Michael D Taylor

Summary

Affiliation: The Hospital for Sick Children
Country: Canada

Publications

  1. pmc Rapid, reliable, and reproducible molecular sub-grouping of clinical medulloblastoma samples
    Paul A Northcott
    The Arthur and Sonia Labatt Brain Tumour Research Center, Hospital for Sick Children, Toronto, ON, Canada
    Acta Neuropathol 123:615-26. 2012
  2. pmc Polo-like kinase 1 (PLK1) inhibition suppresses cell growth and enhances radiation sensitivity in medulloblastoma cells
    Peter S Harris
    Department of Pediatrics and Children s Hospital Colorado, University of Colorado Denver, Anschutz Medical Campus, Aurora, USA
    BMC Cancer 12:80. 2012
  3. pmc Molecular subgroups of medulloblastoma: the current consensus
    Michael D Taylor
    Division of Neurosurgery, Hospital for Sick Children, University of Toronto, Toronto, Canada
    Acta Neuropathol 123:465-72. 2012
  4. pmc Genetic and epigenetic inactivation of Kruppel-like factor 4 in medulloblastoma
    Yukiko Nakahara
    Division of Neurosurgery, Arthur and Sonia Labatt Brain Tumor Research Centre, Hospital for Sick Children, Toronto, Ontario, Canada
    Neoplasia 12:20-7. 2010
  5. ncbi request reprint An epigenetic genome-wide screen identifies SPINT2 as a novel tumor suppressor gene in pediatric medulloblastoma
    Paul N Kongkham
    Program in Cell Biology, Division of Neurosurgery, Arthur and Sonia Labatt Brain Tumor Research Centre, Hospital for Sick Children, and Department of Pathology, University Health Network, University of Toronto, Toronto, Ontario, Canada
    Cancer Res 68:9945-53. 2008
  6. doi request reprint Silencing of thrombospondin-1 is critical for myc-induced metastatic phenotypes in medulloblastoma
    Limei Zhou
    Sonia and Arthur Labatt Brain Tumor Research Centre, Hospital for Sick Children, University Avenue, Toronto, Ontario, Canada M5G 1X8
    Cancer Res 70:8199-210. 2010
  7. ncbi request reprint Duration of the pre-diagnostic interval in medulloblastoma is subgroup dependent
    Vijay Ramaswamy
    Division of Neurosurgery, Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, Ontario, M5G 1X8, Canada Developmental and Stem Cell Biology, Hospital for Sick Children, Toronto, Ontario, M5G 1X8, Canada Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, M5S 1A1, Canada
    Pediatr Blood Cancer 61:1190-4. 2014
  8. doi request reprint Medulloblastoma comprises four distinct molecular variants
    Paul A Northcott
    Hospital for Sick Children, Toronto, Ontario, Canada
    J Clin Oncol 29:1408-14. 2011
  9. pmc Aberrant patterns of H3K4 and H3K27 histone lysine methylation occur across subgroups in medulloblastoma
    Adrian M Dubuc
    Division of Neurosurgery, Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada
    Acta Neuropathol 125:373-84. 2013
  10. pmc Clonal selection drives genetic divergence of metastatic medulloblastoma
    Xiaochong Wu
    Arthur and Sonia Labatt Brain Tumour Research Center, Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada
    Nature 482:529-33. 2012

Detail Information

Publications59

  1. pmc Rapid, reliable, and reproducible molecular sub-grouping of clinical medulloblastoma samples
    Paul A Northcott
    The Arthur and Sonia Labatt Brain Tumour Research Center, Hospital for Sick Children, Toronto, ON, Canada
    Acta Neuropathol 123:615-26. 2012
    ....
