Patrick J McNamara

Summary

Affiliation: The Hospital for Sick Children
Country: Canada

Publications

  1. pmc Towards rational management of the patent ductus arteriosus: the need for disease staging
    Patrick J McNamara
    Patrick J McNamara, The Hospital for Sick Children, 555 University Avenue, Toronto M5G 1X8, Canada
    Arch Dis Child Fetal Neonatal Ed 92:F424-7. 2007
  2. doi request reprint Pharmacology of milrinone in neonates with persistent pulmonary hypertension of the newborn and suboptimal response to inhaled nitric oxide
    Patrick J McNamara
    Departments of Pediatrics, University of Toronto, Toronto, Canada
    Pediatr Crit Care Med 14:74-84. 2013
  3. doi request reprint Patent ductus arteriosus ligation is associated with impaired left ventricular systolic performance in premature infants weighing less than 1000 g
    Patrick J McNamara
    Physiology and Experimental Medicine, The Hospital for Sick Children Research Institute, Toronto, Ontario, Canada
    J Thorac Cardiovasc Surg 140:150-7. 2010
  4. ncbi request reprint Milrinone improves oxygenation in neonates with severe persistent pulmonary hypertension of the newborn
    Patrick J McNamara
    Division of Neonatology, Department of Pediatrics, University of Toronto, Hospital for Sick Children, Toronto, Ontario, Canada M5G 1X8
    J Crit Care 21:217-22. 2006
  5. ncbi request reprint Intraurethral knot in a very-low-birth-weight infant: radiological recognition, surgical management and prevention
    Abhay Lodha
    Division of Neonatology, The Hospital for Sick Children, 555 University Ave, Toronto M5G 1X8, Canada
    Pediatr Radiol 35:713-6. 2005
  6. doi request reprint Effects of rho-kinase inhibition on pulmonary hypertension, lung growth, and structure in neonatal rats chronically exposed to hypoxia
    Adrian J A Ziino
    Clinical Integrative Biology, Sunnybrook Research Institute, Toronto, Ontario, Canada M4N 3M5
    Pediatr Res 67:177-82. 2010
  7. doi request reprint Therapeutic hypercapnia prevents bleomycin-induced pulmonary hypertension in neonatal rats by limiting macrophage-derived tumor necrosis factor-α
    A Charlotte P Sewing
    Physiology and Experimental Medicine Program, Hospital for Sick Children Research Institute, Toronto, Ontario, Canada
    Am J Physiol Lung Cell Mol Physiol 303:L75-87. 2012
  8. ncbi request reprint Acute vasodilator effects of Rho-kinase inhibitors in neonatal rats with pulmonary hypertension unresponsive to nitric oxide
    Patrick J McNamara
    Department of Newborn and Developmental Paediatrics, Sunnybrook Health Sciences Centre, 76 Grenville Street, Toronto, Ontario, Canada
    Am J Physiol Lung Cell Mol Physiol 294:L205-13. 2008
  9. doi request reprint Sustained therapeutic hypercapnia attenuates pulmonary arterial Rho-kinase activity and ameliorates chronic hypoxic pulmonary hypertension in juvenile rats
    Gary Peng
    Physiology and Experimental Medicine Program, Hospital for Sick Children Research Institute, Toronto, Ontario, Canada
    Am J Physiol Heart Circ Physiol 302:H2599-611. 2012
  10. doi request reprint Rescue treatment with a Rho-kinase inhibitor normalizes right ventricular function and reverses remodeling in juvenile rats with chronic pulmonary hypertension
    Emily Z Xu
    Clinical Integrative Biology, Sunnybrook Research Institute, University of Toronto, Toronto, Ontario, Canada
    Am J Physiol Heart Circ Physiol 299:H1854-64. 2010

Collaborators

Detail Information

Publications45

  1. pmc Towards rational management of the patent ductus arteriosus: the need for disease staging
    Patrick J McNamara
    Patrick J McNamara, The Hospital for Sick Children, 555 University Avenue, Toronto M5G 1X8, Canada
    Arch Dis Child Fetal Neonatal Ed 92:F424-7. 2007
  2. doi request reprint Pharmacology of milrinone in neonates with persistent pulmonary hypertension of the newborn and suboptimal response to inhaled nitric oxide
    Patrick J McNamara
    Departments of Pediatrics, University of Toronto, Toronto, Canada
    Pediatr Crit Care Med 14:74-84. 2013
    ..The primary objective was to investigate the pharmacological profile of milrinone in persistent pulmonary hypertension of the newborn. Secondary objectives were to delineate short-term outcomes and safety profile...
