Eve A Roberts

Summary

Affiliation: The Hospital for Sick Children
Country: Canada

Publications

  1. ncbi request reprint Neonatal hepatitis syndrome
    Eve A Roberts
    Division of Gastroenterology and Nutrition, Room 8267, Black Wing, The Hospital for Sick Children, Toronto, Ontario, Canada
    Semin Neonatol 8:357-74. 2003
  2. ncbi request reprint Hepatitis B: the next generation
    Eve A Roberts
    Division of Gastroenterology and Nutrition, The Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada
    Pediatr Res 56:318-20. 2004
  3. ncbi request reprint Nonalcoholic Fatty Liver Disease (NAFLD): Approach in the Adolescent Patient
    Eve A Roberts
    Room 8267, Black Wing, Division of Gastroenterology, Hepatology, and Nutrition, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, M5G 1X8, Canada
    Curr Treat Options Gastroenterol 9:423-31. 2006
  4. ncbi request reprint Pediatric nonalcoholic fatty liver disease (NAFLD): a "growing" problem?
    Eve A Roberts
    Division of Gastroenterology, Hepatology and Nutrition, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
    J Hepatol 46:1133-42. 2007
  5. ncbi request reprint Non-alcoholic steatohepatitis in children
    Eve A Roberts
    Division of Gastroenterology, Hepatology and Nutrition and the Genetics and Genomic Biology Programme, The Hospital for Sick Children, Toronto, Ontario, Canada
    Clin Liver Dis 11:155-72, x. 2007
  6. ncbi request reprint Developmental expression of Commd1 in the liver of the Jackson toxic milk mouse
    Eve A Roberts
    Genetics and Genome Biology Program, Hospital for Sick Children Research Institute, University of Toronto, Toronto, Ont, Canada
    Biochem Biophys Res Commun 363:921-5. 2007
  7. ncbi request reprint Nonalcoholic steatohepatitis in children
    Eve A Roberts
    Division of Gastroenterology and Nutrition, Department of Paediatrics, The Hospital for Sick Children, University of Toronto, Room 8267, Black Family Foundation Wing, 555 University Avenue, Toronto, ON M5G 1X8, Canada
    Curr Gastroenterol Rep 5:253-9. 2003
  8. ncbi request reprint Mitochondrial structure and function in the untreated Jackson toxic milk (tx-j) mouse, a model for Wilson disease
    Eve A Roberts
    Genetics and Genomic Biology Program, Hospital for Sick Children Research Institute, University of Toronto, 555 University Avenue, Toronto, Ontario, Canada
    Mol Genet Metab 93:54-65. 2008
  9. ncbi request reprint Maternal-infant transmission of hepatitis C virus infection
    Eve A Roberts
    Division of Gastroenterology and Nutrition, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
    Hepatology 36:S106-13. 2002
  10. ncbi request reprint Liver as a key organ in the supply, storage, and excretion of copper
    Eve A Roberts
    Genetics and Genome Biology Program, Hospital for Sick Children Research Institute, Toronto, ON, Canada
    Am J Clin Nutr 88:851S-4S. 2008

Collaborators

Detail Information

Publications38

  1. ncbi request reprint Neonatal hepatitis syndrome
    Eve A Roberts
    Division of Gastroenterology and Nutrition, Room 8267, Black Wing, The Hospital for Sick Children, Toronto, Ontario, Canada
    Semin Neonatol 8:357-74. 2003
    ..Alternatively, liver transplantation may be life saving. Supportive care, especially with attention to nutritional needs, is important for all infants with neonatal hepatitis syndrome...
