Patrick J McNamara
Affiliation: The Hospital for Sick Children
- Towards rational management of the patent ductus arteriosus: the need for disease stagingPatrick J McNamara
Patrick J McNamara, The Hospital for Sick Children, 555 University Avenue, Toronto M5G 1X8, Canada
Arch Dis Child Fetal Neonatal Ed 92:F424-7. 2007
- Pharmacology of milrinone in neonates with persistent pulmonary hypertension of the newborn and suboptimal response to inhaled nitric oxidePatrick J McNamara
Departments of Pediatrics, University of Toronto, Toronto, Canada
Pediatr Crit Care Med 14:74-84. 2013..The primary objective was to investigate the pharmacological profile of milrinone in persistent pulmonary hypertension of the newborn. Secondary objectives were to delineate short-term outcomes and safety profile...
- Intraurethral knot in a very-low-birth-weight infant: radiological recognition, surgical management and preventionAbhay Lodha
Division of Neonatology, The Hospital for Sick Children, 555 University Ave, Toronto M5G 1X8, Canada
Pediatr Radiol 35:713-6. 2005..All staff involved in the insertion, maintenance or removal of these catheters should be suitably trained to minimize the risk of knots and related complications...
- Milrinone improves oxygenation in neonates with severe persistent pulmonary hypertension of the newbornPatrick J McNamara
Division of Neonatology, Department of Pediatrics, University of Toronto, Hospital for Sick Children, Toronto, Ontario, Canada M5G 1X8
J Crit Care 21:217-22. 2006..Milrinone is a promising adjunctive therapy because of its pulmonary vasodilator properties and cardiotropic effects...
- Patent ductus arteriosus ligation is associated with impaired left ventricular systolic performance in premature infants weighing less than 1000 gPatrick J McNamara
Physiology and Experimental Medicine, The Hospital for Sick Children Research Institute, Toronto, Ontario, Canada
J Thorac Cardiovasc Surg 140:150-7. 2010..The ability of the immature myocardium to compensate for altered afterload is poorly understood. The aim of this study was to characterize the effects of patent ductus arteriosus ligation on myocardial performance in preterm infants...
- Effects of rho-kinase inhibition on pulmonary hypertension, lung growth, and structure in neonatal rats chronically exposed to hypoxiaAdrian J A Ziino
Clinical Integrative Biology, Sunnybrook Research Institute, Toronto, Ontario, Canada M4N 3M5
Pediatr Res 67:177-82. 2010..Limiting effects on vascular remodeling likely resulted, in major part, from attenuated vascular PDGF-BB/beta-receptor signaling...
- Newborn rat response to single vs. combined cGMP-dependent pulmonary vasodilatorsMasahiro Enomoto
The Hospital for Sick Children Toronto, 555 Univ Ave, Toronto, Ontario M5G 1X8, Canada
Am J Physiol Lung Cell Mol Physiol 306:L207-15. 2014..These data suggest that clinical exposure to one cGMP-dependent pulmonary vasodilator may affect the response to other cGMP- or cAMP-mediated agonists. ..
- Therapeutic hypercapnia prevents bleomycin-induced pulmonary hypertension in neonatal rats by limiting macrophage-derived tumor necrosis factor-αA Charlotte P Sewing
Physiology and Experimental Medicine Program, Hospital for Sick Children Research Institute, Toronto, Ontario, Canada
Am J Physiol Lung Cell Mol Physiol 303:L75-87. 2012....
- Acute vasodilator effects of Rho-kinase inhibitors in neonatal rats with pulmonary hypertension unresponsive to nitric oxidePatrick J McNamara
Department of Newborn and Developmental Paediatrics, Sunnybrook Health Sciences Centre, 76 Grenville Street, Toronto, Ontario, Canada
Am J Physiol Lung Cell Mol Physiol 294:L205-13. 2008..ROCK-mediated vasoconstriction appears to play a key role in chronic PHT in our two neonatal rat models. Inhibitors of ROCK have potential as a testable therapy in neonates with PHT that is refractory to NO...
