Research Topics
Genomes and GenesSpecies | Gino R SomersSummaryAffiliation: The Hospital for Sick Children Country: Canada Publications
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Publications
Sudden unexpected death in infancy and childhood due to undiagnosed neoplasia: an autopsy studyGino R Somers
Division of Pathology, Department of Pediatric Laboratory Medicine, Hospital for Sick Children, Toronto, Ontario, Canada
Am J Forensic Med Pathol 27:64-9. 2006....- Expression of MYCN in pediatric synovial sarcomaGino R Somers
Division of Pathology, Department of Paediatric Laboratory Medicine, Hospital for Sick Children, Toronto, ON, Canada
Mod Pathol 20:734-41. 2007..The clinical and biological significance of this finding deserves further study... - Pediatric undifferentiated sarcoma of the soft tissues: a clinicopathologic studyGino R Somers
Division of Pathology, Hospital for Sick Children, 555 University Avenue, Toronto, ON M5G 1X8, Canada
Pediatr Dev Pathol 9:132-42. 2006.... - Pediatric drowning: a 20-year review of autopsied cases: III. Bathtub drowningsGino R Somers
Division of Pathology, Department of Pediatric Laboratory Medicine, Hospital for Sick Children, Toronto, Ontario, Canada
Am J Forensic Med Pathol 27:113-6. 2006..All toxicologic samples submitted for analysis were negative. The present study highlights the factors associated with bathtub drownings and may aid in the prevention of such deaths in the pediatric population... - Pediatric drowning: a 20-year review of autopsied cases: II. Pathologic featuresGino R Somers
Division of Pathology, Department of Pediatric Laboratory Medicine, Hospital for Sick Children, Toronto, Ontario, Canada
Am J Forensic Med Pathol 27:20-4. 2006..The findings highlight the need for thorough clinicopathologic correlation in cases of drowning to accurately interpret the pathologic findings... - Association of the t(12;22)(q13;q12) EWS/ATF1 rearrangement with polyphenotypic round cell sarcoma of bone: a case reportGino R Somers
Department of Paediatric Laboratory Medicine, Hospital for Sick Children, Toronto, Ontario, Canada
Am J Surg Pathol 29:1673-9. 2005..However, given the lack of morphologic features usually present in CCS, a diagnosis of polyphenotypic round cell sarcoma was made. This tumor thus expands the spectrum of neoplasms associated with the t(12;22)(q13;q12) rearrangement... - Pediatric drowning: a 20-year review of autopsied cases: I. Demographic featuresGino R Somers
Division of Pathology, Department of Pediatric Laboratory Medicine, Hospital for Sick Children, Toronto, Ontario, Canada
Am J Forensic Med Pathol 26:316-9. 2005..0346). The present study highlights differences in the pattern of drowning according to age and sex and may aid in developing targeted educational and preventative campaigns... - HER2 amplification and overexpression is not present in pediatric osteosarcoma: a tissue microarray studyGino R Somers
Department of Pediatric Laboratory Medicine, Hospital for Sick Children, 555 University Avenue, Toronto, ON, M5G 1X8, Canada
Pediatr Dev Pathol 8:525-32. 2005..From a technical standpoint, this study also demonstrates the value of tissue microarrays in screening tumors at the protein and gene levels using conventional light microscopy... - Increased detection of metastatic melanoma in pediatric sentinel lymph node biopsies using RT-PCR on paraffin-embedded tissueGino R Somers
Department of Paediatric Laboratory Medicine, Hospital for Sick Children, University of Toronto, ON, Canada
Appl Immunohistochem Mol Morphol 18:365-70. 2010..Nonetheless, this technique provides a useful tool to determine the clinical significance of RT-PCR positivity in melanoma SLNs... - IGF2 is highly expressed in pediatric undifferentiated sarcomas and reveals two distinct cytoplasmic trafficking patternsGino R Somers
Department of Paediatric Laboratory Medicine, Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, Canada
Pediatr Dev Pathol 13:169-77. 2010..Given that in one subcellular pattern the IGF2 protein does not appear to reach the membrane, these findings may have functional significance... - Association of drowning and myocarditis in a pediatric population: an autopsy-based studyGino R Somers
Division of Pathology, Department of Pediatric Laboratory Medicine, Hospital for Sick Children, Toronto, Ontario, Canada
