J T Rutka

Summary

Affiliation: The Hospital for Sick Children
Country: Canada

Publications

  1. ncbi request reprint Pediatric surgical neuro-oncology: current best care practices and strategies
    James T Rutka
    The Arthur and Sonia Labatt Brain Tumour Research Centre and Division of Neurosurgery, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
    J Neurooncol 69:139-50. 2004
  2. doi request reprint Discovering neurosurgery: new frontiers
    James T Rutka
    Division of Neurosurgery, Department of Surgery, The University of Toronto, Ontario, Canada
    J Neurosurg 115:1053-66. 2011
  3. doi request reprint The evolution and application of techniques in molecular biology to human brain tumors: a 25 year perspective
    James T Rutka
    The Arthur and Sonia Labatt Brain Tumour Research Centre, Division of Neurosurgery, The Hospital for Sick Children, The University of Toronto, Suite 1503, 555 University Avenue, M5G 1X8 Toronto, ON, Canada
    J Neurooncol 92:261-73. 2009
  4. ncbi request reprint Separation of craniopagus twins in the era of modern neuroimaging, interventional neuroradiology, and frameless stereotaxy
    James T Rutka
    Division of Neurosurgery, Hospital for Sick Children, University of Toronto, Suite 1504, 555 University Avenue, Toronto, ON, M5G 1X8, Canada
    Childs Nerv Syst 20:587-92. 2004
  5. ncbi request reprint Advances in the treatment of pediatric brain tumors
    James T Rutka
    The Arthur and Sonia Labatt Brain Tumor Research Centre and Division of Neurosurgery, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, M5G 1X8, Canada
    Expert Rev Neurother 4:879-93. 2004
  6. ncbi request reprint Dipole localization for identification of neuronal generators in independent neighboring interictal EEG spike foci
    A Ochi
    Bloorview Epilepsy Research Program, Department of Pediatrics, The Hospital for Sick Children and the University of Toronto, Ontario, Canada
    Epilepsia 42:483-90. 2001
  7. doi request reprint Predicting who will benefit from endoscopic third ventriculostomy compared with shunt insertion in childhood hydrocephalus using the ETV Success Score
    Abhaya V Kulkarni
    Hospital for Sick Children, Toronto, Canada
    J Neurosurg Pediatr 6:310-5. 2010
  8. ncbi request reprint Magnetoencephalography for surgical treatment of refractory status epilepticus
    I S Mohamed
    Divisions of Neurology, Department of Pediatrics, The Hospital for Sick Children, Toronto, ON, Canada
    Acta Neurol Scand Suppl 186:29-36. 2007
  9. ncbi request reprint Systematic approach to dipole localization of interictal EEG spikes in children with extratemporal lobe epilepsies
    A Ochi
    Department of Neurology, The Hospital for Sick Children, University of Toronto, ON, Canada
    Clin Neurophysiol 111:161-8. 2000
  10. ncbi request reprint Co-expression of nestin and vimentin intermediate filaments in invasive human astrocytoma cells
    J T Rutka
    Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Division of Neurosurgery, The University of Toronto, Ont, Canada
    Int J Dev Neurosci 17:503-15. 1999

Detail Information

Publications101 found, 100 shown here

  1. ncbi request reprint Pediatric surgical neuro-oncology: current best care practices and strategies
    James T Rutka
    The Arthur and Sonia Labatt Brain Tumour Research Centre and Division of Neurosurgery, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
    J Neurooncol 69:139-50. 2004
    ..We review the current treatment strategies of the three most common types of pediatric brain tumors: gliomas, medulloblastomas and ependymomas, and discuss current and future diagnostic and therapeutic modalities...
  2. doi request reprint Discovering neurosurgery: new frontiers
    James T Rutka
    Division of Neurosurgery, Department of Surgery, The University of Toronto, Ontario, Canada
    J Neurosurg 115:1053-66. 2011
    ..Navigating our way through these new frontiers will undoubtedly lead to additional discoveries that are unimaginable at present but bound to improve the future care of neurosurgical patients...
  3. doi request reprint The evolution and application of techniques in molecular biology to human brain tumors: a 25 year perspective
    James T Rutka
    The Arthur and Sonia Labatt Brain Tumour Research Centre, Division of Neurosurgery, The Hospital for Sick Children, The University of Toronto, Suite 1503, 555 University Avenue, M5G 1X8 Toronto, ON, Canada
    J Neurooncol 92:261-73. 2009
    ..What will follow is modeling of these genetic alterations in systems that will allow for the development of novel pharmacotherapeutics and translational research therapies...
  4. ncbi request reprint Separation of craniopagus twins in the era of modern neuroimaging, interventional neuroradiology, and frameless stereotaxy
    James T Rutka
    Division of Neurosurgery, Hospital for Sick Children, University of Toronto, Suite 1504, 555 University Avenue, Toronto, ON, M5G 1X8, Canada
    Childs Nerv Syst 20:587-92. 2004
    ..Craniopagus twinning is a rare embryological event occurring in 1 in 2.5 million births...
  5. ncbi request reprint Advances in the treatment of pediatric brain tumors
    James T Rutka
    The Arthur and Sonia Labatt Brain Tumor Research Centre and Division of Neurosurgery, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, M5G 1X8, Canada
    Expert Rev Neurother 4:879-93. 2004
    ..This review will discuss the current and possible future therapies of the most common pediatric brain tumors and highlight some of the novel imaging modalities that are used pre- and intraoperatively...
