Research Topics
| Eve A RobertsSummaryAffiliation: The Hospital for Sick Children Country: Canada Publications
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Detail Information
Publications
Pediatric nonalcoholic fatty liver disease (NAFLD): a "growing" problem?Eve A Roberts
Division of Gastroenterology, Hepatology and Nutrition, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
J Hepatol 46:1133-42. 2007..Finding effective ways to prevent pediatric NAFLD is an important issue for children's health...- Hepatitis B: the next generationEve A Roberts
Division of Gastroenterology and Nutrition, The Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada
Pediatr Res 56:318-20. 2004 - Neonatal hepatitis syndromeEve A Roberts
Division of Gastroenterology and Nutrition, Room 8267, Black Wing, The Hospital for Sick Children, Toronto, Ontario, Canada
Semin Neonatol 8:357-74. 2003..Alternatively, liver transplantation may be life saving. Supportive care, especially with attention to nutritional needs, is important for all infants with neonatal hepatitis syndrome... - Nonalcoholic Fatty Liver Disease (NAFLD): Approach in the Adolescent PatientEve A Roberts
Room 8267, Black Wing, Division of Gastroenterology, Hepatology, and Nutrition, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, M5G 1X8, Canada
Curr Treat Options Gastroenterol 9:423-31. 2006..Optimal drug treatment requires further research: current front-runners are vitamin E and metformin. The roles of drugs that alter appetite and bariatric surgery for adolescents with NAFLD have not been determined... - Non-alcoholic steatohepatitis in childrenEve A Roberts
Division of Gastroenterology, Hepatology and Nutrition and the Genetics and Genomic Biology Programme, The Hospital for Sick Children, Toronto, Ontario, Canada
Clin Liver Dis 11:155-72, x. 2007..Treatment is gradual weight loss through changes in food intake patterns and increased levels of physical activity; the role of drug treatment of NASH in children is an area of ongoing research... - Developmental expression of Commd1 in the liver of the Jackson toxic milk mouseEve A Roberts
Genetics and Genome Biology Program, Hospital for Sick Children Research Institute, University of Toronto, Toronto, Ont, Canada
Biochem Biophys Res Commun 363:921-5. 2007..Cytosolic NF-kappaB rose then dropped precipitously at 5-6 months. In tx-j mice hepatic copper accumulation leads to decreased Xiap, increased Commd1; these responses ultimately fail to prevent progressive apoptotic cell damage... - Nonalcoholic steatohepatitis in childrenEve A Roberts
Division of Gastroenterology and Nutrition, Department of Paediatrics, The Hospital for Sick Children, University of Toronto, Room 8267, Black Family Foundation Wing, 555 University Avenue, Toronto, ON M5G 1X8, Canada
Curr Gastroenterol Rep 5:253-9. 2003..Gradual weight loss through increased regular exercise and a low-fat, low-refined carbohydrate diet appears to be effective. Drug treatments are being developed. Pediatric NASH is a serious complication of childhood obesity... - Mitochondrial structure and function in the untreated Jackson toxic milk (tx-j) mouse, a model for Wilson diseaseEve A Roberts
Genetics and Genomic Biology Program, Hospital for Sick Children Research Institute, University of Toronto, 555 University Avenue, Toronto, Ontario, Canada
Mol Genet Metab 93:54-65. 2008..Levels of two mitochondrial antioxidant proteins capable of binding copper, thioredoxin-2 and peroxiredoxin-3, rose over the first 6 months of life. Mitochondrial changes occur early in WD and reflect complex, probably oxidative, injury... - Maternal-infant transmission of hepatitis C virus infectionEve A Roberts
Division of Gastroenterology and Nutrition, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
Hepatology 36:S106-13. 2002..The natural history of mother-to-infant hepatitis C remains uncertain, especially the course in the first year of life when some infants appear to have spontaneous resolution... - Liver as a key organ in the supply, storage, and excretion of copperEve A Roberts
Genetics and Genome Biology Program, Hospital for Sick Children Research Institute, Toronto, ON, Canada
Am J Clin Nutr 88:851S-4S. 2008.... - Non-alcoholic fatty liver disease (NAFLD) in childrenEve A Roberts
Division of Gastroenterology, Hepatology and Nutrition, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, M5G 1X8, Canada
Front Biosci 10:2306-18. 2005..In addition to individual treatment, a multifaceted, societal initiative is required for solving the childhood obesity epidemic... - Using immobilized metal affinity chromatography, two-dimensional electrophoresis and mass spectrometry to identify hepatocellular proteins with copper-binding abilityScott D Smith
Department of Structural Biology and Biochemistry, The Hospital for Sick Children Research Institute, Toronto, Canada
J Proteome Res 3:834-40. 2004..Fifty-two of the 67 proteins contain putative metal-binding domains. We have identified many components of the Hep G2 copper metalloproteome including a large number of proteins not previously known to bind copper... - Mild-to-moderate chronic cholestatic liver disease increases leucine oxidation in childrenDiana R Mager
Department of Nutritional Sciences, University of Toronto, Toronto, Canada
J Nutr 136:965-70. 2006..However, F13CO2 and whole-body leucine oxidation did not differ in the fed state. We conclude that the increased need for dietary BCAA in MCC liver disease is mediated in part by increased leucine oxidation in the postabsorptive state... - Effect of orthotopic liver transplantation (OLT) on branched-chain amino acid requirementDiana R Mager
Department of Nutritional Sciences, University of Toronto, The Research Institute, The Hospital for Sick Children, Toronto, Ontario, Canada, M5G IX8
Pediatr Res 59:829-34. 2006.... 
