Philip M Sherman

Summary

Affiliation: The Hospital for Sick Children
Country: Canada

Publications

  1. pmc Enterohemorrhagic Escherichia coli O157:H7 gene expression profiling in response to growth in the presence of host epithelia
    Narveen Jandu
    Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA
    PLoS ONE 4:e4889. 2009
  2. doi request reprint Workshop report: developing a pediatric inflammatory bowel diseases network and data platform in Canada
    Philip M Sherman
    Canadian Institutes of Health Research, Ottawa, Ontario, Canada
    J Pediatr Gastroenterol Nutr 55:125-30. 2012
  3. pmc Matrix metalloproteinase 9 contributes to gut microbe homeostasis in a model of infectious colitis
    David M Rodrigues
    Department of Paediatrics, University of Toronto, 27 Kings College Circle, Toronto, Ontario, Canada
    BMC Microbiol 12:105. 2012
  4. doi request reprint Bacterial infections: new and emerging enteric pathogens
    Philip M Sherman
    Research Institute, Hospital for Sick Children, University of Toronto, Toronto, Canada
    Curr Opin Gastroenterol 26:1-4. 2010
  5. doi request reprint Bacterial infection causes stress-induced memory dysfunction in mice
    Mélanie G Gareau
    Cell Biology Program, Research Institute, Hospital for Sick Children, Toronto, ON, Canada
    Gut 60:307-17. 2011
  6. pmc Strategic plan of the Canadian Institutes of Health Research Institute of Nutrition, Metabolism, and Diabetes
    Philip M Sherman
    Canadian Institutes of Health Research, Ottawa, Ontario, Canada
    Can J Gastroenterol 25:560-4. 2011
  7. doi request reprint Potential roles and clinical utility of prebiotics in newborns, infants, and children: proceedings from a global prebiotic summit meeting, New York City, June 27-28, 2008
    Philip M Sherman
    Department of Paediatrics, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
    J Pediatr 155:S61-70. 2009
  8. doi request reprint A global, evidence-based consensus on the definition of gastroesophageal reflux disease in the pediatric population
    Philip M Sherman
    Gastroenterology Pediatric, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
    Am J Gastroenterol 104:1278-95; quiz 1296. 2009
  9. doi request reprint Unraveling mechanisms of action of probiotics
    Philip M Sherman
    Gastroenterology and Nutrition, Room 8409, Hospital for Sick Children, University of Toronto, 555 University Avenue, Toronto, Ontario, M5G 1X8, Canada
    Nutr Clin Pract 24:10-4. 2009
  10. doi request reprint Probiotics are effective for the prevention and treatment of Citrobacter rodentium-induced colitis in mice
    David M Rodrigues
    Research Institute, Hospital for Sick Children, University of Toronto, Canada
    J Infect Dis 206:99-109. 2012

Detail Information

Publications70

  1. pmc Enterohemorrhagic Escherichia coli O157:H7 gene expression profiling in response to growth in the presence of host epithelia
    Narveen Jandu
    Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA
    PLoS ONE 4:e4889. 2009
    ....
  2. doi request reprint Workshop report: developing a pediatric inflammatory bowel diseases network and data platform in Canada
    Philip M Sherman
    Canadian Institutes of Health Research, Ottawa, Ontario, Canada
    J Pediatr Gastroenterol Nutr 55:125-30. 2012
    ....
  3. pmc Matrix metalloproteinase 9 contributes to gut microbe homeostasis in a model of infectious colitis
    David M Rodrigues
    Department of Paediatrics, University of Toronto, 27 Kings College Circle, Toronto, Ontario, Canada
    BMC Microbiol 12:105. 2012
    ..We therefore sought to determine the contribution of MMP-9 to the pathogenesis of Citrobacter rodentium-induced colitis and its effects on gut microbiome homeostasis...
  4. doi request reprint Bacterial infections: new and emerging enteric pathogens
    Philip M Sherman
    Research Institute, Hospital for Sick Children, University of Toronto, Toronto, Canada
    Curr Opin Gastroenterol 26:1-4. 2010
    ....