  3. doi request reprint Patent ductus arteriosus ligation is associated with impaired left ventricular systolic performance in premature infants weighing less than 1000 g
    Patrick J McNamara
    Physiology and Experimental Medicine, The Hospital for Sick Children Research Institute, Toronto, Ontario, Canada
    J Thorac Cardiovasc Surg 140:150-7. 2010
    ..The ability of the immature myocardium to compensate for altered afterload is poorly understood. The aim of this study was to characterize the effects of patent ductus arteriosus ligation on myocardial performance in preterm infants...
  4. ncbi request reprint Milrinone improves oxygenation in neonates with severe persistent pulmonary hypertension of the newborn
    Patrick J McNamara
    Division of Neonatology, Department of Pediatrics, University of Toronto, Hospital for Sick Children, Toronto, Ontario, Canada M5G 1X8
    J Crit Care 21:217-22. 2006
    ..Milrinone is a promising adjunctive therapy because of its pulmonary vasodilator properties and cardiotropic effects...
  5. ncbi request reprint Intraurethral knot in a very-low-birth-weight infant: radiological recognition, surgical management and prevention
    Abhay Lodha
    Division of Neonatology, The Hospital for Sick Children, 555 University Ave, Toronto M5G 1X8, Canada
    Pediatr Radiol 35:713-6. 2005
    ..All staff involved in the insertion, maintenance or removal of these catheters should be suitably trained to minimize the risk of knots and related complications...
  6. doi request reprint Effects of rho-kinase inhibition on pulmonary hypertension, lung growth, and structure in neonatal rats chronically exposed to hypoxia
    Adrian J A Ziino
    Clinical Integrative Biology, Sunnybrook Research Institute, Toronto, Ontario, Canada M4N 3M5
    Pediatr Res 67:177-82. 2010
    ..Limiting effects on vascular remodeling likely resulted, in major part, from attenuated vascular PDGF-BB/beta-receptor signaling...
  7. doi request reprint Therapeutic hypercapnia prevents bleomycin-induced pulmonary hypertension in neonatal rats by limiting macrophage-derived tumor necrosis factor-α
    A Charlotte P Sewing
    Physiology and Experimental Medicine Program, Hospital for Sick Children Research Institute, Toronto, Ontario, Canada
    Am J Physiol Lung Cell Mol Physiol 303:L75-87. 2012
    ....
  8. ncbi request reprint Acute vasodilator effects of Rho-kinase inhibitors in neonatal rats with pulmonary hypertension unresponsive to nitric oxide
    Patrick J McNamara
    Department of Newborn and Developmental Paediatrics, Sunnybrook Health Sciences Centre, 76 Grenville Street, Toronto, Ontario, Canada
    Am J Physiol Lung Cell Mol Physiol 294:L205-13. 2008
    ..ROCK-mediated vasoconstriction appears to play a key role in chronic PHT in our two neonatal rat models. Inhibitors of ROCK have potential as a testable therapy in neonates with PHT that is refractory to NO...
  9. doi request reprint Sustained therapeutic hypercapnia attenuates pulmonary arterial Rho-kinase activity and ameliorates chronic hypoxic pulmonary hypertension in juvenile rats
    Gary Peng
    Physiology and Experimental Medicine Program, Hospital for Sick Children Research Institute, Toronto, Ontario, Canada
    Am J Physiol Heart Circ Physiol 302:H2599-611. 2012
    ..Increased PKG content and activity appears to play a major upstream role in CO(2)-induced suppression of ROCK activity in pulmonary arterial smooth muscle...