- Sustained therapeutic hypercapnia attenuates pulmonary arterial Rho-kinase activity and ameliorates chronic hypoxic pulmonary hypertension in juvenile ratsGary Peng
Physiology and Experimental Medicine Program, Hospital for Sick Children Research Institute, Toronto, Ontario, Canada
Am J Physiol Heart Circ Physiol 302:H2599-611. 2012..Increased PKG content and activity appears to play a major upstream role in CO(2)-induced suppression of ROCK activity in pulmonary arterial smooth muscle...
- Rescue treatment with a Rho-kinase inhibitor normalizes right ventricular function and reverses remodeling in juvenile rats with chronic pulmonary hypertensionEmily Z Xu
Clinical Integrative Biology, Sunnybrook Research Institute, University of Toronto, Toronto, Ontario, Canada
Am J Physiol Heart Circ Physiol 299:H1854-64. 2010..In addition, our data suggest that ROCK-II may be dominant in enhancing survival of pulmonary arterial smooth muscle...
- Impact of oxygen saturation targets and oxygen therapy during the transport of neonates with clinically suspected congenital heart diseaseSandesh Shivananda
Acute Care Transport Services, University of Toronto, Toronto, Ont, Canada
Neonatology 97:154-62. 2010..In many centers, an SpO(2) range of 75-85% is targeted but there is no published evidence of the clinical consequences of this approach...
- Pulmonary vascular and cardiac effects of peroxynitrite decomposition in newborn ratsJaques Belik
Physiology and Experimental Medicine Program, The Hospital for Sick Children Research Institute, University of Toronto, Toronto, ON, Canada
Free Radic Biol Med 49:1306-14. 2010....
- Haemodynamic changes after delivery room surfactant administration to very low birth weight infantsArvind Sehgal
Division of Neonatology, The Hospital for Sick Children, Toronto, Canada
Arch Dis Child Fetal Neonatal Ed 95:F345-51. 2010..Surfactant replacement therapy (SRT) reduces respiratory morbidity and mortality in premature infants. The goal of this study was to characterise the effects of delivery room SRT on the ductus arteriosus and early neonatal haemodynamics...
- Peroxynitrite mediates right-ventricular dysfunction in nitric oxide-exposed juvenile ratsRobert P Jankov
Clinical Integrative Biology, Sunnybrook Research Institute, Toronto, ON M4N 3M5, Canada
Free Radic Biol Med 49:1453-67. 2010..Our results provide the first evidence that iNO may adversely impact the right ventricle through increased local generation of peroxynitrite...
- Therapeutic hypercapnia prevents chronic hypoxia-induced pulmonary hypertension in the newborn ratCrystal Kantores
Clinical Integrative Biology, Sunnybrook Research Institute, The Hospital for Sick Children Research Institute, Toronto, Ontario, Canada
Am J Physiol Lung Cell Mol Physiol 291:L912-22. 2006....
- Oxygen attenuates atelectasis-induced injury in the in vivo rat lungMichelle Duggan
Programs in Lung and Integrative Biology, The Research Institute, Department of Critical Care Medicine, The Hosptial for Sick Children and the University of Toronto, Ontario, Canada
Anesthesiology 103:522-31. 2005..The authors hypothesized that addition of supplemental oxygen to an atelectasis-prone ventilation strategy would attenuate the pulmonary vascular effects and reduce the local levels of vasoconstrictor eicosanoids...
- Therapeutic effects of hypercapnia on chronic lung injury and vascular remodeling in neonatal ratsAzhar Masood
Canadian Institutes of Health Research Group in Lung Development, Toronto, ON, Canada M5G 1X8
Am J Physiol Lung Cell Mol Physiol 297:L920-30. 2009..Inhaled 5.5% CO2 provided a significant degree of protection against parenchymal and vascular injury in an animal model of chronic neonatal lung injury likely due, at least in part, to its inhibition of a phagocyte influx...
