Genomes and Genes
Freda D Miller
Affiliation: The Hospital for Sick Children
- Yang G, Smibert C, Kaplan D, Miller F. An eIF4E1/4E-T complex determines the genesis of neurons from precursors by translationally repressing a proneurogenic transcription program. Neuron. 2014;84:723-39 pubmed publisher..Thus, neural precursors are transcriptionally primed to generate neurons, but an eIF4E/4E-T complex sequesters and represses translation of proneurogenic proteins to determine appropriate neurogenesis. ..
- Gallagher D, Voronova A, Zander M, Cancino G, Bramall A, Krause M, et al. Ankrd11 is a chromatin regulator involved in autism that is essential for neural development. Dev Cell. 2015;32:31-42 pubmed publisher..Thus, Ankrd11 is a crucial chromatin regulator that controls histone acetylation and gene expression during neural development, thereby providing a likely explanation for its association with cognitive dysfunction and ASD. ..
- Voronova A, Yuzwa S, Wang B, Zahr S, Syal C, Wang J, et al. Migrating Interneurons Secrete Fractalkine to Promote Oligodendrocyte Formation in the Developing Mammalian Brain. Neuron. 2017;94:500-516.e9 pubmed publisher..Thus, in addition to their role in regulating neuronal excitability, interneurons act in a paracrine fashion to promote the developmental genesis of oligodendrocytes. ..
- Feinberg K, Kolaj A, Wu C, Grinshtein N, Krieger J, Moran M, et al. A neuroprotective agent that inactivates prodegenerative TrkA and preserves mitochondria. J Cell Biol. 2017;216:3655-3675 pubmed publisher..These findings identify a new axon degeneration pathway and a potentially clinically useful therapeutic drug. ..