  2. pmc Polo-like kinase 1 (PLK1) inhibition suppresses cell growth and enhances radiation sensitivity in medulloblastoma cells
    Peter S Harris
    Department of Pediatrics and Children s Hospital Colorado, University of Colorado Denver, Anschutz Medical Campus, Aurora, USA
    BMC Cancer 12:80. 2012
    ..Polo-like kinase 1 (PLK1) is highly expressed in many cancers and regulates critical steps in mitotic progression. Recent studies suggest that targeting PLK1 with small molecule inhibitors is a promising approach to tumor therapy...
  3. pmc Molecular subgroups of medulloblastoma: the current consensus
    Michael D Taylor
    Division of Neurosurgery, Hospital for Sick Children, University of Toronto, Toronto, Canada
    Acta Neuropathol 123:465-72. 2012
    ....
  4. pmc Genetic and epigenetic inactivation of Kruppel-like factor 4 in medulloblastoma
    Yukiko Nakahara
    Division of Neurosurgery, Arthur and Sonia Labatt Brain Tumor Research Centre, Hospital for Sick Children, Toronto, Ontario, Canada
    Neoplasia 12:20-7. 2010
    ..We conclude that KLF4 is inactivated by either genetic or epigenetic mechanisms in a large subset of medulloblastomas and that it likely functions as a tumor suppressor gene in the pathogenesis of medulloblastoma...
  5. ncbi request reprint An epigenetic genome-wide screen identifies SPINT2 as a novel tumor suppressor gene in pediatric medulloblastoma
    Paul N Kongkham
    Program in Cell Biology, Division of Neurosurgery, Arthur and Sonia Labatt Brain Tumor Research Centre, Hospital for Sick Children, and Department of Pathology, University Health Network, University of Toronto, Toronto, Ontario, Canada
    Cancer Res 68:9945-53. 2008
    ..0001). Taken together, these data support the role of SPINT2 as a putative tumor suppressor gene in MB, and further implicate dysregulation of the HGF/MET signaling pathway in the pathogenesis of MB...
  6. doi request reprint Silencing of thrombospondin-1 is critical for myc-induced metastatic phenotypes in medulloblastoma
    Limei Zhou
    Sonia and Arthur Labatt Brain Tumor Research Centre, Hospital for Sick Children, University Avenue, Toronto, Ontario, Canada M5G 1X8
    Cancer Res 70:8199-210. 2010
    ..These findings indicate the Myc-regulatory network targets Tsp-1 via multiple mechanisms in medulloblastoma transformation, and highlight a novel critical role for Tsp-1 in Myc-mediated aggressive medulloblastoma phenotypes...
  7. ncbi request reprint Duration of the pre-diagnostic interval in medulloblastoma is subgroup dependent
    Vijay Ramaswamy
    Division of Neurosurgery, Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, Ontario, M5G 1X8, Canada Developmental and Stem Cell Biology, Hospital for Sick Children, Toronto, Ontario, M5G 1X8, Canada Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, M5S 1A1, Canada
    Pediatr Blood Cancer 61:1190-4. 2014
    ..In light of the recent discovery of distinct medulloblastoma subgroups, we sought to define the initial presentation of childhood medulloblastoma in a subgroup specific manner...
  8. doi request reprint Medulloblastoma comprises four distinct molecular variants
    Paul A Northcott
    Hospital for Sick Children, Toronto, Ontario, Canada
    J Clin Oncol 29:1408-14. 2011
    ..We studied a large cohort of medulloblastomas to determine how many subgroups of the disease exist, how they differ, and the extent of overlap between subgroups...
  9. pmc Aberrant patterns of H3K4 and H3K27 histone lysine methylation occur across subgroups in medulloblastoma
    Adrian M Dubuc
    Division of Neurosurgery, Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada
    Acta Neuropathol 125:373-84. 2013
    ..As PRC2-mediated aberrant methylation of H3K27 has recently been targeted for therapy in other diseases, it represents an actionable target for a substantial percentage of medulloblastoma patients with aggressive forms of the disease...