Using metalloproteomics to investigate the cellular physiology of copper in hepatocytesEve A Roberts
Room 8263, Black Family Foundation Wing, Division of Gastroenterology, Hepatology and Nutrition, The Hospital for Sick Children, Toronto, Ontario, Canada M5G 1X8
Metallomics 4:633-40. 2012..It has the potential to elucidate the action of numerous metals in hepatocytes and generate new diagnostic parameters, namely, novel biomarkers...- Prevalence of vitamin K deficiency in children with mild to moderate chronic liver diseaseDiana R Mager
Department of Clinical Dietetics, The Hospital for Sick Children and University of Toronto, Toronto, Ontario, Canada
J Pediatr Gastroenterol Nutr 42:71-6. 2006..The objective of this study was to determine the prevalence of vitamin K deficiency in children with mild to moderate chronic cholestatic and noncholestatic liver disease... - Single pass albumin dialysis (SPAD) in fulminant Wilsonian liver failure: a case reportKatherine L Collins
Department of Paediatrics, The Hospital for Sick Children and the University of Toronto, Toronto, Canada
Pediatr Nephrol 23:1013-6. 2008..We conclude that SPAD is potentially an effective treatment in fulminant Wilson disease with hemolysis but that it should be used in combination with chelation to optimize the removal of copper... - The puzzle posed by COMMD1, a newly discovered protein binding Cu(II)Bibudhendra Sarkar
Molecular Structure and Function Program, The Hospital for Sick Children Research Institute, Department of Biochemistry, University of Toronto, Toronto, Ontario, Canada
Metallomics 3:20-7. 2011..Additionally, or alternatively, COMMD1 may be an important component of an intracellular system for utilizing Cu(II), or for detecting and detoxifying it... - Nonalcoholic fatty liver disease in childrenDiana R Mager
Division of Gastroenterology, Hepatology and Nutrition, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada
Clin Liver Dis 10:109-31, vi-vii. 2006..Overweight/obesity should be identified as early as possible. Comprehensive clinical management to normalize weight should be instituted immediately to avoid hepatic and nonhepatic complications... - Diagnostic challenges of nonalcoholic fatty liver disease (NAFLD) in children of normal weightJason Y K Yap
Division of Gastroenterology, Hepatology and Nutrition, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, Canada M5G 1X8
Clin Res Hepatol Gastroenterol 35:500-5. 2011..Normal-body-weight NAFLD accounts for approximately 15% of all NAFLD and may be more prevalent with certain ethnicities... - Proteomics of metal transport and metal-associated diseasesPrasad P Kulkarni
Department of Biochemistry, University of Toronto, Medical Sciences Building, Toronto, ON, M5S 1A8, Canada
Chemistry 12:2410-22. 2006..Here we discuss the principal aspects of metal metabolism, and the recent developments in the area of the proteomics of metal transport... - Derivation of a clinical prediction rule for the noninvasive diagnosis of varices in childrenJuan Cristóbal Gana
Division of Paediatrics, Gastroenterology, Hepatology, and Nutrition Unit, Facultad de Medicina, Pontificia Universidad Cato lica de Chile, Lira 44 1er piso, Santiago, Chile
J Pediatr Gastroenterol Nutr 50:188-93. 2010..The objective of the study was to derive a noninvasive clinical prediction rule that is able to identify children with esophageal varices... - Diagnosis and treatment of Wilson disease: an updateEve A Roberts
Division of Gastroenterology, Hepatology and Nutrition, The Hospital for Sick Children, and Department of Paediatrics, University of Toronto, Toronto, Ontario, Canada
Hepatology 47:2089-111. 2008 - Identification of metal-binding proteins in human hepatoma lines by immobilized metal affinity chromatography and mass spectrometryYi-Min She
Program in Structural Biology and Biochemistry, The Research Institute, Hospital for Sick Children, Toronto, Ontario, Canada
Mol Cell Proteomics 2:1306-18. 2003..K., et al. (2001) Proteomics 1, 1249-1263). Proteins in the metalloproteomes of human hepatocytes can be identified by these methods. Variations in these metalloproteomes may have important physiological relevance... 