  5. doi request reprint Bacterial infection causes stress-induced memory dysfunction in mice
    Mélanie G Gareau
    Cell Biology Program, Research Institute, Hospital for Sick Children, Toronto, ON, Canada
    Gut 60:307-17. 2011
    ..Whether intestinal events, such as enteric bacterial infections and bacterial colonisation, exert a reciprocal effect on stress-associated behaviour is not well established...
  6. pmc Strategic plan of the Canadian Institutes of Health Research Institute of Nutrition, Metabolism, and Diabetes
    Philip M Sherman
    Canadian Institutes of Health Research, Ottawa, Ontario, Canada
    Can J Gastroenterol 25:560-4. 2011
    ....
  7. doi request reprint Potential roles and clinical utility of prebiotics in newborns, infants, and children: proceedings from a global prebiotic summit meeting, New York City, June 27-28, 2008
    Philip M Sherman
    Department of Paediatrics, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
    J Pediatr 155:S61-70. 2009
    ..Additional well-designed prospective clinical trials and mechanistic studies are needed to advance knowledge further in this promising field...
  8. doi request reprint A global, evidence-based consensus on the definition of gastroesophageal reflux disease in the pediatric population
    Philip M Sherman
    Gastroenterology Pediatric, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
    Am J Gastroenterol 104:1278-95; quiz 1296. 2009
    ..To develop an international consensus on the definition of gastroesophageal reflux disease (GERD) in the pediatric population...
  9. doi request reprint Unraveling mechanisms of action of probiotics
    Philip M Sherman
    Gastroenterology and Nutrition, Room 8409, Hospital for Sick Children, University of Toronto, 555 University Avenue, Toronto, Ontario, M5G 1X8, Canada
    Nutr Clin Pract 24:10-4. 2009
    ..The creation of novel formulations of probiotics could be directed to effectively target certain mechanisms of actions that are altered in specific disease states...
  10. doi request reprint Probiotics are effective for the prevention and treatment of Citrobacter rodentium-induced colitis in mice
    David M Rodrigues
    Research Institute, Hospital for Sick Children, University of Toronto, Canada
    J Infect Dis 206:99-109. 2012
    ..Probiotics prevent disease induced by Citrobacter rodentium, a murine-specific enteric pathogen. Whether probiotics can be used to interrupt the infectious process following initiation of infection was determined...
  11. pmc Chronic psychological stress in rats induces intestinal sensitization to luminal antigens
    Ping Chang Yang
    Department of Pathology and Molecular Medicine, Intestinal Disease Research Program, McMaster University, Hamilton, Ontario, Canada
    Am J Pathol 168:104-14; quiz 363. 2006
    ..Our results indicate that the presence of oral antigen during chronic psychological stress alters the immune response (to sensitization rather than oral tolerance) and causes subsequent antigen-induced gut pathophysiology...
  12. doi request reprint Escherichia albertii and Hafnia alvei are candidate enteric pathogens with divergent effects on intercellular tight junctions
    Kevin A Donato
    Cell Biology Program, Research Institute, Hospital for Sick Children, University of Toronto, Room 8409, 555 University Avenue, Toronto, Ontario, Canada M5G 1X8
    Microb Pathog 45:377-85. 2008
    ..These findings demonstrate that E. albertii and H. alvei are candidate enteric pathogens that have both strain-specific and host epithelial cell-dependent effects...
  13. pmc Helicobacter pylori disrupts STAT1-mediated gamma interferon-induced signal transduction in epithelial cells
    David J Mitchell
    Research Institute, Hospital for Sick Children, Toronto, Ontario, Canada
    Infect Immun 72:537-45. 2004
    ..H. pylori disruption of IFN-gamma-STAT1 signaling in epithelial cells may represent a mechanism by which the bacterium modifies mucosal immune responses to promote its survival in the human host...
  14. doi request reprint Strain-specific probiotic (Lactobacillus helveticus) inhibition of Campylobacter jejuni invasion of human intestinal epithelial cells
    Eytan Wine
    Research Institute, Hospital for Sick Children, Toronto, ON, Canada
    FEMS Microbiol Lett 300:146-52. 2009
    ..The data support the concept of probiotic strain selectivity, which is dependent on the setting in which it is being evaluated and tested...