  2. ncbi request reprint Hepatitis B: the next generation
    Eve A Roberts
    Division of Gastroenterology and Nutrition, The Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada
    Pediatr Res 56:318-20. 2004
  3. ncbi request reprint Nonalcoholic Fatty Liver Disease (NAFLD): Approach in the Adolescent Patient
    Eve A Roberts
    Room 8267, Black Wing, Division of Gastroenterology, Hepatology, and Nutrition, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, M5G 1X8, Canada
    Curr Treat Options Gastroenterol 9:423-31. 2006
    ..Optimal drug treatment requires further research: current front-runners are vitamin E and metformin. The roles of drugs that alter appetite and bariatric surgery for adolescents with NAFLD have not been determined...
  4. ncbi request reprint Pediatric nonalcoholic fatty liver disease (NAFLD): a "growing" problem?
    Eve A Roberts
    Division of Gastroenterology, Hepatology and Nutrition, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
    J Hepatol 46:1133-42. 2007
    ..Finding effective ways to prevent pediatric NAFLD is an important issue for children's health...
  5. ncbi request reprint Non-alcoholic steatohepatitis in children
    Eve A Roberts
    Division of Gastroenterology, Hepatology and Nutrition and the Genetics and Genomic Biology Programme, The Hospital for Sick Children, Toronto, Ontario, Canada
    Clin Liver Dis 11:155-72, x. 2007
    ..Treatment is gradual weight loss through changes in food intake patterns and increased levels of physical activity; the role of drug treatment of NASH in children is an area of ongoing research...
  6. ncbi request reprint Developmental expression of Commd1 in the liver of the Jackson toxic milk mouse
    Eve A Roberts
    Genetics and Genome Biology Program, Hospital for Sick Children Research Institute, University of Toronto, Toronto, Ont, Canada
    Biochem Biophys Res Commun 363:921-5. 2007
    ..Cytosolic NF-kappaB rose then dropped precipitously at 5-6 months. In tx-j mice hepatic copper accumulation leads to decreased Xiap, increased Commd1; these responses ultimately fail to prevent progressive apoptotic cell damage...
  7. ncbi request reprint Nonalcoholic steatohepatitis in children
    Eve A Roberts
    Division of Gastroenterology and Nutrition, Department of Paediatrics, The Hospital for Sick Children, University of Toronto, Room 8267, Black Family Foundation Wing, 555 University Avenue, Toronto, ON M5G 1X8, Canada
    Curr Gastroenterol Rep 5:253-9. 2003
    ..Gradual weight loss through increased regular exercise and a low-fat, low-refined carbohydrate diet appears to be effective. Drug treatments are being developed. Pediatric NASH is a serious complication of childhood obesity...
  8. ncbi request reprint Mitochondrial structure and function in the untreated Jackson toxic milk (tx-j) mouse, a model for Wilson disease
    Eve A Roberts
    Genetics and Genomic Biology Program, Hospital for Sick Children Research Institute, University of Toronto, 555 University Avenue, Toronto, Ontario, Canada
    Mol Genet Metab 93:54-65. 2008
    ..Levels of two mitochondrial antioxidant proteins capable of binding copper, thioredoxin-2 and peroxiredoxin-3, rose over the first 6 months of life. Mitochondrial changes occur early in WD and reflect complex, probably oxidative, injury...
  9. ncbi request reprint Maternal-infant transmission of hepatitis C virus infection
    Eve A Roberts
    Division of Gastroenterology and Nutrition, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
    Hepatology 36:S106-13. 2002
    ..The natural history of mother-to-infant hepatitis C remains uncertain, especially the course in the first year of life when some infants appear to have spontaneous resolution...
  10. ncbi request reprint Liver as a key organ in the supply, storage, and excretion of copper
    Eve A Roberts
    Genetics and Genome Biology Program, Hospital for Sick Children Research Institute, Toronto, ON, Canada
    Am J Clin Nutr 88:851S-4S. 2008
    ....
  11. ncbi request reprint Non-alcoholic fatty liver disease (NAFLD) in children
    Eve A Roberts
    Division of Gastroenterology, Hepatology and Nutrition, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, M5G 1X8, Canada
    Front Biosci 10:2306-18. 2005
    ..In addition to individual treatment, a multifaceted, societal initiative is required for solving the childhood obesity epidemic...