  6. ncbi request reprint Dipole localization for identification of neuronal generators in independent neighboring interictal EEG spike foci
    A Ochi
    Bloorview Epilepsy Research Program, Department of Pediatrics, The Hospital for Sick Children and the University of Toronto, Ontario, Canada
    Epilepsia 42:483-90. 2001
    ..We evaluated dipole localizations of independent neighboring interictal spike foci using scalp electroencephalogram (EEG) to identify neuronal generators of epileptic discharges...
  7. doi request reprint Predicting who will benefit from endoscopic third ventriculostomy compared with shunt insertion in childhood hydrocephalus using the ETV Success Score
    Abhaya V Kulkarni
    Hospital for Sick Children, Toronto, Canada
    J Neurosurg Pediatr 6:310-5. 2010
    ..In this paper, they assess the clinical utility of the ETVSS by determining whether long-term survival outcomes for ETV versus shunt insertion are different within strata of ETVSS (low, moderate, and high scores)...
  8. ncbi request reprint Magnetoencephalography for surgical treatment of refractory status epilepticus
    I S Mohamed
    Divisions of Neurology, Department of Pediatrics, The Hospital for Sick Children, Toronto, ON, Canada
    Acta Neurol Scand Suppl 186:29-36. 2007
    ..The complete resection of clustered MEGSSs can control RSE and possibly lead to a seizure free outcome...
  9. ncbi request reprint Systematic approach to dipole localization of interictal EEG spikes in children with extratemporal lobe epilepsies
    A Ochi
    Department of Neurology, The Hospital for Sick Children, University of Toronto, ON, Canada
    Clin Neurophysiol 111:161-8. 2000
    ..To assess the reliability of dipole localization based on residual variances (RV), using equivalent current dipole analysis of interictal EEG spikes in children with extratemporal lobe epilepsy...
  10. ncbi request reprint Co-expression of nestin and vimentin intermediate filaments in invasive human astrocytoma cells
    J T Rutka
    Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Division of Neurosurgery, The University of Toronto, Ont, Canada
    Int J Dev Neurosci 17:503-15. 1999
    ..Further studies are required to determine the mechanism by which dual-IF protein expression alters other cytoskeletal or cell surface receptor protein components important in the process of astrocytoma invasion...
  11. ncbi request reprint Comparison of electroencephalographic dipoles of interictal spikes from prolonged scalp video-electroencephalography and magnetoencephalographic dipoles from short-term recording in children with extratemporal lobe epilepsy
    A Ochi
    Bloorview Epilepsy Research Program, Toronto, ON
    J Child Neurol 16:661-7. 2001
    ..A combination of EEG dipole analysis from prolonged video-EEG monitoring and magnetoencephalographic dipole analysis provides complementary information for presurgical evaluation in children with intractable extratemporal lobe epilepsy...
  12. doi request reprint Endoscopic third ventriculostomy vs cerebrospinal fluid shunt in the treatment of hydrocephalus in children: a propensity score-adjusted analysis
    Abhaya V Kulkarni
    Division of Neurosurgery, Hospital for Sick Children, Room 1503, 555 University Ave, Toronto, Ontario, Canada M5G 1X8
    Neurosurgery 67:588-93. 2010
    ..Endoscopic third ventriculostomy (ETV) has preferentially been offered to patients with more favorable prognostic features compared with shunt...
  13. ncbi request reprint MEG predicts epileptic zone in lesional extrahippocampal epilepsy: 12 pediatric surgery cases
    H Otsubo
    Division of Neurology, Department of Paediatrics, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
    Epilepsia 42:1523-30. 2001
    ....
  14. ncbi request reprint Characterization of glial filament-cytoskeletal interactions in human astrocytomas: an immuno-ultrastructural analysis
    J T Rutka
    Division of Neurosurgery, The Hospital for Sick Children, The University of Toronto, Ontario, Canada
    Eur J Cell Biol 76:279-87. 1998
    ..These data imply that GFAP may be linked spatially and functionally to cytoskeletal elements which may be altered when this IF is deleted in astrocytomas...
  15. ncbi request reprint The E2F-family proteins induce distinct cell cycle regulatory factors in p16-arrested, U343 astrocytoma cells
    P B Dirks
    Division of Neurosurgery, Hospital for Sick Children, University of Toronto, Ontario, Canada
    Oncogene 17:867-76. 1998
    ..While overcoming this cell cycle block, each of the E2F's uniquely affect the expression of a number of cell cycle regulatory proteins and have distinct abilities to promote cell death...
  16. ncbi request reprint Computerized brain-surface voltage topographic mapping for localization of intracranial spikes from electrocorticography. Technical note
    H Otsubo
    Department of Paediatrics, The Hospital for Sick Children, Toronto, Ontario, Canada
    J Neurosurg 94:1005-9. 2001
    ..This mapping procedure depicted the ictal zone in nine patients and the interictal zone in 12, and proved to be an accurate and useful source of information for planning corrective surgery...
  17. ncbi request reprint Malignant rolandic-sylvian epilepsy in children: diagnosis, treatment, and outcomes
    H Otsubo
    Department of Paediatrics, Division of Neurology, The Hospital for Sick Children and University of Toronto, Ontario, Canada
    Neurology 57:590-6. 2001
    ....
  18. ncbi request reprint Tracking the invasiveness of human astrocytoma cells by using green fluorescent protein in an organotypical brain slice model
    S Jung
    The Arthur and Sonia Labatt Brain Tumour Research Centre, Division of Neurosurgery, The Hospital for Sick Children, The University of Toronto, Ontario, Canada
    J Neurosurg 94:80-9. 2001
    ....
  19. ncbi request reprint Extraoperative cortical stimulation of motor function in children
    S Chitoku
    Division of Neurology and Department of Paediatrics, The Hospital for Sick Children, 555 University Ave, Toronto, Ontario, M5G 1X8, Canada
    Pediatr Neurol 24:344-50. 2001
    ..4). Younger children with neuronal migration disorders require a higher amperage threshold to achieve adequate motor functional mapping with careful observation of afterdischarges...