  10. pmc Clonal selection drives genetic divergence of metastatic medulloblastoma
    Xiaochong Wu
    Arthur and Sonia Labatt Brain Tumour Research Center, Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada
    Nature 482:529-33. 2012
    ..Failure to account for the bicompartmental nature of metastatic medulloblastoma could be a major barrier to the development of effective targeted therapies...
  11. pmc TERT promoter mutations are highly recurrent in SHH subgroup medulloblastoma
    Marc Remke
    The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada
    Acta Neuropathol 126:917-29. 2013
    ..TERT mutations define a subset of SHH medulloblastoma with distinct demographics, cytogenetics, and outcomes...
  12. ncbi request reprint Subgroup-specific prognostic implications of TP53 mutation in medulloblastoma
    Nataliya Zhukova
    University of Toronto, Toronto, Canada
    J Clin Oncol 31:2927-35. 2013
    ..Reports detailing the prognostic impact of TP53 mutations in medulloblastoma offer conflicting conclusions. We resolve this issue through the inclusion of molecular subgroup profiles...
  13. doi request reprint Methylation of the TERT promoter and risk stratification of childhood brain tumours: an integrative genomic and molecular study
    Pedro Castelo-Branco
    The Arthur and Sonia Labatt Brain Tumor Research Centre, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada
    Lancet Oncol 14:534-42. 2013
    ..We investigated whether methylation of the TERT promoter can be a biomarker for malignancy and patient outcome in paediatric brain tumours...
  14. doi request reprint PCDH10 is a candidate tumour suppressor gene in medulloblastoma
    Kelsey C Bertrand
    Division of Neurosurgery, Arthur and Sonia Labatt Brain Tumor Research Centre, Program in Developmental and Stem Cell Biology, Hospital for Sick Children, Toronto, ON, M4N 1X8, Canada
    Childs Nerv Syst 27:1243-9. 2011
    ..We examined the role of PCDH10 as a mediator of medulloblastoma cell proliferation, cell cycle progression, and cell migration...
  15. doi request reprint Genomics of medulloblastoma: from Giemsa-banding to next-generation sequencing in 20 years
    Paul A Northcott
    Division of Neurosurgery, Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, University of Toronto, Ontario, Canada
    Neurosurg Focus 28:E6. 2010
    ....
  16. pmc Subgroup-specific alternative splicing in medulloblastoma
    Adrian M Dubuc
    Division of Neurosurgery, Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada
    Acta Neuropathol 123:485-99. 2012
    ....
  17. ncbi request reprint Failure of a medulloblastoma-derived mutant of SUFU to suppress WNT signaling
    Michael D Taylor
    The Division of Neurosurgery, The Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, Ontario, Canada M5G 1X8
    Oncogene 23:4577-83. 2004
    ..Our results suggest that loss of function of SUFU results in overactivity of both the Sonic Hedgehog, and the WNT signaling pathways, leading to excessive proliferation and failure to differentiate resulting in MB...
  18. pmc MyoD is a tumor suppressor gene in medulloblastoma
    Joyoti Dey
    Authors Affiliations Molecular and Cellular Biology Program, University of Washington Clinical Research Division, Human Biology Division, and Public Health Sciences Division, Fred Hutchinson Cancer Research Center Presage Biosciences Sage Bionetworks Seattle Children s Hospital, Seattle, Washington Arthur and Sonia Labatt Brain Tumor Research Center and Division of Neurosurgery, The Hospital for Sick Children, Toronto, Ontario, Canada
    Cancer Res 73:6828-37. 2013
    ..This suggests that although expression of MyoD in a proliferating tumor is insufficient to prevent tumor progression, its expression in the cerebellum hinders medulloblastoma genesis...
  19. pmc Recurrence patterns across medulloblastoma subgroups: an integrated clinical and molecular analysis
    Vijay Ramaswamy
    Division of Neurosurgery, Hospital for Sick Children, Toronto, ON, Canada Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON, Canada Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada
    Lancet Oncol 14:1200-7. 2013
    ..Studies have confirmed that medulloblastoma consists of at least four distinct subgroups. We sought to delineate subgroup-specific differences in medulloblastoma recurrence patterns...