  15. ncbi request reprint Novel effects of the prototype translocating Escherichia coli, strain C25 on intestinal epithelial structure and barrier function
    Mehri Zareie
    Research Institute, Hospital for Sick Children, Department of Paediatrics and Laboratory Medicine, University of Toronto, Toronto, ON, Canada
    Cell Microbiol 7:1782-97. 2005
    ..coli O157:H7...
  16. ncbi request reprint Amelioration of the effects of Citrobacter rodentium infection in mice by pretreatment with probiotics
    Kathene C Johnson-Henry
    Research Institute, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
    J Infect Dis 191:2106-17. 2005
    ..We sought to determine whether pretreatment of mice with a mixture of Lactobacillus rhamnosus and L. acidophilus probiotics would attenuate C. rodentium-induced colonic disease in mice...
  17. pmc Enterohemorrhagic Escherichia coli O157:H7 Shiga toxins inhibit gamma interferon-mediated cellular activation
    Nathan K Ho
    Department of Paediatrics, The Hospital for Sick Children, Toronto, Ontario, Canada
    Infect Immun 80:2307-15. 2012
    ..We conclude that while other factors are likely involved in the suppression of IFN-γ-mediated Stat-1 tyrosine phosphorylation, E. coli-derived Shiga toxins represent a novel mechanism by which EHEC evades the host immune system...
  18. pmc Adherent-invasive Escherichia coli, strain LF82 disrupts apical junctional complexes in polarized epithelia
    Eytan Wine
    Research Institute, Hospital for Sick Children, Toronto, Ontario, Canada
    BMC Microbiol 9:180. 2009
    ..Therefore, the aim of this study was to delineate the effects of AIEC, strain LF82 (serotype O83:H1) on model polarized epithelial monolayers as a contributor to intestinal injury in IBD...
  19. pmc Conditioned medium from enterohemorrhagic Escherichia coli-infected T84 cells inhibits signal transducer and activator of transcription 1 activation by gamma interferon
    Narveen Jandu
    Research Institute, Gastroenterology and Nutrition Room 8409, Hospital for Sick Children, 555 University Ave, Toronto, Ontario, Canada M5G 1X8
    Infect Immun 74:1809-18. 2006
    ..Thus, suppression of host cell IFN-gamma signaling by production of a contact-dependent, soluble EHEC factor may represent a novel mechanism for this pathogen to evade the host immune system...
  20. doi request reprint Probiotics prevent enterohaemorrhagic Escherichia coli O157:H7-mediated inhibition of interferon-gamma-induced tyrosine phosphorylation of STAT-1
    Narveen Jandu
    Research Institute, Hospital for Sick Children, University of Toronto, Toronto, ON, Canada
    Microbiology 155:531-40. 2009
    ..14 mg ml(-1)) did not restore STAT-1 signalling in EHEC-infected cells. The viable probiotic agent L. helveticus R0052 prevented EHEC O157:H7-mediated subversion of epithelial cell signal transduction responses...
  21. ncbi request reprint Multiple seropathotypes of verotoxin-producing Escherichia coli (VTEC) disrupt interferon-gamma-induced tyrosine phosphorylation of signal transducer and activator of transcription (Stat)-1
    Narveen Jandu
    Research Institute, Hospital for Sick Children, Ont, Canada
    Microb Pathog 42:62-71. 2007
    ..The results of treatment with wortmannin suggest that the bacterial-derived inhibitory factor employs host cell signal transduction to mediate inhibition of Stat1-activation...
  22. doi request reprint Campylobacter jejuni mediated disruption of polarized epithelial monolayers is cell-type specific, time dependent, and correlates with bacterial invasion
    Eytan Wine
    Department of Paediatrics, University of Toronto, Toronto, Ontario, M5G 1X8, Canada
    Pediatr Res 64:599-604. 2008
    ..jejuni disruption of monolayers is mediated by invasion, provide new insights into C. jejuni-host epithelial barrier interactions, and offer potential mechanisms of intestinal injury and chronic immune stimulation...