  20. doi request reprint Surgery for hydrocephalus in sub-Saharan Africa versus developed nations: a risk-adjusted comparison of outcome
    Abhaya V Kulkarni
    Division of Neurosurgery, The Hospital for Sick Children, University of Toronto, Room 1503, 555 University Avenue, Toronto, Ontario, Canada
    Childs Nerv Syst 26:1711-7. 2010
    ..It is not known if the lower success rate is due to inherent differences in prognostic factors...
  21. ncbi request reprint Cerebellar pathology in tuberous sclerosis
    V Jay
    Division of Pathology, Hospital for Sick Children, Toronto, Ontario, Canada
    Ultrastruct Pathol 22:331-9. 1998
    ....
  22. ncbi request reprint Image-guided, frameless stereotactic sectioning of the corpus callosum in children with intractable epilepsy
    M Hodaie
    Division of Neurosurgery, Hospital for Sick Children and University of Toronto, Ont, Canada
    Pediatr Neurosurg 34:286-94. 2001
    ..We conclude that the use of frameless stereotaxy can function as an important adjunct in the planning and conduction of successful sectioning of the corpus callosum in children with intractable seizures...
  23. ncbi request reprint Magnetoencephalography for surgical treatment of refractory status epilepticus
    I S Mohamed
    Division of Neurology, The Hospital for Sick Children, Toronto, ON, Canada
    Acta Neurol Scand 115:29-36. 2007
    ..The complete resection of clustered MEGSSs can control RSE and possibly lead to a seizure free outcome...
  24. ncbi request reprint Oncogene amplification in medulloblastoma: analysis of a case by comparative genomic hybridization and fluorescence in situ hybridization
    V Jay
    Division of Pathology, Hospital for Sick Children University of Toronto, Ontario, Canada
    Pathology 31:337-44. 1999
    ..Thus, CGH is a powerful technique applicable to frozen or paraffin-embedded material which helps to ascertain the presence of gene amplification even without prior knowledge of the gene to be tested...
  25. ncbi request reprint Alterations of the p53 and pRB pathways in human astrocytoma
    J T Rutka
    Arthur and Sonia Labatt Brain Tumor Research Centre, and Division of Neurosurgery, The Hospital for Sick Children, University of Toronto, Ontario, Canada
    Brain Tumor Pathol 17:65-70. 2000
    ..Current research aims to discover effective means of reconstituting p53 and pRB pathway components in an effort to attenuate the aggressive phenotype of astrocytoma...
  26. ncbi request reprint Radiologic-pathologic correlation in focal cortical dysplasia and hemimegalencephaly in 18 children
    C L Woo
    Division of Neurology, The Hospital for Sick Children, Toronto, Ontario, Canada
    Pediatr Neurol 25:295-303. 2001
    ..The presence of ectopic and large neurons and abnormal cortical lamination may be responsible for the MRI characteristics...
  27. ncbi request reprint Benign epileptiform discharges in Rolandic region with mesial temporal lobe epilepsy: MEG, scalp and intracranial EEG features
    R RamachandranNair
    Division of Neurology, Department of Paediatrics, Hospital for Sick Children, Toronto, Ontario, Canada
    Acta Neurol Scand 116:59-64. 2007
    ..To report benign epileptiform discharges (BEDs) in the Rolandic region, coexisting in a pediatric patient with intractable localization-related epilepsy, secondary to hippocampal sclerosis...
  28. doi request reprint The SFRP family of WNT inhibitors function as novel tumor suppressor genes epigenetically silenced in medulloblastoma
    P N Kongkham
    Division of Neurosurgery, Arthur and Sonia Labatt Brain Tumor Research Centre, Toronto, Ontario, Canada M5G 1X8
    Oncogene 29:3017-24. 2010
    ....
  29. ncbi request reprint Molecular genetics of pineal region neoplasms
    M D Taylor
    Division of Neurosurgery, The Hospital for Sick Children, University of Toronto, Canada
    J Neurooncol 54:219-38. 2001
    ..We review the literature on cytogenetics, familial syndromes, animal models and molecular genetics of pineal region neoplasms...
  30. ncbi request reprint Cip/Kip cell-cycle inhibitors: a neuro-oncological perspective
    T G Mainprize
    Division of Neurosurgery and The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, University of Toronto, Canada
    J Neurooncol 51:205-18. 2001
    ..In this review, we will discuss the biochemistry and cell biology of the each of the Cip/Kip CKIs, their role in development as evidenced by targeted mutations in mice, and their role as possible tumor suppressor genes...
  31. pmc Magnetoencephalographic spike sources associated with auditory auras in paediatric localisation-related epilepsy
    I S Mohamed
    Division of Neurology, The Hospital for Sick Children, 555 University Avenue, Toronto, ON M5G 1X8, Canada
    J Neurol Neurosurg Psychiatry 77:1256-61. 2006
    ..To characterise magnetoencephalographic spike sources in paediatric patients with auditory auras and recurrent localisation-related epilepsy...
  32. ncbi request reprint Effect of PSC 833, a potent inhibitor of P-glycoprotein, on the growth of astrocytoma cells in vitro
    V Sadanand
    Division of Neurosurgery, Royal University Hospital, Saskatoon, SK, Canada
    Cancer Lett 198:21-7. 2003
    ..These results suggest a novel therapeutic strategy in the treatment of malignant astrocytomas by inhibitors of Pgp...
