Research Topics
| P W WalesSummaryAffiliation: The Hospital for Sick Children Country: Canada Publications
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Detail Information
Publications
Is the use of parenteral omega-3 lipid emulsions justified in surgical neonates with mild parenteral nutrition-associated liver dysfunction?Ahmed Nasr
Group for Improvement of Intestinal Function and Treatment GIFT, The Hospital for Sick Children, Toronto, Canada
J Pediatr Surg 45:980-6. 2010....- Novel lipid-based approaches to pediatric intestinal failure-associated liver diseaseIvan R Diamond
Child Health Evaluative Sciences Program, The Hospital for Sick Children, Toronto, Ontario, Canada
Arch Pediatr Adolesc Med 166:473-8. 2012..Therefore, there is currently insufficient evidence to support the use of these novel therapies as standard of care in children with no or early IFALD with the goal of preventing the progression of liver disease... - Ethanol locks to prevent catheter-related bloodstream infections in parenteral nutrition: a meta-analysisCarol Oliveira
Group for Improvement of Intestinal Function and Treatment GIFT, Division of General and Thoracic Surgery, The Hospital for Sick Children, Toronto, ON, Canada
Pediatrics 129:318-29. 2012.... 
Percutaneous cholangiography for the treatment of parenteral nutrition-associated cholestasis in surgical neonates: preliminary experiencePaul W Wales
Division of General Surgery, Faculty of Medicine, The Hospital for Sick Children, University of Toronto, Toronto, ON M5G 1X8, Canada
J Pediatr Surg 42:1913-8. 2007..Our aim was to evaluate the effectiveness of percutaneous transhepatic transcholecystic cholangiography (PTTC) in the treatment of PNAC in surgical neonates...- Neonatal short bowel syndrome: a cohort studyPaul W Wales
Division of General Surgery, The Research Institute, The Hospital for Sick Children, Toronto, Ontario, Canada M5G 1X8
J Pediatr Surg 40:755-62. 2005..By applying more rigorous methodology, our aim was to determine outcomes of SBS neonates compared with a control group of neonates without SBS... - Serial transverse enteroplasty as primary therapy for neonates with proximal jejunal atresiaPaul W Wales
Division of General Surgery, The Hospital for Sick Children, Toronto, Ontario, M5G 1X8, Canada
J Pediatr Surg 40:E31-4. 2005.... - Short bowel syndrome: epidemiology and etiologyPaul W Wales
Group for Improvement of Intestinal Function and Treatment GIFT, Hospital for Sick Children, Toronto, Ontario, Canada
Semin Pediatr Surg 19:3-9. 2010..There are very few estimates of SBS incidence and mortality in the literature. The epidemiology of SBS is reviewed and the limitations of the published literature are discussed... - Surgical therapy for short bowel syndromePaul W Wales
Division of General Surgery, The Hospital for Sick Children, 555 University Avenue, Rm 1526, Toronto, Ontario M5G 1X8, Canada
Pediatr Surg Int 20:647-57. 2004..The goal of this review article is to summarize the process of intestinal adaptation and then to outline the surgical principles and techniques available to surgeons who treat this complicated group of patients... - Intermediate outcomes after serial transverse enteroplasty in children with short bowel syndromePaul W Wales
Division of General Surgery, The Hospital for Sick Children, Toronto, Canada M5G 1X8
J Pediatr Surg 42:1804-10. 2007..The aim of this study was to report intermediate outcomes in patients who have received the STEP at our institution using clinical and biochemical assessment of intestinal function... - Ethanol lock therapy to reduce the incidence of catheter-related bloodstream infections in home parenteral nutrition patients with intestinal failure: preliminary experiencePaul W Wales
The Group for Improvement of Intestinal Function and Treatment, The Hospital for Sick Children, Toronto, Ontario, Canada M5G 1X8
J Pediatr Surg 46:951-6. 2011..Ethanol lock of central venous catheters may decrease CRBSI, but limited pediatric data are available... - Advantages of the distal sigmoid colostomy in the management of infants with short bowel syndromeIvan R Diamond
Division of General Surgery, Group for Improvement of Intestinal Function and Treatment, Child Health Evaluative Sciences, The Hospital for Sick Children, Toronto, Canada
