Affiliation: The Hospital for Sick Children
- Diagnosis and management of morphea and lichen sclerosus and atrophicus in childrenElena Pope
Section of Dermatology, Department of Paediatrics, The Hospital for Sick Children, University of Toronto, 555 University Avenue, Toronto, ON M5G 1X8, Canada Electronic address
Pediatr Clin North Am 61:309-19. 2014..Although localized scleroderma has a good prognosis, some clinical subtypes can be deforming and irreversibly disabling, especially when affecting the extremities or the face. ..
- A consensus approach to wound care in epidermolysis bullosaElena Pope
Section of Dermatology, Department of Pediatrics, Hospital for Sick Children and University of Toronto, Toronto, Ontario, Canada
J Am Acad Dermatol 67:904-17. 2012..Wound care is the cornerstone of treatment for patients with epidermolysis bullosa (EB); however, there are currently no guidelines to help practitioners care for these patients...
- Topical imiquimod 5% cream for pediatric plaque morphea: a prospective, multiple-baseline, open-label pilot studyElena Pope
Section of Dermatology, The Hospital for Sick Children, University of Toronto, Toronto, Ont, Canada
Dermatology 223:363-9. 2011..Therapeutic options for the treatment of plaque morphea are limited. We explored the efficacy and safety of imiquimod cream in children with plaque morphea...
- Brain cavernomas associated with en coup de sabre linear scleroderma: Two case reportsEmily T Fain
Department of Pediatrics, Division of Rheumatology, University of Alabama at Birmingham, Birmingham, AL, USA
Pediatr Rheumatol Online J 9:18. 2011..Consideration of neuroimaging studies to disclose abnormal findings in patients with linear scleroderma en coup de sabre is important for potentially preventing and treating neurological manifestations associated with this condition...
- Epidermolysis bullosa care in CanadaElena Pope
The Hospital for Sick Children, Toronto, ON, Canada
Dermatol Clin 28:391-2, xiii. 2010..There are specific challenges faced by patients and families as well as the practitioners looking after patients with EB...
- Mycosis fungoides in the pediatric population: report from an international Childhood Registry of Cutaneous LymphomaElena Pope
Section of Dermatology, The Hospital for Sick Children, Toronto, ON, Canada
J Cutan Med Surg 14:1-6. 2010..There are limited data on the clinical presentation and progression of pediatric cutaneous lymphoma. This study focuses on the clinical characteristics of pediatric patients with mycosis fungoides (MF)...
- Childhood acquired lipodystrophy: a retrospective studyElena Pope
Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
J Am Acad Dermatol 55:947-50. 2006..We sought to describe the clinical characteristics and complications of children with acquired lipodystrophy (LD)...
- Oral versus high-dose pulse corticosteroids for problematic infantile hemangiomas: a randomized, controlled trialElena Pope
University of Toronto, Section of Dermatology, Hospital for Sick Children, 555 University Ave, Toronto, Ontario, Canada M5G 1X8
Pediatrics 119:e1239-47. 2007..We aimed to determine whether systemic steroids are efficacious in proliferating hemangioma and to compare the efficacy and safety of 2 corticosteroid treatment modalities...
- Epidermolysis bullosa and chronic wounds: a model for wound bed preparation of fragile skinElena Pope
Section of Dermatology, The Hospital for Sick Children, and University of Toronto, Toronto, Ontario, Canada
Adv Skin Wound Care 26:177-88; quiz 189-90. 2013..8% of whom reported having 11 or more years' experience with EB care). Inclusion of recommendations was contingent on 80% agreement from reviewers...
- Propranolol in the management of infantile hemangiomas: clinical response and predictorsAlexandra Balma-Mena
Pediatric Dermatology, The Hospital for Sick Children, Toronto, ON
J Cutan Med Surg 16:169-73. 2012..Recent data suggest that propranolol is an effective treatment for infantile hemangiomas (IHs). Data on the optimal dose, duration of therapy, and predictors of response are currently lacking...
- Colonization with community-acquired methicillin-resistant Staphylococcus aureus in children with atopic dermatitis: a cross-sectional studyAlexandra Balma-Mena
Division of Pediatric Dermatology, Department of Pediatrics, Hospital for Sick Children, Toronto, ON, Canada
Int J Dermatol 50:682-8. 2011..Bacterial infection with Staphylococcus aureus is a common complication of atopic dermatitis (AD). The incidence of community-acquired methicillin-resistant S. aureus infection (MRSA) in the AD population is unknown...
- New insights into pustular dermatoses in pediatric patientsClaudia J Posso-De Los Rios
Pediatric Dermatology, Department of Pediatrics, Hospital for Sick Children and University of Toronto, Toronto, Ontario, Canada
J Am Acad Dermatol 70:767-73. 2014..Although these conditions are rare, awareness of them should facilitate early recognition, faster evaluation (including genetic testing, if appropriate), and adequate treatment. ..
