Irena Nulman

Summary

Affiliation: The Hospital for Sick Children
Country: Canada

Publications

  1. ncbi request reprint Long-term neurodevelopment of children exposed to maternal nausea and vomiting of pregnancy and diclectin
    Irena Nulman
    Department of Clinical Pharmacology, Hospital for Sick Children, Toronto, Ontario, Canada
    J Pediatr 155:45-50, 50.e1-2. 2009
  2. doi request reprint Neurodevelopment of children following prenatal exposure to venlafaxine, selective serotonin reuptake inhibitors, or untreated maternal depression
    Irena Nulman
    Motherisk Program, Division of Clinical Pharmacology and Toxicology, Hospital for Sick Children, University of Toronto, Canada
    Am J Psychiatry 169:1165-74. 2012
  3. doi request reprint Long-term neurodevelopment of children exposed in utero to ciclosporin after maternal renal transplant
    Irena Nulman
    The Motherisk Program, Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada
    Paediatr Drugs 12:113-22. 2010
  4. doi request reprint Heavy in utero ethanol exposure is associated with the use of other drugs of abuse in a high-risk population
    Sarit Shor
    Motherisk Program, Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, Canada M5G 1X8
    Alcohol 44:623-7. 2010
  5. ncbi request reprint Universal screening for prenatal alcohol exposure: a progress report of a pilot study in the region of Grey Bruce, Ontario
    Irene Zelner
    Division of Clinical Pharmacology and Toxicology, The Hospital for Sick Children, Toronto, Ontario, Canada
    Ther Drug Monit 32:305-10. 2010
  6. ncbi request reprint Development of Canadian screening tools for fetal alcohol spectrum disorder
    Y Ingrid Goh
    The Motherisk Program, Division of Clinical Pharmacology and Toxicology, The Hospital for Sick Children, Toronto, Ontario
    Can J Clin Pharmacol 15:e344-66. 2008
  7. ncbi request reprint Neurocognitive development of children following in-utero exposure to labetalol for maternal hypertension: a cohort study using a prospectively collected database
    Wee Shian Chan
    Department of Medicine, Women s College Hospital, Toronto, Ontario, Canada
    Hypertens Pregnancy 29:271-83. 2010
  8. ncbi request reprint Effects of aspirin consumption during pregnancy on pregnancy outcomes: meta-analysis
    Eran Kozer
    Department of Paediatrics, The Motherisk Program, Division of Clinical Pharmacology and Toxicology, The Hospital for Sick Children, and University of Toronto, Toronto, Ontario, Canada
    Birth Defects Res B Dev Reprod Toxicol 68:70-84. 2003
  9. ncbi request reprint Both parental psychopathology and prenatal maternal alcohol dependency can predict the behavioral phenotype in children
    Arthur Staroselsky
    Division of Clinical Pharmacology, Motherisk Program, The Hospital for Sick Children, Ontario, Canada
    Paediatr Drugs 11:22-5. 2009
  10. ncbi request reprint Towards identifying a characteristic neuropsychological profile for fetal alcohol spectrum disorders. 2. Specific caregiver-and teacher-rating
    Sara A Stevens
    Division of Clinical Pharmacology Toxicology, Department of Pediatrics, The Hospital for Sick Children, University of Toronto, Canada
    J Popul Ther Clin Pharmacol 20:e53-62. 2013