  10. doi request reprint Rescue treatment with a Rho-kinase inhibitor normalizes right ventricular function and reverses remodeling in juvenile rats with chronic pulmonary hypertension
    Emily Z Xu
    Clinical Integrative Biology, Sunnybrook Research Institute, University of Toronto, Toronto, Ontario, Canada
    Am J Physiol Heart Circ Physiol 299:H1854-64. 2010
    ..In addition, our data suggest that ROCK-II may be dominant in enhancing survival of pulmonary arterial smooth muscle...
  11. doi request reprint Impact of oxygen saturation targets and oxygen therapy during the transport of neonates with clinically suspected congenital heart disease
    Sandesh Shivananda
    Acute Care Transport Services, University of Toronto, Toronto, Ont, Canada
    Neonatology 97:154-62. 2010
    ..In many centers, an SpO(2) range of 75-85% is targeted but there is no published evidence of the clinical consequences of this approach...
  12. doi request reprint Pulmonary vascular and cardiac effects of peroxynitrite decomposition in newborn rats
    Jaques Belik
    Physiology and Experimental Medicine Program, The Hospital for Sick Children Research Institute, University of Toronto, Toronto, ON, Canada
    Free Radic Biol Med 49:1306-14. 2010
    ....
  13. doi request reprint Haemodynamic changes after delivery room surfactant administration to very low birth weight infants
    Arvind Sehgal
    Division of Neonatology, The Hospital for Sick Children, Toronto, Canada
    Arch Dis Child Fetal Neonatal Ed 95:F345-51. 2010
    ..Surfactant replacement therapy (SRT) reduces respiratory morbidity and mortality in premature infants. The goal of this study was to characterise the effects of delivery room SRT on the ductus arteriosus and early neonatal haemodynamics...
  14. doi request reprint Peroxynitrite mediates right-ventricular dysfunction in nitric oxide-exposed juvenile rats
    Robert P Jankov
    Clinical Integrative Biology, Sunnybrook Research Institute, Toronto, ON M4N 3M5, Canada
    Free Radic Biol Med 49:1453-67. 2010
    ..Our results provide the first evidence that iNO may adversely impact the right ventricle through increased local generation of peroxynitrite...
  15. ncbi request reprint Oxygen attenuates atelectasis-induced injury in the in vivo rat lung
    Michelle Duggan
    Programs in Lung and Integrative Biology, The Research Institute, Department of Critical Care Medicine, The Hosptial for Sick Children and the University of Toronto, Ontario, Canada
    Anesthesiology 103:522-31. 2005
    ..The authors hypothesized that addition of supplemental oxygen to an atelectasis-prone ventilation strategy would attenuate the pulmonary vascular effects and reduce the local levels of vasoconstrictor eicosanoids...
  16. ncbi request reprint Therapeutic hypercapnia prevents chronic hypoxia-induced pulmonary hypertension in the newborn rat
    Crystal Kantores
    Clinical Integrative Biology, Sunnybrook Research Institute, The Hospital for Sick Children Research Institute, Toronto, Ontario, Canada
    Am J Physiol Lung Cell Mol Physiol 291:L912-22. 2006
    ....
  17. doi request reprint Therapeutic effects of hypercapnia on chronic lung injury and vascular remodeling in neonatal rats
    Azhar Masood
    Canadian Institutes of Health Research Group in Lung Development, Toronto, ON, Canada M5G 1X8
    Am J Physiol Lung Cell Mol Physiol 297:L920-30. 2009
    ..Inhaled 5.5% CO2 provided a significant degree of protection against parenchymal and vascular injury in an animal model of chronic neonatal lung injury likely due, at least in part, to its inhibition of a phagocyte influx...