- Epinephrine increases mortality after brief asphyxial cardiac arrest in an in vivo rat modelConan L McCaul
The Lung Biology Program, The Research Institute, University of Toronto, Toronto, Ontario, Canada
Anesth Analg 102:542-8. 2006..001) without systolic dysfunction. Epinephrine appears to be harmful in the setting of brief cardiac arrest after asphyxia...
- Accuracy of clinical diagnosis and decision to commence intravenous prostaglandin E1 in neonates presenting with hypoxemia in a transport settingSandesh Shivananda
The Hospital for Sick Children Research Institute, Acute Care Transport Services, University of Toronto, Toronto, Canada M5G 1X8
J Crit Care 25:174.e1-9. 2010..Setting goals for monitoring and initiating life-saving interventions such as prostaglandins (prostaglandin E(1) [PGE(1)]) during transport stabilization are dependent on establishing an accurate clinical diagnosis...
- A case of severe eosinophilia in a preterm infantAbdul R Shahein
Division of aHematology Oncology, Department of Pediatrics, Hospital for Sick Children, Toronto, Ontario, Canada
Pediatrics 127:e767-71. 2011..Nonspecific treatment was the modality of choice because of unclear etiology in our case. Preterm infants with blood eosinophilia might not need immunomodulatory treatment despite extremely high absolute eosinophil counts...
- PDA ligation and health outcomes: a meta-analysisDany E Weisz
Department of Newborn and Developmental Pediatrics, Sunnybrook Health Sciences Center, Toronto, Canada
Pediatrics 133:e1024-46. 2014..The objective was to systematically review and meta-analyze the impact of PDA ligation in preterm infants at <32 weeks' gestation on the risk of mortality, severe neonatal morbidities, and NDI in early childhood...
- Therapeutic hypercapnia prevents inhaled nitric oxide-induced right-ventricular systolic dysfunction in juvenile ratsKristyn Dunlop
Physiology and Experimental Medicine Program, Hospital for Sick Children Research Institute, Toronto, ON, Canada M5G 1X8
Free Radic Biol Med 69:35-49. 2014..Therapeutic hypercapnia also acts synergistically with iNO in normalizing RV hypertrophy, vascular remodeling, and raised pulmonary vascular resistance secondary to chronic hypoxia...
- Non-invasive cardiac output monitoring in neonates using bioreactance: a comparison with echocardiographyDany E Weisz
Department of Pediatrics, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada
Neonatology 102:61-7. 2012..Our aim was to evaluate a new method of non-invasive continuous cardiac output (CO) measurement (NICOM™) based on the principle of bioreactance in neonates...
- Acute changes in myocardial systolic function in preterm infants undergoing patent ductus arteriosus ligation: a tissue Doppler and myocardial deformation studyAfif F El-Khuffash
Department of Pediatrics, Mount Sinai Hospital, Toronto, Ontario, Canada
J Am Soc Echocardiogr 25:1058-67. 2012..Additionally, we sought to study the immediate effect of surgical ligation on the left ventricular tissue Doppler and strain measurements in the first 24 hours after surgery...
- Use of targeted neonatal echocardiography to prevent postoperative cardiorespiratory instability after patent ductus arteriosus ligationAmish Jain
Division of Neonatology and Department of Pediatrics, University of Toronto, Toronto, Ontario, Canada
J Pediatr 160:584-589.e1. 2012..To investigate the value of targeted neonatal echocardiography (TnECHO) in predicting cardiorespiratory instability after patent ductus arteriosus (PDA) ligation, and to evaluate the impact of TnECHO-directed care...
- Enhanced intensive care for the neonatal ductus arteriosusLilian S Teixeira
Division of Neonatology, Department of Paediatrics, The Hospital for Sick Children, Toronto, Canada
Acta Paediatr 95:394-403. 2006..The postoperative course is often complicated by left ventricular failure, pulmonary edema, and/or hemodynamic instability requiring close monitoring and physiologically relevant therapeutic interventions...