  20. pmc Subgroup-specific structural variation across 1,000 medulloblastoma genomes
    Paul A Northcott
    Developmental and Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario M5G 1L7, Canada
    Nature 488:49-56. 2012
    ..Numerous targetable SCNAs, including recurrent events targeting TGF-β signalling in Group 3, and NF-κB signalling in Group 4, suggest future avenues for rational, targeted therapy...
  21. ncbi request reprint Emerging insights into the ependymoma epigenome
    Stephen C Mack
    Developmental and Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada
    Brain Pathol 23:206-9. 2013
    ..This review attempts to highlight existing and emerging evidence implicating the ependymoma epigenome as a key player and that epigenetic modifiers may offer new targeted therapeutic avenues for patients...
  22. ncbi request reprint Canonical TGF-β pathway activity is a predictor of SHH-driven medulloblastoma survival and delineates putative precursors in cerebellar development
    Donya Aref
    Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, Toronto, ON, Canada
    Brain Pathol 23:178-91. 2013
    ..To our knowledge, this is the first study that links TGF-β to MB pathogenesis. Our research suggests that canonical activation of this pathway leads to better prognosis for patients...
  23. doi request reprint Monoallelic expression determines oncogenic progression and outcome in benign and malignant brain tumors
    Erin J Walker
    Division of Haematology Oncology, The Labatt Brain Tumor Research Centre, The Hospital for Sick Children, Toronto General Hospital, Toronto, Ontario, Canada
    Cancer Res 72:636-44. 2012
    ..Further exploration of MAE at relevant genes may contribute to better understanding of tumor development and determine survival in brain tumor patients...
  24. doi request reprint The epigenetics of brain tumors
    Adrian M Dubuc
    Department of Laboratory Medicine and Pathobiology, Division of Neurosurgery, University of Toronto, Toronto, ON, Canada
    Methods Mol Biol 863:139-53. 2012
    ..Here, we describe advances in our understanding of the epigenetics of brain tumors, focusing on DNA methylation, histone modifications, and microRNA deregulation which contribute to the pathogenesis of these diseases...
  25. doi request reprint Pediatric and adult sonic hedgehog medulloblastomas are clinically and molecularly distinct
    Paul A Northcott
    The Arthur and Sonia Labatt Brain Tumour Research Center, Hospital for Sick Children, Toronto, ON, Canada
    Acta Neuropathol 122:231-40. 2011
    ..Collectively, our data demonstrate that pediatric and adult Shh-medulloblastomas are clinically, transcriptionally, genetically, and prognostically distinct...
  26. doi request reprint Expression of MAGE and GAGE genes in medulloblastoma and modulation of resistance to chemotherapy. Laboratory investigation
    Chinatsu Kasuga
    Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Ontario, Canada
    J Neurosurg Pediatr 1:305-13. 2008
    ..The authors undertook this study to examine the expression and role of MAGE proteins in human MB cell lines and specimens...
  27. doi request reprint Multiple CDK/CYCLIND genes are amplified in medulloblastoma and supratentorial primitive neuroectodermal brain tumor
    Meihua Li
    Program in Cell Biology, Hospital for Sick Children, Toronto, Canada
    Cancer Genet 205:220-31. 2012
    ..Our data suggest that CDK/CYCLIND gene amplification may represent important mechanisms for functional inactivation of pRB in medulloblastoma and sPNET...
  28. doi request reprint FISH and chips: the recipe for improved prognostication and outcomes for children with medulloblastoma
    Vijay Ramaswamy
    Developmental and Stem Cell Biology and Division of Neurosurgery, Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada
    Cancer Genet 204:577-88. 2011
    ..In this review, we will summarize the genomic data published over the past decade and attempt to interpret its prognostic significance, relevance to the clinic, and use in upcoming clinical trials...
