Gino R Somers

Summary

Affiliation: The Hospital for Sick Children
Country: Canada

Publications

  1. ncbi request reprint Sudden unexpected death in infancy and childhood due to undiagnosed neoplasia: an autopsy study
    Gino R Somers
    Division of Pathology, Department of Pediatric Laboratory Medicine, Hospital for Sick Children, Toronto, Ontario, Canada
    Am J Forensic Med Pathol 27:64-9. 2006
  2. ncbi request reprint Expression of MYCN in pediatric synovial sarcoma
    Gino R Somers
    Division of Pathology, Department of Paediatric Laboratory Medicine, Hospital for Sick Children, Toronto, ON, Canada
    Mod Pathol 20:734-41. 2007
  3. ncbi request reprint Pediatric undifferentiated sarcoma of the soft tissues: a clinicopathologic study
    Gino R Somers
    Division of Pathology, Hospital for Sick Children, 555 University Avenue, Toronto, ON M5G 1X8, Canada
    Pediatr Dev Pathol 9:132-42. 2006
  4. ncbi request reprint Pediatric drowning: a 20-year review of autopsied cases: III. Bathtub drownings
    Gino R Somers
    Division of Pathology, Department of Pediatric Laboratory Medicine, Hospital for Sick Children, Toronto, Ontario, Canada
    Am J Forensic Med Pathol 27:113-6. 2006
  5. ncbi request reprint Pediatric drowning: a 20-year review of autopsied cases: II. Pathologic features
    Gino R Somers
    Division of Pathology, Department of Pediatric Laboratory Medicine, Hospital for Sick Children, Toronto, Ontario, Canada
    Am J Forensic Med Pathol 27:20-4. 2006
  6. ncbi request reprint Association of the t(12;22)(q13;q12) EWS/ATF1 rearrangement with polyphenotypic round cell sarcoma of bone: a case report
    Gino R Somers
    Department of Paediatric Laboratory Medicine, Hospital for Sick Children, Toronto, Ontario, Canada
    Am J Surg Pathol 29:1673-9. 2005
  7. ncbi request reprint Pediatric drowning: a 20-year review of autopsied cases: I. Demographic features
    Gino R Somers
    Division of Pathology, Department of Pediatric Laboratory Medicine, Hospital for Sick Children, Toronto, Ontario, Canada
    Am J Forensic Med Pathol 26:316-9. 2005
  8. ncbi request reprint HER2 amplification and overexpression is not present in pediatric osteosarcoma: a tissue microarray study
    Gino R Somers
    Department of Pediatric Laboratory Medicine, Hospital for Sick Children, 555 University Avenue, Toronto, ON, M5G 1X8, Canada
    Pediatr Dev Pathol 8:525-32. 2005
  9. doi request reprint Increased detection of metastatic melanoma in pediatric sentinel lymph node biopsies using RT-PCR on paraffin-embedded tissue
    Gino R Somers
    Department of Paediatric Laboratory Medicine, Hospital for Sick Children, University of Toronto, ON, Canada
    Appl Immunohistochem Mol Morphol 18:365-70. 2010
  10. doi request reprint IGF2 is highly expressed in pediatric undifferentiated sarcomas and reveals two distinct cytoplasmic trafficking patterns
    Gino R Somers
    Department of Paediatric Laboratory Medicine, Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, Canada
    Pediatr Dev Pathol 13:169-77. 2010

