Felix A Ratjen

Summary

Affiliation: The Hospital for Sick Children
Country: Canada

Publications

  1. pmc Multiple breath nitrogen washout: a feasible alternative to mass spectrometry
    Renee Jensen
    Division of Respiratory Medicine, Department of Pediatrics, The Hospital for Sick Children, University of Toronto, Toronto, Canada
    PLoS ONE 8:e56868. 2013
  2. pmc Effect of azithromycin on systemic markers of inflammation in patients with cystic fibrosis uninfected with Pseudomonas aeruginosa
    Felix Ratjen
    Division of Respiratory Medicine, Department of Pediatrics, SickKids Research Institute, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada
    Chest 142:1259-66. 2012
  3. ncbi request reprint Long term effects of denufosol tetrasodium in patients with cystic fibrosis
    Felix Ratjen
    Division of Respiratory Medicine, Department of Pediatrics, and Program in Physiology and Experimental Medicine, SickKids Research Institute, The Hospital for Sick Children, and University of Toronto, Toronto, Canada
    J Cyst Fibros 11:539-49. 2012
  4. doi request reprint Cystic fibrosis: the role of the small airways
    Felix Ratjen
    Division of Respiratory Medicine, Department of Pediatrics, and Program in Physiology and Experimental Medicine, SickKids Research Institute, The Hospital for Sick Children, and University of Toronto, Toronto, Canada
    J Aerosol Med Pulm Drug Deliv 25:261-4. 2012
  5. ncbi request reprint New therapies in cystic fibrosis
    Felix Ratjen
    Division of Respiratory Medicine, Hospital for Sick Children, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada
    Curr Pharm Des 18:614-27. 2012
  6. pmc Sequential analysis of surfactant, lung function and inflammation in cystic fibrosis patients
    Matthias Griese
    Children s Hospital, University of Munich, Lindwurmstr 4, 80337 München, Germany
    Respir Res 6:133. 2005
  7. ncbi request reprint Treatment of early Pseudomonas aeruginosa infection in patients with cystic fibrosis
    Felix Ratjen
    Division of Respiratory Medicine, Hospital for Sick Children, Toronto, Ontario, Canada
    Curr Opin Pulm Med 12:428-32. 2006
  8. ncbi request reprint Pharmacokinetics of inhaled colistin in patients with cystic fibrosis
    F Ratjen
    Children s Hospital, University of Duisburg Essen, Essen, Germany
    J Antimicrob Chemother 57:306-11. 2006
  9. ncbi request reprint What's new in CF airway inflammation: an update
    Felix Ratjen
    Hospital for Sick Children, Toronto, Ontario, Canada
    Paediatr Respir Rev 7:S70-2. 2006
  10. doi request reprint Treatment of early Pseudomonas aeruginosa infection in patients with cystic fibrosis: the ELITE trial
    Felix Ratjen
    Division of Respiratory Medicine, Department of Pediatrics, University of Toronto, Hospital for Sick Children, 555 University Avenue, Toronto M5G 1X8, Ontario, Canada
    Thorax 65:286-91. 2010

Collaborators

Detail Information

Publications59

  1. pmc Multiple breath nitrogen washout: a feasible alternative to mass spectrometry
    Renee Jensen
    Division of Respiratory Medicine, Department of Pediatrics, The Hospital for Sick Children, University of Toronto, Toronto, Canada
    PLoS ONE 8:e56868. 2013
    ..Current evidence is based on a customized mass spectrometry system that uses sulfur hexafluoride (SF6) as a tracer gas, which is not widely available. Nitrogen (N2) washout may be better suited for clinical use and multi-center trials...
  2. pmc Effect of azithromycin on systemic markers of inflammation in patients with cystic fibrosis uninfected with Pseudomonas aeruginosa
    Felix Ratjen
    Division of Respiratory Medicine, Department of Pediatrics, SickKids Research Institute, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada
    Chest 142:1259-66. 2012
    ..We examined changes in systemic inflammatory markers in a doubleblind, randomized, controlled trial of oral azithromycin in patients 6-18 years of age with cystic fibrosis who were uninfected with Pseudomonas aeruginosa...
