L Sung

Summary

Affiliation: The Hospital for Sick Children
Country: Canada

Publications

  1. ncbi request reprint Meta-analysis of randomized controlled trials of prophylactic granulocyte colony-stimulating factor and granulocyte-macrophage colony-stimulating factor after autologous and allogeneic stem cell transplantation
    Allison Dekker
    Department of Public Health Sciences, Health Policy Management and Evaluation, and Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada
    J Clin Oncol 24:5207-15. 2006
  2. ncbi request reprint Features at presentation predict children with acute lymphoblastic leukemia at low risk for tumor lysis syndrome
    Tony H Truong
    Division of Hematology Oncology, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
    Cancer 110:1832-9. 2007
  3. doi request reprint Facilitating accrual to cancer control and supportive care trials: the clinical research associate perspective
    David Vanhoff
    Child Health Evaluative Sciences, Toronto, ON, Canada
    BMC Med Res Methodol 13:154. 2013
  4. pmc Validation of a registry-derived risk algorithm based on treatment protocol as a proxy for disease risk in childhood acute lymphoblastic leukemia
    Sumit Gupta
    Division of Haematology Oncology and Program in Child Health Evaluative Sciences, Hospital for Sick Children, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada
    BMC Med Res Methodol 13:68. 2013
  5. pmc Effectiveness of supportive care measures to reduce infections in pediatric AML: a report from the Children's Oncology Group
    Lillian Sung
    Division of Haematology Oncology, The Hospital for Sick Children, Toronto, ON, Canada
    Blood 121:3573-7. 2013
  6. doi request reprint Children's Oncology Group's 2013 blueprint for research: cancer control and supportive care
    Lillian Sung
    Department of Haematology Oncology, The Hospital for Sick Children, Toronto, Ontario, Canada
    Pediatr Blood Cancer 60:1027-30. 2013
  7. doi request reprint Decision making in pediatric oncology: evaluation and incorporation of patient and parent preferences
    Lillian Sung
    The Division of Haematology Oncology and Child Health Evaluative Sciences, Department of Paediatrics, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
    Pediatr Blood Cancer 60:558-63. 2013
  8. pmc A systematic review of symptom assessment scales in children with cancer
    L Lee Dupuis
    Program in Child Health Evaluative Sciences, The Hospital for Sick Children, 555 University Avenue, Toronto, ON, M5G 1X8, Canada
    BMC Cancer 12:430. 2012
  9. doi request reprint Guideline for the management of fever and neutropenia in children with cancer and/or undergoing hematopoietic stem-cell transplantation
    Thomas Lehrnbecher
    Johann Wolfgang Goethe University, Frankfurt, Germany
    J Clin Oncol 30:4427-38. 2012
  10. doi request reprint Discrete choice experiment produced estimates of acceptable risks of therapeutic options in cancer patients with febrile neutropenia
    Lillian Sung
    Department of Pediatrics, Division of Haematology Oncology, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada
    J Clin Epidemiol 65:627-34. 2012

Detail Information

Publications110 found, 100 shown here

  1. ncbi request reprint Meta-analysis of randomized controlled trials of prophylactic granulocyte colony-stimulating factor and granulocyte-macrophage colony-stimulating factor after autologous and allogeneic stem cell transplantation
    Allison Dekker
    Department of Public Health Sciences, Health Policy Management and Evaluation, and Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada
    J Clin Oncol 24:5207-15. 2006
    ..Our secondary objectives were to determine whether prophylactic CSFs affected other outcomes including parenteral antibiotic therapy duration, infection-related mortality, graft-versus-host disease (GVHD), or treatment-related mortality...
  2. ncbi request reprint Features at presentation predict children with acute lymphoblastic leukemia at low risk for tumor lysis syndrome
    Tony H Truong
    Division of Hematology Oncology, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
    Cancer 110:1832-9. 2007
    ..The objectives of the current study were 1) to describe the prevalence and predictors of TLS in childhood ALL and 2) to develop a sensitive prediction rule to identify patients at lower risk of TLS...
  3. doi request reprint Facilitating accrual to cancer control and supportive care trials: the clinical research associate perspective
    David Vanhoff
    Child Health Evaluative Sciences, Toronto, ON, Canada
    BMC Med Res Methodol 13:154. 2013
    ..Our objective was to identify facilitators and perceived barriers to successful Children's Oncology Group (COG) CCL accrual from the clinical research associate (CRA) perspective...
  4. pmc Validation of a registry-derived risk algorithm based on treatment protocol as a proxy for disease risk in childhood acute lymphoblastic leukemia
    Sumit Gupta
    Division of Haematology Oncology and Program in Child Health Evaluative Sciences, Hospital for Sick Children, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada
    BMC Med Res Methodol 13:68. 2013
    ....
  5. pmc Effectiveness of supportive care measures to reduce infections in pediatric AML: a report from the Children's Oncology Group
    Lillian Sung
    Division of Haematology Oncology, The Hospital for Sick Children, Toronto, ON, Canada
    Blood 121:3573-7. 2013
    ..34-2.87; P < .001). Antibacterial and G-CSF prophylaxis reduced infection rates while mandatory hospitalization did not reduce infection or significantly affect NRM. This trial was registered at www.clinicaltrials.gov as #AAML0531...
  6. doi request reprint Children's Oncology Group's 2013 blueprint for research: cancer control and supportive care
    Lillian Sung
    Department of Haematology Oncology, The Hospital for Sick Children, Toronto, Ontario, Canada
    Pediatr Blood Cancer 60:1027-30. 2013
    ..QoL is being assessed in acute leukemia patients. Improved supportive care outcomes will only occur when the most effective interventions are established...
  7. doi request reprint Decision making in pediatric oncology: evaluation and incorporation of patient and parent preferences
    Lillian Sung
    The Division of Haematology Oncology and Child Health Evaluative Sciences, Department of Paediatrics, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
    Pediatr Blood Cancer 60:558-63. 2013
    ..Future work in pediatric oncology decision making should focus on methods to facilitate decision making and elicit preferences from children themselves...