  23. doi request reprint Adherent-invasive Escherichia coli blocks interferon-γ-induced signal transducer and activator of transcription (STAT)-1 in human intestinal epithelial cells
    Juan C Ossa
    Research Institute, Hospital for Sick Children, University of Toronto, Toronto, ON, Canada
    Cell Microbiol 15:446-57. 2013
    ..We conclude that the suppression of epithelial cell STAT1 signal transduction by AIEC strains isolated from patients with Crohn disease represents a novel mechanism by which the pathogen evades host immune responses to the infection...
  24. pmc Development of a nanoparticle-labeled microfluidic immunoassay for detection of pathogenic microorganisms
    Frank Y H Lin
    Research Institute, Hospital for Sick Children, 555 University Ave, Toronto, Ontario M5G 1X8, Canada
    Clin Diagn Lab Immunol 12:418-25. 2005
    ..In addition, the approach has the potential for use for further miniaturization of immunoassays and can be used for long-term archiving of immunoassays...
  25. doi request reprint Detergent-resistant microdomains mediate activation of host cell signaling in response to attaching-effacing bacteria
    Grace Shen-Tu
    Research Institute, Hospital for Sick Children, University of Toronto, Toronto, ON, Canada
    Lab Invest 90:266-81. 2010
    ..These findings advance the current understanding of microbial-eukaryotic cell interactions in response to enteric pathogens that hijack signaling responses mediated through lipid rafts...
  26. pmc Epithelia under metabolic stress perceive commensal bacteria as a threat
    Aisha Nazli
    Intestinal Disease Research Programme, McMaster University, Hamilton, Ontario, Canada
    Am J Pathol 164:947-57. 2004
    ..Such responses could precipitate an inflammatory episode and contribute to existing enteric inflammatory disorders...
  27. pmc Probiotic treatment of rat pups normalises corticosterone release and ameliorates colonic dysfunction induced by maternal separation
    Mélanie G Gareau
    Intestinal Disease Research Program, Department of Pathology and Molecular Medicine, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada
    Gut 56:1522-8. 2007
    ..We previously showed that neonatal maternal separation (MS) of rat pups causes immediate and long-term changes in intestinal physiology...
  28. doi request reprint Probiotic Lactobacillus rhamnosus inhibits the formation of neutrophil extracellular traps
    Linda Vong
    Cell Biology Program, Division of Gastroenterology, Hepatology, and Nutrition, Peter Gilgan Centre for Research and Learning, Hospital for Sick Children, Toronto, Ontario M5G 0A4, Canada
    J Immunol 192:1870-7. 2014
    ..Within the milieu of the gut, this represents a novel mechanism by which probiotics can locally dampen innate immune responses and confer desensitization toward luminal Ags. ..
  29. pmc Pathogenicity, host responses and implications for management of enterohemorrhagic Escherichia coli O157:H7 infection
    Nathan K Ho
    Department of Paediatrics, Hospital for Sick Children, Toronto, Ontario, Canada
    Can J Gastroenterol 27:281-5. 2013
    ....
  30. pmc Cholesterol-enriched membrane microdomains are required for inducing host cell cytoskeleton rearrangements in response to attaching-effacing Escherichia coli
    Jason D Riff
    Research Institute, Hospital for Sick Children, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada
    Infect Immun 73:7113-25. 2005
    ..Differences in initial adherence indicate divergent roles for host membrane cholesterol in the pathogenesis of EHEC and EPEC infections...
  31. pmc Probiotics reduce enterohemorrhagic Escherichia coli O157:H7- and enteropathogenic E. coli O127:H6-induced changes in polarized T84 epithelial cell monolayers by reducing bacterial adhesion and cytoskeletal rearrangements
    Philip M Sherman
    Gastroenterology and Nutrition, Room 8409, Hospital for Sick Children, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada
    Infect Immun 73:5183-8. 2005
    ..These findings demonstrate that probiotics prevent epithelial injury induced by attaching-effacing bacteria...