  29. doi request reprint Multiple recurrent genetic events converge on control of histone lysine methylation in medulloblastoma
    Paul A Northcott
    Division of Neurosurgery, Arthur and Sonia Labatt Brain Tumour Research Centre, Toronto, Ontario, Canada
    Nat Genet 41:465-72. 2009
    ....
  30. ncbi request reprint Medulloblastoma molecular dissection: the way toward targeted therapy
    Marc Remke
    aDivision of Neurosurgery, Hospital for Sick Children bDepartment of Laboratory Medicine and Pathobiology, University of Toronto cLabatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, Ontario, Canada Marc Remke and Vijay Ramaswamy contributed equally to the writing of this article
    Curr Opin Oncol 25:674-81. 2013
    ..We sought to highlight the potential areas for targeted therapy based on our new understanding of the subgroup-specific tumor biology...
  31. ncbi request reprint Identification of differentially expressed and developmentally regulated genes in medulloblastoma using suppression subtraction hybridization
    Naoki Yokota
    The Arthur and Sonia Labatt Brain Tumor Research Centre, The University of Toronto, Toronto, Ontario, Canada
    Oncogene 23:3444-53. 2004
    ..This study has revealed a panel of developmentally regulated genes that may be involved in the pathogenesis of MB...
  32. doi request reprint Somatostatin receptor subtype 2 (sst₂) is a potential prognostic marker and a therapeutic target in medulloblastoma
    Marc Remke
    Division of Neurosurgery, Arthur and Sonia Labatt Brain Tumor Research Centre, Program in Developmental and Stem Cell Biology, Hospital for Sick Children, University of Toronto, Toronto, ON, Canada
    Childs Nerv Syst 29:1253-62. 2013
    ..It controls proliferation of both normal and neoplastic cells. sst₂ has thus been suggested as a therapeutic target and prognostic marker for certain malignancies...
  33. pmc Mouse models of medulloblastoma
    Xiaochong Wu
    Arthur and Sonia Labatt Brain Tumor Research Center, Hospital for Sick Children, Toronto, Ontario, M5G 1L7, Canada
    Chin J Cancer 30:442-9. 2011
    ..In this review, we summarize how such models have been successfully applied to the study of medulloblastoma over the past decade and what we might expect in the coming years...
  34. doi request reprint Survival benefit for pediatric patients with recurrent ependymoma treated with reirradiation
    Eric Bouffet
    Department of Hematology Oncology, The Hospital for Sick Children, and University of Toronto, Toronto, Ontario, Canada
    Int J Radiat Oncol Biol Phys 83:1541-8. 2012
    ..The outcome of recurrent ependymoma in children is dismal. Reirradiation has been proposed as an effective modality for ependymoma at relapse. However, the toxicity and outcome benefits of this approach have not been well established...
  35. pmc Targeting sonic hedgehog-associated medulloblastoma through inhibition of Aurora and Polo-like kinases
    Shirley L Markant
    Authors Affiliations Tumor Initiation and Maintenance Program, National Cancer Institute NCI Designated Cancer Center, Sanford Burnham Medical Research Institute Sanford Consortium for Regenerative Medicine Departments of Pediatrics, Neurosciences, and Neurosurgery, University of California San Diego, La Jolla Rady Children s Hospital, San Diego, California Departments of Pharmacology and Cancer Biology, Medicine, Division of Pulmonary, Allergy, and Critical Care, Pediatrics, Division of Pediatric Hematology Oncology, and Surgery, Duke University Medical Center, Durham, North Carolina German Cancer Research Center DKFZ, Heidelberg, Germany and Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
    Cancer Res 73:6310-22. 2013
    ..Our findings suggest that targeting G2-M regulators may represent a novel approach for treatment of human medulloblastoma...