  8. pmc A systematic review of symptom assessment scales in children with cancer
    L Lee Dupuis
    Program in Child Health Evaluative Sciences, The Hospital for Sick Children, 555 University Avenue, Toronto, ON, M5G 1X8, Canada
    BMC Cancer 12:430. 2012
    ..The objective was to describe symptom assessment scales that have been used in children with cancer...
  9. doi request reprint Guideline for the management of fever and neutropenia in children with cancer and/or undergoing hematopoietic stem-cell transplantation
    Thomas Lehrnbecher
    Johann Wolfgang Goethe University, Frankfurt, Germany
    J Clin Oncol 30:4427-38. 2012
    ..To develop an evidence-based guideline for the empiric management of pediatric fever and neutropenia (FN)...
  10. doi request reprint Discrete choice experiment produced estimates of acceptable risks of therapeutic options in cancer patients with febrile neutropenia
    Lillian Sung
    Department of Pediatrics, Division of Haematology Oncology, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada
    J Clin Epidemiol 65:627-34. 2012
    ....
  11. doi request reprint Fluoroquinolones in children with fever and neutropenia: a systematic review of prospective trials
    Lillian Sung
    Division of Haematology Oncology, The Hospital for Sick Children, Toronto, Ontario, Canada
    Pediatr Infect Dis J 31:431-5. 2012
    ..Our primary objective was to describe the effectiveness and safety of fluoroquinolones as empiric therapy for children with FN...
  12. doi request reprint Life-threatening and fatal infections in children with acute myeloid leukemia: a report from the Children's Oncology Group
    Lillian Sung
    Department of Paediatrics and Program in Child Health Evaluative Sciences, Hospital for Sick Children, Toronto, ON, Canada
    J Pediatr Hematol Oncol 34:e30-5. 2012
    ..Intensive timing was associated with more severe infections compared with standard timing induction. Prophylactic strategies are likely more important with intensive induction regimens...
  13. pmc Determining relative importance of variables in developing and validating predictive models
    Joseph Beyene
    Child Heath Evaluative Sciences, The Hospital for Sick Children, Toronto, Canada
    BMC Med Res Methodol 9:64. 2009
    ..However, determination of relative importance of potential predictors and validating the fitted models for their stability, predictive accuracy and generalizability are often overlooked or not done thoroughly...
  14. pmc A meta-analysis of the effect of antibody therapy for the prevention of severe respiratory syncytial virus infection
    Shaun K Morris
    Pediatric Infectious Diseases, Hospital for Sick Children, University of Toronto, ON, Canada
    BMC Infect Dis 9:106. 2009
    ..Secondary objectives were to determine if antibody therapy decreases the risk of RSV infection, intensive care admission, mechanical ventilation, and mortality in high risk infant populations...
  15. pmc Infections and association with different intensity of chemotherapy in children with acute myeloid leukemia
    Lillian Sung
    Division of Haematology Oncology, Department of Pediatrics, The Hospital for Sick Children, Toronto, Ontario, Canada
    Cancer 115:1100-8. 2009
    ..The objectives were to compare infections during different intensities of therapy in children with acute myeloid leukemia (AML)...
  16. ncbi request reprint Seven items were identified for inclusion when reporting a Bayesian analysis of a clinical study
    Lillian Sung
    Division of Hematology Oncology, Department of Pediatrics, Hospital for Sick Children, Toronto, Ontario, Canada
    J Clin Epidemiol 58:261-8. 2005
    ....
  17. ncbi request reprint Microbiologically documented infections and infection-related mortality in children with acute myeloid leukemia
    Lillian Sung
    Division of Haematology Oncology, Hospital for Sick Children, Toronto, ON, Canada
    Blood 110:3532-9. 2007
    ..Thus, age, ethnicity, and BMI were important contributors to IRM. Fungi and Gram-positive cocci were the most common organisms associated with IRM and, in particular, Aspergillus species was the largest contributor to infectious deaths...
  18. doi request reprint Quality of life during active treatment for pediatric acute lymphoblastic leukemia
    Lillian Sung
    Division of Haematology Oncology, Department of Paediatrics, The Hospital for Sick Children and Department of Paediatrics, University of Toronto, Toronto, ON, Canada
    Int J Cancer 128:1213-20. 2011
    ..Age and gender predicted QoL in high-risk ALL, whereas socioeconomics predicted QoL in standard-risk ALL. Future efforts should focus on longitudinal studies that describe QoL over time within individual patients...
  19. ncbi request reprint A Bayesian meta-analysis of prophylactic granulocyte colony-stimulating factor and granulocyte-macrophage colony-stimulating factor in children with cancer
    L Sung
    Department of Pediatrics, University of Toronto and The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada
    Am J Epidemiol 163:811-7. 2006
    ..Some treatment effect estimates were larger by a clinically important amount when additional data contributed to the pooled estimate...
  20. ncbi request reprint Serial controlled N-of-1 trials of topical vitamin E as prophylaxis for chemotherapy-induced oral mucositis in paediatric patients
    L Sung
    Department of Paediatrics, University of Toronto, Toronto, Canada
    Eur J Cancer 43:1269-75. 2007
    ..3 with placebo. Topical vitamin E does not reduce doxorubicin-induced oral mucositis in children. The use of N-of-1 studies and Bayesian meta-analysis may facilitate the study of some therapies in paediatric oncology...
  21. ncbi request reprint N-of-1 trials: innovative methods to evaluate complementary and alternative medicines in pediatric cancer
    Lillian Sung
    Department of Health Policy Management and Evaluation, University of Toronto, Toronto, Ontario, Canada
    J Pediatr Hematol Oncol 28:263-6. 2006
    ..The use of N-of-1 RCTs may be very beneficial in evaluating CAM therapies in pediatric cancer. However, careful consideration of the advantages and disadvantages of such a design should be undertaken prior to initiating an N-of-1 RCT...