  33. ncbi request reprint The role of surgery in the management of intracranial gliomas: current concepts
    O M Nunez
    Arthur and Sonia Labatt Brain Tumor Research Centre, Hospital for Sick Children, Toronto, Canada
    Indian J Cancer 46:120-6. 2009
    ..At the present time, it seems best that clinicians continue to individualize patient treatment based on a myriad of factors that relate to the patient, the patient's tumor, and the known biology of the disease...
  34. ncbi request reprint Spontaneous intraparenchymal hemorrhage in full-term neonates
    D I Sandberg
    Division of Neurosurgery, The Hospital for Sick Children and the University of Toronto, Ontario, Canada
    Neurosurgery 48:1042-8; discussion 1048-9. 2001
    ..Radiographic evidence of mass effect or signs of elevated intracranial pressure may necessitate surgical hematoma evacuation. Outcome varies widely and may be normal, even in patients with sizeable intraparenchymal hemorrhages...
  35. ncbi request reprint The INK4A/ARF locus: role in cell cycle control and apoptosis and implications for glioma growth
    S M Ivanchuk
    Division of Neurosurgery and The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, University of Toronto, Canada
    J Neurooncol 51:219-29. 2001
    ..The frequent mutation or deletion of INK4A/ARF in human tumours as well as the occurence of tumours in the murine knockout models have identified both p16 and ARF as bona fide tumour suppressors...
  36. ncbi request reprint Crystalline inclusions in a subependymal giant cell tumor in a patient with tuberous sclerosis
    V Jay
    Department of Pathology, Hospital for Sick Children, Toronto, Ontario, Canada
    Ultrastruct Pathol 17:503-13. 1993
    ....
  37. ncbi request reprint Hyaluronate receptors mediating glioma cell migration and proliferation
    Y Akiyama
    Arthur and Sonia Labatt Brain Tumor Research Centre and the Division of Neurosurgery The Hospital for Sick Children, University of Toronto, Ontario, Canada
    J Neurooncol 53:115-27. 2001
    ....
  38. ncbi request reprint Medulloblastoma in a child with Rubenstein-Taybi Syndrome: case report and review of the literature
    M D Taylor
    The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, M5G 1X8 Canada
    Pediatr Neurosurg 35:235-8. 2001
    ..As the product of the CBP gene functions in a variety of signaling pathways, we discuss the molecular implications of findings a medulloblastoma in a child with Rubenstein-Taybi Syndrome...
  39. ncbi request reprint A method to estimate urinary electrolyte excretion in patients at risk for developing cerebral salt wasting
    A P Carlotti
    Department of Critical Care Medicine, Hospital for Sick Children, Toronto, Ontario, Canada
    J Neurosurg 95:420-4. 2001
    ..These data provide information to support or refute a clinical diagnosis of CSW. The danger of relying on balances for these electrolytes measured within a single day to diagnose CSW is illustrated...
  40. ncbi request reprint Dysembryoplastic neuroepithelial tumors in childhood: long-term outcome and prognostic features
    M A Nolan
    Brain and Behavior Program, Division of Neurology, Department of Pediatrics, The Hospital for Sick Children, Toronto, Canada
    Neurology 62:2270-6. 2004
    ..The authors describe the clinical, radiologic, and pathologic characteristics and outcomes in children after surgical resection of pathologically confirmed DNT to ascertain prognostic features for seizure recurrence following surgery...
  41. doi request reprint Endoscopic third ventriculostomy in the treatment of childhood hydrocephalus
    Abhaya V Kulkarni
    Hospital for Sick Children, Toronto, Ontario, Canada
    J Pediatr 155:254-9.e1. 2009
    ..To develop a model to predict the probability of endoscopic third ventriculostomy (ETV) success in the treatment for hydrocephalus on the basis of a child's individual characteristics...
  42. pmc Epigenetic regulation of glial fibrillary acidic protein by DNA methylation in human malignant gliomas
    Andres Restrepo
    Division of Neurosurgery, Arthur and Sonia Labatt Brain Tumor Research Centre, Program in Cell Biology, Suite 1503, The Hospital for Sick Children, University of Toronto, 555 University Avenue, Toronto, ON, Canada M5G 1X8
    Neuro Oncol 13:42-50. 2011
    ..Our results suggest that epigenetic silencing of the GFAP gene through DNA methylation of its promoter region may be one mechanism by which GFAP is downregulated in human gliomas and glioma cell lines...
  43. ncbi request reprint Intrahemispheric reorganization of language in children with medically intractable epilepsy of the left hemisphere
    Darren S Kadis
    Department of Psychology, University of Toronto, Toronto, Ontario, CanadaDepartment of Psychology, Hospital for Sick Children, Toronto, Ontario, Canada
    J Int Neuropsychol Soc 13:505-16. 2007
    ..Findings suggest that left hemisphere insult in young children may result in anterior displacement of language within the frontal cortex...
  44. ncbi request reprint Identifying the primary epileptogenic hemisphere from electroencephalographic (EEG) and magnetoencephalographic dipole lateralizations in children with intractable epilepsy
    Ayako Ochi
    Division of Neurology, The Hospital for Sick Children, Toronto, ON, Canada
    J Child Neurol 20:885-92. 2005
    ..Discordant lateralizations signify an undetermined epileptogenic hemisphere and contraindicate surgery without further testing...
  45. ncbi request reprint Multiple subpial transections in pediatric epilepsy: indications and outcomes
    Mony Benifla
    Division of Neurosurgery, The Hospital for Sick Children, The University of Toronto, 555 University Avenue, Toronto, ON, M5G 1X8, Canada
    Childs Nerv Syst 22:992-8. 2006
    ..In the medical literature, there are relatively few studies reporting the efficacy and safety of this procedure in adults and in children. We review the scientific rationale, the indications, and the results of this procedure...