  18. ncbi request reprint Epinephrine increases mortality after brief asphyxial cardiac arrest in an in vivo rat model
    Conan L McCaul
    The Lung Biology Program, The Research Institute, University of Toronto, Toronto, Ontario, Canada
    Anesth Analg 102:542-8. 2006
    ..001) without systolic dysfunction. Epinephrine appears to be harmful in the setting of brief cardiac arrest after asphyxia...
  19. doi request reprint Newborn rat response to single vs. combined cGMP-dependent pulmonary vasodilators
    Masahiro Enomoto
    The Hospital for Sick Children Toronto, 555 Univ Ave, Toronto, Ontario M5G 1X8, Canada
    Am J Physiol Lung Cell Mol Physiol 306:L207-15. 2014
    ..These data suggest that clinical exposure to one cGMP-dependent pulmonary vasodilator may affect the response to other cGMP- or cAMP-mediated agonists. ..
  20. doi request reprint Accuracy of clinical diagnosis and decision to commence intravenous prostaglandin E1 in neonates presenting with hypoxemia in a transport setting
    Sandesh Shivananda
    The Hospital for Sick Children Research Institute, Acute Care Transport Services, University of Toronto, Toronto, Canada M5G 1X8
    J Crit Care 25:174.e1-9. 2010
    ..Setting goals for monitoring and initiating life-saving interventions such as prostaglandins (prostaglandin E(1) [PGE(1)]) during transport stabilization are dependent on establishing an accurate clinical diagnosis...
  21. doi request reprint A case of severe eosinophilia in a preterm infant
    Abdul R Shahein
    Division of aHematology Oncology, Department of Pediatrics, Hospital for Sick Children, Toronto, Ontario, Canada
    Pediatrics 127:e767-71. 2011
    ..Nonspecific treatment was the modality of choice because of unclear etiology in our case. Preterm infants with blood eosinophilia might not need immunomodulatory treatment despite extremely high absolute eosinophil counts...
  22. ncbi request reprint Therapeutic hypercapnia prevents inhaled nitric oxide-induced right ventricular systolic dysfunction in juvenile rats
    Kristyn Dunlop
    Physiology and Experimental Medicine Program, Hospital for Sick Children Research Institute, Toronto, Ontario, Canada
    Free Radic Biol Med . 2014
    ..Therapeutic hypercapnia also acts synergistically with iNO in normalizing RV hypertrophy, vascular remodeling and raised pulmonary vascular resistance secondary to chronic hypoxia...
  23. doi request reprint Non-invasive cardiac output monitoring in neonates using bioreactance: a comparison with echocardiography
    Dany E Weisz
    Department of Pediatrics, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada
    Neonatology 102:61-7. 2012
    ..Our aim was to evaluate a new method of non-invasive continuous cardiac output (CO) measurement (NICOM™) based on the principle of bioreactance in neonates...
  24. doi request reprint Acute changes in myocardial systolic function in preterm infants undergoing patent ductus arteriosus ligation: a tissue Doppler and myocardial deformation study
    Afif F El-Khuffash
    Department of Pediatrics, Mount Sinai Hospital, Toronto, Ontario, Canada
    J Am Soc Echocardiogr 25:1058-67. 2012
    ..Additionally, we sought to study the immediate effect of surgical ligation on the left ventricular tissue Doppler and strain measurements in the first 24 hours after surgery...
  25. doi request reprint Use of targeted neonatal echocardiography to prevent postoperative cardiorespiratory instability after patent ductus arteriosus ligation
    Amish Jain
    Division of Neonatology and Department of Pediatrics, University of Toronto, Toronto, Ontario, Canada
    J Pediatr 160:584-589.e1. 2012
    ..To investigate the value of targeted neonatal echocardiography (TnECHO) in predicting cardiorespiratory instability after patent ductus arteriosus (PDA) ligation, and to evaluate the impact of TnECHO-directed care...