  3. ncbi request reprint Long term effects of denufosol tetrasodium in patients with cystic fibrosis
    Felix Ratjen
    Division of Respiratory Medicine, Department of Pediatrics, and Program in Physiology and Experimental Medicine, SickKids Research Institute, The Hospital for Sick Children, and University of Toronto, Toronto, Canada
    J Cyst Fibros 11:539-49. 2012
    ..Denufosol stimulates chloride secretion independent of the chloride channel which is dysfunctional in cystic fibrosis (CF) and therefore has the potential to benefit CF patients regardless of genotype...
  4. doi request reprint Cystic fibrosis: the role of the small airways
    Felix Ratjen
    Division of Respiratory Medicine, Department of Pediatrics, and Program in Physiology and Experimental Medicine, SickKids Research Institute, The Hospital for Sick Children, and University of Toronto, Toronto, Canada
    J Aerosol Med Pulm Drug Deliv 25:261-4. 2012
    ....
  5. ncbi request reprint New therapies in cystic fibrosis
    Felix Ratjen
    Division of Respiratory Medicine, Hospital for Sick Children, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada
    Curr Pharm Des 18:614-27. 2012
    ..The current status of these and other new developments in the treatment of cystic fibrosis are reviewed...
  6. pmc Sequential analysis of surfactant, lung function and inflammation in cystic fibrosis patients
    Matthias Griese
    Children s Hospital, University of Munich, Lindwurmstr 4, 80337 München, Germany
    Respir Res 6:133. 2005
    ..So far, longitudinal measurements of surfactant function in CF patients are lacking and it remains unclear how these alterations relate to the progression of airway inflammation as well as decline in pulmonary function over time...
  7. ncbi request reprint Treatment of early Pseudomonas aeruginosa infection in patients with cystic fibrosis
    Felix Ratjen
    Division of Respiratory Medicine, Hospital for Sick Children, Toronto, Ontario, Canada
    Curr Opin Pulm Med 12:428-32. 2006
    ..aeruginosa infection. There are also studies showing that early treatment can eradicate the organism in the majority of cases...
  8. ncbi request reprint Pharmacokinetics of inhaled colistin in patients with cystic fibrosis
    F Ratjen
    Children s Hospital, University of Duisburg Essen, Essen, Germany
    J Antimicrob Chemother 57:306-11. 2006
    ..Inhaled colistin is commonly used in patients with cystic fibrosis (CF), but only limited data are available to define its pharmacokinetic profile...
  9. ncbi request reprint What's new in CF airway inflammation: an update
    Felix Ratjen
    Hospital for Sick Children, Toronto, Ontario, Canada
    Paediatr Respir Rev 7:S70-2. 2006
    ....
  10. doi request reprint Treatment of early Pseudomonas aeruginosa infection in patients with cystic fibrosis: the ELITE trial
    Felix Ratjen
    Division of Respiratory Medicine, Department of Pediatrics, University of Toronto, Hospital for Sick Children, 555 University Avenue, Toronto M5G 1X8, Ontario, Canada
    Thorax 65:286-91. 2010
    ....
  11. ncbi request reprint Cystic fibrosis: pathogenesis and future treatment strategies
    Felix A Ratjen
    Division of Respiratory Medicine, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, Canada M5G 1X8
    Respir Care 54:595-605. 2009
    ..This review summarizes our current understanding of the pathophysiology and treatment of cystic fibrosis lung disease...
  12. ncbi request reprint Diagnosing and managing infection in CF
    Felix Ratjen
    Hospital for Sick Children, Toronto, Ontario, Canada
    Paediatr Respir Rev 7:S151-3. 2006
    ..In addition, the optimal duration of therapy type of inhaled antibiotic as well as the optimal dose has not been clarified. Studies are currently ongoing to resolve these issues...
  13. ncbi request reprint New pulmonary therapies for cystic fibrosis
    Felix Ratjen
    Division of Respiratory Medicine, Hospital for Sick Children, Toronto, Canada
    Curr Opin Pulm Med 13:541-6. 2007
    ..This review addresses recent therapeutic strategies that either target the underlying defect or early steps in cystic fibrosis pathophysiology...
  14. doi request reprint Recent advances in cystic fibrosis
    F Ratjen
    Hospital for Sick Children, Toronto, Ontario, Canada
    Paediatr Respir Rev 9:144-8. 2008
    ..The review specifically focuses on those developments that have direct implications for patient care or those in which clinical trials suggest benefits that may impact on the treatment of CF patients in the near future...
