint Anaplastic large cell lymphoma of the ovary in a pediatric patient
    Amy Lee Chong
    Department of Paediatrics Division of Haematology Oncology, The Hospital for Sick Children, Toronto, Ontario, Canada
    J Pediatr Hematol Oncol 31:702-4. 2009
  7. doi request reprint Increased complications and morbidity in children with hemophagocytic lymphohistiocytosis undergoing hematopoietic stem cell transplantation
    Rahul Naithani
    Division of Haematology Oncology, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada
    Clin Transplant 27:248-54. 2013
  8. doi request reprint Peripheral T-cell lymphoma in children and adolescents: a single-institution experience
    Rabah Al Mahmoud
    Department of Paediatrics, Division of Haematology Oncology, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada
    J Pediatr Hematol Oncol 34:611-6. 2012
  9. ncbi request reprint Comparison of long-term neurocognitive outcomes in young children with acute lymphoblastic leukemia treated with cranial radiation or high-dose or very high-dose intravenous methotrexate
    Brenda J Spiegler
    Department of Paediatrics, Division of Haematology Oncology, The Hospital for Sick Children, The University of Toronto, Toronto, Ontario, Canada
    J Clin Oncol 24:3858-64. 2006
  10. doi request reprint Gene expression using microarrays in transplant recipients at risk of EBV lymphoproliferation after organ transplantation: preliminary proof-of-concept
    Upton Allen
    Division of Infectious Diseases, The Department of Pediatrics, Hospital for Sick Children, University of Toronto, Toronto, ON, Canada
    Pediatr Transplant 13:990-8. 2009

Detail Information

Publications56

  1. ncbi request reprint Langerhans cell histiocytosis: update for the pediatrician
    Sheila Weitzman
    Division of Pediatric Hematology Oncology, The Hospital for Sick Children, Toronto and University of Toronto, Toronto, Canada
    Curr Opin Pediatr 20:23-9. 2008
    ....
  2. ncbi request reprint Uncommon histiocytic disorders: the non-Langerhans cell histiocytoses
    Sheila Weitzman
    Department of Pediatrics, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada
    Pediatr Blood Cancer 45:256-64. 2005
    ..A conceptual way to think of these disorders that make them less confusing and easier to remember is proposed based on immunophenotyping and clinical presentation...
  3. doi request reprint Approach to hemophagocytic syndromes
    Sheila Weitzman
    Division of Hematology Oncology, The Hospital for Sick Children, Toronto, ON, Canada
    Hematology Am Soc Hematol Educ Program 2011:178-83. 2011
    ..This article contains a discussion of the genetic background, clinical presentation, diagnostic dilemmas, and features that are helpful in making the diagnosis of HLH, along with a discussion of common problems in its management...
  4. ncbi request reprint Complementary and alternative (CAM) dietary therapies for cancer
    Sheila Weitzman
    The Division of Hematology Oncology, The Hospital for Sick Children, Toronto, Ontario, Canada
    Pediatr Blood Cancer 50:494-7; discussion 498. 2008
    ..Advantages include involvement of the child and family in decision-making and care. There is no evidence to support the claims that CAM dietary therapies cure cancer...
  5. ncbi request reprint 2'-Chlorodeoxyadenosine (2-CdA) as salvage therapy for Langerhans cell histiocytosis (LCH). results of the LCH-S-98 protocol of the Histiocyte Society
    Sheila Weitzman
    Division of Hematology Oncology, The Hospital for Sick Children, Toronto, Ontario, Canada
    Pediatr Blood Cancer 53:1271-6. 2009
    ..A prospective phase II Histiocyte Society study, LCH-S-98, evaluated the efficacy of 2-chlorodeoxyadenosine (2-CdA) monotherapy as salvage therapy in Langerhans cell histiocytosis (LCH)...
  6. ncbi request reprint Anaplastic large cell lymphoma of the ovary in a pediatric patient
    Amy Lee Chong
    Department of Paediatrics Division of Haematology Oncology, The Hospital for Sick Children, Toronto, Ontario, Canada
    J Pediatr Hematol Oncol 31:702-4. 2009
    ..We describe the unusual case of a 14-year-old adolescent with a locally disseminated ovarian anaplastic large-cell lymphoma, treated with surgery followed by chemotherapy, and who remains disease free at 2 years after diagnosis...