  22. pmc Identification of paediatric cancer patients with poor quality of life
    L Sung
    Division of Haematology Oncology, The Hospital for Sick Children, 555 University Avenue, Toronto, ON, M5G 1X8, Canada
    Br J Cancer 100:82-8. 2009
    ..Sibling and household characteristics are associated with QoL. This information will help to identify children at higher risk of poor QoL during treatment for cancer...
  23. ncbi request reprint Meta-analysis: effect of prophylactic hematopoietic colony-stimulating factors on mortality and outcomes of infection
    Lillian Sung
    Division of Haematology Oncology, The University of Toronto, The Hospital for Sick Children, and University Health Network, Toronto, Ontario, Canada
    Ann Intern Med 147:400-11. 2007
    ..Benefits of prophylactic hematopoietic colony-stimulating factors (CSFs) in adults and children receiving cancer chemotherapy or undergoing stem-cell transplantation (SCT) are unclear...
  24. pmc Respiratory syncytial virus infections in children with acute myeloid leukemia: a report from the Children's Oncology Group
    Lillian Sung
    Division of Haematology Oncology, The Hospital for Sick Children, Toronto, Ontario, Canada M5G 1X8
    Pediatr Blood Cancer 51:784-6. 2008
    ..Morbidity and mortality related to respiratory syncytial virus (RSV) in pediatric acute myeloid leukemia (AML) is not known...
  25. doi request reprint Parental optimism in poor prognosis pediatric cancers
    Lillian Sung
    Division of Haematology Oncology, The Hospital for Sick Children, Toronto, Ontario, Canada
    Psychooncology 18:783-8. 2009
    ..The objectives were to describe parent-rated and physician-rated prognosis in a wide range of pediatric cancers and to describe the prevalence and predictors of parental prognostic optimism in poor prognosis pediatric cancer patients...
  26. ncbi request reprint Validation of the oral mucositis assessment scale in pediatric cancer
    Lillian Sung
    Department of Pediatrics, University of Toronto, Toronto, Ontario, Canada
    Pediatr Blood Cancer 49:149-53. 2007
    ..Our objective was to examine the construct validity of the Oral Mucositis Assessment Scale (OMAS) in children receiving doxorubicin chemotherapy...
  27. ncbi request reprint Inpatient versus outpatient management of low-risk pediatric febrile neutropenia: measuring parents' and healthcare professionals' preferences
    Lillian Sung
    Department of Pediatrics, University of Toronto, Ontario, Canada
    J Clin Oncol 22:3922-9. 2004
    ..Our secondary objective was to identify predictors of strength of preference for oral outpatient treatment...
  28. ncbi request reprint Randomized controlled trial of once- versus thrice-daily tobramycin in febrile neutropenic children undergoing stem cell transplantation
    Lillian Sung
    Department of Pediatrics, University of Toronto, Toronto, Ontario, Canada
    J Natl Cancer Inst 95:1869-77. 2003
    ..In particular, the relative nephrotoxicity and efficacy of tobramycin administered as a single daily dose or as three daily doses among this patient population is not known...
  29. pmc Construct validation of the Health Utilities Index and the Child Health Questionnaire in children undergoing cancer chemotherapy
    L Sung
    Department of Health Policy Management and Evaluation, University of Toronto, Ontario, Canada
    Br J Cancer 88:1185-90. 2003
    ..1, s.d.=3.4 min, P<0.0001). In conclusion, HUI and CHQ demonstrated construct validity in children undergoing cancer chemotherapy. The Health Utilities Index is subject to a ceiling effect whereas CHQ requires more time to complete...
  30. ncbi request reprint Prophylactic granulocyte colony-stimulating factor and granulocyte-macrophage colony-stimulating factor decrease febrile neutropenia after chemotherapy in children with cancer: a meta-analysis of randomized controlled trials
    Lillian Sung
    Department of Pediatrics, University of Toronto, Ontario, Canada
    J Clin Oncol 22:3350-6. 2004
    ....
  31. ncbi request reprint The role of infections in primary hemophagocytic lymphohistiocytosis: a case series and review of the literature
    L Sung
    Department of Pediatrics, The Hospital for Sick Children, Toronto, Ontario, Canada
    Clin Infect Dis 33:1644-8. 2001
    ..Significant infections were common during therapy in children with primary HLH, and fungal infections were an important cause of mortality in this group...
  32. ncbi request reprint Adverse outcomes in primary hemophagocytic lymphohistiocytosis
    Lillian Sung
    Division of Hematology Oncology, Hospital for Sick Children, Toronto, Ontario, Canada
    J Pediatr Hematol Oncol 24:550-4. 2002
    ..This review evaluates unfavorable events in children with primary HLH to suggest methods of improving outcomes...
  33. ncbi request reprint Treatment options for patients with acute myeloid leukemia with a matched sibling donor: a decision analysis
    Lillian Sung
    Department of Pediatrics, University of Toronto, Toronto, Ontario, Canada
    Cancer 97:592-600. 2003
    ....
  34. ncbi request reprint Health-related quality of life (HRQL) scores reported from parents and their children with chronic illness differed depending on utility elicitation method
    L Sung
    Department of Pediatrics, University of Toronto, Toronto, Ontario, Canada
    J Clin Epidemiol 57:1161-6. 2004
    ..To describe the relationship between health-related quality of life (HRQL) as measured by utility when elicited from parents and their children with chronic illness...
  35. ncbi request reprint Smallpox vaccination recommendations for contacts of pediatric cancer patients
    Lillian Sung
    Division of Hematology Oncology, Hospital for Sick Children, Toronto, Ontario, Canada
    Pediatr Blood Cancer 43:4-7. 2004
  36. doi request reprint Health-related quality of life anticipated with different management strategies for febrile neutropenia in adult cancer patients
    O Teuffel
    Division of Haematology Oncology, The Hospital for Sick Children, Toronto, Canada
    Support Care Cancer 20:2755-64. 2012
    ..To describe anticipated health-related quality of life (HRQL) for different hypothetical strategies of febrile neutropenia (FN) management in adult cancer patients...