  15. pmc A pilot study to compare tobramycin 80 mg injectable preparation with 300 mg solution for inhalation in cystic fibrosis patients
    Wilfried H Nikolaizik
    Department of Pediatrics, University Hospital Essen, Essen, Germany
    Can Respir J 15:259-62. 2008
    ..However, to date no comparative data are available for different dose regimens used in clinical practice...
  16. ncbi request reprint Pilot study of safety and tolerability of inhaled hypertonic saline in infants with cystic fibrosis
    Padmaja Subbarao
    Division of Pediatric Respiratory Medicine, The Hospital for Sick Children, University of Toronto, Toronto, Canada
    Pediatr Pulmonol 42:471-6. 2007
    ..There was no difference in microbiologic yield between pre- and post-HS throat swabs. In this pilot study, inhalation of HS was well tolerated in CF infants. These results support a study of the efficacy of HS in this age group...
  17. doi request reprint The approach to Pseudomonas aeruginosa in cystic fibrosis
    Glenda N Bendiak
    Department of Pediatrics, Division of Respiratory Medicine, The Hospital for Sick Children, Toronto, Ontario, M5G 1X8, Canada
    Semin Respir Crit Care Med 30:587-95. 2009
    ..Nonantibiotic approaches to address P. aeruginosa infection are currently being developed and may expand the therapeutic repertoire in the future...
  18. ncbi request reprint beta2 adrenoceptor gene polymorphisms in cystic fibrosis lung disease
    Rainer Buscher
    Children s Hospital, University of Essen, Germany
    Pharmacogenetics 12:347-53. 2002
    ..These data provide the first evidence suggesting that polymorphisms of the beta2AR gene contribute to clinical severity and disease progression in cystic fibrosis...
  19. ncbi request reprint Cystic fibrosis: a review of pulmonary and nutritional therapies
    Reshma Amin
    Division of Respiratory Medicine, Department of Pediatrics, The Hospital for Sick Children, University of Toronto, 555 University Avenue, Toronto, ON, M5G 1X8, Canada
    Adv Pediatr 55:99-121. 2008
    ....
  20. ncbi request reprint Beta2-agonists for asthma: the pediatric perspective
    Padmaja Subbarao
    Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
    Clin Rev Allergy Immunol 31:209-18. 2006
    ..Finally, the potential detrimental effects of long- and short-acting beta-agonists in infants and children are discussed...
  21. doi request reprint The effect of chronic infection with Aspergillus fumigatus on lung function and hospitalization in patients with cystic fibrosis
    Reshma Amin
    Department of Respiratory Medicine, The Hospital for Sick Children, University of Toronto, 555 University Avenue, Toronto, ON M5G 1X8, Canada
    Chest 137:171-6. 2010
    ..Our aim was to determine the effect of persistent infection with A fumigatus on pulmonary exacerbations and lung function in children with CF...
  22. ncbi request reprint Inhaled L-arginine improves exhaled nitric oxide and pulmonary function in patients with cystic fibrosis
    Hartmut Grasemann
    The Hospital for Sick Children, Division of Respiratory Medicine, 555 University Ave, Toronto, ON, M5G 1X8 Canada
    Am J Respir Crit Care Med 174:208-12. 2006
    ..Nitric oxide formation is deficient in airways of patients with cystic fibrosis (CF). Since nitric oxide has bronchodilatory effects, nitric oxide deficiency may contribute to airway obstruction in CF...
  23. doi request reprint Stenotrophomonas maltophilia in cystic fibrosis: serologic response and effect on lung disease
    Valerie Waters
    Division of Infectious Diseases, Department of Pediatrics, Hospital for Sick Children, Toronto, ON, Canada
    Am J Respir Crit Care Med 183:635-40. 2011
    ..maltophilia infection on CF lung disease is unknown...
  24. ncbi request reprint MRI: the next frontier for cystic fibrosis clinicians?
    Reshma Amin
    Division of Respiratory Medicine, The Hospital for Sick Children, 555 University Avenue Toronto, ON M5G 1X8, Canada
    Expert Rev Respir Med 2:179-82. 2008
    ..MRI examinations were found to be comparable to CT scans and may, therefore, potentially be a useful imaging technology to evaluate lung disease in CF patients...
  25. ncbi request reprint Exhaled nitric oxide in children after accidental exposure to chlorine gas
    Hartmut Grasemann
    Children s Hospital, Department of Pediatrics, University of Duisburg Essen, Essen, Germany
    Inhal Toxicol 19:895-8. 2007
    ..No changes in exhaled nitric oxide were seen in asymptomatic children. These data suggest that acute chlorine gas exposure results in a mild increase of exhaled nitric oxide in symptomatic children...
