Myla E Moretti

Summary

Affiliation: The Hospital for Sick Children
Country: Canada

Publications

  1. ncbi request reprint Psychotropic drugs in lactation--Motherisk Update 2008
    Myla E Moretti
    The Motherisk Program, The Hospital for Sick Children, Toronto
    Can J Clin Pharmacol 16:e49-57. 2009
  2. doi request reprint Evaluating the safety of St. John's Wort in human pregnancy
    Myla E Moretti
    The Motherisk Program, Division of Clinical Pharmacology and Toxicology, The Hospital for Sick Children, 555 University Avenue, Toronto, ON, Canada
    Reprod Toxicol 28:96-9. 2009
  3. ncbi request reprint Maternal hyperthermia and the risk for neural tube defects in offspring: systematic review and meta-analysis
    Myla E Moretti
    The Motherisk Program, The Hospital for Sick Children, Toronto, Canada
    Epidemiology 16:216-9. 2005
  4. ncbi request reprint Breast-feeding during maternal use of azathioprine
    Myla E Moretti
    The Motherisk Program and Division of Clinical Pharmacology and Toxicology, The Hospital for Sick Children, Toronto, Ontario, Canada
    Ann Pharmacother 40:2269-72. 2006
  5. ncbi request reprint Collection and analysis of drug safety data in pregnancy
    Myla Moretti
    The Motherisk Program, Hospital for Sick Children, Toronto, Canada
    Can J Clin Pharmacol 14:e34-6. 2007
  6. doi request reprint The safety of quinolones--a meta-analysis of pregnancy outcomes
    Benjamin Bar-Oz
    The Motherisk Program, Hospital for Sick Children, Toronto, Canada
    Eur J Obstet Gynecol Reprod Biol 143:75-8. 2009
  7. doi request reprint Prenatal exposure to HMG-CoA reductase inhibitors: effects on fetal and neonatal outcomes
    Nobuko Taguchi
    The Motherisk Program, Division of Clinical Pharmacology and Toxicology, Department of Pediatrics, Hospital for Sick Children, University of Toronto, Canada
    Reprod Toxicol 26:175-7. 2008
  8. ncbi request reprint Pregnancy outcome following rubella vaccination: a prospective controlled study
    Benjamin Bar-Oz
    The Motherisk Program, Division of Clinical Pharmacology, The Hospital for Sick Children and the University of Toronto, Canada
    Am J Med Genet A 130:52-4. 2004
  9. ncbi request reprint Monitoring lithium in breast milk: an individualized approach for breast-feeding mothers
    Myla E Moretti
    The Motherisk Program and Division of Clinical Pharmacology, Hospital for Sick Children, Toronto, Ontario, Canada
    Ther Drug Monit 25:364-6. 2003
  10. doi request reprint Safety of glyburide for gestational diabetes: a meta-analysis of pregnancy outcomes
    Myla E Moretti
    Motherisk Program, Hospital for Sick Children, Toronto, Ontario, Canada
    Ann Pharmacother 42:483-90. 2008

Collaborators

Detail Information

Publications45

  1. ncbi request reprint Psychotropic drugs in lactation--Motherisk Update 2008
    Myla E Moretti
    The Motherisk Program, The Hospital for Sick Children, Toronto
    Can J Clin Pharmacol 16:e49-57. 2009
    ..The goal of today's discussion is to describe the issues and outline what is currently known about the use of psychotropic drugs in breastfeeding women...
  2. doi request reprint Evaluating the safety of St. John's Wort in human pregnancy
    Myla E Moretti
    The Motherisk Program, Division of Clinical Pharmacology and Toxicology, The Hospital for Sick Children, 555 University Avenue, Toronto, ON, Canada
    Reprod Toxicol 28:96-9. 2009
    ..Though further large scale studies are still needed, this first study on the effects of St. John's Wort in human pregnancy does provide some evidence of fetal safety...
  3. ncbi request reprint Maternal hyperthermia and the risk for neural tube defects in offspring: systematic review and meta-analysis
    Myla E Moretti
    The Motherisk Program, The Hospital for Sick Children, Toronto, Canada
    Epidemiology 16:216-9. 2005
    ..In humans, data are inconclusive and often conflicting. The objective of our report is to determine the risk for neural tube defects associated with maternal hyperthermia in early pregnancy...
