Research Topics
Species | Myla E MorettiSummaryAffiliation: The Hospital for Sick Children Country: Canada Publications
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Detail Information
Publications
Maternal hyperthermia and the risk for neural tube defects in offspring: systematic review and meta-analysisMyla E Moretti
The Motherisk Program, The Hospital for Sick Children, Toronto, Canada
Epidemiology 16:216-9. 2005..In humans, data are inconclusive and often conflicting. The objective of our report is to determine the risk for neural tube defects associated with maternal hyperthermia in early pregnancy...- Breast-feeding during maternal use of azathioprineMyla E Moretti
The Motherisk Program and Division of Clinical Pharmacology and Toxicology, The Hospital for Sick Children, Toronto, Ontario, Canada
Ann Pharmacother 40:2269-72. 2006..To report the clinical outcome of infants whose mothers were taking azathioprine while nursing and to quantify the transfer of 6-mercaptopurine (6-MP), its active metabolite, into breast milk... 
Evaluating the safety of St. John's Wort in human pregnancyMyla E Moretti
The Motherisk Program, Division of Clinical Pharmacology and Toxicology, The Hospital for Sick Children, 555 University Avenue, Toronto, ON, Canada
Reprod Toxicol 28:96-9. 2009..Though further large scale studies are still needed, this first study on the effects of St. John's Wort in human pregnancy does provide some evidence of fetal safety...- Collection and analysis of drug safety data in pregnancyMyla Moretti
The Motherisk Program, Hospital for Sick Children, Toronto, Canada
Can J Clin Pharmacol 14:e34-6. 2007 - Psychotropic drugs in lactation--Motherisk Update 2008Myla E Moretti
The Motherisk Program, The Hospital for Sick Children, Toronto
Can J Clin Pharmacol 16:e49-57. 2009..The goal of today's discussion is to describe the issues and outline what is currently known about the use of psychotropic drugs in breastfeeding women... - The safety of quinolones--a meta-analysis of pregnancy outcomesBenjamin Bar-Oz
The Motherisk Program, Hospital for Sick Children, Toronto, Canada
Eur J Obstet Gynecol Reprod Biol 143:75-8. 2009..We conducted a meta-analysis of all published data in order to evaluate the risk for birth defects, stillbirths, preterm births and low birth weight following exposure to quinolones in the first trimester of pregnancy... - Pregnancy outcome following rubella vaccination: a prospective controlled studyBenjamin Bar-Oz
The Motherisk Program, Division of Clinical Pharmacology, The Hospital for Sick Children and the University of Toronto, Canada
Am J Med Genet A 130:52-4. 2004..4% vs. 0%) (P < 0.05), due to fears of teratogenicity. We conclude that rubella vaccination in pregnancy does not appear to affect pregnancy outcome in general or cause congenital rubella syndrome in particular... - Prenatal exposure to HMG-CoA reductase inhibitors: effects on fetal and neonatal outcomesNobuko Taguchi
The Motherisk Program, Division of Clinical Pharmacology and Toxicology, Department of Pediatrics, Hospital for Sick Children, University of Toronto, Canada
Reprod Toxicol 26:175-7. 2008..However, a recent study based on a series of cases reported to FDA suggests possible teratogenic effects of statins on embryogenesis, such as limb defects and severe central nervous system anomalies... - Polymorphism of the MDR1/ABCB1 C3435T drug-transporter and resistance to anticonvulsant drugs: a meta-analysisFacundo Garcia Bournissen
Divisions of Clinical Pharmacology and Toxicology, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
Epilepsia 50:898-903. 2009.... - Monitoring lithium in breast milk: an individualized approach for breast-feeding mothersMyla E Moretti
The Motherisk Program and Division of Clinical Pharmacology, Hospital for Sick Children, Toronto, Ontario, Canada
Ther Drug Monit 25:364-6. 2003..Since therapeutic drug monitoring of lithium is routine, physicians caring for these women and infants should be encouraged to individualize their recommendations... - Safety of glyburide for gestational diabetes: a meta-analysis of pregnancy outcomesMyla E Moretti
Motherisk Program, Hospital for Sick Children, Toronto, Ontario, Canada