  26. doi request reprint Troponin T, N-terminal pro natriuretic peptide and a patent ductus arteriosus scoring system predict death before discharge or neurodevelopmental outcome at 2 years in preterm infants
    Afif F El-Khuffash
    Department of Neonatology, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, Canada
    Arch Dis Child Fetal Neonatal Ed 96:F133-7. 2011
    ..The use of troponin T (cTnT) and N-terminal Pro-BNP (NTpBNP) in combination with echocardiography assessment may facilitate the development of a superior predictive model...
  27. ncbi request reprint Enhanced intensive care for the neonatal ductus arteriosus
    Lilian S Teixeira
    Division of Neonatology, Department of Paediatrics, The Hospital for Sick Children, Toronto, Canada
    Acta Paediatr 95:394-403. 2006
    ..The postoperative course is often complicated by left ventricular failure, pulmonary edema, and/or hemodynamic instability requiring close monitoring and physiologically relevant therapeutic interventions...
  28. ncbi request reprint Intravenous morphine and topical tetracaine for treatment of pain in [corrected] neonates undergoing central line placement
    Anna Taddio
    Department of Pharmacy, The Hospital for Sick Children, Faculty of Pharmaceutical Sciences, University of Toronto, Toronto, Ontario
    JAMA 295:793-800. 2006
    ..There is limited evidence of the analgesic effectiveness of opioid analgesia or topical anesthesia during central line placement in neonates, and there are no previous studies of their relative effectiveness...
  29. ncbi request reprint The impact of amplitude-integrated electroencephalography on NICU practice
    Juan Pablo Appendino
    Division of Neurology, The Hospital for Sick Children Research Institute and University of Toronto, Toronto, Ontario, Canada
    Can J Neurol Sci 39:355-60. 2012
    ..To examine how the introduction of amplitude-integrated electroencephalography (aEEG) to our neonatal intensive care unit (NICU) influenced clinical practice...
  30. ncbi request reprint The hemodynamically significant ductus arteriosus in critically ill full-term neonates. Two case reports?
    Linh G Ly
    Division of Neonatology, The Hospital for Sick Children, Toronto, Canada
    Neonatology 91:260-5. 2007
    ..PDA ligation should be considered an option for full term neonates with cardiac failure secondary to a HSDA when other therapeutic options fail...
  31. doi request reprint Is routine preoperative 2-dimensional echocardiography necessary for infants with esophageal atresia, omphalocele, or anorectal malformations?
    Ahmed Nasr
    Department of Surgery, Hospital for Sick Children, Toronto, Ontario, Canada M5G1X8
    J Pediatr Surg 45:876-9. 2010
    ..We wished to determine if routine echocardiography is necessary for neonates with these diagnoses, or if appropriate patients could be selected...
  32. ncbi request reprint Atelectasis causes vascular leak and lethal right ventricular failure in uninjured rat lungs
    Michelle Duggan
    The Lung Biology Program, The Research Institute, and the Department of Critical Care Medicine, The Hospital for Sick Children, and the Interdepartmental Division of Critical Care Medicine, University of Toronto, Ontario, Canada
    Am J Respir Crit Care Med 167:1633-40. 2003
    ....
  33. pmc Lessons learned during implementation of therapeutic hypothermia for neonatal hypoxic ischemic encephalopathy in a regional transport program in Ontario
    Faiza Khurshid
    Division of Neonatology, The Hospital for Sick Children
    Paediatr Child Health 16:153-6. 2011
    ..Since the recent introduction of TH for HIE in many centres, reviews of practices during the implementation of TH in Canada have not been published...
  34. doi request reprint Role of amplitude-integrated electroencephalography in neonates with cardiovascular compromise
    Walid I El-Naggar
    Department of Pediatrics, University of Toronto, Toronto, Ontario, Canada M5G 1X8
    J Crit Care 25:317-21. 2010
    ..The role of aEEG in disorders where cerebral perfusion/oxygenation is affected by cardiac or pulmonary disease is unknown...