  4. ncbi request reprint Breast-feeding during maternal use of azathioprine
    Myla E Moretti
    The Motherisk Program and Division of Clinical Pharmacology and Toxicology, The Hospital for Sick Children, Toronto, Ontario, Canada
    Ann Pharmacother 40:2269-72. 2006
    ..To report the clinical outcome of infants whose mothers were taking azathioprine while nursing and to quantify the transfer of 6-mercaptopurine (6-MP), its active metabolite, into breast milk...
  5. ncbi request reprint Collection and analysis of drug safety data in pregnancy
    Myla Moretti
    The Motherisk Program, Hospital for Sick Children, Toronto, Canada
    Can J Clin Pharmacol 14:e34-6. 2007
  6. doi request reprint The safety of quinolones--a meta-analysis of pregnancy outcomes
    Benjamin Bar-Oz
    The Motherisk Program, Hospital for Sick Children, Toronto, Canada
    Eur J Obstet Gynecol Reprod Biol 143:75-8. 2009
    ..We conducted a meta-analysis of all published data in order to evaluate the risk for birth defects, stillbirths, preterm births and low birth weight following exposure to quinolones in the first trimester of pregnancy...
  7. doi request reprint Prenatal exposure to HMG-CoA reductase inhibitors: effects on fetal and neonatal outcomes
    Nobuko Taguchi
    The Motherisk Program, Division of Clinical Pharmacology and Toxicology, Department of Pediatrics, Hospital for Sick Children, University of Toronto, Canada
    Reprod Toxicol 26:175-7. 2008
    ..However, a recent study based on a series of cases reported to FDA suggests possible teratogenic effects of statins on embryogenesis, such as limb defects and severe central nervous system anomalies...
  8. ncbi request reprint Pregnancy outcome following rubella vaccination: a prospective controlled study
    Benjamin Bar-Oz
    The Motherisk Program, Division of Clinical Pharmacology, The Hospital for Sick Children and the University of Toronto, Canada
    Am J Med Genet A 130:52-4. 2004
    ..4% vs. 0%) (P < 0.05), due to fears of teratogenicity. We conclude that rubella vaccination in pregnancy does not appear to affect pregnancy outcome in general or cause congenital rubella syndrome in particular...
  9. ncbi request reprint Monitoring lithium in breast milk: an individualized approach for breast-feeding mothers
    Myla E Moretti
    The Motherisk Program and Division of Clinical Pharmacology, Hospital for Sick Children, Toronto, Ontario, Canada
    Ther Drug Monit 25:364-6. 2003
    ..Since therapeutic drug monitoring of lithium is routine, physicians caring for these women and infants should be encouraged to individualize their recommendations...
  10. doi request reprint Safety of glyburide for gestational diabetes: a meta-analysis of pregnancy outcomes
    Myla E Moretti
    Motherisk Program, Hospital for Sick Children, Toronto, Ontario, Canada
    Ann Pharmacother 42:483-90. 2008
    ..Recent experimental and clinical studies have suggested, however, that the drug is not detectable in umbilical blood...
  11. doi request reprint Polymorphism of the MDR1/ABCB1 C3435T drug-transporter and resistance to anticonvulsant drugs: a meta-analysis
    Facundo Garcia Bournissen
    Divisions of Clinical Pharmacology and Toxicology, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
    Epilepsia 50:898-903. 2009
    ....
  12. ncbi request reprint Fetal safety of loratadine use in the first trimester of pregnancy: a multicenter study
    Myla E Moretti
    Hospital for Sick Children, Toronto, Ontario, Canada
    J Allergy Clin Immunol 111:479-83. 2003
    ..Loratadine, a newer nonsedating antihistamine, is often used because of its preferred side effect profile. To date no published data exist on the safety of loratadine use in pregnancy...
  13. doi request reprint Outcome following high-dose methotrexate in pregnancies misdiagnosed as ectopic
    Laila Nurmohamed
    Department of Pediatrics, Faculty of Medicine, University of Toronto, Toronto, ON, Canada
    Am J Obstet Gynecol 205:533.e1-3. 2011
    ..The objective of this study was to report the outcomes of intrauterine pregnancies misdiagnosed as ectopic and exposed to methotrexate, a major teratogen...
  14. doi request reprint Safety of insulin glargine use in pregnancy: a systematic review and meta-analysis
    Erika Pollex
    Division of Clinical Pharmacology and Toxicology, The Hospital for Sick Children, Toronto, Ontario, Canada
    Ann Pharmacother 45:9-16. 2011
    ..New insulin analogues such as the long-acting analogue insulin glargine may represent beneficial treatment options in pregnancy by ensuring that patients achieve excellent glycemic control without risk of maternal hypoglycemia...