J Pediatr Surg 43:1464-7. 2008..Restoring intestinal continuity may create difficulty with perineal soiling. We propose creation of a distal sigmoid colostomy as an option for select infants with SBS... - Establishing norms for intestinal length in childrenMarie Chantal Struijs
Group for Improvement of Intestinal Function and Treatment, The Hospital for Sick Children, Toronto, Canada
J Pediatr Surg 44:933-8. 2009..Existing data on pediatric intestinal length (IL) are limited because most studies report postmortem values. Using prospective data, appropriate norms for IL were developed... - Changing the paradigm: omegaven for the treatment of liver failure in pediatric short bowel syndromeIvan R Diamond
The Hospital for Sick Children, Toronto, Canada
J Pediatr Gastroenterol Nutr 48:209-15. 2009..Parenteral omega-3 fatty acids, such as Omegaven, may benefit patients with pediatric short bowel syndrome (SBS) who develop parenteral nutrition-associated liver disease (PNALD)... - The use of conjugated hyperbilirubinemia greater than 100 micromol/L as an indicator of irreversible liver disease in infants with short bowel syndromeAhmed Nasr
Division of General Surgery, Faculty of Medicine, The Hospital for Sick Children, University of Toronto, Toronto, Canada M5G 1X8
J Pediatr Surg 42:359-62. 2007..Knowledge of when to refer such children for evaluation for transplantation is crucial. A commonly used criterion is conjugated hyperbilirubinemia greater than 100 micromol/L (CB100)... - Routine use of a SILASTIC spring-loaded silo for infants with gastroschisis: a multicenter randomized controlled trialAimee C Pastor
Pediatric General Surgery, Hospital for Sick Children, Toronto, ON, Canada
J Pediatr Surg 43:1807-12. 2008..Retrospective studies have suggested that routine use of a preformed silo for infants with gastroschisis may be associated with improved outcomes. We performed a prospective multicenter randomized controlled trial to test this hypothesis... - What is the current role for parenteral lipid emulsions containing omega-3 fatty acids in infants with short bowel syndrome?I R Diamond
Group for Improvement of Intestinal Function and Treatment GIFT, Hospital for Sick Children, Toronto, ON, Canada
Minerva Pediatr 61:263-72. 2009..Given the promising results and apparent safety of these emulsions, we shall also consider what the current role for PN lipid emulsions containing w3FA in children with SBS should be... - Neonatal short bowel syndrome: population-based estimates of incidence and mortality ratesPaul W Wales
Division of General Surgery, The Research Institute, The Hospital for Sick Children, Toronto, Ontario, Canada
J Pediatr Surg 39:690-5. 2004..Accurate estimates will assist clinicians in counseling parents, allocating resources, and planning clinical trials... - Absence of the interstitial cells of Cajal in a child with chronic pseudoobstructionMarie Chantal Struijs
Group for Improvement of Intestinal Function and Treatment GIFT, The Hospital for Sick Children, Toronto, Canada M5G 1X8
J Pediatr Surg 43:e25-9. 2008..This report highlights that abnormalities of the ICCs in intestinal pseudoobstruction should be considered early in the diagnostic workup of children with intestinal pseudoobstruction... - Population demographic indicators associated with incidence of pyloric stenosisTeresa To
Population Health Sciences, Research Institute and Departments of Surgery and Pediatrics, Hospital for Sick Children, Toronto, Ontario
Arch Pediatr Adolesc Med 159:520-5. 2005..The rural/urban differences suggest that environmental influences related to living in these areas may have a role in the etiology of pyloric stenosis. Further research is needed to evaluate these differences... - Does the colon play a role in intestinal adaptation in infants with short bowel syndrome? A multiple variable analysisIvan R Diamond
Group for Improvement of Intestinal Function and Treatment GIFT, The Hospital for Sick Children, Toronto, Canada M5G 1X8
J Pediatr Surg 45:975-9. 2010..We sought to examine in a multiple variable model the impact of residual colonic length on time to intestinal adaptation in a cohort of infants with short bowel syndrome... - Long-term outcome after nonoperative management of complete traumatic pancreatic transection in childrenP W Wales
Division of Pediatric General Surgery and Department of Radiology, The Hospital for Sick Children, Toronto, Ontario, Canada