  36. ncbi request reprint Transcriptional profiling of medulloblastoma in children
    Paul C Park
    Ontario Cancer Institute, University of Toronto, Toronto, Ontario, Canada
    J Neurosurg 99:534-41. 2003
    ..The authors have attempted to compare patterns of gene expression in medulloblastoma samples with those in the healthy cerebellum...
  37. pmc Molecular genetics of ependymoma
    Yuan Yao
    Hospital for Sick Children, Toronto, Ontario, Canada
    Chin J Cancer 30:669-81. 2011
    ..This review summarizes our current knowledge in the molecular genetics of ependymoma and proposes future research directions necessary to further advance this field...
  38. ncbi request reprint Molecular subgroups of medulloblastoma
    Paul A Northcott
    The Arthur and Sonia Labatt Brain Tumour Research Center, Hospital for Sick Children, Toronto, ON, Canada
    Expert Rev Neurother 12:871-84. 2012
    ..We present a summary of recent studies that have contributed to our understanding of the core medulloblastoma subgroups, focusing largely on clinically relevant discoveries that have already, and will continue to, shape research...
  39. pmc Frequent amplification of a chr19q13.41 microRNA polycistron in aggressive primitive neuroectodermal brain tumors
    Meihua Li
    Division of Hematology Oncology, Hospital for Sick Children, Toronto, ON M5G 0A3, Canada
    Cancer Cell 16:533-46. 2009
    ..Our data implicate miR-517c and 520g as oncogenes and promising biological markers for CNS-PNET and provide important insights into oncogenic properties of the C19MC locus...
  40. doi request reprint Incorporation of C-1 lateral mass screws in occipitocervical and atlantoaxial fusions for children 8 years of age or younger. Technical note
    Andrew Jea
    Division of Neurosurgery, Department of Surgery, Hospital for Sick Children, University of Toronto Faculty of Medicine, Toronto, Ontario, Canada
    J Neurosurg 107:178-83. 2007
    ..There was one instance of a vertebral artery injury, and the lessons learned from this complication are discussed...
  41. doi request reprint Personalizing the treatment of pediatric medulloblastoma: Polo-like kinase 1 as a molecular target in high-risk children
    Joanna Triscott
    Authors Affiliations Department of Pediatrics Division of Anatomic Pathology, Department of Pathology and Laboratory Medicine Division of Pediatric Neurosurgery, Department of Surgery, BC Children s Hospital, University of British Columbia Department of Pathology and Laboratory Medicine, Centre for Applied Genomics, British Columbia Cancer Agency, Vancouver, British Columbia Division of Neurosurgery, Department of Surgery, Faculty of Health Sciences, McMaster Stem Cell and Cancer Research Institute, McMaster University, Hamilton The Arthur and Sonia Labatt Brain Tumor Research Centre, Hospital for Sick Children, Toronto, Ontario Pediatric Oncology Experimental Therapeutics Investigators Consortium POETIC Laboratory for Pre Clinical and Drug Discovery Studies, Division of Pediatric Oncology, Alberta Children s Hospital, Calgary, Alberta, Canada and Division of Pediatric Neuro Oncology, German Cancer Research Center DKFZ, Heidelberg, Germany
    Cancer Res 73:6734-44. 2013
    ..We conclude that patients with medulloblastoma expressing high levels of PLK1 are at elevated risk. These preclinical studies pave the way for improving the treatment of medulloblastoma through PLK1 inhibition...
  42. pmc Clinical and neuroanatomical predictors of cerebellar mutism syndrome
    Nicole Law
    Program in Neuroscience and Mental Health, Hospital for Sick Children, 555 University Ave, Toronto, ON, M5G 1X8, Canada
    Neuro Oncol 14:1294-303. 2012
    ..Our findings may be relevant for surgical planning and speech-language therapy to mitigate symptoms of CMS...