Collaborators

Detail Information

Publications29

  1. ncbi request reprint Long-term neurodevelopment of children exposed to maternal nausea and vomiting of pregnancy and diclectin
    Irena Nulman
    Department of Clinical Pharmacology, Hospital for Sick Children, Toronto, Ontario, Canada
    J Pediatr 155:45-50, 50.e1-2. 2009
    ..To determine the effects of nausea and vomiting of pregnancy (NVP) and its treatment with diclectin on child neurodevelopment...
  2. doi request reprint Neurodevelopment of children following prenatal exposure to venlafaxine, selective serotonin reuptake inhibitors, or untreated maternal depression
    Irena Nulman
    Motherisk Program, Division of Clinical Pharmacology and Toxicology, Hospital for Sick Children, University of Toronto, Canada
    Am J Psychiatry 169:1165-74. 2012
    ..The authors compared the effects of prenatal exposure to venlafaxine (serotonin-norepinephrine reuptake inhibitor), selective serotonin reuptake inhibitors (SSRIs), and maternal depression...
  3. doi request reprint Long-term neurodevelopment of children exposed in utero to ciclosporin after maternal renal transplant
    Irena Nulman
    The Motherisk Program, Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada
    Paediatr Drugs 12:113-22. 2010
    ..Immunosuppressant therapy is essential in the prevention of organ transplant rejection...
  4. doi request reprint Heavy in utero ethanol exposure is associated with the use of other drugs of abuse in a high-risk population
    Sarit Shor
    Motherisk Program, Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, Canada M5G 1X8
    Alcohol 44:623-7. 2010
    ....
  5. ncbi request reprint Universal screening for prenatal alcohol exposure: a progress report of a pilot study in the region of Grey Bruce, Ontario
    Irene Zelner
    Division of Clinical Pharmacology and Toxicology, The Hospital for Sick Children, Toronto, Ontario, Canada
    Ther Drug Monit 32:305-10. 2010
    ....
  6. ncbi request reprint Development of Canadian screening tools for fetal alcohol spectrum disorder
    Y Ingrid Goh
    The Motherisk Program, Division of Clinical Pharmacology and Toxicology, The Hospital for Sick Children, Toronto, Ontario
    Can J Clin Pharmacol 15:e344-66. 2008
    ..Screening for FASD may facilitate diagnosis and hence management of these children. We present a variety of screening tools for the identification of children at risk for FASD...
  7. ncbi request reprint Neurocognitive development of children following in-utero exposure to labetalol for maternal hypertension: a cohort study using a prospectively collected database
    Wee Shian Chan
    Department of Medicine, Women s College Hospital, Toronto, Ontario, Canada
    Hypertens Pregnancy 29:271-83. 2010
    ..To identify the effect of prenatal labetalol exposure on children's long-term neurodevelopment...
  8. ncbi request reprint Effects of aspirin consumption during pregnancy on pregnancy outcomes: meta-analysis
    Eran Kozer
    Department of Paediatrics, The Motherisk Program, Division of Clinical Pharmacology and Toxicology, The Hospital for Sick Children, and University of Toronto, Toronto, Ontario, Canada
    Birth Defects Res B Dev Reprod Toxicol 68:70-84. 2003
    ..We assessed the effects and safety of aspirin treatment during pregnancy on fetal and neonatal outcomes...
  9. ncbi request reprint Both parental psychopathology and prenatal maternal alcohol dependency can predict the behavioral phenotype in children
    Arthur Staroselsky
    Division of Clinical Pharmacology, Motherisk Program, The Hospital for Sick Children, Ontario, Canada
    Paediatr Drugs 11:22-5. 2009
    ..To identify whether a child's behavior phenotype can be predicted by parental psychopathology and/or prenatal maternal alcohol dependency by using the Child Behavior List (CBCL) as a screening tool...
  10. ncbi request reprint Towards identifying a characteristic neuropsychological profile for fetal alcohol spectrum disorders. 2. Specific caregiver-and teacher-rating
    Sara A Stevens
    Division of Clinical Pharmacology Toxicology, Department of Pediatrics, The Hospital for Sick Children, University of Toronto, Canada
    J Popul Ther Clin Pharmacol 20:e53-62. 2013