Ann Pharmacother 42:483-90. 2008..Recent experimental and clinical studies have suggested, however, that the drug is not detectable in umbilical blood... - Fetal safety of loratadine use in the first trimester of pregnancy: a multicenter studyMyla E Moretti
Hospital for Sick Children, Toronto, Ontario, Canada
J Allergy Clin Immunol 111:479-83. 2003..CONCLUSION: These results suggest that loratadine use in pregnancy is not associated with a large risk for major malformations. Further studies are warranted to confirm these findings and to increase study power... - Outcome following high-dose methotrexate in pregnancies misdiagnosed as ectopicLaila Nurmohamed
Department of Pediatrics, Faculty of Medicine, University of Toronto, Toronto, ON, Canada
Am J Obstet Gynecol 205:533.e1-3. 2011..The objective of this study was to report the outcomes of intrauterine pregnancies misdiagnosed as ectopic and exposed to methotrexate, a major teratogen... - Cyclosporine excretion into breast milkMyla E Moretti
The Motherisk Program, The Hospital for Sick Children, Toronto, Ontario, Canada
Transplantation 75:2144-6. 2003..We show a wide range of infant exposures to the drug in milk, noting that one of the infants had therapeutic blood concentrations of cyclosporine despite relatively low concentrations of the drug in milk... - Safety of insulin glargine use in pregnancy: a systematic review and meta-analysisErika Pollex
Division of Clinical Pharmacology and Toxicology, The Hospital for Sick Children, Toronto, Ontario, Canada
Ann Pharmacother 45:9-16. 2011..New insulin analogues such as the long-acting analogue insulin glargine may represent beneficial treatment options in pregnancy by ensuring that patients achieve excellent glycemic control without risk of maternal hypoglycemia... - Clinical investigation in pediatrics: challenges and opportunities in Toronto, CanadaShinya Ito
Clinical Pharmacology and Toxicology, Hospital for Sick Children, University of Toronto, Ontario, Canada
Paediatr Drugs 11:67-8. 2009..To promote drug research in children, these organizational changes in the research framework need to be seen on a much broader international level... - Is use of nifurtimox for the treatment of Chagas disease compatible with breast feeding? A population pharmacokinetics analysisFacundo Garcia-Bournissen
Division of Clinical Pharmacology and Toxicology, Hospital for Sick Children, University of Toronto, 555 University Avenue, 8th Floor, Black Wing, Room 8232, Toronto, ON M5G 1X8, Canada
Arch Dis Child 95:224-8. 2010..Many patients who would receive treatment with nifurtimox live in extreme poverty, have limited access to resources such as clean water and baby formula and may not have safe alternatives to breast milk... - Is CFTR dysfunction in cystic fibrosis compensated by MRPs?Shinya Ito
Department of Pediatrics, Hospital for Sick Children, University of Toronto, Ontario, M5G 1X8, Canada
Pediatr Res 54:625-6. 2003 - Drug excretion into breast milk--overviewShinya Ito
Division of Clinical Pharmacology and Toxicology, Hospital for Sick Children, Department of Pediatrics, 555 University Avenue, ON M5G 1X8, Toronto, Canada
Adv Drug Deliv Rev 55:617-27. 2003..This article provides an overview of the benefits of breastfeeding, the effect of medication use during breastfeeding on maternal decisions and infant health, and factors determining infant exposure to medication through the breast milk... - Xenobiotic transporter expression and function in the human mammary glandShinya Ito
Division of Clinical Pharmacology and Toxicology, Department of Pediatrics, Hospital for Sick Children, 555 University Avenue, Ont, M5G 1X8, Toronto, Canada
Adv Drug Deliv Rev 55:653-65. 2003..The in vivo relevance of the expression of such xenobiotic and nutrient transporters and their involvement in drug disposition at the mammary gland requires investigation... - Use of proton pump inhibitors during pregnancy and rates of major malformations: a meta-analysisShekoufeh Nikfar
The Motherisk Program, Hospital for Sick Children, Toronto, Ontario, Canada
Dig Dis Sci 47:1526-9. 2002..72-1.94. In conclusion, proton pump inhibitors do not present a major teratogenic risk when used in recommend doses. These data are reassuring for the countless patients who have used these agents in the early part of their pregnancies... 