  46. ncbi request reprint The role of magnetoencephalography in pediatric epilepsy surgery
    Ron Grondin
    Division of Neurosurgery, The Hospital for Sick Children, The University of Toronto, 555 University Avenue, Toronto, ON, M5G 1X8, Canada
    Childs Nerv Syst 22:779-85. 2006
    ....
  47. ncbi request reprint Imaging surgical epilepsy in children
    Charles Raybaud
    Division of Neuroradiology, Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, M5G 1X8, Canada
    Childs Nerv Syst 22:786-809. 2006
    ..Technical developments have brought significantly improved efficacy of MR imaging in detecting and assessing surgical epileptogenic lesions, while more clinical experience has brought better definition of the pathological groups...
  48. ncbi request reprint Malignant brain tumors: two steps forward
    Stephanie Puget
    Department of Paediatric Neurosurgery, Necker Hopsital, Paris, France
    Clin Neurosurg 54:4-9. 2007
  49. ncbi request reprint Preoperative simulation of intracerebral epileptiform discharges: synthetic aperture magnetometry virtual sensor analysis of interictal magnetoencephalography data
    Makoto Oishi
    Division of Neurology, Department of Diagnostic Imaging, The Hospital for Sick Children, University of Toronto, Ontario, Canada
    J Neurosurg 105:41-9. 2006
    ....
  50. doi request reprint Somatosensory-evoked fields on magnetoencephalography for epilepsy infants younger than 4 years with total intravenous anesthesia
    Eduard Bercovici
    Division of Neurology, Department of Pediatrics, The Hospital for Sick Children, 555 University Avenue, Toronto, Ont, Canada M5G 1X8
    Clin Neurophysiol 119:1328-34. 2008
    ..This paper demonstrates that MEG can detect, characterize and localize somatosensory-evoked fields (SEF) in infants younger than 4 years of age with or without total intravenous anesthesia (TIVA)...
  51. ncbi request reprint Topographic movie of ictal high-frequency oscillations on the brain surface using subdural EEG in neocortical epilepsy
    Tomoyuki Akiyama
    Division of Neurology, The Hospital for Sick Children, Toronto, Ontario, Canada
    Epilepsia 47:1953-7. 2006
    ..To understand the rapid dynamic changes of ictal intracranial high-frequency oscillations (HFOs) in neocortical epilepsy...
  52. ncbi request reprint MEG predicts outcome following surgery for intractable epilepsy in children with normal or nonfocal MRI findings
    Rajesh RamachandranNair
    Division of Neurology, Department of Paediatrics, The Hospital for Sick Children, Toronto, Ontario, Canada
    Epilepsia 48:149-57. 2007
    ..To identify the predictors of postsurgical seizure freedom in children with refractory epilepsy and normal or nonfocal MRI findings...
  53. ncbi request reprint Dynamic changes of ictal high-frequency oscillations in neocortical epilepsy: using multiple band frequency analysis
    Ayako Ochi
    The Divisions of Neurology, The Hospital for Sick Children and University of Toronto, Toronto, Ontario, Canada
    Epilepsia 48:286-96. 2007
    ..To characterize the spatial and temporal course of ictal high-frequency oscillations (HFOs) recorded by subdural EEG in children with intractable neocortical epilepsy...
  54. ncbi request reprint Gliomas: quo vadis
    James T Rutka
    Division of Neurosurgery, The Hospital for Sick Children, University of Toronto, Ontario, Canada
    Clin Neurosurg 53:58-63. 2006
  55. doi request reprint Epileptic spasms in older pediatric patients: MEG and ictal high-frequency oscillations suggest focal-onset seizures in a subset of epileptic spasms
    Rajesh RamachandranNair
    Division of Neurology, Department of Paediatrics, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada M5G1X8
    Epilepsy Res 78:216-24. 2008
    ....
  56. ncbi request reprint Preserved structural integrity of white matter adjacent to low-grade tumors
    Daniel Nilsson
    Diagnostic Imaging, Hospital for Sick Children, 555 University Avenue, Toronto, ON M5G 1X8, Canada
    Childs Nerv Syst 24:313-20. 2008
    ..We hypothesized that the structural integrity of the adjacent WM tracts would be preserved in these slow-growing tumors...
  57. ncbi request reprint Efficacy of dexamathasone on cerebral swelling and seizures during subdural grid EEG recording in children
    Takashi Araki
    Division of Neurosurgery, Department of Pediatrics, The Hospital for Sick Children and University of Toront, Toronto, Ontario, Canada
    Epilepsia 47:176-80. 2006
    ..To evaluate the impact of steroid treatment on cerebral swelling and seizures during subdural grid EEG (SGEEG) monitoring...
  58. ncbi request reprint Focal cortical high-frequency oscillations trigger epileptic spasms: confirmation by digital video subdural EEG
    Tomoyuki Akiyama
    Divisions of Neurology, Neurosurgery, The Hospital for Sick Children, Toronto, Ont, Canada
    Clin Neurophysiol 116:2819-25. 2005
    ..To localize high-frequency oscillations (HFOs) on the cortex during epileptic spasms using video subdural EEG and Multiple Band Frequency Analysis (MBFA)...
  59. ncbi request reprint Measuring the health status of children with hydrocephalus by using a new outcome measure
    Abhaya V Kulkarni
    Division of Neurosurgery, Hospital for Sick Children, University of Toronto, Canada
    J Neurosurg 101:141-6. 2004
    ..In the present study, they present their initial experience in using the HOQ to quantify the health status in a typical cohort of children with hydrocephalus...