  7. doi request reprint Increased complications and morbidity in children with hemophagocytic lymphohistiocytosis undergoing hematopoietic stem cell transplantation
    Rahul Naithani
    Division of Haematology Oncology, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada
    Clin Transplant 27:248-54. 2013
    ..Hematopoietic stem cell transplantation (HSCT) is the only curative option for patients with primary hemophagocytic lymphohistiocytosis (HLH) and for patients with secondary HLH who fail to respond to therapy...
  8. doi request reprint Peripheral T-cell lymphoma in children and adolescents: a single-institution experience
    Rabah Al Mahmoud
    Department of Paediatrics, Division of Haematology Oncology, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada
    J Pediatr Hematol Oncol 34:611-6. 2012
    ..Peripheral T-cell lymphoma (PTCL) is rare in pediatric patients and is associated with worse outcome compared with other pediatric non-Hodgkin lymphomas. We report our institutional experience over a 10-year period...
  9. ncbi request reprint Comparison of long-term neurocognitive outcomes in young children with acute lymphoblastic leukemia treated with cranial radiation or high-dose or very high-dose intravenous methotrexate
    Brenda J Spiegler
    Department of Paediatrics, Division of Haematology Oncology, The Hospital for Sick Children, The University of Toronto, Toronto, Ontario, Canada
    J Clin Oncol 24:3858-64. 2006
    ..The impact of chemotherapy-only protocols on neurocognitive outcomes is unclear, and the importance of systemic MTX dose has not been established...
  10. doi request reprint Gene expression using microarrays in transplant recipients at risk of EBV lymphoproliferation after organ transplantation: preliminary proof-of-concept
    Upton Allen
    Division of Infectious Diseases, The Department of Pediatrics, Hospital for Sick Children, University of Toronto, Toronto, ON, Canada
    Pediatr Transplant 13:990-8. 2009
    ..In summary, we demonstrated varying degrees of alignment between levels of VL and gene clusters. Analyses for differential expression of genes showed genes that could be implicated in the pathogenesis of EBV-PTLD...
  11. ncbi request reprint Survival and late effects in children with Hodgkin's lymphoma treated with MOPP/ABV and low-dose, extended-field irradiation
    Lionel M L Chow
    Division of Haematology and Oncology, Department of Paediatrics, Toronto Sunnybrook Regional Cancer Centre, The Hospital for Sick Children, Toronto, Ontario, Canada
    J Clin Oncol 24:5735-41. 2006
    ..Reduced-intensity protocols for pediatric Hodgkin's lymphoma are aimed at preserving excellent relapse-free survival while decreasing the incidence of late effects...
  12. doi request reprint Hemophagocytic lymphohistiocytosis onset during induction therapy for precursor B-cell acute lymphoblastic leukemia
    Vicky R Breakey
    Division of Pediatric Haematology and Oncology, Department of Paediatric Medicine, Hospital for Sick Children, Toronto, Canada
    J Pediatr Hematol Oncol 30:956-8. 2008
    ..His symptoms improved significantly after an increased dosage of steroids...
  13. ncbi request reprint Langerhans cell histiocytosis: Current concepts and treatments
    Oussama Abla
    Department of Paediatrics, The Hospital for Sick Children, Toronto, Ontario, Canada
    Cancer Treat Rev 36:354-9. 2010
    ..Due to the rarity of LCH in children and adults, patients must be enrolled on multi-national clinical trials, whenever possible, to advance our knowledge of the optimal therapeutic strategies and long-term outcomes...
  14. ncbi request reprint Post-transplant lymphoproliferative disorder in pediatric heart transplant recipients
    Cedric Manlhiot
    Labatt Family Heart Centre, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
    J Heart Lung Transplant 29:648-57. 2010
    ..Post-transplantation lymphoproliferative disorder (PTLD) is a major cause of morbidity and mortality after pediatric heart transplantation...
  15. doi request reprint Human metapneumovirus (hMPV) infection in children with cancer
    Muhammad Ali
    Division of Hematology Oncology, The Hospital for Sick Children, Toronto, ON, Canada
    J Pediatr Hematol Oncol 35:444-6. 2013
    ..Infections may result in significant disease but is usually not fatal. In the absence of specific anti-viral drug, good symptomatic therapy appears to be the optimal therapy. ..
  16. ncbi request reprint Primary and secondary hemophagocytic lymphohistiocytosis: clinical features, pathogenesis and therapy
    Sumit Gupta
    Division of Haematology Oncology, The Hospital for Sick Children, 555 University Avenue, Toronto, ON M5G 1X8, Canada
    Expert Rev Clin Immunol 6:137-54. 2010
    ..This article examines recent advances in our understanding of the pathophysiology, clinical features, diagnosis, etiology and treatment of HLH, as well as the challenges that lie ahead...