    ..This study compares the behavioral profile of children with fetal alcohol spectrum disorder (FASD) who were diagnosed using the Canadian Guidelines with children with prenatal alcohol exposure who did not meet criteria for a FASD diagnosis...
  11. ncbi request reprint Hearing in children with fetal alcohol spectrum disorder (FASD)
    Raanan Cohen-Kerem
    Division of Clinical Pharmacology and Toxicology, Motherisk Program, Department of Pediatrics, Hospital for Sick Children, Toronto, Canada
    Can J Clin Pharmacol 14:e307-12. 2007
    ..Although not listed as a major part of the fetal alcohol spectrum disorder (FASD), different texts list hearing loss as a characteristic of the FASD, based on several small studies...
  12. ncbi request reprint Pharmacokinetic comparison of a delayed-release combination of doxylamine succinate and pyridoxine hydrocholoride (Diclectin) and oral solutions of these drugs in healthy women of childbearing age
    Irena Nulman
    The Motherisk Program, Division of Clinical Pharmacology and Toxicology, The Hospital for Sick Children, Toronto, Canada
    Can J Clin Pharmacol 16:e400-6. 2009
    ..The drug is widely used today in Canada (Diclectin). The pharmacokinetics of Diclectin has never been described in humans...
  13. ncbi request reprint Towards identifying a characteristic neuropsychological profile for fetal alcohol spectrum disorders. 1. Analysis of the Motherisk FASD clinic
    Kelly Nash
    The Motherisk Program, Department of Pediatrics, The Hospital for Sick Children, Toronto, Ontario, Canada
    J Popul Ther Clin Pharmacol 20:e44-52. 2013
    ..We compared groups on domains of intellectual functioning, memory, attention, executive functioning, motor functioning, language/communication and achievement...
  14. ncbi request reprint Social problem solving in children with fetal alcohol spectrum disorders
    Sara A Stevens
    Department of Psychology, University of Toronto, and Neuroscience and Mental Health Program, The Hospital for Sick Children, Toronto
    J Popul Ther Clin Pharmacol 19:e99-110. 2012
    ..However, the factors underlying these impairments are poorly understood. Recent evidence has shown that social problem solving is a critical component of effective social functioning...
  15. ncbi request reprint Malformation rates in children of women with untreated epilepsy: a meta-analysis
    Shawn Fried
    University of Toronto, Toronto, Ontario, Canada
    Drug Saf 27:197-202. 2004
    ..It is widely quoted that women with epilepsy have a higher than baseline risk for giving birth to a child with malformations, independent of the effects of antiepileptic drugs...
  16. ncbi request reprint Diagnostic radiation in pregnancy: perception versus true risks
    Raanan Cohen-Kerem
    Motherisk Program, Division of Clinical Pharmacology and Toxicology, Department of Pediatrics, The Hospital for Sick Children, Toronto, Ontario
    J Obstet Gynaecol Can 28:43-8. 2006
    ..However, available data suggest that current diagnostic radiation procedures are not teratogenic...
  17. pmc Age and CYP3A5 genotype affect tacrolimus dosing requirements after transplant in pediatric heart recipients
    Violette Gijsen
    Intensive Care and Department of Pediatric Surgery, Erasmus MC Sophia Children s Hospital, Rotterdam, The Netherlands
    J Heart Lung Transplant 30:1352-9. 2011
    ..Limited data are available on the interaction of age, CYP3A5 and ABCB1 genotype, and disease severity on the variation in disposition and outcome in pediatric heart transplant recipients...
  18. pmc Major malformations with valproic acid
    Gideon Koren
    Motherisk Team, Hospital for Sick Children, Toronto
    Can Fam Physician 52:441-2, 444, 447. 2006
    ..77 when compared with risk in the general population. There is compelling evidence that the risk is dose dependent. The risks appear to begin increasing at doses of 600 mg/d and to become more prominent at doses above 1000 mg/d...
  19. ncbi request reprint Managing fetal alcohol spectrum disorder in the public school system: a needs assessment pilot
    Gal I Koren
    Hospital for Sick Children, Motherisk Program, Toronto, Canada
    Can J Clin Pharmacol 17:e79-89. 2010
