B A Stewart

Summary

Affiliation: The Hospital for Sick Children
Country: Canada

Publications

  1. ncbi SNARE-dependent signaling at the Drosophila wing margin
    B A Stewart
    Program in Developmental Biology, The Hospital for Sick Children Research Institute, Toronto, Ontario, M5G 1X8, Canada
    Dev Biol 234:13-23. 2001
  2. ncbi Analysis of the mutant Drosophila N-ethylmaleimide sensitive fusion-1 protein in comatose reveals molecular correlates of the behavioural paralysis
    M Mohtashami
    Programme in Cell Biology, Developmental Biology, Hospital for Sick Children, Toronto, Ontario, Canada
    J Neurochem 77:1407-17. 2001
  3. pmc SNARE proteins contribute to calcium cooperativity of synaptic transmission
    B A Stewart
    Department of Molecular and Medical Genetics, Zoology, and Biochemistry, University of Toronto, 555 University Avenue, Toronto, ON, Canada
    Proc Natl Acad Sci U S A 97:13955-60. 2000
  4. ncbi Improved stability of Drosophila larval neuromuscular preparations in haemolymph-like physiological solutions
    B A Stewart
    Department of Physiology, University of Toronto, Ontario, Canada
    J Comp Physiol A 175:179-91. 1994
  5. ncbi Drosophila Amphiphysin is a post-synaptic protein required for normal locomotion but not endocytosis
    P A Leventis
    Department of Zoology, University of Toronto, Toronto, Canada
    Traffic 2:839-50. 2001
  6. ncbi Homeostasis of synaptic transmission in Drosophila with genetically altered nerve terminal morphology
    B A Stewart
    Department of Physiology, University of Toronto, Ontario, Canada
    J Neurosci 16:3877-86. 1996
  7. pmc Two distinct effects on neurotransmission in a temperature-sensitive SNAP-25 mutant
    S S Rao
    Department of Neurobiology and Behavior, Cornell University, Ithaca, NY 14853, USA
    EMBO J 20:6761-71. 2001
  8. ncbi Distinct requirements for evoked and spontaneous release of neurotransmitter are revealed by mutations in the Drosophila gene neuronal-synaptobrevin
    D L Deitcher
    Department of Molecular and Cellular Physiology, Beckman Center, Stanford University Medical Center, Stanford, California 94305, USA
    J Neurosci 18:2028-39. 1998

Collaborators

  • L Zhou
  • Jinhai Wang
  • P K Rivlin
  • D L Deitcher
  • P A Leventis
  • G L Boulianne
  • M Mohtashami
  • S S Rao
  • W S Trimble
  • I Vilinsky
  • A R Campos
  • B M Chow
  • B Iyengar
  • G Boulianne
  • B O Watson
  • M M Salpeter
  • C Lang
  • T L Schwarz
  • Y Kidokoro
  • R W Burgess
  • A Ueda

Detail Information

Publications8

  1. ncbi SNARE-dependent signaling at the Drosophila wing margin
    B A Stewart
    Program in Developmental Biology, The Hospital for Sick Children Research Institute, Toronto, Ontario, M5G 1X8, Canada
    Dev Biol 234:13-23. 2001
    ..We conclude that SNARE-mediated membrane trafficking is an important component of wing margin development and that dosage-sensitive developmental pathways will act as a sensitive reporter of partial membrane-trafficking disruption...
  2. ncbi Analysis of the mutant Drosophila N-ethylmaleimide sensitive fusion-1 protein in comatose reveals molecular correlates of the behavioural paralysis
    M Mohtashami
    Programme in Cell Biology, Developmental Biology, Hospital for Sick Children, Toronto, Ontario, Canada
    J Neurochem 77:1407-17. 2001
    ..Together, these results suggest that dNSF-1 is required for adult neuronal function, but that in the larval nmj function may be maintained by other isoforms...
  3. pmc SNARE proteins contribute to calcium cooperativity of synaptic transmission
    B A Stewart
    Department of Molecular and Medical Genetics, Zoology, and Biochemistry, University of Toronto, 555 University Avenue, Toronto, ON, Canada
    Proc Natl Acad Sci U S A 97:13955-60. 2000
    ..Surprisingly, we found that reducing these SNARE proteins also reduced Ca(2+) cooperativity. Thus, SNARE proteins are important for determining the cooperative relationship between calcium and synaptic transmission...
  4. ncbi Improved stability of Drosophila larval neuromuscular preparations in haemolymph-like physiological solutions
    B A Stewart
    Department of Physiology, University of Toronto, Ontario, Canada
    J Comp Physiol A 175:179-91. 1994
    ..Thus, haemolymph-like solutions allow for prolonged, stable recording of synaptic transmission...
  5. ncbi Drosophila Amphiphysin is a post-synaptic protein required for normal locomotion but not endocytosis
    P A Leventis
    Department of Zoology, University of Toronto, Toronto, Canada
    Traffic 2:839-50. 2001
    ..However, Drosophila Amphiphysin function is required in both larvae and adults for normal locomotion...
  6. ncbi Homeostasis of synaptic transmission in Drosophila with genetically altered nerve terminal morphology
    B A Stewart
    Department of Physiology, University of Toronto, Ontario, Canada
    J Neurosci 16:3877-86. 1996
    ..These results show that morphological parameters of transmitting nerve terminals can be adjusted to functionally compensate for genetic perturbations, thereby maintaining optimal synaptic transmission...
  7. pmc Two distinct effects on neurotransmission in a temperature-sensitive SNAP-25 mutant
    S S Rao
    Department of Neurobiology and Behavior, Cornell University, Ithaca, NY 14853, USA
    EMBO J 20:6761-71. 2001
    ..Our data suggest that at 22 degrees C the mutation causes the SNARE complex to be more fusion competent but, at 37 degrees C the same mutation leads to SNARE multimer instability and fusion incompetence...
  8. ncbi Distinct requirements for evoked and spontaneous release of neurotransmitter are revealed by mutations in the Drosophila gene neuronal-synaptobrevin
    D L Deitcher
    Department of Molecular and Cellular Physiology, Beckman Center, Stanford University Medical Center, Stanford, California 94305, USA
    J Neurosci 18:2028-39. 1998
    ..Thus, at least a portion of the spontaneous "minis" that are seen at the synapse can be generated by a protein complex that is distinct from that required for an evoked synaptic response...