  17. pmc Primary CNS lymphoma in children and adolescents: a descriptive analysis from the International Primary CNS Lymphoma Collaborative Group (IPCG)
    Oussama Abla
    Division of Haematology Oncology, Department of Paediatrics, Hospital for Sick Children, University of Toronto, Toronto, Canada
    Clin Cancer Res 17:346-52. 2011
    ..To describe the demographic and clinical features and outcomes for children and adolescents with primary CNS lymphoma (PCNSL)...
  18. ncbi request reprint Cutaneous Langerhans cell histiocytosis in children under one year
    Loretta Lau
    Division of Haematology Oncology, Department of Paediatrics, The Hospital for Sick Children, Toronto, Ontario, Canada
    Pediatr Blood Cancer 46:66-71. 2006
    ..To evaluate the clinical course and outcome of infants with Langerhans cell histiocytosis (LCH) involving skin and to estimate the incidence of progression to multi-system (M-S) disease in those with isolated skin involvement...
  19. ncbi request reprint Herpes simplex virus in febrile neutropenic children undergoing chemotherapy for cancer: a prospective cohort study
    Raveena Ramphal
    Division of Haematology Oncology, The Hospital for Sick Children, Toronto, Ontario, Canada
    Pediatr Infect Dis J 26:700-4. 2007
    ..Our secondary objectives were to describe the association between oral HSV and prolonged fever, neutropenia, mucositis, and response to initial antimicrobial therapy...
  20. ncbi request reprint Childhood acute myeloid leukemia with hemophagocytosis by the blasts and inv(8)(p11q13) with MOZ-TIF2 fusion transcripts
    Mohamed Abdelhaleem
    Division of Haematopathology, Department of Paediatric Laboratory Medicine, Hospital for Sick Children, Toronto, Ontario, Canada
    J Pediatr Hematol Oncol 29:643-5. 2007
    ..To our knowledge, this is the eighth overall and the fourth childhood case of acute myeloid leukemia with inv(8) (p11q13) with MOZ-TIF2 fusion...
  21. ncbi request reprint The role of hemophagocytosis in bone marrow aspirates in the diagnosis of hemophagocytic lymphohistiocytosis
    Abha Gupta
    Division of Hematology Oncology, Hospital for Sick Children, Toronto, Ontario, Canada
    Pediatr Blood Cancer 50:192-4. 2008
  22. doi request reprint The role of the initial bone marrow aspirate in the diagnosis of hemophagocytic lymphohistiocytosis
    Abha Gupta
    Division of Hematology Oncology, Hospital for Sick Children, Toronto, Ontario, Canada
    Pediatr Blood Cancer 51:402-4. 2008
    ..The purpose of this study was to quantify the number of HPC in the initial BMA in patients diagnosed with HLH at our institution...
  23. ncbi request reprint Risk factors for post-transplant lymphoproliferative disorder in pediatric patients: a case-control study
    Upton D Allen
    Division of Infectious Diseases, The Department of Pediatrics, Hospital for Sick Children, University of Toronto, Ontario, Canada
    Pediatr Transplant 9:450-5. 2005
    ..Additional studies are warranted to further define the factors associated with PTLD in EBV-seropositive transplant recipients...
  24. ncbi request reprint Initial experience with FSE STIR whole-body MR imaging for staging lymphoma in children
    Christian J Kellenberger
    Department of Diagnostic Imaging, The Hospital for Sick Children, 555 University Avenue, Toronto, ON, Canada
    Eur Radiol 14:1829-41. 2004
    ..Larger prospective trials are needed to determine if FSE STIR whole-body MR can replace standard radiographic procedures for initial staging and contribute in the follow-up of lymphoma in children...
  25. ncbi request reprint Leptomeningeal precursor B-cell lymphoblastic lymphoma in a child with minimal bone marrow involvement
    Oussama Abla
    University of Toronto, Division of Hematology Oncology, The Hospital for Sick Children, ON, Canada
    J Pediatr Hematol Oncol 26:469-72. 2004
    ..This patient was treated on a high-risk ALL protocol with intensive systemic/intrathecal chemotherapy plus cranial irradiation, and he remained in complete remission 6 months after his initial diagnosis...