J Pediatr Surg 36:823-7. 2001..To the authors' knowledge, this is the first report to show the effectiveness of nonoperative management after complete pancreatic transection... - Pediatric blunt and penetrating trauma deaths in Ontario: a population-based studyIvan R Diamond
The Hospital for Sick Children, Toronto, Canada
J Pediatr Surg 44:981-6. 2009..The purpose of the study was to describe the mechanisms of injury and causes of death in children dying in a modern, integrated trauma system... - What's the incidence of delayed splenic bleeding in children after blunt trauma? An institutional experience and review of the literatureDafydd A Davies
Division of General Surgery, Hospital for Sick Children, Toronto, Ontario, Canada
J Trauma 67:573-7. 2009..The existence and incidence of delayed splenic bleeding (DSB) in children are controversial but the implications are significant. We sought to determine the incidence of DSB in children and to look for similarities between reported cases... - Predictors of metachronous inguinal hernias in childrenMohammed Zamakhshardy
Division of General Surgery, The Hospital for Sick Children, Room 1526, 555 University Avenue, Toronto, ON, M5G 1X8, Canada
Pediatr Surg Int 25:69-71. 2009..Surgical management of the contralateral groin in unilateral inguinal hernia remains controversial. Our aim was to determine predictors of metachronous inguinal hernias in children using multivariable analysis... - The versatility of the umbilical incision in the management of Hirschsprung's diseaseCarolien J E Sauer
Division of General Surgery, Hospital for Sick Children, Toronto, Ontario, M5G 1X8, Canada
J Pediatr Surg 40:385-9. 2005..The umbilical incision is an excellent, safe, and versatile alternative to laparoscopy for the treatment of patients with the full spectrum of HD... - Ectopic drainage of the common bile duct into the lesser curvature of the gastric antrum in a newborn with pyloric atresia, annular pancreas and congenital short bowel syndromeNicola Scheida
Department of Diagnostic Imaging, Division of Image Guided Therapy, The Hospital for Sick Children, 555 University Ave, Toronto M5G 1X8, Canada
Pediatr Radiol 39:66-9. 2009..Radiologic, sonographic and percutaneous transhepatic transcholecystic cholangiographic (PTTC) findings, with surgical correlation, are presented... - Neonatal short bowel syndrome outcomes after the establishment of the first Canadian multidisciplinary intestinal rehabilitation program: preliminary experienceIvan R Diamond
Division of General Surgery, The Hospital for Sick Children, Toronto, Ontario, Canada M5G 1X8
J Pediatr Surg 42:806-11. 2007.... - Predicting the need for fundoplication at the time of congenital diaphragmatic hernia repairIvan R Diamond
Division of General Surgery, The Hospital for Sick Children, Toronto, Canada M5G 1X8
J Pediatr Surg 42:1066-70. 2007..This study was conducted to examine the preoperative factors predictive of subsequent intervention for gastroesophageal reflux (GER) in children with congenital diaphragmatic hernia (CDH)... - Isolated liver transplantation in pediatric short bowel syndrome: is there a role?Ivan R Diamond
Group for the Improvement of Intestinal Function and Treatment GIFT and the Pediatric Academic Multi organ Transplant Program, Division of General Surgery, The Hospital for Sick Children, Toronto, Canada M5G 1X8
J Pediatr Surg 41:955-9. 2006..The role of isolated liver transplantation in infants with parenteral nutrition-associated cholestasis (PNAC) associated with short bowel syndrome (SBS) is unclear... - Lung torsion after tracheoesophageal fistula repair: a case report and review of literatureCarol Oliveira
Division of General Surgery, The Hospital for Sick Children, Toronto, Ontario, Canada
J Pediatr Surg 42:E5-9. 2007..Patients with complete interlobar fissures may benefit from pulmonary lobe fixation as a prophylaxis against occurrence or recurrence of this complication... - The optimal timing of intestinal transplantation for children with intestinal failure: a Markov analysisSteven R Lopushinsky
Department of Surgery, Hospital for Sick Children, Toronto, Ontario, Canada
Ann Surg 246:1092-9. 2007..Identify an optimal approach to the timing of intestinal transplantation for children dependent on total parenteral nutrition (PN)... - The rationale for the use of parenteral omega-3 lipids in children with short bowel syndrome and liver diseaseIvan R Diamond