Collaborators

Detail Information

Publications34

  1. ncbi request reprint Sudden unexpected death in infancy and childhood due to undiagnosed neoplasia: an autopsy study
    Gino R Somers
    Division of Pathology, Department of Pediatric Laboratory Medicine, Hospital for Sick Children, Toronto, Ontario, Canada
    Am J Forensic Med Pathol 27:64-9. 2006
    ....
  2. ncbi request reprint Expression of MYCN in pediatric synovial sarcoma
    Gino R Somers
    Division of Pathology, Department of Paediatric Laboratory Medicine, Hospital for Sick Children, Toronto, ON, Canada
    Mod Pathol 20:734-41. 2007
    ..The clinical and biological significance of this finding deserves further study...
  3. ncbi request reprint Pediatric undifferentiated sarcoma of the soft tissues: a clinicopathologic study
    Gino R Somers
    Division of Pathology, Hospital for Sick Children, 555 University Avenue, Toronto, ON M5G 1X8, Canada
    Pediatr Dev Pathol 9:132-42. 2006
    ....
  4. ncbi request reprint Pediatric drowning: a 20-year review of autopsied cases: III. Bathtub drownings
    Gino R Somers
    Division of Pathology, Department of Pediatric Laboratory Medicine, Hospital for Sick Children, Toronto, Ontario, Canada
    Am J Forensic Med Pathol 27:113-6. 2006
    ..All toxicologic samples submitted for analysis were negative. The present study highlights the factors associated with bathtub drownings and may aid in the prevention of such deaths in the pediatric population...
  5. ncbi request reprint Pediatric drowning: a 20-year review of autopsied cases: II. Pathologic features
    Gino R Somers
    Division of Pathology, Department of Pediatric Laboratory Medicine, Hospital for Sick Children, Toronto, Ontario, Canada
    Am J Forensic Med Pathol 27:20-4. 2006
    ..The findings highlight the need for thorough clinicopathologic correlation in cases of drowning to accurately interpret the pathologic findings...
  6. ncbi request reprint Association of the t(12;22)(q13;q12) EWS/ATF1 rearrangement with polyphenotypic round cell sarcoma of bone: a case report
    Gino R Somers
    Department of Paediatric Laboratory Medicine, Hospital for Sick Children, Toronto, Ontario, Canada
    Am J Surg Pathol 29:1673-9. 2005
    ..However, given the lack of morphologic features usually present in CCS, a diagnosis of polyphenotypic round cell sarcoma was made. This tumor thus expands the spectrum of neoplasms associated with the t(12;22)(q13;q12) rearrangement...
  7. ncbi request reprint Pediatric drowning: a 20-year review of autopsied cases: I. Demographic features
    Gino R Somers
    Division of Pathology, Department of Pediatric Laboratory Medicine, Hospital for Sick Children, Toronto, Ontario, Canada
    Am J Forensic Med Pathol 26:316-9. 2005
    ..0346). The present study highlights differences in the pattern of drowning according to age and sex and may aid in developing targeted educational and preventative campaigns...
  8. ncbi request reprint HER2 amplification and overexpression is not present in pediatric osteosarcoma: a tissue microarray study
    Gino R Somers
    Department of Pediatric Laboratory Medicine, Hospital for Sick Children, 555 University Avenue, Toronto, ON, M5G 1X8, Canada
    Pediatr Dev Pathol 8:525-32. 2005
    ..From a technical standpoint, this study also demonstrates the value of tissue microarrays in screening tumors at the protein and gene levels using conventional light microscopy...
  9. doi request reprint Increased detection of metastatic melanoma in pediatric sentinel lymph node biopsies using RT-PCR on paraffin-embedded tissue
    Gino R Somers
    Department of Paediatric Laboratory Medicine, Hospital for Sick Children, University of Toronto, ON, Canada
    Appl Immunohistochem Mol Morphol 18:365-70. 2010
    ..Nonetheless, this technique provides a useful tool to determine the clinical significance of RT-PCR positivity in melanoma SLNs...
  10. doi request reprint IGF2 is highly expressed in pediatric undifferentiated sarcomas and reveals two distinct cytoplasmic trafficking patterns
    Gino R Somers
    Department of Paediatric Laboratory Medicine, Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, Canada
    Pediatr Dev Pathol 13:169-77. 2010
    ..Given that in one subcellular pattern the IGF2 protein does not appear to reach the membrane, these findings may have functional significance...
  11. ncbi request reprint Association of drowning and myocarditis in a pediatric population: an autopsy-based study
    Gino R Somers
    Division of Pathology, Department of Pediatric Laboratory Medicine, Hospital for Sick Children, Toronto, Ontario, Canada
    Arch Pathol Lab Med 129:205-9. 2005
    ..Drowning is a frequent cause of accidental death in childhood, but the association of myocarditis and drowning has only rarely been reported...