  37. ncbi request reprint Validity of a modified standard gamble elicited from parents of a hospital-based cohort of children
    L Sung
    Division of Hematology Oncology, and Population Health Sciences, Hospital for Sick Children, Toronto, Ontario, M5G 1X8
    J Clin Epidemiol 56:848-55. 2003
    ....
  38. pmc Health-related quality of life anticipated with different management strategies for paediatric febrile neutropaenia
    S Cheng
    Department of Paediatrics, University of Toronto, 27 King s College Circle, Toronto, Ontario, Canada M5S 1A1
    Br J Cancer 105:606-11. 2011
    ..To describe (1) anticipated health-related quality of life during different strategies for febrile neutropaenia (FN) management and (2) attributes of those preferring inpatient management...
  39. pmc Mould-active compared with fluconazole prophylaxis to prevent invasive fungal diseases in cancer patients receiving chemotherapy or haematopoietic stem-cell transplantation: a systematic review and meta-analysis of
    M C Ethier
    Program in Child Health Evaluative Sciences, The Hospital for Sick Children, Toronto M5G 1X8, Ontario, Canada
    Br J Cancer 106:1626-37. 2012
    ..Objectives were to compare systemic mould-active vs fluconazole prophylaxis in cancer patients receiving chemotherapy or haematopoietic stem cell transplantation (HSCT)...
  40. doi request reprint Family-centred care: a qualitative study of Chinese and South Asian immigrant parents' experiences of care in paediatric oncology
    L Watt
    Department of Pediatrics, McMaster University, Hamilton, ON, Canada
    Child Care Health Dev 39:185-93. 2013
    ..The purpose of this paper is to describe Chinese and South Asian immigrant parents' experiences of FCC in paediatric oncology settings in Canada...
  41. doi request reprint Outpatient management of cancer patients with febrile neutropenia: a systematic review and meta-analysis
    O Teuffel
    Division of Haematology Oncology, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, Canada
    Ann Oncol 22:2358-65. 2011
    ..Our objective was to evaluate the current level of evidence before supporting widespread adoption of outpatient management for this population...
  42. doi request reprint Invasive fungal infections in paediatric acute myeloid leukaemia
    D L Johnston
    Hematology Oncology, Children s Hospital of Eastern Ontario, Ottawa, ON, Canada
    Mycoses 56:482-7. 2013
    ..Invasive fungal infections occurred in 12.0% of paediatric AML patients. Risk factors for IFI and IFI-related sepsis were identified. This knowledge may help to consider targeted strategies...
  43. pmc Cost effectiveness of outpatient treatment for febrile neutropaenia in adult cancer patients
    O Teuffel
    Division of Haematology Oncology, Child Health Evaluative Sciences, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, Canada M6G 1X8
    Br J Cancer 104:1377-83. 2011
    ..There is uncertainty whether low-risk episodes of febrile neutropaenia (FN) in adult cancer patients are best managed in the in- or outpatient setting...
  44. doi request reprint Pediatric standard-risk AML with fully matched sibling donors: to transplant in first CR or not?
    A Gassas
    Division of Haematology Oncology BMT, Hospital for Sick Children, University of Toronto, Ontario, Canada
    Bone Marrow Transplant 42:393-6. 2008
    ..Larger studies, such as the MRC-UK 10 and 12, reported 60-62% EFS. Outcome of children with standard-risk AML transplanted from a matched sibling donor in CR1 is very encouraging with minimal toxicity...
  45. ncbi request reprint Consolidation therapy with autologous bone marrow transplantation in adults with acute myeloid leukemia: a meta-analysis
    Paul C Nathan
    Department of Paediatrics, Division of Haematology Oncology, The Hospital for Sick Children, Toronto, Ontario, Canada
    J Natl Cancer Inst 96:38-45. 2004
    ..We conducted a meta-analysis to compare the efficacy of autologous bone marrow transplantation with that of non-myeloablative chemotherapy alone (or no further treatment)...
  46. doi request reprint Caregiving demands in parents of children with cancer: psychometric validation of the Care of My Child with Cancer questionnaire
    Anne Klassen
    Department of Pediatrics, McMaster University, Hamilton, Ontario, Canada
    J Pediatr Nurs 25:258-63. 2010
    ..The CMCC will be helpful for assessing increasing parental responsibility for caregiving tasks associated with cancer care...
  47. doi request reprint Outpatient and oral antibiotic management of low-risk febrile neutropenia are effective in children--a systematic review of prospective trials
    A Manji
    Division of Haematology Oncology, The Hospital for Sick Children, 555 University Avenue, Toronto, ON, Canada
    Support Care Cancer 20:1135-45. 2012
    ..Our secondary objective was to compare oral and parenteral antibiotic therapy in this population...
  48. ncbi request reprint The Gap Study (GapS) interview--developing a process to determine the meaning and determinants of quality of life in children with arthritis and rheumatic disease
    G W K Gong
    Division of Rheumatology, Research Institute, The Hospital for Sick Children, and Department of Pediatrics, University of Toronto, Ontario, Canada
    Clin Exp Rheumatol 25:486-93. 2007
    ..We performed this study to develop items and methods for measuring and valuing these gaps in order to better determine individual QOL for children with rheumatic diseases...
  49. ncbi request reprint Predictors of viridans streptococcal shock syndrome in bacteremic children with cancer and stem-cell transplant recipients
    Adam Gassas
    Department of Pediatrics, Hospital for Sick Children, Toronto, Ontario, Canada
    J Clin Oncol 22:1222-7. 2004
    ....