  26. doi request reprint Hypertonic saline improves the LCI in paediatric patients with CF with normal lung function
    Reshma Amin
    Hospital for Sick Children, 555 University Avenue, Toronto Ontario M5G 1X8, Canada
    Thorax 65:379-83. 2010
    ..Clinical trial number NCT00635141...
  27. doi request reprint Rapid pulmonary delivery of inhaled tobramycin for Pseudomonas infection in cystic fibrosis: a pilot project
    Allan L Coates
    Division of Nuclear Medicine, Hospital for Sick Children Research Institute, University of Toronto, Toronto, Canada
    Pediatr Pulmonol 43:753-9. 2008
    ..Patients with cystic fibrosis spend as much 30 min a day inhaling tobramycin. Could a new rapid system deposit the equivalent amount of tobramycin faster?..
  28. doi request reprint Aminoglycoside therapy against Pseudomonas aeruginosa in cystic fibrosis: a review
    Felix Ratjen
    Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, Canada M5G1X8
    J Cyst Fibros 8:361-9. 2009
    ..An optimal treatment regimen for patients with CF with early or intermittent P. aeruginosa infections remains a high priority to maintain long-term lung health...
  29. ncbi request reprint Increased arginase activity in cystic fibrosis airways
    Hartmut Grasemann
    Children s Hospital, University of Duisburg Essen, Essen, Germany
    Am J Respir Crit Care Med 172:1523-8. 2005
    ..Airway nitric oxide concentrations are reduced in cystic fibrosis (CF). Arginases compete for L-arginine, the substrate of nitric oxide synthesis...
  30. ncbi request reprint Inhalation of Moli1901 in patients with cystic fibrosis
    Hartmut Grasemann
    The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, Canada
    Chest 131:1461-6. 2007
    ..Moli1901 stimulates an alternative chloride channel and may thus compensate for the CFTR deficiency in the airway epithelium of CF patients...
  31. ncbi request reprint A multicenter, randomized, double-blind, placebo-controlled trial to evaluate the metabolic and respiratory effects of growth hormone in children with cystic fibrosis
    Dirk Schnabel
    Department of Pediatric Endocrinology and Diabetology, Children s Hospital, Charite, Berlin, Germany
    Pediatrics 119:e1230-8. 2007
    ..This trial was designed as a multicenter, randomized, placebo-controlled, double-blind study to assess the efficacy and safety of 2 dosages of growth hormone in cystic fibrosis...
  32. ncbi request reprint Pharmacokinetic modelling of a once-daily dosing regimen for intravenous tobramycin in paediatric cystic fibrosis patients
    Wallace Lam
    Department of Pharmacy Services, Princess Margaret Hospital, University Health Network, Toronto, Ontario, Canada
    J Antimicrob Chemother 59:1135-40. 2007
    ..In addition, we aimed to assess whether certain patient characteristics affect tobramycin pharmacokinetics and, therefore, dosing...
  33. ncbi request reprint Pulmonary surfactant, lung function, and endobronchial inflammation in cystic fibrosis
    Matthias Griese
    Children s Hospital, University of Munich, Munich, Germany
    Am J Respir Crit Care Med 170:1000-5. 2004
    ....
  34. ncbi request reprint Early interventions in CF
    Felix Ratjen
    Department of Pediatrics, Children s Hospital, University of Essen, Germany
    Pediatr Pulmonol Suppl 26:88-90. 2004
  35. ncbi request reprint Cystic fibrosis
    Felix Ratjen
    Department of Paediatrics, University of Essen, Essen, Germany
    Lancet 361:681-9. 2003
    ..Here, we summarise advances in understanding and treatment of cystic fibrosis, focusing on pulmonary disease, which accounts for most morbidity and deaths...
  36. doi request reprint Plastic bronchitis as an unusual cause of mucus plugging in cystic fibrosis
    Dimas Mateos-Corral
    Division of Respiratory Medicine, Hospital for Sick Children, Toronto, Canada
    Pediatr Pulmonol 44:939-40. 2009
    ..Histological analysis and in-vitro testing of the cast were important factors in choosing the adequate therapy in this patient...