The Fetal Safety of Angiotensin Converting Enzyme Inhibitors and Angiotensin II Receptor BlockersMyla E Moretti
The Motherisk Program, The Hospital for Sick Children, 555 University Avenue, Toronto, ON, Canada M5G 1X8
Obstet Gynecol Int 2012:658310. 2012..001). These results suggest that ACE inhibitors/ARBs are not major human teratogens; however, they may be associated with an increased risk for miscarriage...- Major malformations with valproic acidGideon Koren
Motherisk Team, Hospital for Sick Children, Toronto
Can Fam Physician 52:441-2, 444, 447. 2006..77 when compared with risk in the general population. There is compelling evidence that the risk is dose dependent. The risks appear to begin increasing at doses of 600 mg/d and to become more prominent at doses above 1000 mg/d... - Nonsteroidal antiinflammatory drugs during third trimester and the risk of premature closure of the ductus arteriosus: a meta-analysisGideon Koren
Division of Clinical Pharmacology and Toxicology, The Hospital for Sick Children, Toronto, ON, Canada
Ann Pharmacother 40:824-9. 2006..An evaluation of the risk of premature closure of the ductus arteriosus is useful in determining the safety of NSAIDs at different stages of pregnancy... - A pitfall of measuring lithium levels in neonatesToshihiro Tanaka
Motherisk Program, Division of Clinical Pharmacology and Toxicology, Department of Paediatrics, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
Ther Drug Monit 30:752-4. 2008..of effects of sampling devices on lithium levels indicated that levels of >3 mmol/L were possible if a sampling volume of blood was substantially small compared with the capacity of a tube containing lithium heparin [corrected].. - Prediction of milk/plasma concentration ratio of drugsLine Alleslev Larsen
The Motherisk Program, The Hospital for Sick Children, University of Toronto, Toronto, Canada
Ann Pharmacother 37:1299-306. 2003..CONCLUSIONS: Reliable data on m/p concentration ratios exist for few medications. Presently, there is no appropriate model to predict milk concentrations of drugs in humans... - Folate Intake, MTHFR Polymorphisms, and the Risk of Colorectal Cancer: A Systematic Review and Meta-AnalysisDeborah A Kennedy
The Motherisk Program, Division of Clinical Pharmacology and Toxicology, The Hospital for Sick Children, 555 University Avenue, Toronto, ON, Canada M5G 1X8 Leslie Dan Faculty of Pharmacy, University of Toronto, 144 College Street, Toronto, ON, Canada M5S 3M2
J Cancer Epidemiol 2012:952508. 2012..Conclusion. These results suggest that the 677TT genotype is associated with a reduced risk of developing CRC, under conditions of high total folate intake, and this associated risk remains reduced for both MTHFR 677 CC and TT genotypes... - Effect of domperidone on insufficient lactation in puerperal women: a systematic review and meta-analysis of randomized controlled trialsAlla Osadchy
Motherisk Program, Division of Clinical Pharmacology and Toxicology, Hospital for Sick Children, Toronto, ON, Canada M5G 1X8
Obstet Gynecol Int 2012:642893. 2012..No maternal or neonatal adverse events were observed in any of the trials. Conclusions. Evidence from a few small RCTs of moderate to high quality suggests that domperidone produces a greater increase in breast milk supply than placebo... - The safety of St. John's wort (Hypericum perforatum) during breastfeedingAmy Lee
Division of Clinical Pharmacology and Toxicology, The Hospital for Sick Children, Department of Pediatrics, University of Toronto, Toronto, Ontario, Canada
J Clin Psychiatry 64:966-8. 2003..CONCLUSION: These results provide a framework for the management of breastfeeding women receiving St. John's wort... - Challenges for drug studies in children: CYP3A phenotyping as exampleSaskia N de Wildt
Division of Clinical Pharmacology and Toxicology, Department of Pediatrics, Hospital for Sick Children, University of Toronto, Toronto, Canada
Drug Discov Today 14:6-15. 2009..The aim of this review is to identify these challenges and offer feasible solutions for studying drugs in young children, with an emphasis on CYP3A phenotyping as an example... - Carnitine/xenobiotics transporters in the human mammary gland epithelia, MCF12ABruce Kwok
Division of Clinical Pharmacology and Toxicology, Department of Pediatrics, Research Institute, Hospital for Sick Children, 555 Univ. Ave, Toronto, Ontario, Canada M5G 1X8
Am J Physiol Regul Integr Comp Physiol 290:R793-802. 2006..Our findings suggest functional roles of a network of multiple SLC organic cation/nutrient transporters in human mammary gland drug transfer... - Induction of cytochrome P450 1A by cow milk-based formula: a comparative study between human milk and formulaHaibo Xu
Division of Clinical Pharmacology and Toxicology, Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, Canada M5G 1X8