  60. ncbi request reprint Three-dimensionally reconstructed magnetic source imaging and neuronavigation in pediatric epilepsy: technical note
    Stephanie A Holowka
    Department of Diagnostic Imaging, The Hospital for Sick Children, Toronto, Ontario, Canada
    Neurosurgery 55:1226. 2004
    ..To determine the role of reconstructing three-dimensional magnetic source imaging (MSI) data on cortical resections for children undergoing epilepsy surgery using neuronavigation...
  61. ncbi request reprint Pediatric supratentorial high-grade gliomas
    Mandeep S Tamber
    Division of Neurosurgery, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
    Neurosurg Focus 14:e1. 2003
    ....
  62. ncbi request reprint Advances in the surgical management of epilepsy
    James T Rutka
    Division of Neurosurgery, The Hospital for Sick Children, Toronto, Ontario, Canada
    Clin Neurosurg 51:170-6. 2004
  63. ncbi request reprint Characteristics of prolonged afterdischarges in children with malformations of cortical development
    Shiro Chitoku
    Department of Pediatrics, The Hospital for Sick Children, University of Toronto, Toronto, ON
    J Child Neurol 18:247-53. 2003
    ..Remote afterdischarges over focal dysplastic cortex suggest aberrant cortical excitability and neural circuits...
  64. ncbi request reprint Evaluation of dietetic intervention in children with medulloblastoma or supratentorial primitive neuroectodermal tumors
    Jaimie Bakish
    Division of Haematology Oncology, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada
    Cancer 98:1014-20. 2003
    ..The goal of the current study was to evaluate the effect of dietetic intervention in a cohort of children treated for medulloblastoma and supratentorial primitive neuroectodermal tumors (PNET) over a 10-year period...
  65. pmc Analysis of mammalian septin expression in human malignant brain tumors
    Dong Seok Kim
    The Arthur and Sonia Labatt Brain Tumor Research Centre and Division of Neurosurgery, The Hospital for Sick Children, The University of Toronto, Toronto, Ontario, Canada
    Neoplasia 6:168-78. 2004
    ..These results suggest that septins are variably expressed in human brain tumors. Stable expression of the DN SEPT2 mutant leads to a G2-M cell cycle block in astrocytoma cells...
  66. ncbi request reprint Change in neurocognitive functioning after treatment with cranial radiation in childhood
    Brenda J Spiegler
    Department of Psychology, The Hospital for Sick Children, 555 University Ave, Toronto, ON M5G 1X8, Canada
    J Clin Oncol 22:706-13. 2004
    ..To evaluate the pattern of stability and change over time across multiple domains of neurocognitive function in radiated survivors of posterior fossa (PF) tumors...
  67. ncbi request reprint Multiple subpial transections in the treatment of pediatric epilepsy
    Jeffrey P Blount
    Division of Neurosurgery and Neurology, The Hospital for Sick Children, The University of Toronto, Ontario, Canada
    J Neurosurg 100:118-24. 2004
    ..The authors present their experience in 30 children who underwent MSTs during the surgical management of the seizure disorder...
  68. ncbi request reprint The significance of ear plugging in localization-related epilepsy
    Dave F Clarke
    Department of Pediatrics, Division of Neurology, The Hospital for Sick Children, University of Toronto, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada
    Epilepsia 44:1562-7. 2003
    ..We propose that ear plugging is a clinical response to a sensory seizure manifested as an auditory hallucination and a tool for identifying the seizure focus in the auditory cortex on the superior temporal gyrus...
  69. ncbi request reprint Cortical dysplastic lesions in children with intractable epilepsy: role of complete resection
    Walter J Hader
    Division of Neurosurgery, Department of Surgery, The Hospital for Sick Children, University of Toronto, Ontario, Canada
    J Neurosurg 100:110-7. 2004
    ..The authors conducted a study to determine seizure-related outcomes in a group of pediatric patients with pathologically proven focal cortical dysplasia (FCD) treated by focal cortical resections and multiple subpial transections (MSTs)...
  70. ncbi request reprint Complications of invasive subdural grid monitoring in children with epilepsy
    Cagatay Onal
    Division of Neurosurgery, The Hospital for Sick Children, The University of Toronto, Ontario, Canada
    J Neurosurg 98:1017-26. 2003
    ..This study was performed to evaluate the complications of invasive subdural grid monitoring during epilepsy surgery in children...
  71. ncbi request reprint Nonmalignant pediatric brain tumors
    Mahmoud Rashidi
    Division of Neurosurgery, Hospital for Sick Children, University of Toronto, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada
    Curr Neurol Neurosci Rep 3:200-5. 2003
    ..Advances in the therapeutic management of patients with these tumors have considerably improved their prognosis...
  72. ncbi request reprint Serial evaluation of academic and behavioral outcome after treatment with cranial radiation in childhood
    Donald J Mabbott
    Paediatric Brain Tumor Program, The Hospital for Sick Children, 555 University Ave, Toronto, Ontario, M5G 1X8, Canada
    J Clin Oncol 23:2256-63. 2005
    ..To evaluate academic and behavioral outcome in radiated survivors of posterior fossa (PF) tumors...
  73. ncbi request reprint Characterizing magnetic spike sources by using magnetoencephalography-guided neuronavigation in epilepsy surgery in pediatric patients
    Koji Iida
    Division of Neurology, The Hospital for Sick Children and University of Toronto, Ontario, Canada
    J Neurosurg 102:187-96. 2005
    ..The authors sought to validate magnetoencephalography spike sources (MEGSSs) in neuronavigation during epilepsy surgery in pediatric patients...
