G David Smith

Summary

Affiliation: The Hospital for Sick Children
Country: Canada

Publications

  1. ncbi request reprint The structure of T6 human insulin at 1.0 A resolution
    G David Smith
    Structural Biology and Biochemistry, Hospital for Sick Children, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada
    Acta Crystallogr D Biol Crystallogr 59:474-82. 2003
  2. ncbi request reprint Lessons from an aged, dried crystal of T(6) human insulin
    G David Smith
    Structural Biology and Biochemistry, Hospital for Sick Children, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada
    Acta Crystallogr D Biol Crystallogr 59:1384-94. 2003
  3. pmc Structure of Staphylococcus aureus 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase
    Karen K W Siu
    Program in Molecular Structure and Function, Research Institute, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada
    Acta Crystallogr Sect F Struct Biol Cryst Commun 64:343-50. 2008
  4. ncbi request reprint Structural snapshots of MTA/AdoHcy nucleosidase along the reaction coordinate provide insights into enzyme and nucleoside flexibility during catalysis
    Jeffrey E Lee
    Structural Biology and Biochemistry, Research Institute, Hospital for Sick Children, 555 University Avenue, Toronto, Ont, Canada
    J Mol Biol 352:559-74. 2005
  5. ncbi request reprint The structure of T6 bovine insulin
    G David Smith
    Structural Biology and Biochemistry, Hospital for Sick Children, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada
    Acta Crystallogr D Biol Crystallogr 61:1476-82. 2005
  6. ncbi request reprint ADP-2Ho as a phasing tool for nucleotide-containing proteins
    Shao Yang Ku
    Program in Molecular Structure and Function, Research Institute, Hospital for Sick Children, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada
    Acta Crystallogr D Biol Crystallogr 63:493-9. 2007
  7. ncbi request reprint Substructure determination in multiwavelength anomalous diffraction, single anomalous diffraction, and single isomorphous replacement with anomalous scattering data using Shake-and-Bake
    G David Smith
    Structural Biology and Biochemistry, Hospital for Sick Children, Toronto, Ontario, Canada
    Methods Mol Biol 364:183-96. 2007
  8. pmc Structural studies of duck delta2 crystallin mutants provide insight into the role of Thr161 and the 280s loop in catalysis
    Liliana M Sampaleanu
    Structural Biology and Biochemistry, Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, Canada M5G 1X8
    Biochem J 384:437-47. 2004
  9. ncbi request reprint S-SAD, Se-SAD and S/Se-SIRAS using Cu Kalpha radiation: why wait for synchrotron time?
    Christopher T Lemke
    Structural Biology and Biochemistry, Research Institute, Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, M5G 1X8, Canada
    Acta Crystallogr D Biol Crystallogr 58:2096-101. 2002

Collaborators

  • Shao-Yang Ku
  • P Lynne Howell
  • Jeffrey E Lee
  • Karen K W Siu
  • Cathy Horvatin
  • Liliana M Sampaleanu
  • Christopher T Lemke
  • Cathy Horvatin-Mrakovcic
  • David J T Huang
  • Michael K Riscoe
  • Kenneth A Cornell
  • Yuri D Lobsanov
  • May Tsai
  • Penelope W Codding

Detail Information

Publications9

  1. ncbi request reprint The structure of T6 human insulin at 1.0 A resolution
    G David Smith
    Structural Biology and Biochemistry, Hospital for Sick Children, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada
    Acta Crystallogr D Biol Crystallogr 59:474-82. 2003
    ..H.O-C(=O)-] such that the H atom is equally shared between the two partially charged O atoms...
  2. ncbi request reprint Lessons from an aged, dried crystal of T(6) human insulin
    G David Smith
    Structural Biology and Biochemistry, Hospital for Sick Children, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada
    Acta Crystallogr D Biol Crystallogr 59:1384-94. 2003
    ....
  3. pmc Structure of Staphylococcus aureus 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase
    Karen K W Siu
    Program in Molecular Structure and Function, Research Institute, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada
    Acta Crystallogr Sect F Struct Biol Cryst Commun 64:343-50. 2008
    ..coli enzyme. The implications of this structure for broad-based antibiotic design are discussed...
  4. ncbi request reprint Structural snapshots of MTA/AdoHcy nucleosidase along the reaction coordinate provide insights into enzyme and nucleoside flexibility during catalysis
    Jeffrey E Lee
    Structural Biology and Biochemistry, Research Institute, Hospital for Sick Children, 555 University Avenue, Toronto, Ont, Canada
    J Mol Biol 352:559-74. 2005
    ..A "catalytic movie" detailing substrate binding, catalysis, and product release is presented...
  5. ncbi request reprint The structure of T6 bovine insulin
    G David Smith
    Structural Biology and Biochemistry, Hospital for Sick Children, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada
    Acta Crystallogr D Biol Crystallogr 61:1476-82. 2005
    ..24 A decrease in the c dimension of the unit cell. Thus, the net effect of the change in sequence at A10 is to strengthen the stabilizing hydrophobic interactions between hexamers...
  6. ncbi request reprint ADP-2Ho as a phasing tool for nucleotide-containing proteins
    Shao Yang Ku
    Program in Molecular Structure and Function, Research Institute, Hospital for Sick Children, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada
    Acta Crystallogr D Biol Crystallogr 63:493-9. 2007
    ..The isomorphous substitution of holmium for magnesium in the MTR kinase-nucleotide complex suggests that this could be a useful phasing tool for other metal-dependent nucleotide-containing proteins...
  7. ncbi request reprint Substructure determination in multiwavelength anomalous diffraction, single anomalous diffraction, and single isomorphous replacement with anomalous scattering data using Shake-and-Bake
    G David Smith
    Structural Biology and Biochemistry, Hospital for Sick Children, Toronto, Ontario, Canada
    Methods Mol Biol 364:183-96. 2007
    ....
  8. pmc Structural studies of duck delta2 crystallin mutants provide insight into the role of Thr161 and the 280s loop in catalysis
    Liliana M Sampaleanu
    Structural Biology and Biochemistry, Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, Canada M5G 1X8
    Biochem J 384:437-47. 2004
    ..The 280s loop in ddeltac1 is in the closed conformation...
  9. ncbi request reprint S-SAD, Se-SAD and S/Se-SIRAS using Cu Kalpha radiation: why wait for synchrotron time?
    Christopher T Lemke
    Structural Biology and Biochemistry, Research Institute, Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, M5G 1X8, Canada
    Acta Crystallogr D Biol Crystallogr 58:2096-101. 2002
    ..The success of these methods has profound implications for crystallographers experiencing difficulty with heavy-atom incorporation or with limited access to a synchrotron source...