- Troponin T, N-terminal pro natriuretic peptide and a patent ductus arteriosus scoring system predict death before discharge or neurodevelopmental outcome at 2 years in preterm infantsAfif F El-Khuffash
Department of Neonatology, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, Canada
Arch Dis Child Fetal Neonatal Ed 96:F133-7. 2011..The use of troponin T (cTnT) and N-terminal Pro-BNP (NTpBNP) in combination with echocardiography assessment may facilitate the development of a superior predictive model...
- Vasopressin improves survival compared with epinephrine in a neonatal piglet model of asphyxial cardiac arrestPatrick J McNamara
1 Division of Neonatology, Department of Pediatrics, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada 2 Physiology and Experimental Medicine Program, Hospital for Sick Children, Toronto, Ontario, Canada
Pediatr Res 75:738-48. 2014..Vasopressin is a pulmonary vasodilator and systemic vasopressor. We investigated the effect of epinephrine vs. vasopressin on survival and hemodynamics after neonatal porcine cardiac arrest (CA)...
- Intravenous morphine and topical tetracaine for treatment of pain in [corrected] neonates undergoing central line placementAnna Taddio
Department of Pharmacy, The Hospital for Sick Children, Faculty of Pharmaceutical Sciences, University of Toronto, Toronto, Ontario
JAMA 295:793-800. 2006..There is limited evidence of the analgesic effectiveness of opioid analgesia or topical anesthesia during central line placement in neonates, and there are no previous studies of their relative effectiveness...
- The impact of amplitude-integrated electroencephalography on NICU practiceJuan Pablo Appendino
Division of Neurology, The Hospital for Sick Children Research Institute and University of Toronto, Toronto, Ontario, Canada
Can J Neurol Sci 39:355-60. 2012..To examine how the introduction of amplitude-integrated electroencephalography (aEEG) to our neonatal intensive care unit (NICU) influenced clinical practice...
- Is routine preoperative 2-dimensional echocardiography necessary for infants with esophageal atresia, omphalocele, or anorectal malformations?Ahmed Nasr
Department of Surgery, Hospital for Sick Children, Toronto, Ontario, Canada M5G1X8
J Pediatr Surg 45:876-9. 2010..We wished to determine if routine echocardiography is necessary for neonates with these diagnoses, or if appropriate patients could be selected...
- The hemodynamically significant ductus arteriosus in critically ill full-term neonates. Two case reports?Linh G Ly
Division of Neonatology, The Hospital for Sick Children, Toronto, Canada
Neonatology 91:260-5. 2007..PDA ligation should be considered an option for full term neonates with cardiac failure secondary to a HSDA when other therapeutic options fail...
- Atelectasis causes vascular leak and lethal right ventricular failure in uninjured rat lungsMichelle Duggan
The Lung Biology Program, The Research Institute, and the Department of Critical Care Medicine, The Hospital for Sick Children, and the Interdepartmental Division of Critical Care Medicine, University of Toronto, Ontario, Canada
Am J Respir Crit Care Med 167:1633-40. 2003....
- Lessons learned during implementation of therapeutic hypothermia for neonatal hypoxic ischemic encephalopathy in a regional transport program in OntarioFaiza Khurshid
Division of Neonatology, The Hospital for Sick Children
Paediatr Child Health 16:153-6. 2011..Since the recent introduction of TH for HIE in many centres, reviews of practices during the implementation of TH in Canada have not been published...
- Role of amplitude-integrated electroencephalography in neonates with cardiovascular compromiseWalid I El-Naggar
Department of Pediatrics, University of Toronto, Toronto, Ontario, Canada M5G 1X8
J Crit Care 25:317-21. 2010..The role of aEEG in disorders where cerebral perfusion/oxygenation is affected by cardiac or pulmonary disease is unknown...