  26. ncbi request reprint Hepatosplenic gammadelta T-cell lymphoma in a 10-year-old boy successfully treated with hematopoietic stem cell transplantation
    Adam Gassas
    Division of Hematology Oncology, Department of Pediatrics, The Hospital for Sick Children, University of Toronto, Ontario, Canada
    Am J Hematol 75:113-4. 2004
    ..Conventional multi-agent chemotherapy appears to be inadequate for cure. This is the first report with this type of lymphoma in a boy less than 15 years old treated with hematopoietic stem cell transplantation (HSCT)...
  27. ncbi request reprint CNS-directed therapy in young children with T-lineage acute lymphoblastic leukemia: High-dose methotrexate versus cranial irradiation
    Paul C Nathan
    Department of Paediatrics, Division of Haematology Oncology, The Hospital for Sick Children Research Institute, The University of Toronto, Toronto, Ontario, Canada
    Pediatr Blood Cancer 42:24-9. 2004
    ..We conducted a retrospective cohort study to determine the effect on survival of substituting HD-MTX for CRT in young children with T-ALL, a group that faces a high risk of long-term sequelae from CRT...
  28. doi request reprint Isolated central nervous system relapse in childhood acute promyelocytic leukemia
    Katrin Scheinemann
    Division of Hematology Oncology, The Hospital for Sick Children, Toronto, Ontario, Canada
    J Pediatr Hematol Oncol 30:160-2. 2008
    ..The patient remains in molecular remission at 9 months after autologous stem cell transplant. Prognostic factors of CNS relapse in children with APL are needed to define the indications for CNS prophylaxis in this group of patients...
  29. ncbi request reprint Skeletal Langerhans cell histiocytosis in children: permanent consequences and health-related quality of life in long-term survivors
    Loretta M S Lau
    Division of Haematology Oncology, Hospital for Sick Children, University of Toronto, Ontario, Canada
    Pediatr Blood Cancer 50:607-12. 2008
    ..Although permanent consequences (PC) are described in half of the survivors thus raising concerns for quality of life (QOL), the impact on quality of life has not been formally studied...
  30. ncbi request reprint Lumbar spinal fluid collections in children treated with intrathecal chemotherapy: elevated CSF protein as a diagnostic clue
    Fahd Almanjomi
    Division of Haematology Oncology, Department of Diagnostic Imaging, The Hospital for Sick Children, Toronto, Ontario, Canada
    Pediatr Blood Cancer 51:295-8. 2008
    ..Awareness and detection of this complication by imaging is important because of its potential to interfere with effective CNS-directed chemotherapy of ALL...
  31. ncbi request reprint Features at presentation predict children with acute lymphoblastic leukemia at low risk for tumor lysis syndrome
    Tony H Truong
    Division of Hematology Oncology, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
    Cancer 110:1832-9. 2007
    ..The objectives of the current study were 1) to describe the prevalence and predictors of TLS in childhood ALL and 2) to develop a sensitive prediction rule to identify patients at lower risk of TLS...
  32. ncbi request reprint Risk for complications in patients with hemophagocytic lymphohistiocytosis who undergo hematopoietic stem cell transplantation: myeloablative versus reduced-intensity conditioning regimens
    Tal Schechter
    Division of Haematology Oncology, The Hospital for Sick Children, University of Toronto, Toronto, Canada
    Expert Rev Clin Immunol 10:1101-6. 2014
    ..In this review we compare the potential complications of myeloablative and RIC regimens for HSCT in HLH patients. ..
  33. doi request reprint Adult hemophagocytic lymphohistiocytosis with severe pulmonary hypertension and a novel perforin gene mutation
    Lauren M Gerard
    Department of Internal Medicine, University of Toronto, Toronto, Canada
    Int J Hematol 95:445-50. 2012
    ....
  34. ncbi request reprint Predictors of surgical outcome in Wilms' tumor: a single-institution comparative experience
    Gregory Hall
    Division of General Surgery, Hospital for Sick Children, Toronto, Ontario, Canada M5G 1X8
    J Pediatr Surg 41:966-71. 2006
    ..Patients with WT at our institution were managed with PC until 1996; subsequently, they underwent PN. This study compares these approaches as they affect tumor spillage, local recurrence, and survival...
  35. doi request reprint WT1 expression and hemihypertrophy in congenital mesoblastic nephroma
    Ibraheem Abosoudah
    Division of Pediatric Hematology Oncology, The Hospital for Sick Children SickKids, University of Toronto, Toronto, Ontario, Canada
    J Pediatr Hematol Oncol 30:768-71. 2008
    ..In conclusion, contrary to previous reports, WT1 may be expressed in CMN and CMN can be associated with hemihypertrophy in the absence of Beckwith-Wiedemann syndrome...