  50. doi request reprint Evaluating family-centred service in paediatric oncology with the measure of processes of care (MPOC-20)
    A F Klassen
    Department of Pediatrics, McMaster University, 3A, 1200 Main Street W, Hamilton, ON L8N 3Z5, Canada
    Child Care Health Dev 35:16-22. 2009
    ..We performed a comprehensive evaluation of the psychometric properties of the 20-item Measure of Processes of Care (MPOC-20) in parents of children undergoing treatment for cancer at five paediatric oncology centres in Canada...
  51. ncbi request reprint Graft-versus-leukemia effect in hematopoietic stem cell transplantation for pediatric acute lymphoblastic leukemia: significantly lower relapse rate in unrelated transplantations
    A Gassas
    Division of Hematology Oncology Bone Marrow Transplantation, The Hospital for Sick Children, University of Toronto, Ontario, Canada
    Bone Marrow Transplant 40:951-5. 2007
    ..In children with ALL receiving dual GVHD prophylaxis, relapse rate is significantly higher among recipients of MSD compared to MUD transplantation, which may in part be attributed to a better GVL effect with the unrelated graft...
  52. ncbi request reprint Comparative outcome of hematopoietic stem cell transplantation for pediatric acute lymphoblastic leukemia following cyclophosphamide and total body irradiation or VP16 and total body irradiation conditioning regimens
    A Gassas
    Division of Hematology Oncology Bone Marrow Transplantation, The Hospital for Sick Children, University of Toronto, Ontario, Canada
    Bone Marrow Transplant 38:739-43. 2006
    ..There were no significant differences in the prevalence of acute or chronic GVHD and transplant-related mortality between the two groups. Both VP16/FTBI and CY/FTBI regimen are equally effective regimens...
  53. ncbi request reprint Ewing sarcoma: favourable results with combined modality therapy and conservative use of radiotherapy
    George Zogopoulos
    Division of Hematology Oncology, Hospital for Sick Children, Toronto, Ontario, Canada
    Pediatr Blood Cancer 43:35-9. 2004
    ..Our objective was to describe the outcome and prognostic factors associated with this strategy...
  54. ncbi request reprint Carboplatin hypersensitivity reaction in pediatric patients with low-grade glioma: a Canadian Pediatric Brain Tumor Consortium experience
    Lucie Lafay-Cousin
    Pediatric Brain Tumor Program, Hospital for Sick Children, Toronto, Ontario, Canada
    Cancer 112:892-9. 2008
    ..Carboplatin-based regimens have demonstrated activity in pediatric patients with low-grade glioma (LGG). However, carboplatin hypersensitivity reaction (Cb HSR) represents a common and limiting factor for the continuation of therapy...
  55. doi request reprint Acute gut GVHD in children: does skin involvement matter?
    A Gassas
    Division of Haematology Oncology BMT, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
    Bone Marrow Transplant 48:1129-32. 2013
    ..02). Extension of G-GVHD to the skin may suggest a better outcome. ..
  56. doi request reprint Adolescents with acute lymphoblastic leukemia treated at pediatric versus adult hospitals
    J D Pole
    Pediatric Oncology Group of Ontario, Toronto, Canada
    Ann Oncol 24:801-6. 2013
    ..The objective was to compare 5-year overall survival (OS) between adolescent and young adult (AYA) patients (age 15-19) with acute lymphoblastic leukemia (ALL) treated at a pediatric versus an adult center...
  57. doi request reprint Disease self-management needs of adolescents with cancer: perspectives of adolescents with cancer and their parents and healthcare providers
    J N Stinson
    Child Health Evaluative Sciences, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, M5G 1X8, Canada
    J Cancer Surviv 6:278-86. 2012
    ..To ensure that self-management programming developed for AWC meets the needs of this group, discussion with key stakeholders (i.e., AWC, parents, and healthcare providers) is required...
  58. ncbi request reprint Tumor necrosis in pediatric osteosarcoma: impact of modern therapies
    Eleanor Hendershot
    Division of Hematology Oncology, Hospital for Sick Children in Toronto, Ontario, Canada
    J Pediatr Oncol Nurs 23:176-81. 2006
    ..This study stresses the importance of rigorous retrospective reviews before implementing treatment changes...
  59. doi request reprint A systematic review of faces scales for the self-report of pain intensity in children
    Deborah Tomlinson
    Child Health Evaluative Services, Hospital for Sick Children, Toronto, Ontario, Canada
    Pediatrics 126:e1168-98. 2010
    ..It remains unclear whether any one of the faces scales is better for a particular purpose with regard to validity, reliability, feasibility, and preference...
  60. ncbi request reprint Distinctive clinical course and pattern of relapse in adolescents with medulloblastoma
    Uri Tabori
    Pediatric Brain Tumor Program, The Hospital for Sick Children, Toronto, and Department of Hematology Oncology, McMaster University, Hamilton, Ontario, Canada
    Int J Radiat Oncol Biol Phys 64:402-7. 2006
    ..To report the clinical course of adolescents with medulloblastoma, with specific emphasis on prognosis and pattern of relapse...
  61. ncbi request reprint Measurement of oral mucositis in children: a review of the literature
    Deborah Tomlinson
    Ches, Hospital for Sick Children, Room 424, 123 Edward Street, Toronto, ON, M5G 1E2, Canada
    Support Care Cancer 15:1251-8. 2007
    ..There is a paucity of validated oral mucositis assessment instruments for use in children. This paper reviews the available mucositis measurement tools and their applicability to a paediatric population...
  62. doi request reprint Symptom assessment in children receiving cancer therapy: the parents' perspective
    L Lee Dupuis
    Department of Pharmacy, The Hospital for Sick Children, 555 University Ave, Toronto, ON M5G 1X8, Canada
    Support Care Cancer 18:281-99. 2010
    ..We aimed to develop an instrument to assess cancer-treatment-related adverse effects that parents believe children find most bothersome and use it to solicit the opinions of parents regarding this issue...
  63. doi request reprint Postoperative fevers in pediatric solid tumor patients: how should they be managed?