  43. doi request reprint Anaplastic medulloblastoma in a child with Duchenne muscular dystrophy
    Machiel van den Akker
    Division of Haematology Oncology, Hospital for Sick Children, University of Toronto, Ontario, Canada
    J Neurosurg Pediatr 10:21-4. 2012
    ..This is the second report of a malignant brain tumor in a boy with DMD. The possible link between the 2 conditions is discussed, as are ethical considerations regarding the management of medulloblastoma in children with DMD...
  44. ncbi request reprint Advanced cancer genetics in neurosurgical research
    Michael D Taylor
    Division of Neurosurgery, Hospital for Sick Children, Arthur and Sonia Labatt Brain Tumor Research Center, University of Toronto, Toronto, Ontario, Canada
    Neurosurgery 53:1168-78; discussion 1178. 2003
    ..High demand from an increasingly educated patient population means that neurosurgeons will need to be familiar with many of these techniques...
  45. doi request reprint Genome-wide methylation analysis
    Alexander Unterberger
    Division of Neurosurgery, The Hospital for Sick Children, Toronto, ON, Canada
    Methods Mol Biol 863:303-17. 2012
    ..These techniques allow for the determination of changes in global methylation levels, as well as regional changes in methylation throughout the genome...
  46. doi request reprint Neurosurgical management of extraaxial central nervous system infections in children
    Sanjay Gupta
    Division of Neurosurgery, The Hospital for Sick Children, The University of Toronto, Ontario, Canada
    J Neurosurg Pediatr 7:441-51. 2011
    ..Symptoms are usually progressive, and early diagnosis is therefore important. Early intervention with appropriate treatment offers the best opportunity for eradicating the infection and promoting maximal neurological recovery...
  47. doi request reprint Intracerebral malignant peripheral nerve sheath tumor in a child with neurofibromatosis Type 1 and middle cerebral artery aneurysm treated with endovascular coil embolization
    Michael J Ellis
    Division of Neurosurgery, Hospital for Sick Children, University of Toronto, Ontario, Canada
    J Neurosurg Pediatr 8:346-52. 2011
    ..While patients with NF1 represent a population with genetic susceptibility to radiation-induced tumors, the pathogenesis of intracerebral MPNSTs remains poorly understood...
  48. doi request reprint The genetics of pediatric brain tumors
    Adrian M Dubuc
    Division of Neurosurgery, Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada
    Curr Neurol Neurosci Rep 10:215-23. 2010
    ..This review summarizes our current state of knowledge, emphasizes recent seminal findings in the field, and proposes future research efforts needed to further characterize the genetic basis of pediatric brain tumors...
  49. doi request reprint Universal poor survival in children with medulloblastoma harboring somatic TP53 mutations
    Uri Tabori
    Divisions of Haematology Oncology, The LabattBrain Tumor Research Centre, TheHospital for Sick Children, Toronto, Ontario, Canada
    J Clin Oncol 28:1345-50. 2010
    ....
  50. pmc The miR-17/92 polycistron is up-regulated in sonic hedgehog-driven medulloblastomas and induced by N-myc in sonic hedgehog-treated cerebellar neural precursors
    Paul A Northcott
    Division of Neurosurgery, Arthur and Sonia Labatt Brain Tumour Research Centre, Program in Developmental and Stem Cell Biology, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
    Cancer Res 69:3249-55. 2009
    ..We conclude that miR-17/92 is a positive effector of Shh-mediated proliferation and that aberrant expression/amplification of this miR confers a growth advantage to medulloblastomas...
  51. ncbi request reprint Impact of craniospinal dose, boost volume, and neurologic complications on intellectual outcome in patients with medulloblastoma
    Iska Moxon-Emre
    Iska Moxon Emre, Eric Bouffet, Michael D Taylor, Nadia Scantlebury, Nicole Law, Brenda J Spiegler, David Malkin, Laura Janzen, and Donald Mabbott, Hospital for Sick Children Iska Moxon Emre, Michael D Taylor, Normand Laperriere, Brenda J Spiegler, David Malkin, and Laura Janzen, University of Toronto and Normand Laperriere, Ontario Cancer Institute, Princess Margaret Hospital, Toronto, Ontario, Canada
    J Clin Oncol 32:1760-8. 2014
    ....