  32. doi request reprint Probiotics prevent death caused by Citrobacter rodentium infection in neonatal mice
    Mélanie G Gareau
    Cell Biology Program, Research Institute, Hospital for Sick Children, University of Toronto, Ontario, Canada
    J Infect Dis 201:81-91. 2010
    ..Therefore, the aims of this study were to characterize Citrobacter rodentium infection in neonatal mice and determine the role played by specific probiotics in ameliorating disease severity...
  33. ncbi request reprint Multiplexed high-throughput electrokinetically-controlled immunoassay for the detection of specific bacterial antibodies in human serum
    Yali Gao
    Department of Mechanical and Industrial Engineering, University of Toronto, 5 King s College Road, Toronto, Ontario M5S 3G8, Canada
    Anal Chim Acta 606:98-107. 2008
    ..pylori antibodies, could be simultaneously detected from human serum. This electrokinetically-controlled immunoassay shows an excellent potential for efficiently detecting multiple pathogenic infections in clinical environments...
  34. pmc Up-regulation of Annexin-A1 and lipoxin A(4) in individuals with ulcerative colitis may promote mucosal homeostasis
    Linda Vong
    Hospital for Sick Children, Research Institute, Toronto, Ontario, Canada
    PLoS ONE 7:e39244. 2012
    ..To define the contribution of these mediators, we measured their expression in biopsies from individuals with UC...
  35. doi request reprint Probiotics and the gut microbiota in intestinal health and disease
    Mélanie G Gareau
    Cell Biology Program, Research Institute, Hospital for Sick Children, University of Toronto, 555 University Avenue, Toronto, ON M5G 1X8, Canada
    Nat Rev Gastroenterol Hepatol 7:503-14. 2010
    ..An overview of recent in vitro and in vivo research related to potential mechanisms of action of various probiotic formulations is also considered...
  36. doi request reprint Enterohaemorrhagic, but not enteropathogenic, Escherichia coli infection of epithelial cells disrupts signalling responses to tumour necrosis factor-alpha
    Mélanie G Gareau
    Research Institute, Hospital for Sick Children, Toronto, ON M5G 1X8, Canada
    Microbiology 157:2963-73. 2011
    ..These findings indicate the potential for developing novel therapeutic targets to interrupt the infectious process...
  37. pmc Identifying mechanisms by which Escherichia coli O157:H7 subverts interferon-γ mediated signal transducer and activator of transcription-1 activation
    Nathan K Ho
    Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada
    PLoS ONE 7:e30145. 2012
    ..We conclude that E. coli O157:H7 subverts Stat-1 tyrosine phosphorylation in response to interferon-gamma through a still as yet unidentified secreted bacterial protein...
  38. ncbi request reprint Surface-layer protein extracts from Lactobacillus helveticus inhibit enterohaemorrhagic Escherichia coli O157:H7 adhesion to epithelial cells
    Kathene C Johnson-Henry
    Research Institute, Hospital for Sick Children, University of Toronto, Toronto, ON, Canada
    Cell Microbiol 9:356-67. 2007
    ..These in vitro studies indicate that a non-viable constituent derived from a probiotic strain may prove effective in interrupting the infectious process of an intestinal pathogen...
  39. ncbi request reprint Cytoskeletal rearrangements in gastric epithelial cells in response to Helicobacter pylori infection
    Bin Su
    Research Institute, Hospital for Sick Children, Department of Paediatrics, University of Toronto, Toronto, Ontario, Canada M5G 1X8
    J Med Microbiol 52:861-7. 2003
    ..In addition to CagA and VacA, cagE also impacts on the morphology of infected gastric epithelial cells...
  40. doi request reprint Lactobacillus rhamnosus GG attenuates interferon-{gamma} and tumour necrosis factor-alpha-induced barrier dysfunction and pro-inflammatory signalling
    Kevin A Donato
    Cell Biology Program, Research Institute, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
    Microbiology 156:3288-97. 2010
    ..These findings indicate that LGG alleviates the effects of pro-inflammatory cytokines on epithelial barrier integrity and inflammation, mediated, at least in part, through inhibition of NF-κB signalling...