Br J Pharmacol 146:296-305. 2005..In conclusion, infant formula, but not human milk, enhances in vitro CYP1A expression via an AhR-mediated pathway, providing a potential mechanistic basis for the increased caffeine elimination in formula-fed infants... - Activation of nuclear factor (erythroid-2 like) factor 2 by toxic bile acids provokes adaptive defense responses to enhance cell survival at the emergence of oxidative stressKah Poh Tan
Division of Clinical Pharmacology and Toxicology, Department of Pediatrics, Hospital for Sick Children, 555 University Ave, Toronto, Ontario M5G 1X8, Canada
Mol Pharmacol 72:1380-90. 2007..Nrf2 is centrally involved in counteracting such oxidative stress by enhancing adaptive antioxidative response, particularly GSH biosynthesis, and hence cell survival... - The attitude of physicians toward cold remedies for upper respiratory infection in infants and children: a questionnaire surveyRaanan Cohen-Kerem
Division of Clinical Pharmacology and Toxicology, Department of Pediatrics, University of Toronto, Hospital for Sick Children, Toronto, Ontario, Canada
Clin Pediatr (Phila) 45:828-34. 2006..Despite that cold remedies are not proven to be effective and some safety issues are associated with their use in the pediatric age group, physicians still recommend them. Continuing medical education programs should address the issue... - Frequency of infant adverse events that are associated with citalopram use during breast-feedingAmy Lee
Division of Clinical Pharmacology and Toxicology, Hospital for Sick Children, and the Department of Pharmacology, University of Toronto, Toronto, Ontario, Canada
Am J Obstet Gynecol 190:218-21. 2004..4 mg per day (range, 10-60 mg/d). CONCLUSION: To our knowledge, this is the first prospective, controlled study to examine the safety of citalopram during breast-feeding, which should be continued during maternal citalopram therapy... - Lead exposure during breastfeedingJacquelyn Choi
Can Fam Physician 54:515-6. 2008..Switching to formula feeding is not necessary and not recommended, as improperly prepared formula can have higher Pb levels... - Exposure to attention deficit hyperactivity disorder medications during pregnancyCaitlin Humphreys
Can Fam Physician 53:1153-5. 2007..Human data for methylphenidate and atomoxetine treatment in pregnancy are very limited. Documented cases do not suggest teratogenicity, but we cannot rule out this risk with the information available... - Re: use of contemporary antidepressants during breastfeeding: a proposal for a specific safety indexAdrienne Einarson
Drug Saf 30:643; author reply 643-4. 2007 - Excretion of quetiapine in breast milkAmy Lee
Am J Psychiatry 161:1715-6. 2004 - Perinatal outcome following third trimester exposure to paroxetineAdriana Moldovan Costei
The Motherisk Program, Division of Clinical Pharmacology/Toxicology, The Hospital for Sick Children, Toronto, Ontario, Canada
Arch Pediatr Adolesc Med 156:1129-32. 2002..53; 95% confidence interval, 1.14-79.3). CONCLUSION: When used near term, paroxetine is associated with a high rate of neonatal complications, possibly caused by its common discontinuation syndrome... - The kidney--the body's playground for drugs: an overview of renal drug handling with selected clinical correlatesDan Perri
Department of Medicine, McMaster University, Hamilton, Canada
Can J Clin Pharmacol 10:17-23. 2003..At the patient level, this may lead to novel approaches to alter in vivo pharmacokinetics and improve drug safety through a greater understanding of toxic substrate clearance and drug interactions... - Use of lipid-lowering agents (statins) during pregnancyAkiko Hosokawa
Family Medicine Program, University of Toronto
Can Fam Physician 49:747-9. 2003..If a patient is inadvertently exposed during pregnancy, however, termination does not appear to be medically indicated... - Antenatal use of selective serotonin-reuptake inhibitors and QT interval prolongation in newbornsGal Dubnov-Raz
Hospital for Sick Children, Motherisk Program, Divisions of Clinical Pharmacology and Toxicology and Emergency Medicine, Department of Pediatrics, 555 University Avenue Toronto, Ontario, Canada
Pediatrics 122:e710-5. 2008..The aim of this study was to determine the effect of maternal use of selective serotonin-reuptake inhibitor antidepressants during pregnancy on the QTc interval of the offspring... - When breastfeeding mothers need CNS-acting drugsEvelyn T Rubin
Department of Pediatrics, The Hospial for Sick Children, University of Toronto
Can J Clin Pharmacol 11:e257-66. 2004..CONCLUSIONS: CNS-acting drugs taken by the mother do not appear to pose any major risks of immediate adverse effects to the breastfeeding infant, although with most of the newer drugs further research is needed to be conclusive...