  37. ncbi request reprint Endothelial nitric oxide synthase variants in cystic fibrosis lung disease
    Hartmut Grasemann
    Children s Hospital, University of Essen, Essen, Germany
    Am J Respir Crit Care Med 167:390-4. 2003
    ..aeruginosa...
  38. doi request reprint Sputum induction in routine clinical care of children with cystic fibrosis
    Suhail Al-Saleh
    Division of Respiratory Medicine, Toronto, Ontario, Canada Research Institute, The Hospital for Sick Children, and the University of Toronto, Toronto, Ontario, Canada
    J Pediatr 157:1006-1011.e1. 2010
    ..To determine the microbiological yield of induced sputum (IS) samples compared with conventional airway samples, spontaneously expectorated sputum and throat swabs, in children with cystic fibrosis (CF) attending an outpatient clinic...
  39. ncbi request reprint Effects of sex and of gene variants in constitutive nitric oxide synthases on exhaled nitric oxide
    Hartmut Grasemann
    Department of Pediatrics, University of Essen, Germany
    Am J Respir Crit Care Med 167:1113-6. 2003
    ..These data suggest that variants in the neuronal nitric oxide synthase gene contribute to the variability of airway nitric oxide concentrations in healthy females...
  40. ncbi request reprint Multidrug-resistant organisms in cystic fibrosis: management and infection-control issues
    Valerie Waters
    Division of Infectious Diseases, The Hospital for Sick Children, 555 University Avenue, Toronto, ON, M5G 1X8 Canada
    Expert Rev Anti Infect Ther 4:807-19. 2006
    ..Until more is known about their pathogenicity and effect on clinical outcomes, physicians should be aware of the potential transmissibility of these organisms and implement adequate infection control strategies...
  41. pmc Symptomatic liver involvement in neonatal hereditary hemorrhagic telangiectasia
    Suhail Al-Saleh
    University of Toronto, Toronto, Ontario, Canada
    Pediatrics 127:e1615-20. 2011
    ..Early transcatheter embolization seems to be effective, but long-term outcomes still need to be assessed...
  42. doi request reprint Reliability and validity of the habitual activity estimation scale (HAES) in patients with cystic fibrosis
    Greg D Wells
    Division of Respiratory Medicine, The Hospital for Sick Children, Toronto, Ontario, Canada
    Pediatr Pulmonol 43:345-53. 2008
    ..The Habitual Activity Estimation Scale (HAES) questionnaire has been shown to be a feasible tool to measure physical activity however the reliability and validity have yet to be determined in the CF population...
  43. ncbi request reprint Dornase in non-CF
    Felix Ratjen
    Department of Pediatrics, Children s Hospital, University of Essen, Germany
    Pediatr Pulmonol Suppl 26:154-5. 2004
  44. doi request reprint Exercise and physical activity in children with cystic fibrosis
    Donna L Wilkes
    Division of Respiratory Medicine, The Hospital for Sick Children, Toronto, Ontario, Canada M5G 1X8
    Paediatr Respir Rev 10:105-9. 2009
    ....
  45. ncbi request reprint P2Y2 receptor polymorphisms and haplotypes in cystic fibrosis and their impact on Ca2+ influx
    Rainer Buscher
    Department of Pediatrics, University Children s Hospital, Hufelandstr 55, 45122 Essen, Germany
    Pharmacogenet Genomics 16:199-205. 2006
    ..We also assessed the impact of the genetic variants on Ca2+-influx of P2Y2-null cells transfected with several P2Y2 receptor haplotypes...
  46. doi request reprint Assessment of body composition in pediatric patients with cystic fibrosis
    Greg D Wells
    Physiology and Experimental Medicine, The Hospital for Sick Children, Toronto, Ontario, Canada
    Pediatr Pulmonol 43:1025-32. 2008
    ..Maintaining nutritional sufficiency is challenging for CF patients and therefore accurate monitoring is important for their clinical management...
  47. ncbi request reprint Nitrogen redox balance in the cystic fibrosis airway: effects of antipseudomonal therapy
    Benjamin Gaston
    Department of Pediatric Pulmonary Medicine, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
    Am J Respir Crit Care Med 165:387-90. 2002
    ..We speculate that normalization of airway nitrogen redox balance could contribute to the beneficial effects of antipseudomonal therapy on lung function in CF...