  74. ncbi request reprint Electroencephalographic dipoles of spikes with and without myoclonic jerks caused by epilepsia partialis continua
    Ayako Ochi
    Department of Pediatrics, The Hospital for Sick Children, Toronto, Ontario, Canada
    J Child Neurol 17:127-31. 2002
    ..Electroencephalographic dipole analysis of averaged spikes differentiated the generator of jerking and nonjerking spikes in epilepsia partialis continua. Individual dipoles demonstrated the area of epileptogenic cortical dysplasia...
  75. ncbi request reprint Tumors of the skull base in children: review of tumor types and management strategies
    Eve C Tsai
    Division of Neurosurgery, The University of Toronto, Ontario, Canada
    Neurosurg Focus 12:e1. 2002
    ..Outcomes in this population may be better than those in adults, in part because of the benign histopathology that frequently affects the pediatric skull base, as well as the plasticity of the maturing nervous system...
  76. ncbi request reprint Recurrent intractable seizures in children with cortical dysplasia adjacent to dysembryoplastic neuroepithelial tumor
    Ryoichi Sakuta
    Division of Pathology, The Hospital for Sick Children, University of Toronto, ON, Canada
    J Child Neurol 20:377-84. 2005
    ..Complete resection of a dysembryoplastic neuroepithelial tumor and its adjacent cortical dysplasia should be considered...
  77. ncbi request reprint Neurophysiologic findings of neuronal migration disorders: intrinsic epileptogenicity of focal cortical dysplasia on electroencephalography, electrocorticography, and magnetoencephalography
    Hiroshi Otsubo
    Division of Neurology, The Hospital for Sick Children, Toronto, ON, Canada
    J Child Neurol 20:357-63. 2005
    ..For surgical seizure control, EEG, electrocorticography, and magnetoencephalography must delineate the intrinsic epileptogenic zone within and extending from the focal cortical dysplasia identified by MRI...
  78. ncbi request reprint Complex central cortex in pediatric patients with malformations of cortical development
    Takuya Akai
    Department of Pediatrics and Surgery, The Hospital for Sick Children, Toronto, Ontario
    J Child Neurol 17:347-52. 2002
    ....
  79. ncbi request reprint p16(ink4a) and retinoic acid modulate rhoA and GFAP expression during induction of a stellate phenotype in U343 MG-A astrocytoma cells
    Agnes Langlois
    Arthur and Sonia Labatt Brain Tumour Research Centre, and Division of Neurosurgery, Hospital for Sick Children, University of Toronto, Toronto, Canada
    Glia 40:85-94. 2002
    ....
  80. doi request reprint Corpus callosotomy in children and the disconnection syndromes: a review
    Andrew Jea
    Division of Neurosurgery, Department of Surgery, Hospital for Sick Children, University of Toronto Faculty of Medicine, Suite 1503, 555 University Avenue, Toronto, Ontario, Canada M5G 1X8
    Childs Nerv Syst 24:685-92. 2008
    ..In addition, most published case reports and case series of corpus callosotomy seldom report neurological deficits. We sought to categorize these deficits based on surgical anatomy...
  81. ncbi request reprint Characteristics of dipoles in clustered individual spikes and averaged spikes
    Shiro Chitoku
    Department of Paediatrics, Division of Neurology, The Hospital for Sick Children, University of Toronto, 555 University Avenue, ON, Toronto, Canada M5G 1X8
    Brain Dev 25:14-21. 2003
    ..Characteristics of clustered interictal spikes need careful examination before the use of dipole analysis of averaged spikes for epilepsy evaluation...
  82. doi request reprint Expression of MAGE and GAGE genes in medulloblastoma and modulation of resistance to chemotherapy. Laboratory investigation
    Chinatsu Kasuga
    Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Ontario, Canada
    J Neurosurg Pediatr 1:305-13. 2008
    ..The authors undertook this study to examine the expression and role of MAGE proteins in human MB cell lines and specimens...
  83. doi request reprint Clinical predictors of developmental outcome in patients with cephaloceles
    Benjamin W Y Lo
    Division of Neurosurgery, Department of Surgery, McMaster University, Hamilton General Hospital Neurosurgery, Hamilton, Ontario, Canada
    J Neurosurg Pediatr 2:254-7. 2008
    ..The purpose of this study was to investigate the potential risk factors for the occurrence of developmental delay in patients with cephaloceles, using both univariate and multivariable regression techniques...
  84. ncbi request reprint Expression of Nedd5, a mammalian septin, in human brain tumors
    Keiichi Sakai
    The Division of Neurosurgery, The Arthur and Sonia Labatt Brain Tumour Research Centre, Toronto, Ontario, Canada
    J Neurooncol 57:169-77. 2002
    ..Nedd5 expression may be cell cycle-dependent with increased levels found at G2M phase. Blocking Nedd5 expression in astrocytoma cells by antisense interferes with the process of cytokinesis during cell division...
  85. ncbi request reprint Transcriptional profiling of medulloblastoma in children
    Paul C Park
    Ontario Cancer Institute, University of Toronto, Toronto, Ontario, Canada
    J Neurosurg 99:534-41. 2003
    ..The authors have attempted to compare patterns of gene expression in medulloblastoma samples with those in the healthy cerebellum...
  86. pmc The role of fascin in the migration and invasiveness of malignant glioma cells
    Jeong Hyun Hwang
    Department of Neurosurgery, School of Medicine, Kyungpook National University, Daegu, South Korea
    Neoplasia 10:149-59. 2008
    ..Finally, we show a decreased invasiveness of U251-GFP cells by fascin knockdown in an ex vivo rat brain slice model system. This is the first study to demonstrate a role for fascin in glioma cell morphology, motility, and invasiveness...