Arch Pathol Lab Med 129:205-9. 2005..Drowning is a frequent cause of accidental death in childhood, but the association of myocarditis and drowning has only rarely been reported... - Primary subcutaneous primitive neuroectodermal tumor with aggressive behavior and an unusual karyotype: case reportGino R Somers
Division of Pathology, Department of Paediatric Laboratory Medicine, Hospital for Sick Children, M5G 1X8, Toronto, ON, Canada
Pediatr Dev Pathol 7:538-45. 2004..The clinical behavior and atypical and complex cytogenetic abnormalities exhibited by the tumor in this patient are unusual and represent the most aggressive end of the clinical spectrum of cutaneous and subcutaneous PNET/ES... - Intrascrotal lipoblastoma with a complex karyotype: a case report and review of the literatureGino R Somers
Division of Pathology, Hospital for Sick Children, Toronto, Ontario, Canada
Arch Pathol Lab Med 128:797-800. 2004..To our knowledge, this is the first reported case of such a complex karyotype in lipoblastoma and adds to the expanding list of karyotypic abnormalities seen in such tumors... - Expression of insulin-like growth factor pathway proteins in rhabdomyosarcoma: IGF-2 expression is associated with translocation-negative tumorsShalini Makawita
Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada
Pediatr Dev Pathol 12:127-35. 2009..Furthermore, the in vitro results are supportive of a role for the PAX3/FKHR fusion gene in the inhibition of IGF2 expression... - Detailed cytogenetic and array analysis of pediatric primitive sarcomas reveals a recurrent CIC-DUX4 fusion gene eventMaisa Yoshimoto
Department of Pathology and Molecular Medicine, Queen s University, Kingston, ON, Canada
Cancer Genet Cytogenet 195:1-11. 2009..Molecular and cytogenetic techniques for the detection of the CIC-DUX4 fusion gene are described, to aid in recognition and diagnosis... - The CIC-DUX4 fusion transcript is present in a subgroup of pediatric primitive round cell sarcomasCassandra Graham
Department of Paediatric Laboratory Medicine, Hospital for Sick Children, Toronto, ON, Canada M5G 1X8
Hum Pathol 43:180-9. 2012..The current findings further define a novel genetic subset of pediatric primitive round cell sarcomas and provide an additional diagnostic tool for their characterization and diagnosis... - Predisposing factors and outcomes of malignant skin tumors in childrenCypel Tatiana K S
Department of Surgery, Division of Plastic Surgery, University of Toronto, Canada
Plast Reconstr Surg 126:508-14. 2010..In this study, the authors aimed to determine the incidence, risk factors, treatment, reconstruction details, and outcome of malignant skin tumors occurring in pediatric patients at the Hospital for Sick Children... - Fatal lung fibrosis associated with immunodeficiency and gonadal dysgenesis in 46XX sisters--a new syndromeRaz Somech
Department of Pediatrics, The Canadian Centre for Primary Immunodeficiency, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
Am J Med Genet A 146:8-14. 2008..The distinct findings in these two sisters have not been reported before and thus suggest a hitherto unknown autosomal recessive condition that includes immune dysfunction, gonadal dysgenesis, and pulmonary fibrosis... - Presence of periorbital and conjunctival petechial hemorrhages in accidental pediatric drowningGino R Somers
Department of Paediatric Laboratory Medicine, Hospital for Sick Children, Toronto, Ont, Canada
Forensic Sci Int 175:198-201. 2008..The presence of periorbital/conjunctival hemorrhages in a significant proportion of pediatric drowning victims confirms that the pathologist must add this finding to the spectrum of changes seen in pediatric drowning... - JNK1 determines the oncogenic or tumor-suppressive activity of the integrin-linked kinase in human rhabdomyosarcomaAdam D Durbin
Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada
J Clin Invest 119:1558-70. 2009.... - Characterization of trisomy 8 in pediatric undifferentiated sarcomas using advanced molecular cytogenetic techniquesShamini Selvarajah
Department of Pathology and Laboratory Medicine, The Hospital for Sick Children, 555 University Avenue, Room 3 206, Toronto, Ontario M5G 1X8, Canada
Cancer Genet Cytogenet 174:35-41. 2007..The occurrence of trisomy 8 in a subset of pediatric USTS confirms a shared genomic alteration with several other soft tissue sarcomas. Further studies are required to determine the clinical implications of such a finding... - Immunohistochemical expression and cluster analysis of mesenchymal and neural stem cell-associated proteins in pediatric soft tissue sarcomasBekim Sadikovic