  41. ncbi request reprint Development of a novel microfluidic immunoassay for the detection of Helicobacter pylori infection
    Frank Y H Lin
    Research Institute, Hospital for Sick Children, Toronto, Ontario, Canada
    Analyst 129:823-8. 2004
    ..Volumes of solutions used were 100-fold less compared with conventional immunoassays. Miniaturization of the ELISA using this technique provides a means for the accurate diagnosis of microbial infection while minimizing waste production...
  42. ncbi request reprint Probiotics reduce bacterial colonization and gastric inflammation in H. pylori-infected mice
    Kathene Candace Johnson-Henry
    University of Toronto, Research Institute, Hospital for Sick Children, Department of Gastroenterology and Nutrition, Infection, Immunity, Injury and Repair, Toronto, Ontario, Canada
    Dig Dis Sci 49:1095-102. 2004
    ..pylori-induced apoptosis in the gastric mucosa. This preparation of probiotics provided a safe and novel approach for reducing H. pylori colonization and bacterial-induced inflammation of mice...
  43. ncbi request reprint An electrokinetically-controlled immunoassay for simultaneous detection of multiple microbial antigens
    Yali Gao
    Department of Mechanical and Industrial Engineering, University of Toronto, 5 King s College Road, Toronto, Ontario M5S 3G8, Canada
    Biomed Microdevices 7:301-12. 2005
    ..While still an un-optimized prototype, this automatic-operating, high-throughput immunoassay microchip shows a great potential in detecting multiple pathogenic infections efficiently for clinical applications...
  44. ncbi request reprint Epithelial cell signaling responses to enterohemorrhagic Escherichia coli infection
    Peter J M Ceponis
    Research Institute, Hospital for Sick Children, Deparment of Laboratory Medicine, University of Toronto, Ontario M5G 1X8, Canada
    Mem Inst Oswaldo Cruz 100:199-203. 2005
    ..Identification of critical signaling pathways could result in the development of novel strategies for intervention to both prevent and treat this microbial infection in humans...
  45. pmc Single nucleotide polymorphisms that increase expression of the guanosine triphosphatase RAC1 are associated with ulcerative colitis
    Aleixo M Muise
    Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, University of Toronto, Toronto, Ontario, Canada
    Gastroenterology 141:633-41. 2011
    ..Chronic inflammatory bowel diseases are associated with dysregulation of immune defenses. We studied the role of RAC1 in inflammatory bowel diseases using human genetic and functional studies and animal models of colitis...
  46. ncbi request reprint Protein-tyrosine phosphatase sigma is associated with ulcerative colitis
    Aleixo M Muise
    Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, University of Toronto, 555 University Ave, Toronto, Ontario, Canada
    Curr Biol 17:1212-8. 2007
    ..We propose that polymorphisms in the human PTPRS gene lead to ulcerative colitis...
  47. ncbi request reprint What is new related to Helicobacter pylori infection in children and teenagers?
    Seiichi Kato
    Research Institute, Hospital for Sick Children, Department of Paediatrics, University of Toronto, Toronto, Ontario, Canada
    Arch Pediatr Adolesc Med 159:415-21. 2005
    ..Testing and eradication therapy for H pylori are currently recommended only for the subset of infected persons in whom the disease sequelae are proven or highly suspected...
  48. pmc Enterohemorrhagic Escherichia coli O157:H7 disrupts Stat1-mediated gamma interferon signal transduction in epithelial cells
    Peter J M Ceponis
    Research Institute, Hospital for Sick Children, University of Toronto, Toronto, Canada
    Infect Immun 71:1396-404. 2003
    ..These findings indicate the novel disruption of host cell signaling caused by EHEC infection but not by EPEC infection...
  49. ncbi request reprint JlpA of Campylobacter jejuni interacts with surface-exposed heat shock protein 90alpha and triggers signalling pathways leading to the activation of NF-kappaB and p38 MAP kinase in epithelial cells
    Songmu Jin
    Department of Medical Genetics and Microbiology, Medical Science Building, 1 King s College Circle, University of Toronto, Toronto, ON, M5S 1A8, Canada
    Cell Microbiol 5:165-74. 2003
    ..The activation of NF-kappaB and p38 MAP kinase in HEp-2 cells suggest that JlpA triggers inflammatory/immune responses in host cells following C. jejuni infection...