  52. ncbi request reprint Bioinformatics in neurosurgery
    Michael D Taylor
    Division of Neurosurgery, Hospital for Sick Children, Arthur and Sonia Labatt Brain Tumor Research Centre, University of Toronto, Ontario, Canada
    Neurosurgery 52:723-30; discussion 730-1. 2003
    ..Neurosurgeons must be aware of the power and potential applications of bioinformatics for the analysis of neurosurgical diseases...
  53. ncbi request reprint The history of neurosurgery at the Hospital for Sick Children in Toronto
    Andrew Jea
    Division of Neurosurgery, Department of Surgery, Hospital for Sick Children, University of Toronto Faculty of Medicine, Toronto, Canada
    Neurosurgery 61:612-24; discussion 624-5. 2007
    ..The purpose of this article is to review the history of the individuals who founded the Hospital for Sick Children and its Division of Neurosurgery...
  54. ncbi request reprint Imaging of murine brain tumors using a 1.5 Tesla clinical MRI system
    Wouter R van Furth
    Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, Ontario, Canada
    Can J Neurol Sci 30:326-32. 2003
    ..In this study, we investigated the feasibility of using a 1.5 Tesla (T) clinical magnetic resonance imaging (MRI) system for in vivo assessment of three histopathologically different brain tumor models in mice...
  55. doi request reprint The genetic and epigenetic basis of ependymoma
    Stephen C Mack
    Division of Neurosurgery, Arthur and Sonia Labatt Brain Tumor Research Center, Hospital for Sick Children, Toronto, ON, Canada
    Childs Nerv Syst 25:1195-201. 2009
    ..This is due in part to the heterogeneity of the disease, as well as the small sample size of the cohorts analyzed in most studies...
  56. pmc WIP1 enhances tumor formation in a sonic hedgehog-dependent model of medulloblastoma
    Tiffany A Doucette
    Department of Neurosurgery, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    Neurosurgery 70:1003-10; discussion 1010. 2012
    ..Although p53 deficiency enhances tumor formation in mice, inactivation of the p53 gene is seen in a minority of MBs. Wild-type p53-induced phosphatase 1 (WIP1) downregulates p53 expression and has been shown to be overexpressed in MBs...
  57. ncbi request reprint The RAG-1/2 endonuclease causes genomic instability and controls CNS complications of lymphoblastic leukemia in p53/Prkdc-deficient mice
    Rebecca A Gladdy
    Program in Developmental Biology, The Hospital for Sick Children and Department of Surgery, University of Toronto, Toronto, Ontario, Canada
    Cancer Cell 3:37-50. 2003
    ..Unexpectedly, RAG-2/p53/Prkdc-deficient mice also developed leptomeningeal leukemia, providing a novel spontaneous model for this frequent complication of human lymphoblastic malignancies...
  58. doi request reprint Posterior fossa ependymomas: new radiological classification with surgical correlation
    Jean Marie U-King-Im
    Department of Diagnostic Imaging, Hospital for Sick Children and the University of Toronto, 555 University Ave, Toronto, ON, Canada
    Childs Nerv Syst 26:1765-72. 2010
    ..We describe a new radiological classification system which is validated against surgical findings and correlated with risk of post-operative residual tumour...
  59. ncbi request reprint Mutations in SUFU predispose to medulloblastoma
    Michael D Taylor
    Division of Neurosurgery, The Arthur and Sonia Labatt Brain Tumour Research Centre, Toronto, Canada
    Nat Genet 31:306-10. 2002
    ..SUFU is a newly identified tumor-suppressor gene that predisposes individuals to medulloblastoma by modulating the SHH signaling pathway through a newly identified mechanism...