Norman D Rosenblum
Affiliation: The Hospital for Sick Children
D Cruz R, Stronks K, Rowan C, Rosenblum N. Lineage-specific roles of hedgehog-GLI signaling during mammalian kidney development. Pediatr Nephrol. 2019;: pubmed publisher
..Here, we review the current understanding of the lineage-specific roles of Hh signaling during renal morphogenesis and how aberrant Hh signaling during embryonic kidney development contributes to renal malformation. ..
Rosenblum N. Developmental biology of the human kidney. Semin Fetal Neonatal Med. 2008;13:125-32 pubmed
..These models reveal mechanisms by which cell lineages are established in the embryonic kidney and the genetic pathways that are involved in their establishment and maintenance. ..
Dos Santos J, Parekh R, Piscione T, Hassouna T, Figueroa V, Gonima P, et al
. A New Grading System for the Management of Antenatal Hydronephrosis. Clin J Am Soc Nephrol. 2015;10:1783-90 pubmed publisher
..89; 95% CI, 1.17 to 3.05). These results suggest a grading system combining APD and diffuse caliectasis distinguishes those children with moderate degrees of upper tract hydronephrosis that are at higher risk of surgery. ..
Smeeton J, Dhir P, Hu D, Feeney M, Chen L, Rosenblum N. Integrin-linked Kinase Controls Renal Branching Morphogenesis via Dual Specificity Phosphatase 8. J Am Soc Nephrol. 2016;27:1465-77 pubmed publisher
..Together, these data demonstrate that Ilk controls branching morphogenesis by regulating the expression of DUSP8, which inhibits p38MAPK activity and decreases branching morphogenesis. ..
Rowan C, Li W, Martirosyan H, Erwood S, Hu D, Kim Y, et al
. Hedgehog-GLI signaling in Foxd1-positive stromal cells promotes murine nephrogenesis via TGF? signaling. Development. 2018;145: pubmed publisher
..Together, our data suggest a mechanism whereby a stromal hedgehog-TGF?2 signaling axis acts to control nephrogenesis. ..
Rosenblum N. The path ahead for MD/PhD programs in Canada Commentary on Jones et al. Clin Invest Med. 2016;39:E140-1 pubmed
..The authors are to be commended for their efforts and productivity. ..
Iskander S, Feeney M, Yee K, Rosenblum N. Protein Kinase 2β Is Expressed in Neural Crest-Derived Urinary Pacemaker Cells and Required for Pyeloureteric Contraction. J Am Soc Nephrol. 2018;29:1198-1209 pubmed publisher
..Together, these results demonstrate that utPMCs are derived from NCCs, identify new markers of utPMCs, and demonstrate a functional contribution of PTK2β to utPMC function. ..
Rowan C, Sheybani Deloui S, Rosenblum N. Origin and Function of the Renal Stroma in Health and Disease. Results Probl Cell Differ. 2017;60:205-229 pubmed publisher
..To conclude, stromal cells and the contribution of stromal cells to renal fibrosis and chronic kidney disease are described. ..
Sheybani Deloui S, Chi L, Staite M, Cain J, Nieman B, Henkelman R, et al
. Activated Hedgehog-GLI Signaling Causes Congenital Ureteropelvic Junction Obstruction. J Am Soc Nephrol. 2018;29:532-544 pubmed publisher
..Together, these results demonstrate a Hedgehog-dependent mechanism underlying mammalian intrinsic ureteropelvic junction obstruction. ..