  87. ncbi request reprint Expression of fascin, an actin-bundling protein, in astrocytomas of varying grades
    Aurelia Peraud
    Arthur and Sonia Labatt Brain Tumour Research Centre, Toronto, Ontario, Canada
    Brain Tumor Pathol 20:53-8. 2003
    ..This is the first study to demonstrate the expression of fascin in human astrocytic neoplasms. The role that fascin plays in contributing to the invasive phenotype of anaplastic astrocytomas awaits further study and investigation...
  88. ncbi request reprint [Clinical diagnosis and treatment of pediatric head trauma]
    Takashi Araki
    Division of Neurosurgery, The Hospital for Sick Children
    No Shinkei Geka 34:135-46. 2006
  89. ncbi request reprint Molecular biology of human gliomas
    Krishan Bansal
    The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada
    Technol Cancer Res Treat 5:185-94. 2006
    ..In this review, we provide an up-to-date discussion of the many of key technologies and tools that are being used in molecular biology to advance our understanding of the biological behavior of human malignant gliomas...
  90. ncbi request reprint Vagal nerve stimulation for refractory epilepsy in children: indications and experience at The Hospital for Sick Children
    Mony Benifla
    Division of Neurosurgery, The Hospital for Sick Children, The University of Toronto, Toronto, ON, Canada
    Childs Nerv Syst 22:1018-26. 2006
    ..We have reviewed the historical and clinical background of VNS treatment. We also include our experience at The Hospital for Sick Children in children who underwent VNS implantation...
  91. ncbi request reprint Molecular pathways triggering glioma cell invasion
    Bodour Salhia
    The Arthur and Sonia Labatt Brain Tumour Research Center, The Hospital for Sick Children, The University of Toronto, Toronto, Ontario, Canada
    Expert Rev Mol Diagn 6:613-26. 2006
    ..Progress in understanding molecular mechanisms driving glioma invasion will be critical to the success of managing and improving the outcome of patients with this grave disease...
  92. ncbi request reprint Inhibition of Rho-kinase affects astrocytoma morphology, motility, and invasion through activation of Rac1
    Bodour Salhia
    The Arthur and Sonia Labatt Brain Tumour Research Center and Division of Neurosurgery, The Hospital for Sick Children, The University of Toronto, Toronto, Ontario, Canada
    Cancer Res 65:8792-800. 2005
    ..These findings warrant further investigation to determine precisely how the modulation of Rac1 and ROCK can be exploited to inhibit glioma invasion...
  93. ncbi request reprint Current concepts in the molecular genetics of pediatric brain tumors: implications for emerging therapies
    Mandeep S Tamber
    Division of Neurosurgery, The Hospital for Sick Children, The University of Toronto, Toronto, Ontario, Canada
    Childs Nerv Syst 22:1379-94. 2006
    ..Application of these tools has greatly advanced our understanding of the molecular pathogenesis of these lesions...
  94. ncbi request reprint Endoscopic fenestration of a symptomatic cavum septum pellucidum: technical case report
    Astrid Weyerbrock
    Department of Neurosurgery, University Hospital Freiburg, Freiburg, Germany
    Neurosurgery 59:ONSE491; discussion ONSE491. 2006
    ..Endoscopic fenestration may be the most effective and least invasive technique to treat this pathological condition...
  95. ncbi request reprint A clinicobiological model predicting survival in medulloblastoma
    Amit Ray
    Division of Neurosurgery, The Hospital for Sick Children, Toronto, Ontario, Canada
    Clin Cancer Res 10:7613-20. 2004
    ..The purpose of this study was to determine the relative contributions of biological and clinical predictors of survival in patients with medulloblastoma (MB)...
  96. ncbi request reprint Inducible expression of p57KIP2 inhibits glioma cell motility and invasion
    K Sakai
    Department of Neurosurgery, Shinshu University School of Medicine
    J Neurooncol 68:217-23. 2004
    ..These data suggest that p57KIP2 is expressed in at least some malignant gliomas. Inducible expression of 57KIP2 in cell lines deficient in this cyclin-dependent kinase inhibitor reduces their otility and invasiveness...
  97. ncbi request reprint Erythropoietin and astrocytomas
    James T Rutka
    J Neurosurg 106:337; discussion 337. 2007
  98. ncbi request reprint Massive plexiform neurofibromas in childhood: natural history and management issues
    Demitre Serletis
    Division of Neurosurgery, The Hospital for Sick Children, University of Toronto, Ontario, Canada
    J Neurosurg 106:363-7. 2007
    ..The authors review their experience with massive plexiform neurofibromas (PNs) in patients with pediatric neurofibromatosis Type 1 (NF1) to better characterize the natural history and management of these complex lesions...
  99. ncbi request reprint Role of myosin II activity and the regulation of myosin light chain phosphorylation in astrocytomas
    Bodour Salhia
    The Arthur and Sonia Labatt Brain Tumor Research Center, The Hospital for Sick Children, The University of Toronto, Toronto, Ontario, Canada
    Cell Motil Cytoskeleton 65:12-24. 2008
    ..In addition, these findings suggest that there are at least two populations of MLC that are differentially regulated...
  100. doi request reprint Tyrosine kinase expression in pediatric high grade astrocytoma
    Muh Lii Liang
    Department of Neurosurgery, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan, ROC
    J Neurooncol 87:247-53. 2008
    ....
  101. ncbi request reprint Neurosurgical implications of neurofibromatosis Type I in children
    Merdas Al-Otibi
    Division of Neurosurgery, University of Toronto, Ontario, Canada
    Neurosurg Focus 20:E2. 2006
    ..Today, optimum care of the child with NF1 is provided by a multidisciplinary team comprising neurosurgeons, neurologists, ophthalmologists, radiologists, orthopedic surgeons, and plastic surgeons...