  12. ncbi request reprint Primary subcutaneous primitive neuroectodermal tumor with aggressive behavior and an unusual karyotype: case report
    Gino R Somers
    Division of Pathology, Department of Paediatric Laboratory Medicine, Hospital for Sick Children, M5G 1X8, Toronto, ON, Canada
    Pediatr Dev Pathol 7:538-45. 2004
    ..The clinical behavior and atypical and complex cytogenetic abnormalities exhibited by the tumor in this patient are unusual and represent the most aggressive end of the clinical spectrum of cutaneous and subcutaneous PNET/ES...
  13. ncbi request reprint Intrascrotal lipoblastoma with a complex karyotype: a case report and review of the literature
    Gino R Somers
    Division of Pathology, Hospital for Sick Children, Toronto, Ontario, Canada
    Arch Pathol Lab Med 128:797-800. 2004
    ..To our knowledge, this is the first reported case of such a complex karyotype in lipoblastoma and adds to the expanding list of karyotypic abnormalities seen in such tumors...
  14. doi request reprint Expression of insulin-like growth factor pathway proteins in rhabdomyosarcoma: IGF-2 expression is associated with translocation-negative tumors
    Shalini Makawita
    Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada
    Pediatr Dev Pathol 12:127-35. 2009
    ..Furthermore, the in vitro results are supportive of a role for the PAX3/FKHR fusion gene in the inhibition of IGF2 expression...
  15. doi request reprint Detailed cytogenetic and array analysis of pediatric primitive sarcomas reveals a recurrent CIC-DUX4 fusion gene event
    Maisa Yoshimoto
    Department of Pathology and Molecular Medicine, Queen s University, Kingston, ON, Canada
    Cancer Genet Cytogenet 195:1-11. 2009
    ..Molecular and cytogenetic techniques for the detection of the CIC-DUX4 fusion gene are described, to aid in recognition and diagnosis...
  16. doi request reprint The CIC-DUX4 fusion transcript is present in a subgroup of pediatric primitive round cell sarcomas
    Cassandra Graham
    Department of Paediatric Laboratory Medicine, Hospital for Sick Children, Toronto, ON, Canada M5G 1X8
    Hum Pathol 43:180-9. 2012
    ..The current findings further define a novel genetic subset of pediatric primitive round cell sarcomas and provide an additional diagnostic tool for their characterization and diagnosis...
  17. doi request reprint Predisposing factors and outcomes of malignant skin tumors in children
    Cypel Tatiana K S
    Department of Surgery, Division of Plastic Surgery, University of Toronto, Canada
    Plast Reconstr Surg 126:508-14. 2010
    ..In this study, the authors aimed to determine the incidence, risk factors, treatment, reconstruction details, and outcome of malignant skin tumors occurring in pediatric patients at the Hospital for Sick Children...
  18. ncbi request reprint Fatal lung fibrosis associated with immunodeficiency and gonadal dysgenesis in 46XX sisters--a new syndrome
    Raz Somech
    Department of Pediatrics, The Canadian Centre for Primary Immunodeficiency, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
    Am J Med Genet A 146:8-14. 2008
    ..The distinct findings in these two sisters have not been reported before and thus suggest a hitherto unknown autosomal recessive condition that includes immune dysfunction, gonadal dysgenesis, and pulmonary fibrosis...
  19. ncbi request reprint Presence of periorbital and conjunctival petechial hemorrhages in accidental pediatric drowning
    Gino R Somers
    Department of Paediatric Laboratory Medicine, Hospital for Sick Children, Toronto, Ont, Canada
    Forensic Sci Int 175:198-201. 2008
    ..The presence of periorbital/conjunctival hemorrhages in a significant proportion of pediatric drowning victims confirms that the pathologist must add this finding to the spectrum of changes seen in pediatric drowning...
  20. pmc JNK1 determines the oncogenic or tumor-suppressive activity of the integrin-linked kinase in human rhabdomyosarcoma
    Adam D Durbin
    Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada
    J Clin Invest 119:1558-70. 2009
    ....
  21. ncbi request reprint Characterization of trisomy 8 in pediatric undifferentiated sarcomas using advanced molecular cytogenetic techniques
    Shamini Selvarajah
    Department of Pathology and Laboratory Medicine, The Hospital for Sick Children, 555 University Avenue, Room 3 206, Toronto, Ontario M5G 1X8, Canada
    Cancer Genet Cytogenet 174:35-41. 2007
    ..The occurrence of trisomy 8 in a subset of pediatric USTS confirms a shared genomic alteration with several other soft tissue sarcomas. Further studies are required to determine the clinical implications of such a finding...
  22. doi request reprint Immunohistochemical expression and cluster analysis of mesenchymal and neural stem cell-associated proteins in pediatric soft tissue sarcomas