  12. ncbi request reprint Using immobilized metal affinity chromatography, two-dimensional electrophoresis and mass spectrometry to identify hepatocellular proteins with copper-binding ability
    Scott D Smith
    Department of Structural Biology and Biochemistry, The Hospital for Sick Children Research Institute, Toronto, Canada
    J Proteome Res 3:834-40. 2004
    ..Fifty-two of the 67 proteins contain putative metal-binding domains. We have identified many components of the Hep G2 copper metalloproteome including a large number of proteins not previously known to bind copper...
  13. ncbi request reprint Mild-to-moderate chronic cholestatic liver disease increases leucine oxidation in children
    Diana R Mager
    Department of Nutritional Sciences, University of Toronto, Toronto, Canada
    J Nutr 136:965-70. 2006
    ..However, F13CO2 and whole-body leucine oxidation did not differ in the fed state. We conclude that the increased need for dietary BCAA in MCC liver disease is mediated in part by increased leucine oxidation in the postabsorptive state...
  14. ncbi request reprint Effect of orthotopic liver transplantation (OLT) on branched-chain amino acid requirement
    Diana R Mager
    Department of Nutritional Sciences, University of Toronto, The Research Institute, The Hospital for Sick Children, Toronto, Ontario, Canada, M5G IX8
    Pediatr Res 59:829-34. 2006
    ....
  15. ncbi request reprint Proteomics of metal transport and metal-associated diseases
    Prasad P Kulkarni
    Department of Biochemistry, University of Toronto, Medical Sciences Building, Toronto, ON, M5S 1A8, Canada
    Chemistry 12:2410-22. 2006
    ..Here we discuss the principal aspects of metal metabolism, and the recent developments in the area of the proteomics of metal transport...
  16. doi request reprint Using metalloproteomics to investigate the cellular physiology of copper in hepatocytes
    Eve A Roberts
    Room 8263, Black Family Foundation Wing, Division of Gastroenterology, Hepatology and Nutrition, The Hospital for Sick Children, Toronto, Ontario, Canada M5G 1X8
    Metallomics 4:633-40. 2012
    ..It has the potential to elucidate the action of numerous metals in hepatocytes and generate new diagnostic parameters, namely, novel biomarkers...
  17. ncbi request reprint Prevalence of vitamin K deficiency in children with mild to moderate chronic liver disease
    Diana R Mager
    Department of Clinical Dietetics, The Hospital for Sick Children and University of Toronto, Toronto, Ontario, Canada
    J Pediatr Gastroenterol Nutr 42:71-6. 2006
    ..The objective of this study was to determine the prevalence of vitamin K deficiency in children with mild to moderate chronic cholestatic and noncholestatic liver disease...
  18. doi request reprint Single pass albumin dialysis (SPAD) in fulminant Wilsonian liver failure: a case report
    Katherine L Collins
    Department of Paediatrics, The Hospital for Sick Children and the University of Toronto, Toronto, Canada
    Pediatr Nephrol 23:1013-6. 2008
    ..We conclude that SPAD is potentially an effective treatment in fulminant Wilson disease with hemolysis but that it should be used in combination with chelation to optimize the removal of copper...
  19. ncbi request reprint The puzzle posed by COMMD1, a newly discovered protein binding Cu(II)
    Bibudhendra Sarkar
    Molecular Structure and Function Program, The Hospital for Sick Children Research Institute, Department of Biochemistry, University of Toronto, Toronto, Ontario, Canada
    Metallomics 3:20-7. 2011
    ..Additionally, or alternatively, COMMD1 may be an important component of an intracellular system for utilizing Cu(II), or for detecting and detoxifying it...