    Eleanor Hendershot
    Division of Hematology Oncology, Hospital for Sick Children, Toronto, Ontario, Canada
    J Pediatr Hematol Oncol 31:485-8. 2009
    ..Little data exists on this subject. Therefore, a retrospective study of patients treated at our center was undertaken to examine this...
  64. ncbi request reprint A case series of pediatric primary central nervous system lymphoma: favorable outcome without cranial irradiation
    Oussama Abla
    Division of Hematology Oncology, The Hospital for Sick Children, Toronto, Ontario, Canada
    Pediatr Blood Cancer 47:880-5. 2006
    ..To describe the outcome of childhood primary central nervous system lymphoma (PCNSL) treated with chemotherapy alone or with chemotherapy plus cranial radiotherapy (CRT)...
  65. ncbi request reprint Parental decision making in pediatric cancer end-of-life care: using focus group methodology as a prephase to seek participant design input
    Deborah Tomlinson
    Population Health Sciences, Hospital for Sick Children, 123 Edward Street, Toronto, Ont, Canada M5G 1E2
    Eur J Oncol Nurs 10:198-206. 2006
    ..We found it was extremely beneficial to include a focus group pre-phase in a study that will interview parents in a high sensitivity area...
  66. doi request reprint Understandability, content validity, and overall acceptability of the Children's International Mucositis Evaluation Scale (ChIMES): child and parent reporting
    Deborah Tomlinson
    Child Health Evaluative Sciences, Room 424, 123 Edward Street, Hospital for Sick Children, Toronto, Ontario M5G 1E2, Canada
    J Pediatr Hematol Oncol 31:416-23. 2009
    ..After discussion of the results, a refined version of ChIMES was produced that accounts for the views of the target population...
  67. doi request reprint Refinement of the Children's International Mucositis Evaluation Scale (ChIMES): child and parent perspectives on understandability, content validity and acceptability
    Deborah Tomlinson
    Child Health Evaluative Sciences, Hospital for Sick Children, Room 424, 123 Edward Street, Toronto, Ontario M5G 1E2, Canada
    Eur J Oncol Nurs 14:29-41. 2010
    ..A draft of ChIMES was developed that required further refinement. This paper describes two iterations of refinements of ChIMES using child and parent reporting of understandability, content validity and overall acceptability...
  68. ncbi request reprint Role of spinal MRI in the follow-up of children treated for medulloblastoma
    Ute Bartels
    Division of Haematology Oncology, Hospital for Sick Children, Toronto, Ontario, Canada
    Cancer 107:1340-7. 2006
    ..The purpose of the current study was to describe the usefulness of spinal magnetic resonance imaging (MRI) in children with medulloblastoma or primitive neuroectodermal tumor (PNET) of the posterior fossa...
  69. ncbi request reprint Medulloblastoma in the second decade of life: a specific group with respect to toxicity and management: a Canadian Pediatric Brain Tumor Consortium Study
    Uri Tabori
    Pediatric Brain Tumor Program, The Hospital for Sick Children, Toronto, Ontario, Canada
    Cancer 103:1874-80. 2005
    ..To consider the feasibility of this approach in adolescents, the authors studied their clinical course with specific emphasis on toxicity, tolerability, and prognosis...
  70. ncbi request reprint Efficacy and safety of caspofungin for the empiric management of fever in neutropenic children
    Alicia Koo
    Department of Pharmacy, The Hospital for Sick Children, Toronto, Ont, Canada
    Pediatr Infect Dis J 26:854-6. 2007
    ..Rash and hypokalemia were the most commonly identified adverse effects. One of 19 children receiving caspofungin and cyclosporine concurrently developed hepatotoxicity possibly related to caspofungin...
  71. ncbi request reprint Challenges to participation in paediatric palliative care research: a review of the literature
    Deborah Tomlinson
    Child Health Evaluative Sciences, Hospital for Sick Children, Toronto, Ontario, Canada
    Palliat Med 21:435-40. 2007
    ..These elements include obtaining the opinions on study design and interview script from experienced families and maximizing the partnership between health care professionals and the research team...
  72. ncbi request reprint Supratentorial primitive neuroectodermal tumors: a Canadian pediatric brain tumor consortium report
    Donna L Johnston
    Division of Hematology Oncology, Children s Hospital of Eastern Ontario, 401 Smyth Road, Ottawa, ON, Canada, K1H 8L1
    J Neurooncol 86:101-8. 2008
    ..5% of childhood brain tumors. The purpose of this study was to describe the range of treatment regimens used to treat pediatric SPNET in Canada and to identify prognostic factors for overall survival in this population...
  73. doi request reprint Determining the understandability and acceptability of an oral mucositis daily questionnaire
    Deborah Tomlinson
    Dip Cancer Nursing, is at CHES, Hospital for Sick Children, Toronto, Ontario, Canada
    J Pediatr Oncol Nurs 25:107-11. 2008
    ..As a result of their comments, minor changes were made. Evaluation of the psychometric properties of this instrument can now be performed...
  74. doi request reprint Establishing literature-based items for an oral mucositis assessment tool in children
    Deborah Tomlinson
    Ches, Hospital for Sick Children, Toronto, Ontario, Canada
    J Pediatr Oncol Nurs 25:139-47. 2008
    ..The resultant list included 23 items that have been used in mucositis assessment scales. This list of items may be used as an initial step in developing a new pediatric OM scale that particularly focuses on the unique issues in children...
  75. ncbi request reprint Tobramycin pharmacokinetics in children with febrile neutropenia undergoing stem cell transplantation: once-daily versus thrice-daily administration
    L Lee Dupuis
    Department of Pharmacy, Research Institute, The Hospital for Sick Children, Toronto, Ontario, Canada
    Pharmacotherapy 24:564-73. 2004
    ....