    Bekim Sadikovic
    Department of Paediatric Laboratory Medicine, Hospital for Sick Children, Toronto, ON, Canada
    Pediatr Dev Pathol 14:259-72. 2011
    ..The current study demonstrates the usefulness of applying stem cell markers to pediatric sarcomas and indicates that USTSs and ESs are closely related and may share a common histogenesis...
  23. doi request reprint Undiagnosed heart disease leading to sudden unexpected death in childhood: a retrospective study
    Maria V Ilina
    Division of Pediatric Cardiology, Hospital for Sick Children, Toronto, Ontario, Canada
    Pediatrics 128:e513-20. 2011
    ..We describe here demographic features, pathological conditions, and the frequency of premonitory symptoms in a retrospective series of cases of sudden unexpected cardiac death (SUCD) attributable to undiagnosed structural heart disease...
  24. doi request reprint Sickle cell trait mimicking multiple inflicted injuries in a 5-year-old boy
    Charis Kepron
    Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada
    J Forensic Sci 54:1141-5. 2009
    ..This case highlights the importance of clinicopathological correlation and is the first to describe SCT pathology as a mimic of nonaccidental injury...
  25. doi request reprint Splenic hamartoma in a child in the era of PET-CT
    Laura Avila
    Division of Hematology Oncology, Hospital for Sick Children, Toronto, Ontario, Canada
    Pediatr Blood Cancer 53:114-6. 2009
    ..This case highlights the diagnostic challenge of splenic lesions and that the role of positron emission tomography/computerized tomography (PET/CT) in defining splenic lesions in the pediatric population remains to be defined...
  26. doi request reprint Small intestinal B-cell lymphoma in a patient with lymphangiectasia secondary to abdominal lymphangioma
    Rupinder Chera
    Division of Hematology Oncology, Hospital for Sick Children, Toronto, Ontario, Canada
    J Clin Oncol 26:675-8. 2008
  27. doi request reprint Invasive aspergillosis in cystic fibrosis: a fatal case in an adolescent and review of the literature
    Joanna Massam
    Division of Respiratory Medicine, Department of Pediatrics, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
    Pediatr Infect Dis J 30:178-80. 2011
    ..The patient developed fatal disseminated aspergillosis in the absence of any preexisting risk factors after a short course of intravenous corticosteroid treatment...
  28. ncbi request reprint Verrucous hemangioma: a challenging vascular lesion
    Irene Lara-Corrales
    Department of Paediatrics, Section of Dermatology, The Hospital for Sick Children, Toronto, ON
    J Cutan Med Surg 14:144-6. 2010
    ..We present a case of a 13-year-old girl with a congenital vascular lesion in her right ankle...
  29. doi request reprint Friedreich ataxia presenting as sudden cardiac death in childhood: clinical, genetic and pathological correlation, with implications for genetic testing and counselling
    Nada Quercia
    Division of Clinical and Metabolic Genetics, Hospital for Sick Children, University of Toronto, Toronto, Canada
    Neuromuscul Disord 20:340-2. 2010
    ..Molecular genetic testing subsequently confirmed the diagnosis of Friedreich ataxia. To our knowledge, this is the first report of Friedreich ataxia presenting as sudden cardiac death in early childhood...
  30. doi request reprint Pleuropulmonary blastoma in a child with autosomal-recessive polycystic kidney disease
    Jeffrey Traubici
    Department of Diagnostic Imaging, The Hospital for Sick Children, Toronto, Canada
    Pediatr Radiol 41:1465-8. 2011
    ..Knowledge of this potential association is important in the clinical management of these children and may open new avenues of genetic research...
  31. ncbi request reprint Prenatal presentation of an intracardiac infantile type of haemangioendothelioma
    Kevin S Roman
    Department of Pediatrics, Division of Cardiology, The Hospital for Sick Children, University of Toronto, Ontario M5G 1X8, Canada
    Cardiol Young 15:182-3. 2005
  32. ncbi request reprint Pagetoid spread of melanocytes in Spitz naevi
    Gino R Somers
    Pathology 34:590; author reply 591. 2002
  33. ncbi request reprint Probable herbal medication induced fulminant hepatic failure
    Annette N Webb
    Department of Gastroenterology and Clinical Nutrition, Royal Children s Hospital, Melbourne, Victoria, Australia
    J Paediatr Child Health 41:530-1. 2005
  34. ncbi request reprint Expression of IFI 16 in epithelial cells and lymphoid tissues
    Wu Wei
    Peter MacCallum Cancer Institute, St Andrews Place, 3002 East Melbourne, Victoria, Australia
    Histochem Cell Biol 119:45-54. 2003
    ..In contrast to the perceived role of HIN-200 proteins as suppressors of cell growth, maximal expression of IFI 16 was in cells with high proliferative potential...