  35. ncbi request reprint Inhaled nitric oxide therapy for persistent pulmonary hypertension of the newborn: when is it enough?
    Robert P Jankov
    Department of Paediatrics, University of Toronto, Toronto, Ontario, Canada M5G 1X8
    J Crit Care 20:294-5. 2005
  36. doi request reprint Cardiovascular support in preterm infants: a survey of practices in Australia and New Zealand
    Arvind Sehgal
    Monash Newborn, Monash Medical Centre and Monash University, Melbourne, Victoria, Ontario, Australia
    J Paediatr Child Health 48:317-23. 2012
    ..The aim of this study was to characterise practices related to the management of haemodynamic instability in premature infants...
  37. doi request reprint Neonatologist-performed functional echocardiography in the neonatal intensive care unit
    Afif F El-Khuffash
    Department of Neonatology, Hospital for Sick Children, 555 University Avenue, Toronto, Ontario M5G1X8, Canada
    Semin Fetal Neonatal Med 16:50-60. 2011
    ..This review examines the potential clinical role of ultrasound methods in the NICU; specifically, its applications in different disease states, and how the technology may be introduced safely in the NICU...
  38. ncbi request reprint Challenges of implementing point-of-care testing (POCT) glucose meters in a pediatric acute care setting
    Peter A Kavsak
    Division of Clinical Biochemistry, Hospital for Sick Children, University of Toronto, Toronto, ON, M5G 1X8, Canada
    Clin Biochem 37:811-7. 2004
    ..To investigate factors contributing to analytical bias in POCT glucose values generated by the NICU versus the core laboratory...
  39. pmc Protein binding predictions in infants
    Patrick J McNamara
    Division of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY 40536 0082, USA
    AAPS PharmSci 4:E4. 2002
    ..A model that incorporates the fraction unbound in adults and the ratio of the binding protein concentration between infants and adults successfully predicted the fraction unbound in infants and children...
  40. ncbi request reprint Hydromorphone transfer into breast milk after intranasal administration
    Jeffrey E Edwards
    Graduate Center for Toxicology, College of Pharmacy, University of Kentucky, Lexington 40536 0082, USA
    Pharmacotherapy 23:153-8. 2003
    ..To determine the distribution of hydromorphone into breast milk and the potential exposure of the suckling infant, and whether the distribution of hydromorphone into milk can be predicted accurately by a passive diffusion model...
  41. ncbi request reprint Effect of fluticasone propionate nasal spray on bioavailability of intranasal hydromorphone hydrochloride in patients with allergic rhinitis
    George A Davis
    Division of Pharmacy Practice and Science, College of Pharmacy, University of Kentucky, Lexington 40536 0293, USA
    Pharmacotherapy 24:26-32. 2004
    ..To investigate the effect of the nasal corticosteroid fluticasone propionate on the bioavailability and pharmacokinetics of single-dose intranasal hydromorphone hydrochloride in patients with allergic rhinitis...
  42. ncbi request reprint Too much of a good thing? Epinephrine on trial!
    Patrick J McNamara
    J Perinatol 25:223-4; author reply 225. 2005
  43. ncbi request reprint Sodium dependence of nitrofurantoin active transport across mammary epithelia and effects of dipyridamole, nucleosides, and nucleobases
    Phillip M Gerk
    University of Kentucky College of Pharmacy, Division of Pharmaceutical Science Lexington, 40536 0082, USA
    Pharm Res 19:299-305. 2002
    ..The sodium dependence and effects of nucleoside and nucleobase transport inhibitors were determined to ascertain the role of sodium dependent nucleoside or nucleobase transporters in nitrofurantoin active transport across mammary epithelia...
  44. ncbi request reprint Hazardous course of an end-tidal carbon dioxide catheter in a premature infant
    Dana Al-Nabhani
    Anesthesiology 107:180-1. 2007
  45. ncbi request reprint Caution with prolonged or high-dose infusions of catecholamines in premature infants
    Patrick J McNamara
    Acta Paediatr 94:980-2. 2005