  76. doi request reprint Challenges of mucositis assessment in children: expert opinion
    Deborah Tomlinson
    Child Health Evaluative Sciences, Hospital for Sick Children, Toronto, Ontario, Canada
    Eur J Oncol Nurs 12:469-75. 2008
    ..The results provide a basis from which guidelines for the oral assessment of mucositis in children can begin. This information could be used to aid in the development of a new scale for the assessment of oral mucositis in children...
  77. ncbi request reprint Update on childhood neutropenia: molecular and clinical advances
    Yigal Dror
    Division of Hematology Oncology, The Hospital for Sick Children and the University of Toronto, 555 University Avenue, Toronto, ON M5G 1X8, Canada
    Hematol Oncol Clin North Am 18:1439-58, x. 2004
    ..This article focuses on recent advances in understanding the cellular and molecular defects in inherited neutropenias as well as issues that are related to clinical presentation, diagnosis, and complications...
  78. doi request reprint Designing an oral mucositis assessment instrument for use in children: generating items using a nominal group technique
    Deborah Tomlinson
    Child Health Evaluative Sciences, Hospital for Sick Children, 123 Edward Street, Toronto, Ontario M5G 1E2, Canada
    Support Care Cancer 17:555-62. 2009
    ..This paper describes the step of generating items in the process of developing a new instrument for the assessment of oral mucositis in children...
  79. doi request reprint Chest health surveillance utility in the early detection of bronchiolitis obliterans syndrome in children after allo-SCT
    A Gassas
    Division of Haematology Oncology BMT, The Hospital for Sick Children, University of Toronto, Ontario, Canada
    Bone Marrow Transplant 48:814-8. 2013
    ..5%, P=0.01). Changes in PFT, but not history/physical examination, allow the early detection of BOS in children after SCT. Our study is limited by the small sample size...
  80. ncbi request reprint Disease progression in recently diagnosed patients with inherited marrow failure syndromes: a Canadian Inherited Marrow Failure Registry (CIMFR) report
    J M Steele
    Canadian Inherited Marrow Failure Registry, Toronto, Ontario, Canada
    Pediatr Blood Cancer 47:918-25. 2006
    ..We examined recently diagnosed IMFS patients to determine distribution of diagnoses, disease progression and development of significant outcomes...
  81. ncbi request reprint Herpes simplex virus in febrile neutropenic children undergoing chemotherapy for cancer: a prospective cohort study
    Raveena Ramphal
    Division of Haematology Oncology, The Hospital for Sick Children, Toronto, Ontario, Canada
    Pediatr Infect Dis J 26:700-4. 2007
    ..Our secondary objectives were to describe the association between oral HSV and prolonged fever, neutropenia, mucositis, and response to initial antimicrobial therapy...
  82. ncbi request reprint Neurofibromatosis in children with Rhabdomyosarcoma: a report from the Intergroup Rhabdomyosarcoma study IV
    Lillian Sung
    Division of Hematology Oncology, Hospital for Sick Children, Toronto, Ontario, Canada
    J Pediatr 144:666-8. 2004
    ..Among 1025 eligible patients, 5 (0.5 %) had NF1. Three children had relapses, two of whom died of progressive disease. Patients with NF1 and rhabdomyosarcoma should be treated with intensive contemporary therapy protocols...
  83. ncbi request reprint Clinical applications of granulocyte-colony stimulating factor
    Lillian Sung
    Division of Haematology and Oncology, Department of Paediatrics, The Hospital for Sick Children, University of Toronto, 555 University Ave Toronto, Ontario, Canada, M5G 1X8
    Front Biosci 12:1988-2002. 2007
    ..This review will focus on the clinical applications of G-CSF in the setting of inherited and acquired bone marrow failure, cancer treatment-related neutropenia and hematopoietic stem cell transplantation...
  84. doi request reprint Impact of caring for a child with cancer on parents' health-related quality of life
    Anne F Klassen
    DPhil, Department of Pediatrics, McMaster University, 3A, 1200 Main St W, Hamilton, Ontario, L8N 3Z5, Canada
    J Clin Oncol 26:5884-9. 2008
    ..To compare the health-related quality of life (QOL) of parents of children who are undergoing treatment for cancer with that of Canadian population norms and to identify important parent and child predictors of parental QOL...
  85. ncbi request reprint Early hematopoietic reconstitution after clinical stem cell transplantation: evidence for stochastic stem cell behavior and limited acceleration in telomere loss
    Ian Thornley
    Division of Hematology Oncology, The Hospital for Sick Children, University Health Network, University of Toronto, 610 University Avenue, Toronto, Ontario M5G 2M9, Canada
    Blood 99:2387-96. 2002
    ....
  86. doi request reprint Utility of peripheral blood cultures in bacteremic pediatric cancer patients with a central line
    Katrin Scheinemann
    The Hospital for Sick Children, Toronto, Ontario, Canada
    Support Care Cancer 18:913-9. 2010
    ..Our secondary objectives were to describe true bloodstream infections detected only by CVC culture and to describe probable contaminants detected in both types of blood cultures...
  87. doi request reprint No association between protein C levels and bacteremia in children with febrile neutropenia
    Alisha Kassam
    Department of Paediatrics, Division of Haematology Oncology, The Hospital for Sick Children, McMaster University, Hamilton, Ontario, Canada
    J Pediatr Hematol Oncol 31:647-50. 2009
    ..The primary aim was to evaluate the relationship between markers of activated coagulation including protein C levels and bacteremia in pediatric oncology patients with febrile neutropenia...
  88. ncbi request reprint A prospective, longitudinal study of central venous catheter-related deep venous thrombosis in boys with hemophilia
    V E Price
    Division of Hematology Oncology, Department of Pediatrics, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
    J Thromb Haemost 2:737-42. 2004
    ..Less frequently reported is CVC-related deep venous thrombosis (DVT). We conducted a prospective study to determine the frequency and outcome of this complication...