  15. ncbi request reprint Cyclosporine excretion into breast milk
    Myla E Moretti
    The Motherisk Program, The Hospital for Sick Children, Toronto, Ontario, Canada
    Transplantation 75:2144-6. 2003
    ..We show a wide range of infant exposures to the drug in milk, noting that one of the infants had therapeutic blood concentrations of cyclosporine despite relatively low concentrations of the drug in milk...
  16. doi request reprint Is use of nifurtimox for the treatment of Chagas disease compatible with breast feeding? A population pharmacokinetics analysis
    Facundo Garcia-Bournissen
    Division of Clinical Pharmacology and Toxicology, Hospital for Sick Children, University of Toronto, 555 University Avenue, 8th Floor, Black Wing, Room 8232, Toronto, ON M5G 1X8, Canada
    Arch Dis Child 95:224-8. 2010
    ..Many patients who would receive treatment with nifurtimox live in extreme poverty, have limited access to resources such as clean water and baby formula and may not have safe alternatives to breast milk...
  17. ncbi request reprint Xenobiotic transporter expression and function in the human mammary gland
    Shinya Ito
    Division of Clinical Pharmacology and Toxicology, Department of Pediatrics, Hospital for Sick Children, 555 University Avenue, Ont, M5G 1X8, Toronto, Canada
    Adv Drug Deliv Rev 55:653-65. 2003
    ..The in vivo relevance of the expression of such xenobiotic and nutrient transporters and their involvement in drug disposition at the mammary gland requires investigation...
  18. ncbi request reprint Is CFTR dysfunction in cystic fibrosis compensated by MRPs?
    Shinya Ito
    Department of Pediatrics, Hospital for Sick Children, University of Toronto, Ontario, M5G 1X8, Canada
    Pediatr Res 54:625-6. 2003
  19. ncbi request reprint Drug excretion into breast milk--overview
    Shinya Ito
    Division of Clinical Pharmacology and Toxicology, Hospital for Sick Children, Department of Pediatrics, 555 University Avenue, ON M5G 1X8, Toronto, Canada
    Adv Drug Deliv Rev 55:617-27. 2003
    ..This article provides an overview of the benefits of breastfeeding, the effect of medication use during breastfeeding on maternal decisions and infant health, and factors determining infant exposure to medication through the breast milk...
  20. ncbi request reprint Clinical investigation in pediatrics: challenges and opportunities in Toronto, Canada
    Shinya Ito
    Clinical Pharmacology and Toxicology, Hospital for Sick Children, University of Toronto, Ontario, Canada
    Paediatr Drugs 11:67-8. 2009
    ..To promote drug research in children, these organizational changes in the research framework need to be seen on a much broader international level...
  21. ncbi request reprint Use of proton pump inhibitors during pregnancy and rates of major malformations: a meta-analysis
    Shekoufeh Nikfar
    The Motherisk Program, Hospital for Sick Children, Toronto, Ontario, Canada
    Dig Dis Sci 47:1526-9. 2002
    ..72-1.94. In conclusion, proton pump inhibitors do not present a major teratogenic risk when used in recommend doses. These data are reassuring for the countless patients who have used these agents in the early part of their pregnancies...
  22. pmc A clinical tool for reducing central nervous system depression among neonates exposed to codeine through breast milk
    Lauren E Kelly
    Department of Physiology and Pharmacology, Schulich School of Medicine, University of Western Ontario, London, Ontario, Canada
    PLoS ONE 8:e70073. 2013
    ..The primary objective of this study was to prospectively evaluate the effectiveness of these guidelines in ensuring neonatal safety...
  23. ncbi request reprint Nonsteroidal antiinflammatory drugs during third trimester and the risk of premature closure of the ductus arteriosus: a meta-analysis
    Gideon Koren
    Division of Clinical Pharmacology and Toxicology, The Hospital for Sick Children, Toronto, ON, Canada
    Ann Pharmacother 40:824-9. 2006
    ..An evaluation of the risk of premature closure of the ductus arteriosus is useful in determining the safety of NSAIDs at different stages of pregnancy...
  24. pmc Major malformations with valproic acid
    Gideon Koren
    Motherisk Team, Hospital for Sick Children, Toronto
    Can Fam Physician 52:441-2, 444, 447. 2006
    ..77 when compared with risk in the general population. There is compelling evidence that the risk is dose dependent. The risks appear to begin increasing at doses of 600 mg/d and to become more prominent at doses above 1000 mg/d...