  20. ncbi request reprint Nonalcoholic fatty liver disease in children
    Diana R Mager
    Division of Gastroenterology, Hepatology and Nutrition, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada
    Clin Liver Dis 10:109-31, vi-vii. 2006
    ..Overweight/obesity should be identified as early as possible. Comprehensive clinical management to normalize weight should be instituted immediately to avoid hepatic and nonhepatic complications...
  21. doi request reprint Diagnostic challenges of nonalcoholic fatty liver disease (NAFLD) in children of normal weight
    Jason Y K Yap
    Division of Gastroenterology, Hepatology and Nutrition, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, Canada M5G 1X8
    Clin Res Hepatol Gastroenterol 35:500-5. 2011
    ..Normal-body-weight NAFLD accounts for approximately 15% of all NAFLD and may be more prevalent with certain ethnicities...
  22. doi request reprint Derivation of a clinical prediction rule for the noninvasive diagnosis of varices in children
    Juan Cristóbal Gana
    Division of Paediatrics, Gastroenterology, Hepatology, and Nutrition Unit, Facultad de Medicina, Pontificia Universidad Cato lica de Chile, Lira 44 1er piso, Santiago, Chile
    J Pediatr Gastroenterol Nutr 50:188-93. 2010
    ..The objective of the study was to derive a noninvasive clinical prediction rule that is able to identify children with esophageal varices...
  23. ncbi request reprint Identification of metal-binding proteins in human hepatoma lines by immobilized metal affinity chromatography and mass spectrometry
    Yi Min She
    Program in Structural Biology and Biochemistry, The Research Institute, Hospital for Sick Children, Toronto, Ontario, Canada
    Mol Cell Proteomics 2:1306-18. 2003
    ..K., et al. (2001) Proteomics 1, 1249-1263). Proteins in the metalloproteomes of human hepatocytes can be identified by these methods. Variations in these metalloproteomes may have important physiological relevance...
  24. doi request reprint Diagnosis and treatment of Wilson disease: an update
    Eve A Roberts
    Division of Gastroenterology, Hepatology and Nutrition, The Hospital for Sick Children, and Department of Paediatrics, University of Toronto, Toronto, Ontario, Canada
    Hepatology 47:2089-111. 2008
  25. pmc Strategic plan of the Canadian Institutes of Health Research Institute of Nutrition, Metabolism, and Diabetes
    Philip M Sherman
    Canadian Institutes of Health Research, Ottawa, Ontario, Canada
    Can J Gastroenterol 25:560-4. 2011
    ....
  26. ncbi request reprint Steatohepatitis in children
    Eve A Roberts
    Division of Gastroenterology and Nutrition, Room 8267, Black Wing, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, M5G 1X8, Canada
    Best Pract Res Clin Gastroenterol 16:749-65. 2002
    ..Other causes of chronic hepatitis, such as chronic viral hepatitis, must also be excluded. Multisystemic inherited diseases with hyperinsulinaemia plus insulin resistance may have NAFLD as hepatic involvement and should be identified...
  27. doi request reprint Biliary atresia with associated structural malformations in Canadian infants
    Orlee R Guttman
    Division of Gastroenterology, Hepatology and Nutrition, BC Children s Hospital, Vancouver, BC, Canada
    Liver Int 31:1485-93. 2011
    ..The term commonly applied to this subgroup is 'BASM' for biliary atresia splenic malformation syndrome, as spleen abnormalities are prominent...
  28. ncbi request reprint Branched-chain amino acid needs in children with mild-to-moderate chronic cholestatic liver disease
    Diana R Mager
    Department of Nutritional Sciences, University of Toronto, Toronto, Canada
    J Nutr 136:133-9. 2006
    ..Total BCAA estimated average requirements using the IAAO were significantly higher than mean requirements established previously for healthy children (P < 0.05)...