  48. ncbi request reprint Airway nitric oxide in Duchenne muscular dystrophy
    Volker Straub
    Children s Hospital, University of Essen, Germany
    J Pediatr 141:132-4. 2002
    ..02) or 17 adult male control subjects (18.5 +/- 1.8 parts per billion, P <.001). These findings provide indirect evidence that NOS1 contributes significantly to fractional exhaled nitric oxide in healthy children...
  49. ncbi request reprint Reduced lung function in cystic fibrosis: a primary or secondary phenotype?
    Stephanie D Davis
    Am J Respir Crit Care Med 178:2-3. 2008
  50. ncbi request reprint Restoring airway surface liquid in cystic fibrosis
    Felix Ratjen
    N Engl J Med 354:291-3. 2006
  51. ncbi request reprint Improvement of alveolar glutathione and lung function but not oxidative state in cystic fibrosis
    Matthias Griese
    Department of Pediatric Ludwig Maximilians University, Munich, Germany
    Am J Respir Crit Care Med 169:822-8. 2004
    ..Reversion of markers of oxidative injury may need longer treatment, higher doses, or different types of antioxidants...
  52. ncbi request reprint Diagnostic value of serum antibodies in early Pseudomonas aeruginosa infection in cystic fibrosis patients
    Felix Ratjen
    Division of Respiratory Medicine Hospital for Sick Children, Canada
    Pediatr Pulmonol 42:249-55. 2007
    ..However, because variability between patients is considerable, treatment decisions should not be based on P. aeruginosa antibody levels alone...
  53. ncbi request reprint Effect of treatment with dornase alpha on airway inflammation in patients with cystic fibrosis
    Karl Paul
    Department of Pediatric Pneumology and Immunology, Charite, Germany
    Am J Respir Crit Care Med 169:719-25. 2004
    ..We conclude that in patients with CF, an increase in neutrophilic airway inflammation is found that is positively influenced by rhDNase treatment...
  54. ncbi request reprint Mucolytics in cystic fibrosis
    Markus O Henke
    Department of Pulmonary Medicine, Philipps University Marburg, 35043 Marburg, Germany
    Paediatr Respir Rev 8:24-9. 2007
    ..Ultimately, drugs that are mucokinetic, which preserve viscoelasticity, rather than mucolytic may prove to be beneficial for CF lung disease in the future...
  55. pmc Nasal Staphylococcus aureus carriage is not a risk factor for lower-airway infection in young cystic fibrosis patients
    Sabine Ridder-Schaphorn
    Institute of Medical Microbiology, University of Muenster Hospital, Domagkstr 10, 48149 Muenster, Germany
    J Clin Microbiol 45:2979-84. 2007
    ..In CF patients, the oropharynx, and not the nose, was the predominant site of S. aureus infection and persistence. Hence, it is unlikely that CF patients will benefit from topical treatment strategies to eradicate nasal carriage...
  56. ncbi request reprint Gender-specific disease modification by NOS3
    Hartmut Grasemann
    Br J Haematol 126:160; author reply 161. 2004
  57. ncbi request reprint Bronchoalveolar lavage protein patterns in children with malignancies, immunosuppression, fever and pulmonary infiltrates
    Manfred Neumann
    Kinderklinik and Kinderpoliklinik im Dr von Haunerschen Kinderspital, Ludwig Maximilians University, Munich, Germany
    Proteomics 2:683-9. 2002
    ..Future target regions of interest were identified. Sample prefractionation and the selection of suitable narrow isoelectric point ranges will be necessary for optimized detection and separating conditions...
  58. ncbi request reprint Influence of interleukin-10 on Aspergillus fumigatus infection in patients with cystic fibrosis
    Jacques Brouard
    Inserm E213, Armand Trousseau Hospital, Paris, and the Department of Pediatrics, Georges Clemenceau Hospital, Caen, France
    J Infect Dis 191:1988-91. 2005
    ..fumigatus. These results suggest that polymorphisms in the promoter region of the IL-10 gene may influence the host response to A. fumigatus in the context of CF...
  59. ncbi request reprint Human adenosine 2B receptor: SNP discovery and evaluation of expression in patients with cystic fibrosis
    Chih Min Tang
    Department of Pharmacology, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0636, USA
    Pharmacogenet Genomics 15:321-7. 2005
    ..Using PCR and restriction fragment length polymorphism (RFLP) analysis, we assessed 53 American subjects of mixed ethnicity, 64 European Caucasian control subjects and 148 Caucasian patients with CF for A2B SNPs...