Freda D Miller


Affiliation: The Hospital for Sick Children
Country: Canada


  1. Miller F, Kaplan D. Mobilizing endogenous stem cells for repair and regeneration: are we there yet?. Cell Stem Cell. 2012;10:650-652 pubmed publisher
    ..Recent advances in tissue stem cells indicate that this goal may now be achievable. Here we consider both the promise and the hurdles we still have to overcome. ..
  2. Carr M, Toma J, Johnston A, Steadman P, Yuzwa S, Mahmud N, et al. Mesenchymal Precursor Cells in Adult Nerves Contribute to Mammalian Tissue Repair and Regeneration. Cell Stem Cell. 2019;24:240-256.e9 pubmed publisher
    ..These findings support a model where peripheral nerves directly contribute mesenchymal precursor cells to promote repair and regeneration of injured mammalian tissues. ..
  3. Storer M, Gallagher D, Fatt M, Simonetta J, Kaplan D, Miller F. Interleukin-6 Regulates Adult Neural Stem Cell Numbers during Normal and Abnormal Post-natal Development. Stem Cell Reports. 2018;10:1464-1480 pubmed publisher
    ..Thus, IL-6 signaling is both necessary and sufficient for adult NSC self-renewal, and acute perturbations in circulating IL-6, as observed in many pathological situations, have long-lasting effects on the size of adult NSC pools. ..
  4. Naska S, Yuzwa S, Johnston A, Paul S, Smith K, Paris M, et al. Identification of Drugs that Regulate Dermal Stem Cells and Enhance Skin Repair. Stem Cell Reports. 2016;6:74-84 pubmed publisher
    ..These findings identify candidates for potential clinical use in human skin repair, and provide support for the idea that pharmacological activation of endogenous tissue precursors represents a viable therapeutic strategy. ..
  5. Johnston A, Yuzwa S, Carr M, Mahmud N, Storer M, Krause M, et al. Dedifferentiated Schwann Cell Precursors Secreting Paracrine Factors Are Required for Regeneration of the Mammalian Digit Tip. Cell Stem Cell. 2016;19:433-448 pubmed publisher
    ..As all peripheral tissues contain nerves, these results could have broad implications for mammalian tissue repair and regeneration. ..
  6. Yuzwa S, Borrett M, Innes B, Voronova A, Ketela T, Kaplan D, et al. Developmental Emergence of Adult Neural Stem Cells as Revealed by Single-Cell Transcriptional Profiling. Cell Rep. 2017;21:3970-3986 pubmed publisher
    ..Together, these findings support a model wherein cortical RPs maintain a core transcriptional identity from embryogenesis through to adulthood and wherein the transition to a quiescent adult NSC occurs during late neurogenesis. ..
  7. Zahr S, Yang G, Kazan H, Borrett M, Yuzwa S, Voronova A, et al. A Translational Repression Complex in Developing Mammalian Neural Stem Cells that Regulates Neuronal Specification. Neuron. 2018;97:520-537.e6 pubmed publisher
  8. Yang G, Cancino G, Zahr S, Guskjolen A, Voronova A, Gallagher D, et al. A Glo1-Methylglyoxal Pathway that Is Perturbed in Maternal Diabetes Regulates Embryonic and Adult Neural Stem Cell Pools in Murine Offspring. Cell Rep. 2016;17:1022-1036 pubmed publisher
    ..Thus, the Glo1-methylglyoxal pathway integrates maternal and NPC metabolism to regulate neural development, and perturbations in this pathway lead to long-lasting alterations in adult neurons and NPC pools. ..
  9. Tsui D, Voronova A, Gallagher D, Kaplan D, Miller F, Wang J. CBP regulates the differentiation of interneurons from ventral forebrain neural precursors during murine development. Dev Biol. 2014;385:230-41 pubmed publisher

More Information


  1. Yang G, Smibert C, Kaplan D, Miller F. An eIF4E1/4E-T complex determines the genesis of neurons from precursors by translationally repressing a proneurogenic transcription program. Neuron. 2014;84:723-39 pubmed publisher
    ..Thus, neural precursors are transcriptionally primed to generate neurons, but an eIF4E/4E-T complex sequesters and represses translation of proneurogenic proteins to determine appropriate neurogenesis. ..
  2. Gallagher D, Voronova A, Zander M, Cancino G, Bramall A, Krause M, et al. Ankrd11 is a chromatin regulator involved in autism that is essential for neural development. Dev Cell. 2015;32:31-42 pubmed publisher
    ..Thus, Ankrd11 is a crucial chromatin regulator that controls histone acetylation and gene expression during neural development, thereby providing a likely explanation for its association with cognitive dysfunction and ASD. ..
  3. Amadei G, Zander M, Yang G, Dumelie J, Vessey J, Lipshitz H, et al. A Smaug2-Based Translational Repression Complex Determines the Balance between Precursor Maintenance versus Differentiation during Mammalian Neurogenesis. J Neurosci. 2015;35:15666-81 pubmed publisher
  4. Yuzwa S, Yang G, Borrett M, Clarke G, Cancino G, Zahr S, et al. Proneurogenic Ligands Defined by Modeling Developing Cortex Growth Factor Communication Networks. Neuron. 2016;91:988-1004 pubmed publisher
  5. Voronova A, Yuzwa S, Wang B, Zahr S, Syal C, Wang J, et al. Migrating Interneurons Secrete Fractalkine to Promote Oligodendrocyte Formation in the Developing Mammalian Brain. Neuron. 2017;94:500-516.e9 pubmed publisher
    ..Thus, in addition to their role in regulating neuronal excitability, interneurons act in a paracrine fashion to promote the developmental genesis of oligodendrocytes. ..
  6. Feinberg K, Kolaj A, Wu C, Grinshtein N, Krieger J, Moran M, et al. A neuroprotective agent that inactivates prodegenerative TrkA and preserves mitochondria. J Cell Biol. 2017;216:3655-3675 pubmed publisher
    ..These findings identify a new axon degeneration pathway and a potentially clinically useful therapeutic drug. ..