  29. doi request reprint Current issues in the management of paediatric viral hepatitis
    Latifa T F Yeung
    Rouge Valley Health System, Centenary Health Centre, Galaxy 12 Child and Teen Clinic, Scarborough, ON, Canada
    Liver Int 30:5-18. 2010
    ..Treatment of children chronically infected with genotype 2 or 3 is highly successful: combination therapy of pegylated interferon-alpha and ribavirin is well tolerated and superior to pegylated interferon-alpha alone...
  30. ncbi request reprint Abnormalities in villin gene expression and canalicular microvillus structure in progressive cholestatic liver disease of childhood
    M James Phillips
    Department of Multi organ Transplantation Research, Toronto General Hospital, University Health Network, ON, Toronto, Canada
    Lancet 362:1112-9. 2003
    ..We aimed to investigate the role of canalicular cytoskeletal proteins in three genetically unrelated children with a biliary atresia-like clinical disorder, each of whom developed liver failure requiring liver transplantation...
  31. doi request reprint Portal hypertensive biliopathy: a rare cause of childhood cholestasis
    Wael El-Matary
    Division of Gastroenterology, Hepatology and Nutrition, The Hospital for Sick Children, Toronto, ON, Canada
    Eur J Pediatr 167:1339-42. 2008
    ..Hepaticojejunostomy may have a therapeutic role in selected patients in whom endoscopic or percutaneous manipulation of the biliary tree is unsuccessful and who have not responded to a surgical portal-systemic shunt procedure...
  32. ncbi request reprint A practice guideline on Wilson disease
    Eve A Roberts
    Division of Gastroenterology and Nutrition, Hospital for Sick Children, Toronto, Ontario, Canada
    Hepatology 37:1475-92. 2003
  33. doi request reprint Clinicopathologic spectrum of massive and submassive hepatic necrosis in infants and children
    Richard Kirsch
    Division of Pathology, Department of Pediatric Laboratory Medicine, Mount Sinai Hospital, Toronto, Ontario, M5G 1X8 Canada
    Hum Pathol 40:516-26. 2009
    ..In summary, this study describes the spectrum of changes seen in massive and submassive necrosis in children and identifies clinical features that might differentiate between 2 broad patterns of necrosis...
  34. pmc Anthropometric and metabolic characteristics in children with clinically diagnosed nonalcoholic fatty liver disease
    Diana R Mager
    Division of Gastroenterology, Hepatology and Nutrition
    Paediatr Child Health 13:111-7. 2008
    ..Childhood obesity is currently approaching epidemic proportions worldwide. Various chronic diseases are associated with obesity, but nonalcoholic fatty liver disease (NAFLD) has received little attention from paediatricians...
  35. ncbi request reprint Modeling of human hepatic CYP3A4 enzyme kinetics, protein, and mRNA indicates deviation from log-normal distribution in CYP3A4 gene expression
    Sherwin K B Sy
    Department of Pharmacology, University of Toronto, Medical Sciences Building, Toronto, Ontario, Canada
    Eur J Clin Pharmacol 58:357-65. 2002
    ..To determine whether the variability in cytochrome P(450) (CYP)3A4 metabolic function is exhibited at both transcription and translation levels and to examine the population distribution of CYP3A4 enzyme kinetics, protein, and mRNA...
  36. ncbi request reprint Controversies in the management of pediatric liver disease: Hepatitis B, C and NAFLD: Summary of a single topic conference
    Benjamin L Shneider
    Division of Pediatric Hepatology, Department of Pediatrics, Mount Sinai School of Medicine, New York, NY, USA
    Hepatology 44:1344-54. 2006
  37. ncbi request reprint Biliary atresia: the Canadian experience
    Richard A Schreiber
    Department of Pediatrics, University of British Columbia, Vancouver, British Columbia
    J Pediatr 151:659-65, 665.e1. 2007
    ..To determine the outcomes of Canadian children with biliary atresia...
  38. ncbi request reprint Mulitvariate cluster analysis of a human hepatic cytochrome P450 database
    Sherwin K B Sy
    Eur J Clin Pharmacol 58:559-62. 2002