- Principles of wound care in patients with epidermolysis bullosaIrene Lara-Corrales
Department of Dermatology, Hospital for Sick Children, Toronto, Ontario, Canada
Pediatr Dermatol 27:229-37. 2010....
- Timolol maleate 0.5% or 0.1% gel-forming solution for infantile hemangiomas: a retrospective, multicenter, cohort studyAjith Chakkittakandiyil
Department of Dermatology, Hospital for Sick Children, Toronto, Canada
Pediatr Dermatol 29:28-31. 2012..04). Sleeping disturbance was noted in one patient. This study further demonstrates the efficacy and tolerability of topical timolol maleate and gradual improvement with longer treatment in patients with superficial IH...
- The efficacy of trimethoprim in wound healing of patients with epidermolysis bullosa: a feasibility trialIrene Lara-Corrales
Hospital for Sick Children, Toronto, Ontario, Canada
J Am Acad Dermatol 66:264-70. 2012..There are no systemic therapies known to facilitate wound healing in patients with recessive dystrophic epidermolysis bullosa (RDEB)...
- Dilated cardiomyopathy in epidermolysis bullosa: a retrospective, multicenter studyIrene Lara-Corrales
Hospital for Sick Children Toronto, Toronto, Ontario, Canada
Pediatr Dermatol 27:238-43. 2010..This study substantiates the association between DC and EB. Currently, there is no single risk factor identified in EB patients that leads to DC. Further prospective studies are needed...
- Development of a disease severity score for newborns with collodion membraneGustavo A Rubio-Gomez
Section of Dermatology, Hospital for Sick Children, and University of Toronto, Toronto, Ontario, Canada
J Am Acad Dermatol 70:506-11. 2014..Collodion membrane in the neonate may be the initial presentation of a number of different conditions. There is a lack of data correlating the extent of clinical involvement to the underlying disease and prognosis...
- Predisposing factors and outcomes of malignant skin tumors in childrenCypel Tatiana K S
Department of Surgery, Division of Plastic Surgery, University of Toronto, Canada
Plast Reconstr Surg 126:508-14. 2010..In this study, the authors aimed to determine the incidence, risk factors, treatment, reconstruction details, and outcome of malignant skin tumors occurring in pediatric patients at the Hospital for Sick Children...
- Retrospective review of relapse after systemic cyclosporine in children with atopic dermatitisCathryn Sibbald
Department of Dermatology, University of Toronto, Toronto, Ontario, Canada
Pediatr Dermatol 32:36-40. 2015..These results suggest that a longer duration of low-dose cyclosporine may help decrease the risk of relapse in patients with severe AD who are resistant to topical therapies...
- Amniotic membrane grafting in patients with epidermolysis bullosa with chronic woundsVenetia Lo
Division of Pediatric Medicine, Hospital for Sick Children, Toronto, Ontario, Canada
J Am Acad Dermatol 62:1038-44. 2010..Severe forms of epidermolysis bullosa (EB) are characterized by chronic, nonhealing wounds...
- Eczema herpeticum in children: clinical features and factors predictive of hospitalizationNadia Jennifer Chiara Luca
Division of Pediatrics, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
J Pediatr 161:671-5. 2012..To describe the clinical characteristics of pediatric patients with eczema herpeticum and to determine the predictors of hospitalization, and recurrence and repeat episodes...
- Topical imiquimod in the treatment of infantile hemangiomas: a retrospective studyNhung T C Ho
Department of Pediatrics, Section of Dermatology, The Hospital for Sick Children, Faculty of Medicine, University of Toronto, Ontario, M5G 1X8, Canada
J Am Acad Dermatol 56:63-8. 2007....
- Dermatological complications of continuous subcutaneous insulin infusion in children and adolescentsLouise S Conwell
Division of Endocrinology, Department of Pediatrics, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
J Pediatr 152:622-8. 2008..To assess their association with duration of CSII, age, adiposity, HbA1(c), insulin dose, insulin brand, infusion set or site...
- Identification of major clonal complexes and toxin producing strains among Staphylococcus aureus associated with atopic dermatitisMelinda Yeung
Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario M5S1A8, Canada
Microbes Infect 13:189-97. 2011..CC1 harbored the only CA-MRSA that was identified, and was a source of isolates that expressed both seb and sec, and closely resembled the USA400 strain of CA-MRSA...
- Trichodysplasia spinulosa--a rare complication in immunosuppressed patientsAgnes Schwieger-Briel
Department of Pediatrics, Hospital for Sick Children, Toronto, ON, Canada
Pediatr Dermatol 27:509-13. 2010..Treatment trials included reduction of immunosuppression combined with topical and oral retinoids, topical acyclovir, and oral valganciclovir with limited success...