  89. ncbi request reprint Replicative stress after allogeneic bone marrow transplantation: changes in cycling of CD34+CD90+ and CD34+CD90- hematopoietic progenitors
    I Thornley
    Division of Hematology/Oncology, The Hospital for Sick Children, and the Department of Medical Oncology and Hematology, University Health Network, University of Toronto, Ontario, Canada
    Blood 97:1876-8. 2001
    ..9% +/- 1% vs 9.6% +/- 2% in donors; P =.04). Replicative stress after BMT is borne predominantly by cells in a diminished CD34+CD90+ population...
  90. doi request reprint Dexamethasone versus prednisone for induction therapy in childhood acute lymphoblastic leukemia: a systematic review and meta-analysis
    O Teuffel
    Division of Haematology Oncology, The Hospital for Sick Children, Toronto, Ontario, Canada
    Leukemia 25:1232-8. 2011
    ..However, DEX is also associated with more toxicity, and currently it remains unclear whether short-term superiority of DEX will also result in better overall survival...
  91. pmc Incidence and predictors of treatment-related mortality in paediatric acute leukaemia in El Salvador
    S Gupta
    Division of Haematology Oncology and Program in Child Health Evaluative Sciences, The Hospital for Sick Children, Toronto, ON, Canada
    Br J Cancer 100:1026-31. 2009
    ..In this low-income country, toxic death significantly contributes to mortality in both ALL and AML. A better understanding of the effect of socioeconomic status on TRM may suggest specific strategies for patients with ALL...
  92. doi request reprint Factors affecting the delivery of family-centered care in pediatric oncology
    David B Dix
    Department of Pediatrics, University of British Columbia, Vancouver, British Columbia, Canada
    Pediatr Blood Cancer 53:1079-85. 2009
    ..Our study examines factors related to parental perception of the family-centeredness of pediatric oncology services...
  93. ncbi request reprint Ototoxicity following pediatric hematopoietic stem cell transplantation: a prospective cohort study
    Angela Punnett
    Department of Pediatrics, University of Toronto, Ontario, Canada
    Pediatr Blood Cancer 42:598-603. 2004
    ..Our objectives were to describe the frequency and determine risk factors for hearing deterioration following pediatric stem cell transplantation (SCT)...
  94. ncbi request reprint Life-threatening pulmonary hemorrhages post bone marrow transplantation in Hurler syndrome. Report of three cases and review of the literature
    A Gassas
    Division of Hematology Oncology, The Hospital for Sick Children, University of Toronto, 555 University Avenue, Toronto, Ontario, Canada M5G 1X8
    Bone Marrow Transplant 32:213-5. 2003
    ..We report three children with MPS-IH with life-threatening PH around the time of engraftment. All needed intensive-care support and one child developed recurrent PH that required prolonged ventilation...
  95. doi request reprint Risk factors for infection-related outcomes during induction therapy for childhood acute lymphoblastic leukemia
    Samina Afzal
    Division of Haematology Oncology, The Hospital for Sick Children, Toronto, Ontario, Canada
    Pediatr Infect Dis J 28:1064-8. 2009
    ..The secondary objectives were to describe risk factors for microbiologically documented infections and for patients with a febrile episode, to identify risk factors for recurrence of fever or reinitiation of antibiotics...
  96. doi request reprint Association between tumor necrosis factor-alpha promoter -308 A/G polymorphism and susceptibility to sepsis and sepsis mortality: a systematic review and meta-analysis
    Oliver Teuffel
    the Division of Haematology Oncology, Hospital for Sick Children, Toronto, Canada
    Crit Care Med 38:276-82. 2010
    ..We conducted a systematic review and meta-analysis to determine whether the TNF-alpha -308 A/G polymorphism TNF2 (G/A or A/A) confers susceptibility to sepsis or is associated with increased risk of death from sepsis...
  97. ncbi request reprint Achievement of target cyclosporine concentrations as a predictor of severe acute graft versus host disease in children undergoing hematopoietic stem cell transplantation and receiving cyclosporine and methotrexate prophylaxis
    Angela Punnett
    Department of Pediatrics, The Hospital for Sick Children, Toronto, Canada
    Ther Drug Monit 29:750-7. 2007
    ..99; P=0.045). These results suggest that achievement of our CSA target concentrations is important to aGvHD outcomes...
  98. ncbi request reprint Long-term results of an ultra low-dose cytarabine-based regimen for the treatment of acute megakaryoblastic leukaemia in children with Down syndrome
    Ali Al-Ahmari
    Division of Hematology Oncology, The Hospital for Sick Children, University of Toronto, Toronto, Ont, Canada
    Br J Haematol 133:646-8. 2006
    ..Event-free (67 +/- 11%) and overall survival (77 +/- 10%) at 5 years were not significantly different in both groups. Further reduction of treatment intensity in AMKL of children with DS, therefore, appears feasible...
  99. doi request reprint Infections in pediatric acute myeloid leukemia: lessons learned and unresolved questions
    Lillian Sung
    Division of Haematology Oncology and Program in Child Health Evaluative Sciences, The Hospital for Sick Children, Toronto, Canada
    Pediatr Blood Cancer 51:458-60. 2008
  100. ncbi request reprint Late events occurring five years or more after successful therapy for childhood rhabdomyosarcoma: a report from the Soft Tissue Sarcoma Committee of the Children's Oncology Group
    Lillian Sung
    The Division of Hematology Oncology, Hospital for Sick Children, 555 University Avenue, Toronto, Ont, M5G 1X8, Canada
    Eur J Cancer 40:1878-85. 2004
    ..Late events after successful treatment for rhabdomyosarcoma occur in 9%. Those with advanced disease and large primary tumours have the highest risk of late events...
  101. doi request reprint Cost-effectiveness of outpatient management for febrile neutropenia in children with cancer
    Oliver Teuffel
    Division of Haematology Oncology, Hospital for Sick Children, Toronto, Ontario, Canada
    Pediatrics 127:e279-86. 2011
    ..Clinical data suggest, however, that outpatient management might be a safe and efficacious alternative for patients with low-risk FN episodes...