Group for Improvement of Intestinal Function and Treatment GIFT, The Hospital for Sick Children, 555 University Avenue, Toronto, ON, Canada, M5G 1X8
Pediatr Surg Int 24:773-8. 2008..The early clinical experience with omega3FAs in SBS and PNALD is briefly reviewed and the implications of such, and future directions are considered... - Fundoplication and gastrostomy versus image-guided gastrojejunal tube for enteral feeding in neurologically impaired children with gastroesophageal refluxPaul W Wales
Division of Pediatric General Surgery and the Department Diagnostic Imaging, The Hospital for Sick Children, Toronto, Ontario, Canada
J Pediatr Surg 37:407-12. 2002..Each approach, however, still is associated with a significant complication rate. A randomized prospective study comparing these 2 approaches is needed... - Survival after CCAM associated with ascites: a report of a case and review of the literatureIvan R Diamond
Division of Pediatric General Surgery, The Hospital for Sick Children, Toronto, Ontario, Canada
J Pediatr Surg 38:E1-3. 2003..This has important implications for prenatal counseling particularly in centers in which fetal intervention is not available... - Understanding neonatal bowel obstruction: building knowledge to advance practiceNicole T de Silva
NICU, Hospital for Sick Children, Ontario, Canada
Neonatal Netw 25:303-18. 2006..This article describes features of the neonatal GI tract and discusses common causes of neonatal bowel obstruction... - The use of Surgisis for abdominal wall reconstruction in the separation of omphalopagus conjoined twinsRoshni Dasgupta
Division of Pediatric General Surgery, Hospital for Sick Children, Toronto, ON, Canada
Pediatr Surg Int 23:923-6. 2007..Surgisis can be successfully used for the reconstruction of complex abdominal wall defects in the pediatric patient, including reconstruction after separation of conjoined twins... - Omega-3 lipids for intestinal failure associated liver diseaseIvan R Diamond
Group for Improvement of Intestinal Function and Treatment GIFT, The Hospital for Sick Children, Toronto, Canada
Semin Pediatr Surg 18:239-45. 2009..Mechanisms explaining their effects will be considered as will future research directions... - Delayed, life-threatening lower gastrointestinal hemorrhage in an infant after serial transverse enteroplasty: treatment with transcatheter n-butyl-2-cyanoacrylate embolizationConor O Bogue
Division of Image Guided Therapy, Department of Diagnostic Imaging, The Hospital for Sick Children, Toronto M5G 1X8, Canada
Pediatr Radiol 39:1098-101. 2009..To the best of our knowledge this is both the first report of successful glue embolization for LGI bleeding in a child and also the first report of severe hemorrhage after the STEP procedure... - Preventable pediatric trauma deaths in Ontario: a comparative population-based studyIvan R Diamond
Division of General Surgery, The Hospital for Sick Children, Toronto, Canada
J Trauma 66:1189-94; discussion 1194-5. 2009..This study aims to examine the current preventable trauma death rate in our system using identical methodology to our previous study... - Outcomes and management of rectal injuries in childrenArnaud Bonnard
Division of General Surgery, Hospital for Sick Children, Room 1526, 555 University Avenue, Toronto, ON, Canada M5G 1X8
Pediatr Surg Int 23:1071-6. 2007..Laparoscopy may be used for the immediate management of the penetrating trauma patient to rule out intraperitoneal extension, repair a perforation and guide the colostomy if necessary... - Management of blunt splenic injury in children: evolution of the nonoperative approachDafydd A Davies
Division of Pediatric General Surgery, The Hospital for Sick Children, Toronto, ON, Canada
J Pediatr Surg 44:1005-8. 2009..Since that time, treatment of patients with BSI has evolved from routine splenectomy to an aggressive spleen-preserving philosophy. This report summarizes our institutional experience for the last 50 years... - Nonoperative management of perianal abscess in infants is associated with decreased risk for fistula formationEmily R Christison Lagay
Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
Pediatrics 120:e548-52. 2007..We sought to determine the frequency of progression in infants of perianal abscess with and without surgical drainage to fistula in ano to optimize a treatment plan for these children...