  36. ncbi request reprint Pulmonary Langerhans cell histiocytosis: a variable disease in childhood
    Isaac Odame
    Department of Pediatrics, Division of Hematology Oncology, McMaster University Medical Center, Hamilton, Ontario, Canada
    Pediatr Blood Cancer 47:889-93. 2006
    ..This retrospective study describes the clinical manifestation, course, and outcome of PLCH in children consecutively diagnosed at two Canadian institutions...
  37. ncbi request reprint Primary central nervous system lymphoma in children
    Oussama Abla
    Division of Hematology Oncology, The Hospital for Sick Children and Department of Paediatrics, University of Toronto, Ontario, Canada
    Neurosurg Focus 21:E8. 2006
    ..Further progress in the management of childhood PCNSL will require prospective multinational studies...
  38. ncbi request reprint Mycosis fungoides in the pediatric population: report from an international Childhood Registry of Cutaneous Lymphoma
    Elena Pope
    Section of Dermatology, The Hospital for Sick Children, Toronto, ON, Canada
    J Cutan Med Surg 14:1-6. 2010
    ..There are limited data on the clinical presentation and progression of pediatric cutaneous lymphoma. This study focuses on the clinical characteristics of pediatric patients with mycosis fungoides (MF)...
  39. ncbi request reprint Factors influencing survival in children with recurrent neuroblastoma
    Loretta Lau
    Division of Hematology Oncology, Department of Pediatrics, The Hospital for Sick Children, University of Toronto, Toronto, Canada
    J Pediatr Hematol Oncol 26:227-32. 2004
    ....
  40. ncbi request reprint A basic classification and a comprehensive examination of pediatric myeloproliferative syndromes
    Adam Gassas
    Divisions of Hematology Oncology, Department of Pediatrics, The Hospital for Sick Children, University of Toronto, Ontario M5G 1X8, Canada
    J Pediatr Hematol Oncol 27:192-6. 2005
    ..The authors found that all the cases could be easily classified. MPS in children is different from adult-type MPS in terms of biology, categories, classification, and prognosis...
  41. doi request reprint Unusual functional manifestations of a novel STX11 frameshift mutation in two infants with familial hemophagocytic lymphohistiocytosis type 4 (FHL4)
    Christine A Macartney
    The Division of Hematology Oncology, The Hospital for Sick Children, Toronto, Ontario, Canada
    Pediatr Blood Cancer 56:654-7. 2011
    ..Importantly, these observations imply that STX11 should be sequenced in HLH patients even when impaired NK cell degranulation is not found...
  42. doi request reprint Experience with hemophagocytic lymphohistiocytosis/macrophage activation syndrome at a single institution
    Abha A Gupta
    Division of Hematology Oncology, Hospital for Sick Children, Toronto, Ontario, Canada
    J Pediatr Hematol Oncol 31:81-4. 2009
    ..However, patients are often started on corticosteroid alone with or without the addition of intravenous gamma-globulin. The role of the various therapies in HLH/MAS remains undefined...
  43. ncbi request reprint A case series of pediatric primary central nervous system lymphoma: favorable outcome without cranial irradiation
    Oussama Abla
    Division of Hematology Oncology, The Hospital for Sick Children, Toronto, Ontario, Canada
    Pediatr Blood Cancer 47:880-5. 2006
    ..To describe the outcome of childhood primary central nervous system lymphoma (PCNSL) treated with chemotherapy alone or with chemotherapy plus cranial radiotherapy (CRT)...
  44. ncbi request reprint Low incidence of ototoxicity with continuous infusion of cisplatin in the treatment of pediatric germ cell tumors
    Abha A Gupta
    Division of Hematology Oncology, Hospital for Sick Children, Toronto, Canada
    J Pediatr Hematol Oncol 28:91-4. 2006
    ..The authors conclude that continuous administration of cisplatin is associated with minimal ototoxicity while maintaining good tumoricidal efficacy, and further studies using this regimen are warranted...
  45. ncbi request reprint Assessment of residual posttreatment masses in Hodgkin's disease and the need for biopsy in children
    Ahmed Nasr
    Division of General Surgery, Hospital for Sick Children, Toronto, Ontario, Canada M5G 1X8
    J Pediatr Surg 41:972-4. 2006
    ..Various imaging modalities are available to assess this mass, including chest x-ray (CXR), computed tomographic (CT) scan, and gallium scan. Our aim was to determine the sensitivity and specificity of each modality for residual HD...