- Autoimmune blistering diseases in childrenIrene Lara-Corrales
Department of Pediatrics, University of Toronto, Hospital for Sick Children, Toronto, Canada
Semin Cutan Med Surg 29:85-91. 2010..In addition, prompt recognition and treatment avoids unnecessary morbidity and improves ultimate outcome...
- Vincristine for successful treatment of steroid-dependent infantile hemangiomasJonathan D Wasserman
Divisions of Endocrinology, Department of Pediatrics, University of Toronto, Toronto, Ontario, Canada
Pediatrics 135:e1501-5. 2015..It also stresses the importance of close anthropometric monitoring of infants and toddlers receiving glucocorticoid therapy and intervention when growth compromise becomes evident. ..
- Infrared thermography to assess proliferation and involution of infantile hemangiomas: a prospective cohort studyJaved Ayoub Mohammed
Department of Pediatrics, Children s Hospital at London Health Science Centre, University of Western Ontario, London, Ontario, Canada
JAMA Dermatol 150:964-9. 2014..Infantile hemangiomas (IHs) are common benign tumors of infancy that have the potential to interfere with vital organ function and cause permanent disfigurement. Currently, few objective and validated measures exist to assess IHs...
- A systematic review of systemic medications for pustular psoriasis in pediatricsClaudia J Posso-De Los Rios
Section of Dermatology, Department of Pediatrics, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
Pediatr Dermatol 31:430-9. 2014..Furthermore, physicians may encounter difficulties after discontinuing or tapering medications. ..
- Primitive myxoid mesenchymal tumor of infancy in a preterm infantJoseph Lam
Department of Pediatrics, Department of Dermatology, University of British Columbia, Vancouver, British Columbia, Canada
Pediatr Dermatol 27:635-7. 2010..We present the case and clinical course of a preterm boy with a primitive myxoid mesenchymal tumor of infancy that occurred following excision of a congenital juvenile xanthogranuloma...
- Kaposiform hemangioendothelioma presenting antenatally with a pericardial effusionMark A Walsh
Department of Pediatrics, Hospital for Sick Children, University of Toronto School of Medicine, Toronto, Canada
J Pediatr Hematol Oncol 30:761-3. 2008..Diagnosis was made of Kaposiform hemangioendothelioma surrounding the base of the heart, trachea, and esophagus as well as Kasabach-Merritt phenomenon. The infant responded well to treatment with vincristine and prednisone...
- Vincristine and corticosteroids as first-line treatment of Kasabach-Merritt syndrome in kaposiform hemangioendotheliomaAaron M Drucker
Department of Paediatrics and Paediatric Dermatology, The Hospital for Sick Children, University of Toronto, Toronto, ON
J Cutan Med Surg 13:155-9. 2009..Recently, there have been increasing reports of the use of the chemotherapeutic drug vincristine in these patients...
- Dilated cardiomyopathy in epidermolysis bullosaIrene Lara-Corrales
The Hospital for Sick Children, Toronto, ON, Canada
Dermatol Clin 28:347-51, xi. 2010..Early detection allows for medical treatment that delays clinical progression and prolongs survival...
- Pediatric psychocutaneous disorders: a review of primary psychiatric disorders with dermatologic manifestationsKhalid Al Hawsawi
Section of Dermatology, The Hospital for Sick Children, University of Toronto, Ontario, Canada
Am J Clin Dermatol 12:247-57. 2011..The choice of psychopharmacologic agent depends on the nature of the underlying psychopathology (e.g. anxiety, depression, obsessive-compulsive disorder, psychosis). This article reviews the spectrum of PPDDM in children...
- Percutaneous interventional radiology procedures in patients with epidermolysis bullosa: modifications and challengesErtugrul Mavili
Department of Diagnostic Imaging, Image Guided Therapy Centre, The Hospital for Sick Children, Toronto, ON, Canada
AJR Am J Roentgenol 195:468-75. 2010..The purpose of this study is to describe the role of interventional radiology in palliation and maintenance of nutritional support in children with epidermolysis bullosa, with a focus on safety and required procedural modifications...
- Epidermolysis bullosa pruriginosa: a systematic review exploring genotype-phenotype correlationWhan B Kim
Michael G DeGroote School of Medicine, McMaster University, 1280 Main St W, Hamilton, ON, L8S 4L8, Canada
Am J Clin Dermatol 16:81-7. 2015..These clinical findings have been attributed to various mutations in the COL7A1 gene. Previous reports have yielded inconsistent findings regarding a possible genotype-phenotype relationship in EBP...