Strategic plan of the Canadian Institutes of Health Research Institute of Nutrition, Metabolism, and DiabetesPhilip M Sherman
Canadian Institutes of Health Research, Ottawa, Ontario, Canada
Can J Gastroenterol 25:560-4. 2011....- Steatohepatitis in childrenEve A Roberts
Division of Gastroenterology and Nutrition, Room 8267, Black Wing, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, M5G 1X8, Canada
Best Pract Res Clin Gastroenterol 16:749-65. 2002..Other causes of chronic hepatitis, such as chronic viral hepatitis, must also be excluded. Multisystemic inherited diseases with hyperinsulinaemia plus insulin resistance may have NAFLD as hepatic involvement and should be identified... - Biliary atresia with associated structural malformations in Canadian infantsOrlee R Guttman
Division of Gastroenterology, Hepatology and Nutrition, BC Children s Hospital, Vancouver, BC, Canada
Liver Int 31:1485-93. 2011..The term commonly applied to this subgroup is 'BASM' for biliary atresia splenic malformation syndrome, as spleen abnormalities are prominent... - Portal hypertensive biliopathy: a rare cause of childhood cholestasisWael El-Matary
Division of Gastroenterology, Hepatology and Nutrition, The Hospital for Sick Children, Toronto, ON, Canada
Eur J Pediatr 167:1339-42. 2008..Hepaticojejunostomy may have a therapeutic role in selected patients in whom endoscopic or percutaneous manipulation of the biliary tree is unsuccessful and who have not responded to a surgical portal-systemic shunt procedure... - Current issues in the management of paediatric viral hepatitisLatifa T F Yeung
Rouge Valley Health System, Centenary Health Centre, Galaxy 12 Child and Teen Clinic, Scarborough, ON, Canada
Liver Int 30:5-18. 2010..Treatment of children chronically infected with genotype 2 or 3 is highly successful: combination therapy of pegylated interferon-alpha and ribavirin is well tolerated and superior to pegylated interferon-alpha alone... - Branched-chain amino acid needs in children with mild-to-moderate chronic cholestatic liver diseaseDiana R Mager
Department of Nutritional Sciences, University of Toronto, Toronto, Canada
J Nutr 136:133-9. 2006..Total BCAA estimated average requirements using the IAAO were significantly higher than mean requirements established previously for healthy children (P < 0.05)... - Abnormalities in villin gene expression and canalicular microvillus structure in progressive cholestatic liver disease of childhoodM James Phillips
Department of Multi organ Transplantation Research, Toronto General Hospital, University Health Network, ON, Toronto, Canada
Lancet 362:1112-9. 2003..We aimed to investigate the role of canalicular cytoskeletal proteins in three genetically unrelated children with a biliary atresia-like clinical disorder, each of whom developed liver failure requiring liver transplantation... - A practice guideline on Wilson diseaseEve A Roberts
Division of Gastroenterology and Nutrition, Hospital for Sick Children, Toronto, Ontario, Canada
Hepatology 37:1475-92. 2003 - Clinicopathologic spectrum of massive and submassive hepatic necrosis in infants and childrenRichard Kirsch
Division of Pathology, Department of Pediatric Laboratory Medicine, Mount Sinai Hospital, Toronto, Ontario, M5G 1X8 Canada
Hum Pathol 40:516-26. 2009..In summary, this study describes the spectrum of changes seen in massive and submassive necrosis in children and identifies clinical features that might differentiate between 2 broad patterns of necrosis... - Anthropometric and metabolic characteristics in children with clinically diagnosed nonalcoholic fatty liver diseaseDiana R Mager
Division of Gastroenterology, Hepatology and Nutrition
Paediatr Child Health 13:111-7. 2008..Childhood obesity is currently approaching epidemic proportions worldwide. Various chronic diseases are associated with obesity, but nonalcoholic fatty liver disease (NAFLD) has received little attention from paediatricians... - Modeling of human hepatic CYP3A4 enzyme kinetics, protein, and mRNA indicates deviation from log-normal distribution in CYP3A4 gene expressionSherwin K B Sy
Department of Pharmacology, University of Toronto, Medical Sciences Building, Toronto, Ontario, Canada
Eur J Clin Pharmacol 58:357-65. 2002..To determine whether the variability in cytochrome P(450) (CYP)3A4 metabolic function is exhibited at both transcription and translation levels and to examine the population distribution of CYP3A4 enzyme kinetics, protein, and mRNA... - Controversies in the management of pediatric liver disease: Hepatitis B, C and NAFLD: Summary of a single topic conferenceBenjamin L Shneider
Division of Pediatric Hepatology, Department of Pediatrics, Mount Sinai School of Medicine, New York, NY, USA
Hepatology 44:1344-54. 2006 - Biliary atresia: the Canadian experienceRichard A Schreiber
Department of Pediatrics, University of British Columbia, Vancouver, British Columbia
J Pediatr 151:659-65, 665.e1. 2007..To determine the outcomes of Canadian children with biliary atresia... - Mulitvariate cluster analysis of a human hepatic cytochrome P450 databaseSherwin K B Sy
Eur J Clin Pharmacol 58:559-62. 2002