Department of Paediatric Laboratory Medicine, Hospital for Sick Children, Toronto, ON, Canada
Pediatr Dev Pathol 14:259-72. 2011..The current study demonstrates the usefulness of applying stem cell markers to pediatric sarcomas and indicates that USTSs and ESs are closely related and may share a common histogenesis... - Undiagnosed heart disease leading to sudden unexpected death in childhood: a retrospective studyMaria V Ilina
Division of Pediatric Cardiology, Hospital for Sick Children, Toronto, Ontario, Canada
Pediatrics 128:e513-20. 2011..We describe here demographic features, pathological conditions, and the frequency of premonitory symptoms in a retrospective series of cases of sudden unexpected cardiac death (SUCD) attributable to undiagnosed structural heart disease... - Sickle cell trait mimicking multiple inflicted injuries in a 5-year-old boyCharis Kepron
Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada
J Forensic Sci 54:1141-5. 2009..This case highlights the importance of clinicopathological correlation and is the first to describe SCT pathology as a mimic of nonaccidental injury... - Splenic hamartoma in a child in the era of PET-CTLaura Avila
Division of Hematology Oncology, Hospital for Sick Children, Toronto, Ontario, Canada
Pediatr Blood Cancer 53:114-6. 2009..This case highlights the diagnostic challenge of splenic lesions and that the role of positron emission tomography/computerized tomography (PET/CT) in defining splenic lesions in the pediatric population remains to be defined... - Small intestinal B-cell lymphoma in a patient with lymphangiectasia secondary to abdominal lymphangiomaRupinder Chera
Division of Hematology Oncology, Hospital for Sick Children, Toronto, Ontario, Canada
J Clin Oncol 26:675-8. 2008 - Invasive aspergillosis in cystic fibrosis: a fatal case in an adolescent and review of the literatureJoanna Massam
Division of Respiratory Medicine, Department of Pediatrics, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
Pediatr Infect Dis J 30:178-80. 2011..The patient developed fatal disseminated aspergillosis in the absence of any preexisting risk factors after a short course of intravenous corticosteroid treatment... - Verrucous hemangioma: a challenging vascular lesionIrene Lara-Corrales
Department of Paediatrics, Section of Dermatology, The Hospital for Sick Children, Toronto, ON
J Cutan Med Surg 14:144-6. 2010..The appearance of verrucous hemangiomas evolves with time and may represent a diagnostic challenge. We present this case report and a review of the literature... - Friedreich ataxia presenting as sudden cardiac death in childhood: clinical, genetic and pathological correlation, with implications for genetic testing and counsellingNada Quercia
Division of Clinical and Metabolic Genetics, Hospital for Sick Children, University of Toronto, Toronto, Canada
Neuromuscul Disord 20:340-2. 2010..Molecular genetic testing subsequently confirmed the diagnosis of Friedreich ataxia. To our knowledge, this is the first report of Friedreich ataxia presenting as sudden cardiac death in early childhood... - Pleuropulmonary blastoma in a child with autosomal-recessive polycystic kidney diseaseJeffrey Traubici
Department of Diagnostic Imaging, The Hospital for Sick Children, Toronto, Canada
Pediatr Radiol 41:1465-8. 2011..Knowledge of this potential association is important in the clinical management of these children and may open new avenues of genetic research... - Prenatal presentation of an intracardiac infantile type of haemangioendotheliomaKevin S Roman
Department of Pediatrics, Division of Cardiology, The Hospital for Sick Children, University of Toronto, Ontario M5G 1X8, Canada
Cardiol Young 15:182-3. 2005 - Pagetoid spread of melanocytes in Spitz naeviGino R Somers
Pathology 34:590; author reply 591. 2002 - Probable herbal medication induced fulminant hepatic failureAnnette N Webb
Department of Gastroenterology and Clinical Nutrition, Royal Children's Hospital, Melbourne, Victoria, Australia
J Paediatr Child Health 41:530-1. 2005 - Expression of IFI 16 in epithelial cells and lymphoid tissuesWu Wei
Peter MacCallum Cancer Institute, St. Andrews Place, 3002 East Melbourne, Victoria, Australia
Histochem Cell Biol 119:45-54. 2003..In contrast to the perceived role of HIN-200 proteins as suppressors of cell growth, maximal expression of IFI 16 was in cells with high proliferative potential...