    ..Documentation of school experiences associated with FASDs is needed to aid in developing appropriate and efficient intervention models for FASDs...
  20. doi request reprint Pediatric cancer rates after universal folic acid flour fortification in Ontario
    Sandy G Grupp
    Institute of Medical Science, University of Toronto, Hospital for Sick Children, Toronto, Canada
    J Clin Pharmacol 51:60-5. 2011
    ..This corroborates a recent case-control study from Germany. These data may also provide some reassurance that universal flour fortification does not heighten the risk of pediatric cancer...
  21. ncbi request reprint Aspirin consumption during the first trimester of pregnancy and congenital anomalies: a meta-analysis
    Eran Kozer
    Motherisk Program, Division of Clinical Pharmacology and Toxicology, Hospital for Sick Children, Toronto, Onatario, Canada
    Am J Obstet Gynecol 187:1623-30. 2002
    ..The purpose of this study was to determine, on the basis of published reports, whether aspirin use during the first trimester of pregnancy is associated with an increased risk of congenital malformations...
  22. doi request reprint P450 oxidoreductase *28 (POR*28) and tacrolimus disposition in pediatric kidney transplant recipients--a pilot study
    Violette M G J Gijsen
    Intensive Care and Department of Pediatric Surgery, Erasmus MC Sophia Children s Hospital, Rotterdam, the Netherlands Division of Clinical Pharmacology and Toxicology, The Hospital for Sick Children, Toronto, ON, Canada Department of Clinical Chemistry, Erasmus MC, Rotterdam, The Netherlands Departments of Oncology Medicine Pharmacology Physiology Biophysics, Georgetown University Medical Center, Washington, DC and Department of Medicine, University of Western Ontario, London, ON, Canada
    Ther Drug Monit 36:152-8. 2014
    ..The authors aimed to evaluate the additional contribution of POR*28 to early tacrolimus disposition in pediatric kidney transplant recipients...
  23. ncbi request reprint Implications of serum creatinine measurements on GFR estimation and vancomycin dosing in children
    Gal Neuman
    Division of Clinical Pharmacology and Toxicology, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
    J Clin Pharmacol 54:785-91. 2014
    ..Different serum creatinine (sCr) assays may obtain different values in the same patient, causing discrepancies in estimated glomerular filtration rate (eGFR) and sCr-based vancomycin dosing calculations...
  24. doi request reprint Neurocognitive development of children exposed to doxylamine-pyridoxine combination in utero for morning sickness
    Gideon Koren
    The Hospital for Sick Children, Toronto, Ontario, Canada
    Obstet Gynecol 123:151S. 2014
    ..However, some women receive off-label higher doses, up to 12 tablets per day. The objective of this study was to assess long-term neurodevelopmental fetal safety of this drug combination...
  25. pmc Prenatal paracetamol exposure and child neurodevelopment: a sibling-controlled cohort study
    Ragnhild Eek Brandlistuen
    School of Pharmacy, University of Oslo, Oslo, Norway, Division of Mental Health, Norwegian Institute of Public Health, Oslo, Norway and Department of Pediatrics, Hospital for Sick Children, University of Toronto, Toronto, Canada
    Int J Epidemiol 42:1702-13. 2013
    ....
  26. pmc Fetal alcohol spectrum disorder
    Gideon Koren
    Motherisk Program, Division of Clinical Pharmacology and Toxicology, Hospital for Sick Children and University of Toronto, Toronto, Ont
    CMAJ 169:1181-5. 2003
  27. ncbi request reprint Chronic cocaine exposure in a toddler revealed by hair test
    Nobuko Taguchi
    Department of Pediatrics, Division of Clinical Pharmacology and Toxicology, The Hospital for Sick Children, Toronto, Ontario, Canada
    Clin Pediatr (Phila) 46:272-5. 2007
  28. ncbi request reprint Critical appraisal rounds: a new training model for clinical pharmacologists
    Gideon Koren
    The Division of Clinical Pharmacology and Toxicology, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
    Can J Clin Pharmacol 14:e81-5. 2007
    ..Formal evaluation of this model by trainees revealed high marks for "critical thinking", "learning study design", and "how to write/not to write"...