  25. ncbi request reprint A pitfall of measuring lithium levels in neonates
    Toshihiro Tanaka
    Motherisk Program, Division of Clinical Pharmacology and Toxicology, Department of Paediatrics, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
    Ther Drug Monit 30:752-4. 2008
    ..of effects of sampling devices on lithium levels indicated that levels of >3 mmol/L were possible if a sampling volume of blood was substantially small compared with the capacity of a tube containing lithium heparin [corrected]..
  26. pmc The Fetal Safety of Angiotensin Converting Enzyme Inhibitors and Angiotensin II Receptor Blockers
    Myla E Moretti
    The Motherisk Program, The Hospital for Sick Children, 555 University Avenue, Toronto, ON, Canada M5G 1X8
    Obstet Gynecol Int 2012:658310. 2012
    ..001). These results suggest that ACE inhibitors/ARBs are not major human teratogens; however, they may be associated with an increased risk for miscarriage...
  27. ncbi request reprint Prediction of milk/plasma concentration ratio of drugs
    Line Alleslev Larsen
    The Motherisk Program, The Hospital for Sick Children, University of Toronto, Toronto, Canada
    Ann Pharmacother 37:1299-306. 2003
    ....
  28. pmc Folate Intake, MTHFR Polymorphisms, and the Risk of Colorectal Cancer: A Systematic Review and Meta-Analysis
    Deborah A Kennedy
    The Motherisk Program, Division of Clinical Pharmacology and Toxicology, The Hospital for Sick Children, 555 University Avenue, Toronto, ON, Canada M5G 1X8 Leslie Dan Faculty of Pharmacy, University of Toronto, 144 College Street, Toronto, ON, Canada M5S 3M2
    J Cancer Epidemiol 2012:952508. 2012
    ..Conclusion. These results suggest that the 677TT genotype is associated with a reduced risk of developing CRC, under conditions of high total folate intake, and this associated risk remains reduced for both MTHFR 677 CC and TT genotypes...
  29. pmc Effect of domperidone on insufficient lactation in puerperal women: a systematic review and meta-analysis of randomized controlled trials
    Alla Osadchy
    Motherisk Program, Division of Clinical Pharmacology and Toxicology, Hospital for Sick Children, Toronto, ON, Canada M5G 1X8
    Obstet Gynecol Int 2012:642893. 2012
    ..No maternal or neonatal adverse events were observed in any of the trials. Conclusions. Evidence from a few small RCTs of moderate to high quality suggests that domperidone produces a greater increase in breast milk supply than placebo...
  30. ncbi request reprint The safety of St. John's wort (Hypericum perforatum) during breastfeeding
    Amy Lee
    Division of Clinical Pharmacology and Toxicology, The Hospital for Sick Children, Department of Pediatrics, University of Toronto, Toronto, Ontario, Canada
    J Clin Psychiatry 64:966-8. 2003
    ..We examined the safety of St. John's wort to nursing mothers and their infants...
  31. ncbi request reprint Carnitine/xenobiotics transporters in the human mammary gland epithelia, MCF12A
    Bruce Kwok
    Division of Clinical Pharmacology and Toxicology, Department of Pediatrics, Research Institute, Hospital for Sick Children, 555 Univ Ave, Toronto, Ontario, Canada M5G 1X8
    Am J Physiol Regul Integr Comp Physiol 290:R793-802. 2006
    ..Our findings suggest functional roles of a network of multiple SLC organic cation/nutrient transporters in human mammary gland drug transfer...
  32. doi request reprint Challenges for drug studies in children: CYP3A phenotyping as example
    Saskia N de Wildt
    Division of Clinical Pharmacology and Toxicology, Department of Pediatrics, Hospital for Sick Children, University of Toronto, Toronto, Canada
    Drug Discov Today 14:6-15. 2009
    ..The aim of this review is to identify these challenges and offer feasible solutions for studying drugs in young children, with an emphasis on CYP3A phenotyping as an example...
  33. pmc Induction of cytochrome P450 1A by cow milk-based formula: a comparative study between human milk and formula
    Haibo Xu
    Division of Clinical Pharmacology and Toxicology, Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, Canada M5G 1X8
    Br J Pharmacol 146:296-305. 2005
    ..In conclusion, infant formula, but not human milk, enhances in vitro CYP1A expression via an AhR-mediated pathway, providing a potential mechanistic basis for the increased caffeine elimination in formula-fed infants...