  50. ncbi request reprint Hemolytic uremic syndrome after pediatric liver transplantation
    Dan Turner
    Division of Gastroenterology, Hepatology and Nutrition, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
    J Pediatr Gastroenterol Nutr 43:109-12. 2006
  51. ncbi request reprint Age-specific frequencies of antibodies to Escherichia coli verocytotoxins (Shiga toxins) 1 and 2 among urban and rural populations in southern Ontario
    Mohamed A Karmali
    Laboratory for Foodborne Zoonoses, Population and Public Health Branch, Health Canada, Guelph, Ontario, Canada
    J Infect Dis 188:1724-9. 2003
    ....
  52. ncbi request reprint Appropriate strategies for testing and treating Helicobacter pylori in children: when and how?
    Philip M Sherman
    Department of Pediatrics and Microbiology, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
    Am J Med 117:30S-35S. 2004
    ....
  53. pmc Enhanced disease severity in Helicobacter pylori-infected mice deficient in Fas signaling
    Nicola L Jones
    Department of Physiology, Research Institute, The Hospital for Sick Children, University of Toronto, Toronto, Canada
    Infect Immun 70:2591-7. 2002
    ..The Fas death pathway modulates disease pathophysiology following murine infection with H. pylori. Deregulation of the Fas pathway could be involved in the transition from gastritis to gastric cancers during H. pylori infection...
  54. ncbi request reprint Neonatal enteropathies: defining the causes of protracted diarrhea of infancy
    Philip M Sherman
    Research Institute, Hospital for Sick Children, University of Toronto, Ontario, Canada
    J Pediatr Gastroenterol Nutr 38:16-26. 2004
    ..These include microvillus inclusion disease, tufting enteropathy, autoimmune enteropathy and IPEX syndrome - and it is these conditions that are the subject of the current review...
  55. ncbi request reprint Development of a novel hand-held immunoassay for the detection of enterohemorrhagic Escherichia coli O157:H7
    Frank Y H Lin
    Research Institute, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
    Biomed Microdevices 6:125-30. 2004
    ..Furthermore, this device can be adapted to perform diagnostics for other microbial pathogens currently detected using immunoassay methodology...
  56. ncbi request reprint Extradigestive manifestation of Helicobacter pylori infection in children and adolescents
    Philip M Sherman
    Research Institute, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
    Can J Gastroenterol 19:421-4. 2005
    ..Moderate evidence supports H. pylori gastric infection as a cause of some cases of immune thrombocytopenic purpura due to molecular mimicry. Guidelines should be adjusted in accordance with advancing knowledge in the field...
  57. doi request reprint Research agenda to support sodium reduction in Canada
    Philip M Sherman
    Canadian Institutes of Health Research, 160 Elgin Street, 9th Floor, 4809A, Ottawa, ON K1A 0W9, Canada
    Appl Physiol Nutr Metab 39:396-8. 2014
    ..CIHR aims to provide leadership in working together with other funders and partners to catalyze a broad range of sodium research. ..
  58. doi request reprint Protein Kinase C Mediates Enterohemorrhagic Escherichia coli O157:H7-Induced Attaching and Effacing Lesions
    Grace Shen-Tu
    Cell Biology Program, Research Institute, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
    Infect Immun 82:1648-56. 2014
    ..coli O157:H7. These findings contribute further to the understanding of the complex array of microbe-eukaryotic cell interactions that occur in response to infection. ..
  59. doi request reprint Quantification and visualization of neutrophil extracellular traps (NETs) from murine bone marrow-derived neutrophils
    Linda Vong
    Faculty of Medicine, University of Toronto, Toronto, ON, Canada
    Methods Mol Biol 1031:41-50. 2013
    ..Herein we describe protocols to isolate murine bone marrow-derived neutrophils, and spectrophotometrically quantify, immunolabel, and visualize NET structures in vitro. ..