- Childhood mycosis fungoides: experience of 28 patients and response to phototherapyPhilip M Laws
Department of Medicine, University of Toronto, Toronto, Ontario, Canada
Pediatr Dermatol 31:459-64. 2014..The majority of patients in our cohort had hypopigmented MF. Phototherapy offers an effective option for treatment of childhood MF, although the period of remission may be greater in patients treated with PUVA. ..
- Infliximab-induced psoriasis and psoriasiform skin lesions in pediatric Crohn disease and a potential association with IL-23 receptor polymorphismsMary E Sherlock
Division of Gastroenterology, and Nutrition, McMaster Children s Hospital, Hamilton, Ontario, Canada
J Pediatr Gastroenterol Nutr 56:512-8. 2013..Paradoxically, there have been numerous reports of new-onset psoriasis following tumor necrosis factor-α antagonist therapy in adult patients with inflammatory bowel disease, but pediatric data are sparse...
- A child with autoimmune polyendocrinopathy candidiasis and ectodermal dysplasia treated with immunosuppression: a case reportClodagh S O'Gorman
Divisions of Endocrinology, The Hospital for Sick Children, Toronto, Canada
J Med Case Rep 7:44. 2013....
- Finasteride for the treatment of hidradenitis suppurativa in children and adolescentsHarkamal Kaur Randhawa
Hospital for Sick Children, 555 University Ave, Toronto, ON M5G 1X8, Canada
JAMA Dermatol 149:732-5. 2013..Patients typically present at puberty with tender subcutaneous nodules that can progress to dermal abscess formation. Antiandrogens have been used in the treatment of HS, and studies have primarily focused on adult patients...
- En coup de sabre scleroderma and Parry-Romberg syndrome in adolescents: surgical options and patient-related outcomesMaria Lourdes H Palmero
Section of Dermatology, Division of Paediatric Medicine, Hospital for Sick Children, Toronto, Ontario, Canada
J Rheumatol 37:2174-9. 2010..We evaluated the surgical outcomes of procedures performed for linear scleroderma of the face in the pediatric age group; and assessed psychosocial effects of surgical interventions on the affected children...
- Sporotrichoid aspergillosis in an immunocompromised child: a case report and review of the literatureMaria Lourdes Palmero
Section of Dermatology, Division of Paediatric Medicine, Hospital for Sick Children, Toronto, Ontario, Canada
Pediatr Dermatol 26:592-6. 2009..Early diagnosis and management of primary cutaneous aspergillosis prevents invasive aspergillosis, minimizing morbidity and mortality in the immunocompromised patients...
- Eruptive pyogenic granulomas developing after drug hypersensitivity reactionMaria Lourdes Palmero
Section of Dermatology, Division of Pediatric Medicine, Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada
J Am Acad Dermatol 60:855-7. 2009..We present a patient with disseminated pyogenic granulomas occurring after a drug hypersensitivity reaction, and address possible pathogenic factors related to their formation...
- Recurrence and outcomes of Stevens-Johnson syndrome and toxic epidermal necrolysis in childrenYaron Finkelstein
Department of Pediatrics, Divisions of Emergency Medicine, Hospital for Sick Children, Toronto, Ontario, Canada
Pediatrics 128:723-8. 2011..To report clinical course, etiology, management, and long-term outcomes of children suffering from Stevens-Johnson syndrome (SJS) or toxic epidermal necrolysis (TEN)...
- Yellow nail syndromeKhalid Al Hawsawi
Section of Dermatology, Hospital for Sick Children, Toronto, Ontario, Canada
Pediatr Dermatol 27:675-6. 2010..We report an 8-year-old girl with this syndrome who showed improvement with Fluconazole, 200 mg once weekly and vitamin E, 1000 IU once daily...
- Multifocal lymphangioendotheliomatosis with thrombocytopeniaJensen Yeung
Department of Dermatology, University of Toronto, Canada
J Am Acad Dermatol 54:S214-7. 2006..Histopathologic and immunohistochemical studies of vascular lesions demonstrate a lymphatic endothelial cell origin. Treatment often is not satisfactory. We herein describe a 4-week-old infant with this uncommon clinicopathologic entity...
- A comparison of disease severity among affected male versus female patients with PHACE syndromeDenise W Metry
Department of Dermatology at Baylor College of Medicine, Houston, Texas, USA
J Am Acad Dermatol 58:81-7. 2008....
- Pancreatic panniculitis in a 4-year-old child with nephrotic syndromePitiporn Suwattee
Department of Dermatology, University of Minnesota, Minneapolis, Minnesota, USA
Pediatr Dermatol 24:659-60. 2007..Pancreatic panniculitis is an uncommon disorder with a distinctive histopathology. We report the youngest patient with pancreatic panniculitis caused by hypertriglyceridemia in association with nephrotic syndrome...