  46. ncbi request reprint Folic acid food fortification is associated with a decline in neuroblastoma
    Amy E French
    Motherrisk Program and Division of Hematology and Oncology, The Hospital for Sick Children, and Department of Medicine and Prehospital Care Programme, Sunnybrook and Women s College Health Sciences Center, University of Toronto, Ontario, Canada
    Clin Pharmacol Ther 74:288-94. 2003
    ..In January 1997, Canada began fortifying flour with folic acid for the prevention of neural tube defects. The effect of folic acid fortification on the rate of neuroblastoma in offspring is not known...
  47. ncbi request reprint Ewing sarcoma: favourable results with combined modality therapy and conservative use of radiotherapy
    George Zogopoulos
    Division of Hematology Oncology, Hospital for Sick Children, Toronto, Ontario, Canada
    Pediatr Blood Cancer 43:35-9. 2004
    ..Our objective was to describe the outcome and prognostic factors associated with this strategy...
  48. ncbi request reprint Significance of p53 expression in immature teratomas
    Pimlak Charoenkwan
    Division of Hematology Oncology, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, Canada, M5G 1X8
    Pediatr Dev Pathol 5:499-507. 2002
    ..The finding of frequent p53-positive cells in immature teratoma should prompt a search for malignant elements within the tumor and affected patients should be followed closely for evidence of recurrence...
  49. ncbi request reprint A patient with mutations in DNA Ligase IV: clinical features and overlap with Nijmegen breakage syndrome
    Tawfeg I Ben-Omran
    Division of Clinical and Metabolic Genetics, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
    Am J Med Genet A 137:283-7. 2005
    ..In this study, we review the clinical features of this rare syndrome and provide suggestions for differential diagnosis...
  50. ncbi request reprint Pediatric non-Hodgkin's lymphoma: clinical and biologic prognostic factors and risk allocation
    Sheila Weitzman
    Division of Hematology Oncology, The Hospital for Sick Children, 555 University Avenue, Toronto, ON M5G 1X8, Canada
    Curr Oncol Rep 4:107-13. 2002
    ....
  51. ncbi request reprint Advanced-stage large-cell lymphoma in children and adolescents: results of a randomized trial incorporating intermediate-dose methotrexate and high-dose cytarabine in the maintenance phase of the APO regimen: a Pediatric Oncology Group phase III trial
    Joseph H Laver
    Department of Pediatrics, Medical College of Virginia, PO Box 980646, Richmond, VA 23298 0646, USA
    J Clin Oncol 23:541-7. 2005
    ..In this study, we assessed the effects of an intense antimetabolite therapy alternating with APO on overall survival (OS) and event-free survival (EFS) and looked into biologic correlates...
  52. ncbi request reprint Successful treatment of life-threatening generalized infantile myofibromatosis using low-dose chemotherapy
    Minal M Gandhi
    Department of Haematology Oncology, Great Ormond Street Hospital for Sick Children NHS Trust, London, United Kingdom
    J Pediatr Hematol Oncol 25:750-4. 2003
    ..The authors propose a prospective international trial using a safe low-dose chemotherapy protocol to test the efficacy of this treatment strategy...
  53. ncbi request reprint Getting there? Salvage therapy for refractory Langerhans cell histiocytosis in children
    Sheila Weitzman
    Eur J Cancer 41:2592-4. 2005
  54. ncbi request reprint Reactivations in multisystem Langerhans cell histiocytosis: data of the international LCH registry
    Milen Minkov
    St Anna Children s Hospital, Vienna, Austria
    J Pediatr 153:700-5, 705.e1-2. 2008
    ..To assess multisystem Langerhans cell histiocytosis reactivation and its impact on morbidity and mortality...
  55. ncbi request reprint Screening of infants and mortality due to neuroblastoma
    William G Woods
    AFLAC Cancer Center, Emory University and Children s Healthcare of Atlanta, GA 30322, USA
    N Engl J Med 346:1041-6. 2002
    ..However, it is unknown whether routine screening for neuroblastoma reduces mortality due to this disease...
  56. ncbi request reprint The efficacy of rituximab in high-grade pediatric B-cell lymphoma/leukemia: a review of available evidence
    Dina Attias
    Division of Pediatric Hematology Oncology, Bnai Zion Medical Center, Bruce Rappoport Faculty of Medicine, Technion Institute, Haifa, Israel
    Curr Opin Pediatr 20:17-22. 2008
    ....