- Vasopressin as a rescue therapy for refractory pulmonary hypertension in neonates: case seriesAdel Mohamed
1Division of Neonatology, Mount Sinai Hospital, Toronto, ON, Canada 2Department of Paediatrics, University of Toronto, Toronto, ON, Canada 3Division of Neonatology, Hospital for Sick Children, Toronto, ON, Canada 4Department of Physiology, University of Toronto, Toronto, ON, Canada
Pediatr Crit Care Med 15:148-54. 2014..To determine the effect of vasopressin therapy on the efficacy of oxygenation and arterial pressure in infants with severe persistent pulmonary hypertension of the newborn...
- Inhaled nitric oxide therapy for persistent pulmonary hypertension of the newborn: when is it enough?Robert P Jankov
Department of Paediatrics, University of Toronto, Toronto, Ontario, Canada M5G 1X8
J Crit Care 20:294-5. 2005
- Cardiovascular support in preterm infants: a survey of practices in Australia and New ZealandArvind Sehgal
Monash Newborn, Monash Medical Centre and Monash University, Melbourne, Victoria, Ontario, Australia
J Paediatr Child Health 48:317-23. 2012..The aim of this study was to characterise practices related to the management of haemodynamic instability in premature infants...
- Challenges of implementing point-of-care testing (POCT) glucose meters in a pediatric acute care settingPeter A Kavsak
Division of Clinical Biochemistry, Hospital for Sick Children, University of Toronto, Toronto, ON, M5G 1X8, Canada
Clin Biochem 37:811-7. 2004..To investigate factors contributing to analytical bias in POCT glucose values generated by the NICU versus the core laboratory...
- Neonatologist-performed functional echocardiography in the neonatal intensive care unitAfif F El-Khuffash
Department of Neonatology, Hospital for Sick Children, 555 University Avenue, Toronto, Ontario M5G1X8, Canada
Semin Fetal Neonatal Med 16:50-60. 2011..This review examines the potential clinical role of ultrasound methods in the NICU; specifically, its applications in different disease states, and how the technology may be introduced safely in the NICU...
- Hazardous course of an end-tidal carbon dioxide catheter in a premature infantDana Al-Nabhani
Anesthesiology 107:180-1. 2007
- Protein binding predictions in infantsPatrick J McNamara
Division of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY 40536 0082, USA
AAPS PharmSci 4:E4. 2002..A model that incorporates the fraction unbound in adults and the ratio of the binding protein concentration between infants and adults successfully predicted the fraction unbound in infants and children...
- Hydromorphone transfer into breast milk after intranasal administrationJeffrey E Edwards
Graduate Center for Toxicology, College of Pharmacy, University of Kentucky, Lexington 40536 0082, USA
Pharmacotherapy 23:153-8. 2003..To determine the distribution of hydromorphone into breast milk and the potential exposure of the suckling infant, and whether the distribution of hydromorphone into milk can be predicted accurately by a passive diffusion model...
- Too much of a good thing? Epinephrine on trial!Patrick J McNamara
J Perinatol 25:223-4; author reply 225. 2005
- Sodium dependence of nitrofurantoin active transport across mammary epithelia and effects of dipyridamole, nucleosides, and nucleobasesPhillip M Gerk
University of Kentucky College of Pharmacy, Division of Pharmaceutical Science Lexington, 40536 0082, USA
Pharm Res 19:299-305. 2002..The sodium dependence and effects of nucleoside and nucleobase transport inhibitors were determined to ascertain the role of sodium dependent nucleoside or nucleobase transporters in nitrofurantoin active transport across mammary epithelia...
- Effect of fluticasone propionate nasal spray on bioavailability of intranasal hydromorphone hydrochloride in patients with allergic rhinitisGeorge A Davis
Division of Pharmacy Practice and Science, College of Pharmacy, University of Kentucky, Lexington 40536 0293, USA
Pharmacotherapy 24:26-32. 2004..To investigate the effect of the nasal corticosteroid fluticasone propionate on the bioavailability and pharmacokinetics of single-dose intranasal hydromorphone hydrochloride in patients with allergic rhinitis...
- Caution with prolonged or high-dose infusions of catecholamines in premature infantsPatrick J McNamara
Acta Paediatr 94:980-2. 2005