  60. doi request reprint The gastrointestinal phenotype of germline biallelic mismatch repair gene mutations
    Carol A Durno
    Zane Cohen Familial Gastrointestinal Cancer Registry and Department of Surgery, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada
    Am J Gastroenterol 105:2449-56. 2010
    ..The aim of this study was to characterize patients with GI small bowel and/or colorectal cancers (CRCs) who have germline biallelic MMR mutations...
  61. ncbi request reprint Community-based case-control study of childhood chronic abdominal pain: role of selected laboratory investigations
    Gordon S Soon
    Division of Paediatric Medicine, The Hospital for Sick Children Toronto, and Department of Paediatrics, University of Toronto Faculty of Medicine, Toronto, Ontario, Canada
    J Pediatr Gastroenterol Nutr 44:524-6. 2007
    ..Our hypothesis was that parasitic infection was not a causal factor for chronic abdominal pain and that there would be no difference in leukocyte count, hemoglobin level, or erythrocyte sedimentation rate (ESR) between the 2 groups...
  62. pmc Helicobacter pylori activates Toll-like receptor 4 expression in gastrointestinal epithelial cells
    Bin Su
    Research Institute, Hospital for Sick Children, Department of Paediatrics, University of Toronto, Ontario, Canada
    Infect Immun 71:3496-502. 2003
    ..01). These results indicate that H. pylori activates TLR4 expression in epithelial cells and that TLR4 can serve as a receptor for H. pylori binding...
  63. ncbi request reprint Use of LARA-urea breath test in the diagnosis of Helicobacter pylori infection in children and adolescents: a preliminary study
    Andrew S Day
    Division of Gastroenterology and Nutrition, Research Institute, Hospital for Sick Children, Toronto, Ontario, Canada
    Can J Gastroenterol 17:701-6. 2003
    ....
  64. doi request reprint Scurvy diagnosed in a pediatric liver transplant patient awaiting combined kidney and liver retransplantation
    Victoria A Samonte
    Pediatric Academic Multi Organ Transplant PAMOT Program, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada
    Pediatr Transplant 12:363-7. 2008
    ..This case highlights the importance of awareness and recognition of this historic diagnosis, and particularly in children with end-stage organ disease with severely compromised nutrition...
  65. ncbi request reprint Defining mechanisms of interaction between enterohemorrhagic Escherichia coli O157:H7 and host epithelia
    Peter J Ceponis
    The Hospital for Sick Children, University of Toronto, Canada
    J Pediatr Gastroenterol Nutr 38:230-1. 2004
  66. ncbi request reprint Chronic stress induces mast cell-dependent bacterial adherence and initiates mucosal inflammation in rat intestine
    Johan D Soderholm
    Intestinal Disease Research Program, Department of Pathology and Molecular Medicine, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada
    Gastroenterology 123:1099-108. 2002
    ..Chronic psychological stress is an important factor in relapses of intestinal disorders, but it remains unclear if stress can induce primary gut inflammation in a previously healthy host...
  67. ncbi request reprint A model for partnership and research between the CAG and sponsors
    Philip M Sherman
    Canadian Association of Gastroenterology CAG, Ottawa, Canada
    Can J Gastroenterol 16:337-40. 2002
  68. pmc Escherichia coli shiga-like toxins induce apoptosis and cleavage of poly(ADP-ribose) polymerase via in vitro activation of caspases
    Joyce C Y Ching
    Research Institute, Hospital for Sick Children, University of Toronto, Canada
    Infect Immun 70:4669-77. 2002
    ....
  69. ncbi request reprint Accuracy of office-based immunoassays for the diagnosis of Helicobacter pylori infection in children
    Andrew S Day
    Division of Gastroenterology and Nutrition, Research Institute, The Hospital for Sick Children, Department of Paediatrics, University of Toronto, Ontario, Canada
    Helicobacter 7:205-9. 2002
    ..The aim of this study was to determine the accuracy of two immunoassays (Flex-Sure and MedMira), developed for use outside the laboratory setting by practitioners, in the setting of a low prevalence of H. pylori infection...
  70. ncbi request reprint Bacterial interactions with host epithelium in vitro
    Nicola Jones
    Division of Gastroenterology and Nutrition, Research Institute, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
    Methods Mol Biol 188:383-400. 2002