  34. ncbi request reprint The attitude of physicians toward cold remedies for upper respiratory infection in infants and children: a questionnaire survey
    Raanan Cohen-Kerem
    Division of Clinical Pharmacology and Toxicology, Department of Pediatrics, University of Toronto, Hospital for Sick Children, Toronto, Ontario, Canada
    Clin Pediatr (Phila) 45:828-34. 2006
    ..Despite that cold remedies are not proven to be effective and some safety issues are associated with their use in the pediatric age group, physicians still recommend them. Continuing medical education programs should address the issue...
  35. ncbi request reprint Activation of nuclear factor (erythroid-2 like) factor 2 by toxic bile acids provokes adaptive defense responses to enhance cell survival at the emergence of oxidative stress
    Kah Poh Tan
    Division of Clinical Pharmacology and Toxicology, Department of Pediatrics, Hospital for Sick Children, 555 University Ave, Toronto, Ontario M5G 1X8, Canada
    Mol Pharmacol 72:1380-90. 2007
    ..Nrf2 is centrally involved in counteracting such oxidative stress by enhancing adaptive antioxidative response, particularly GSH biosynthesis, and hence cell survival...
  36. ncbi request reprint Frequency of infant adverse events that are associated with citalopram use during breast-feeding
    Amy Lee
    Division of Clinical Pharmacology and Toxicology, Hospital for Sick Children, and the Department of Pharmacology, University of Toronto, Toronto, Ontario, Canada
    Am J Obstet Gynecol 190:218-21. 2004
    ..The purpose of this study was to determine the frequency of infantile adverse events from exposure through breast-feeding to maternal citalopram therapy...
  37. pmc Lead exposure during breastfeeding
    Jacquelyn Choi
    Can Fam Physician 54:515-6. 2008
    ..Switching to formula feeding is not necessary and not recommended, as improperly prepared formula can have higher Pb levels...
  38. ncbi request reprint Re: use of contemporary antidepressants during breastfeeding: a proposal for a specific safety index
    Adrienne Einarson
    Drug Saf 30:643; author reply 643-4. 2007
  39. pmc Exposure to attention deficit hyperactivity disorder medications during pregnancy
    Caitlin Humphreys
    Can Fam Physician 53:1153-5. 2007
    ..Human data for methylphenidate and atomoxetine treatment in pregnancy are very limited. Documented cases do not suggest teratogenicity, but we cannot rule out this risk with the information available...
  40. ncbi request reprint Perinatal outcome following third trimester exposure to paroxetine
    Adriana Moldovan Costei
    The Motherisk Program, Division of Clinical Pharmacology Toxicology, The Hospital for Sick Children, Toronto, Ontario, Canada
    Arch Pediatr Adolesc Med 156:1129-32. 2002
    ..The drug readily crosses the human placenta. Although it does not appear to increase teratogenic risk, there have been case reports of neonatal withdrawal. Symptoms were described soon after birth and lasted up to 1 month...
  41. ncbi request reprint The kidney--the body's playground for drugs: an overview of renal drug handling with selected clinical correlates
    Dan Perri
    Department of Medicine, McMaster University, Hamilton, Canada
    Can J Clin Pharmacol 10:17-23. 2003
    ..At the patient level, this may lead to novel approaches to alter in vivo pharmacokinetics and improve drug safety through a greater understanding of toxic substrate clearance and drug interactions...
  42. doi request reprint Antenatal use of selective serotonin-reuptake inhibitors and QT interval prolongation in newborns
    Gal Dubnov-Raz
    Hospital for Sick Children, Motherisk Program, Divisions of Clinical Pharmacology and Toxicology and Emergency Medicine, Department of Pediatrics, 555 University Avenue Toronto, Ontario, Canada
    Pediatrics 122:e710-5. 2008
    ..The aim of this study was to determine the effect of maternal use of selective serotonin-reuptake inhibitor antidepressants during pregnancy on the QTc interval of the offspring...
  43. pmc Use of lipid-lowering agents (statins) during pregnancy
    Akiko Hosokawa
    Family Medicine Program, University of Toronto
    Can Fam Physician 49:747-9. 2003
    ..If a patient is inadvertently exposed during pregnancy, however, termination does not appear to be medically indicated...
  44. ncbi request reprint When breastfeeding mothers need CNS-acting drugs
    Evelyn T Rubin
    Department of Pediatrics, The Hospial for Sick Children, University of Toronto
    Can J Clin Pharmacol 11:e257-66. 2004
    ..Summarized information on infant exposure levels to drugs in milk and associated side effect profiles will help clinicians to rationalize and justify important drug therapy for a breastfeeding patient...
  45. ncbi request reprint Excretion of quetiapine in breast milk
    Amy Lee
    Am J Psychiatry 161:1715-6. 2004